Metabolomics applied to the pancreatic islet.

Journal Article (Journal Article;Review)

Metabolomics, the characterization of the set of small molecules in a biological system, is advancing research in multiple areas of islet biology. Measuring a breadth of metabolites simultaneously provides a broad perspective on metabolic changes as the islets respond dynamically to metabolic fuels, hormones, or environmental stressors. As a result, metabolomics has the potential to provide new mechanistic insights into islet physiology and pathophysiology. Here we summarize advances in our understanding of islet physiology and the etiologies of type-1 and type-2 diabetes gained from metabolomics studies.

Full Text

Duke Authors

Cited Authors

  • Gooding, JR; Jensen, MV; Newgard, CB

Published Date

  • January 1, 2016

Published In

Volume / Issue

  • 589 /

Start / End Page

  • 120 - 130

PubMed ID

  • 26116790

Pubmed Central ID

  • PMC4863644

Electronic International Standard Serial Number (EISSN)

  • 1096-0384

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • United States