Christopher Bang Newgard

Christopher Bang Newgard
W. David and Sarah W. Stedman Professor of Nutrition in the School of Medicine

Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) Development of methods for protection of β-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies on the mechanisms involved in lipid-induced impairment of insulin secretion and action in diabetes.

Current Appointments & Affiliations

W. David and Sarah W. Stedman Professor of Nutrition in the School of Medicine, Pharmacology & Cancer Biology, Basic Science Departments 2002
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2002
Director, Sarah W. Stedman Nutrition and Metabolism Center, Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute 2002
Professor of Biochemistry, Biochemistry, Basic Science Departments 2002
Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2006
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2002
Affiliate, Duke Global Health Institute, Duke Global Health Institute, University Institutes and Centers 2009

Contact Information

300 North Duke Street, Durham, NC 27701
Duke Box 104775, Durham, NC 27710
newga002@mc.duke.edu (919) 668-6059

Background
Education, Training, & Certifications
- Ph.D., University of Texas at Dallas 1984
Duke Appointment History
- Research Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2002 - 2006
- Instructor, Temporary in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2002
Recognition
In the News
- DEC 13, 2016
  
  Duke Teams Tapped to Examine the Molecular Benefits of Exercise
- SEP 25, 2015
  
  Newly Identified Biochemical Pathway Could Be Target For Insulin Control
- APR 15, 2015 WNCN
  
