Overview
Current Appointments & Affiliations
W. David and Sarah W. Stedman Distinguished Professor of Nutrition in the School of Medicine
·
2002 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Professor of Pharmacology and Cancer Biology
·
2002 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Director, Sarah W. Stedman Nutrition and Metabolism Center
·
2002 - Present
Sarah Stedman Nutrition & Metabolism Center,
Duke Molecular Physiology Institute
Professor in Medicine
·
2020 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Member of the Duke Cancer Institute
·
2002 - Present
Duke Cancer Institute,
Institutes and Centers
Affiliate, Duke Global Health Institute
·
2009 - Present
Duke Global Health Institute,
University Institutes and Centers
Recent Publications
Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF.
Journal Article JACC Basic Transl Sci · March 2025 Growing evidence supports therapeutic ketosis in heart failure with reduced ejection fraction, though uncertainty exists regarding use with SGLT2i and dose-dependent effects. In a phase I trial of 2 ketone ester (KE) doses in 20 heart failure with reduced ... Full text Link to item CiteIntegration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism.
Journal Article Cell Rep · February 25, 2025 The transcription factor carbohydrate response element binding protein (ChREBP) activates genes of glucose, fructose, and lipid metabolism in response to carbohydrate feeding. Integrated transcriptomic and metabolomic analyses in rats with GalNac-siRNA-med ... Full text Link to item CiteMetabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction.
Journal Article Circ Heart Fail · November 2024 BACKGROUND: Mechanisms of benefit with SGLT2is (sodium-glucose cotransporter-2 inhibitors) in heart failure (HF) remain incompletely characterized. Dapagliflozin alters ketone and fatty acid metabolism in HF with reduced ejection fraction though similar ef ... Full text Link to item CiteRecent Grants
Fibro/Adipogenic Progenitor Metabolic Reprogramming for Age-Related Muscle Fibrosis
ResearchMentor · Awarded by National Institutes of Health · 2024 - 2029Endocrinology and Metabolism Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Reprogramming glutamine metabolism in pancreatic beta cells
ResearchPrincipal Investigator · Awarded by University of Pennsylvania · 2024 - 2028View All Grants
Education, Training & Certifications
University of Texas, Dallas ·
1984
Ph.D.