  Durham Innovation District attracts Duke I&E Initiative
Awards & Honors
- MERIT Award. National Institutes of Health. 2005
- Endocrinology and Metabolism Section Awards/Solomon A. Berson Distinguished Lecture. American Physiological Society. 2003
Expertise
Global Scholarship
- Research
  - Singapore (Country)
Research
Selected Grants
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Center for Atypical Diabetes Research and Evaluation (CADRE) awarded by Baylor College of Medicine 2018 - 2023
- The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Myocardial Fuel Section awarded by National Institutes of Health 2018 - 2023
- Core Laboratory - targeted metabolomics study awarded by Axcella Health 2019 - 2023
- Serotonin as a Novel Biomarker for Progression to Type 2 Diabetes in Obese Adolescents awarded by National Institutes of Health 2018 - 2022
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism awarded by National Institutes of Health 2018 - 2022
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2022
- A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics awarded by National Institutes of Health 2016 - 2021
- AHA Career Development Award awarded by American Heart Association 2018 - 2021
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
- IPA - Michael Hauser awarded by Durham Veterans Affairs Medical Center 2019 - 2021
- The Effects of a Novel Statin-Induced Protein Modification on Fatty Acid Synthase awarded by National Institutes of Health 2017 - 2020
- Engineered Glucose Metabolism in Insulin Secreting Cells awarded by National Institutes of Health 2002 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Weston Family Microbiome Initiative 2018 awarded by University of Alberta - Edmonton 2018 - 2020
- Small molecules with pleiotropic positive effects on beta-cell health awarded by Eli Lilly and Company 2019 - 2020
- 13C-Metabolic Flux Analysis for Understanding Cardiac Energy Homeostasis awarded by National Institutes of Health 2017 - 2019
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Networks of nutritional stress in human pancreatic islet cells awarded by Merck Sharp & Dohme 2018 - 2019
- A Biochemical Roadmap of Exercise Signaling awarded by Broad Institute 2016 - 2019
- EED Project awarded by Washington University in St. Louis 2017 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Novel SIRT5 Enzymatic Activity Regulates Cellular Mechanisms of Aging and Disease awarded by National Institutes of Health 2014 - 2019
- Metabolomic Biomarkers Predictores of Long-term Success Following Bariatric Surgery awarded by Columbia University 2015 - 2019
- Metabolomics Core A awarded by Washington University in St. Louis 2014 - 2019
- Project 1 awarded by Washington University in St. Louis 2014 - 2019
- Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2014 - 2019
- Core Laboratory - metabolomics analysis-healthy baseline awarded by Axcella Health 2019
- Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Buck Institute for Research on Aging 2017 - 2019
- Biomarkers of Mental Stress Induced Myocardial Ischemia and CHD Prognosis awarded by National Institutes of Health 2014 - 2019
- Metabolic fate of orally-administered isopentanol in wild-type Black 6 mice awarded by Synlogic 2018 - 2019
- Biochemical Mechanisms of NNMT Inhibitors awarded by Eli Lilly and Company 2017 - 2018
- Collaborative Study on Biomarkers of Fatty Liver Diseases awarded by Pfizer, Inc. 2017 - 2018
- Growth Failure in Extremely Preterm Infants: Microbiomic and Metabolomic Analysis awarded by Gerber Foundation 2014 - 2018
- Duke Research Training Program for Pediatricians awarded by National Institutes of Health 2002 - 2018
- Eli Lilly Collaboration awarded by Eli Lilly and Company 2017 - 2018
- HIRN UCSD awarded by University of California - San Diego 2017 - 2018
- Ethanol-induced Protein Acylation Regulates Metabolism awarded by National Institutes of Health 2013 - 2018
- Gene expression programs of lactic acidosis in human cancers awarded by National Institutes of Health 2007 - 2018
- Mitochondrial Protein Acetylation and Energy Metabolism in Muscle awarded by National Institutes of Health 2015 - 2018
- Center for Molecular & Cellular Studies of Ped Disease awarded by National Institutes of Health 2003 - 2018
- Microbiome engineering to affect host nitrogen/amino acid metabolism awarded by Synlogic 2017 - 2018
- Role of Protein Malonylation in Regulating Mitochondrial Function awarded by National Institutes of Health 2015 - 2017
- Supplement - A Biochemical Roadmap of Exercise Signaling awarded by Broad Institute 2017
- Development of Novel Therapies for NIDDM awarded by National Institutes of Health 1984 - 2017
- Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Gladstone 2010 - 2017
- Sponsored Research Agreement awarded by Eli Lilly and Company 2015 - 2017
- Beta cell development and type 2 diabetes: the role of lactogen signaling awarded by American Diabetes Association 2014 - 2016
- The Breast Milk, Gut Microbiome and Immunity Project awarded by Washington University in St. Louis 2013 - 2016
- VA268-15-J-0133 awarded by Durham Veterans Affairs Medical Center 2015 - 2016
- VA240-13-R-0080 awarded by Department of Veterans Affairs 2013 - 2016
- Regulation of Islet Beta-Cell Function via Islet-Derived VGF Peptides awarded by National Institutes of Health 2013 - 2016
- Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD awarded by National Institutes of Health 2009 - 2016
- Iron homeostasis in mammalian muscle awarded by National Institutes of Health 2011 - 2016
- Mass Spectrometry, Immunological and Clinical Chemistry Assessment of Target Metabolomic awarded by Durham Veterans Affairs Medical Center 2014 - 2015
- Exploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory disease awarded by National Institutes of Health 2015
- Metabolic Regulators of Insulin Secretion and Insulin Resistance awarded by National Institutes of Health 2013 - 2015
- T cell metabolism as a determinant of differentiation in allergic asthma awarded by National Institutes of Health 2011 - 2015
- Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication awarded by Mount Sinai School of Medicine 2013 - 2015
- Multidisciplinary Neonatal Training Grant awarded by National Institutes of Health 2010 - 2015
- VA contract Base year awarded by Department of Veterans Affairs 2013 - 2014
- Fat Oxidation, Redox Stress and Insulin Resistance in Skeletal Muscle awarded by National Institutes of Health 2011 - 2014
- Glucose Transport in Regulation of T Cell Activation and Inflammation awarded by National Institutes of Health 2012 - 2014
- Glucose metabolism and cell death in cancer awarded by National Institutes of Health 2007 - 2014
- Hormonal regulation of a Ca2+/AMPK signaling pathway awarded by National Institutes of Health 1984 - 2011
- Integration of Oncogenic Networks in Cancer Phenotypes awarded by National Institutes of Health 2004 - 2011
- G(alpha)Z signaling in insulin secretion and glucose tolerance awarded by National Institutes of Health 2008 - 2010
- Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & Obesity awarded by National Institutes of Health 2007 - 2010
- Regulation and metabolic impact of mitochondrial CD36 in skeletal muscle awarded by National Institutes of Health 2006 - 2009
- Mechanisms to Induce Islet Proliferation awarded by National Institutes of Health 2007 - 2009
- Molecular Genetics of Muscle Specialization awarded by National Institutes of Health 2001 - 2009
- Developmental, nutritional and hormonal reg. of Ghrelin awarded by National Institutes of Health 2005 - 2009
- Engineering of Immunoprotection in B-Cell Lines awarded by National Institutes of Health 2002 - 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Harskamp, RE, Granger, TM, Clare, RM, White, KR, Lopes, RD, Pieper, KS, Granger, CB, Newgard, CB, Shah, SH, and Newby, LK. "Peripheral blood metabolite profiles associated with new onset atrial fibrillation." American Heart Journal 211 (May 2019): 54-59. Full Text
  - Kadakia, R, Nodzenski, M, Talbot, O, Kuang, A, Bain, JR, Muehlbauer, MJ, Stevens, RD, Ilkayeva, OR, O'Neal, SK, Lowe, LP, Metzger, BE, Newgard, CB, Scholtens, DM, Lowe, WL, and HAPO Study Cooperative Research Group, . "Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries." Diabetologia 62, no. 3 (March 2019): 473-484. Full Text
  - Teh, JT, Zhu, WL, Newgard, CB, Casey, PJ, and Wang, M. "Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers." Molecular Cancer Therapeutics 18, no. 3 (March 2019): 693-705. Full Text
  - Haldeman, JM, Conway, AE, Arlotto, ME, Slentz, DH, Muoio, DM, Becker, TC, and Newgard, CB. "Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing." Nucleic Acids Research 47, no. 4 (February 2019): e23-null. Full Text
  - Hohmeier, HE, An, J, and Newgard, CB. "Improving human β-cell maturation in vitro." Nature Cell Biology 21, no. 2 (February 2019): 119-121. Full Text
  - White, PJ, and Newgard, CB. "Branched-chain amino acids in disease." Science (New York, N.Y.) 363, no. 6427 (February 2019): 582-583. Full Text
  - Ravi, S, Parry, TL, Willis, MS, Lockyer, P, Patterson, C, Bain, JR, Stevens, RD, Ilkayeva, OR, Newgard, CB, and Schisler, JC. "Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP." Journal of Cardiovascular Development and Disease 5, no. 3 (August 15, 2018). Full Text
  - Shantavasinkul, PC, Muehlbauer, MJ, Bain, JR, Ilkayeva, OR, Craig, DM, Newgard, CB, Svetkey, LP, Shah, SH, and Torquati, A. "Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid." Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery 14, no. 8 (August 2018): 1126-1132. Full Text
  - Bhupathiraju, SN, Guasch-Ferré, M, Gadgil, MD, Newgard, CB, Bain, JR, Muehlbauer, MJ, Ilkayeva, OR, Scholtens, DM, Hu, FB, Kanaya, AM, and Kandula, NR. "Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk." The Journal of Nutrition 148, no. 7 (July 2018): 1150-1159. Full Text Open Access Copy
  - Peterson, BS, Campbell, JE, Ilkayeva, O, Grimsrud, PA, Hirschey, MD, and Newgard, CB. "Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition." Cell Reports 24, no. 1 (July 2018): 209-223.e6. Full Text
  - White, PJ, McGarrah, RW, Grimsrud, PA, Tso, S-C, Yang, W-H, Haldeman, JM, Grenier-Larouche, T, An, J, Lapworth, AL, Astapova, I, Hannou, SA, George, T, Arlotto, M, Olson, LB, Lai, M, Zhang, G-F, Ilkayeva, O, Herman, MA, Wynn, RM, Chuang, DT, and Newgard, CB. "The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase." Cell Metabolism 27, no. 6 (June 2018): 1281-1293.e7. Full Text
  - Chondronikola, M, Magkos, F, Yoshino, J, Okunade, AL, Patterson, BW, Muehlbauer, MJ, Newgard, CB, and Klein, S. "Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial." Obesity (Silver Spring, Md.) 26, no. 4 (April 2018): 683-688. Full Text
  - McGarrah, RW, Crown, SB, Zhang, G-F, Shah, SH, and Newgard, CB. "Cardiovascular Metabolomics." Circulation Research 122, no. 9 (April 2018): 1238-1258. (Review) Full Text
  - An, J, Wang, L, Patnode, ML, Ridaura, VK, Haldeman, JM, Stevens, RD, Ilkayeva, O, Bain, JR, Muehlbauer, MJ, Glynn, EL, Thomas, S, Muoio, D, Summers, SA, Vath, JE, Hughes, TE, Gordon, JI, and Newgard, CB. "Physiological mechanisms of sustained fumagillin-induced weight loss." Jci Insight 3, no. 5 (March 8, 2018). Full Text
  - Meyer, JG, Softic, S, Basisty, N, Rardin, MJ, Verdin, E, Gibson, BW, Ilkayeva, O, Newgard, CB, Kahn, CR, and Schilling, B. "Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose." Plos One 13, no. 12 (January 2018): e0208973-null. Full Text
  - Sugi, K, Hsieh, PN, Ilkayeva, O, Shelkay, S, Moroney, B, Baadh, P, Haynes, B, Pophal, M, Fan, L, Newgard, CB, Prosdocimo, DA, and Jain, MK. "Kruppel-like factor 15 is required for the cardiac adaptive response to fasting." Plos One 13, no. 2 (January 2018): e0192376-null. Full Text
  - Jensen, BC, Parry, TL, Huang, W, Beak, JY, Ilaiwy, A, Bain, JR, Newgard, CB, Muehlbauer, MJ, Patterson, C, Johnson, GL, and Willis, MS. "Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis." British Journal of Pharmacology 174, no. 24 (December 2017): 4797-4811. Full Text
  - Softic, S, Gupta, MK, Wang, G-X, Fujisaka, S, O'Neill, BT, Rao, TN, Willoughby, J, Harbison, C, Fitzgerald, K, Ilkayeva, O, Newgard, CB, Cohen, DE, and Kahn, CR. "Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling." The Journal of Clinical Investigation 127, no. 11 (November 2017): 4059-4074. Full Text
  - Bolton, JL, Wiley, MG, Ryan, B, Truong, S, Strait, M, Baker, DC, Yang, NY, Ilkayeva, O, O'Connell, TM, Wroth, SW, Sánchez, CL, Swamy, G, Newgard, C, Kuhn, C, Bilbo, SD, and Simmons, LA. "Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood." Brain and Behavior 7, no. 10 (October 2017): e00828-null. Full Text
  - Jensen, MV, Gooding, JR, Ferdaoussi, M, Dai, X-Q, Peterson, BS, MacDonald, PE, and Newgard, CB. "Metabolomics applied to islet nutrient sensing mechanisms." Diabetes, Obesity & Metabolism 19 Suppl 1 (September 2017): 90-94. (Review) Full Text
  - Stephens, SB, Edwards, RJ, Sadahiro, M, Lin, W-J, Jiang, C, Salton, SR, and Newgard, CB. "The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis." Cell reports 20, no. 10 (September 2017): 2480-2489. Full Text
  - Wang, H, Muehlbauer, MJ, O'Neal, SK, Newgard, CB, Hauser, ER, Bain, JR, and Shah, SH. "Recommendations for Improving Identification and Quantification in Non-Targeted, GC-MS-Based Metabolomic Profiling of Human Plasma." Metabolites 7, no. 3 (August 25, 2017). Full Text
  - Wang, H, Anstrom, K, Ilkayeva, O, Muehlbauer, MJ, Bain, JR, McNulty, S, Newgard, CB, Kraus, WE, Hernandez, A, Felker, GM, Redfield, M, and Shah, SH. "Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial." Jama Cardiology 2, no. 8 (August 2017): 896-901. Full Text
  - Abdullah, M, Kornegay, JN, Honcoop, A, Parry, TL, Balog-Alvarez, CJ, O'Neal, SK, Bain, JR, Muehlbauer, MJ, Newgard, CB, Patterson, C, and Willis, MS. "Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo." Metabolites 7, no. 3 (July 29, 2017). Full Text
  - Fu, J, Dai, X, Plummer, G, Suzuki, K, Bautista, A, Githaka, JM, Senior, L, Jensen, M, Greitzer-Antes, D, Manning Fox, JE, Gaisano, HY, Newgard, CB, Touret, N, and MacDonald, PE. "Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction." Diabetes 66, no. 7 (July 2017): 1890-1900. Full Text
  - Jacob, S, Nodzenski, M, Reisetter, AC, Bain, JR, Muehlbauer, MJ, Stevens, RD, Ilkayeva, OR, Lowe, LP, Metzger, BE, Newgard, CB, Scholtens, DM, Lowe, WL, and HAPO Study Cooperative Research Group, . "Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups." Diabetes care 40, no. 7 (July 2017): 911-919. Full Text
  - Lowe, WL, Bain, JR, Nodzenski, M, Reisetter, AC, Muehlbauer, MJ, Stevens, RD, Ilkayeva, OR, Lowe, LP, Metzger, BE, Newgard, CB, Scholtens, DM, and HAPO Study Cooperative Research Group, . "Maternal BMI and Glycemia Impact the Fetal Metabolome." Diabetes Care 40, no. 7 (July 2017): 902-910. Full Text
  - Dean, ED, Li, M, Prasad, N, Wisniewski, SN, Von Deylen, A, Spaeth, J, Maddison, L, Botros, A, Sedgeman, LR, Bozadjieva, N, Ilkayeva, O, Coldren, A, Poffenberger, G, Shostak, A, Semich, MC, Aamodt, KI, Phillips, N, Yan, H, Bernal-Mizrachi, E, Corbin, JD, Vickers, KC, Levy, SE, Dai, C, Newgard, C, Gu, W, Stein, R, Chen, W, and Powers, AC. "Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation." Cell Metabolism 25, no. 6 (June 2017): 1362-1373.e5. Full Text
  - Masko, EM, Alfaqih, MA, Solomon, KR, Barry, WT, Newgard, CB, Muehlbauer, MJ, Valilis, NA, Phillips, TE, Poulton, SH, Freedland, AR, Sun, S, Dambal, SK, Sanders, SE, Macias, E, Freeman, MR, Dewhirst, MW, Pizzo, SV, and Freedland, SJ. "Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model." The Prostate 77, no. 5 (April 2017): 446-457. Full Text
  - Luo, N, Craig, D, Ilkayeva, O, Muehlbauer, M, Kraus, WE, Newgard, CB, Shah, SH, and Rajagopal, S. "Plasma acylcarnitines are associated with pulmonary hypertension." Pulmonary Circulation 7, no. 1 (March 2017): 211-218. Full Text
  - Sandler, V, Reisetter, AC, Bain, JR, Muehlbauer, MJ, Nodzenski, M, Stevens, RD, Ilkayeva, O, Lowe, LP, Metzger, BE, Newgard, CB, Scholtens, DM, Lowe, WL, and HAPO Study Cooperative Research Group, . "Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes." Diabetologia 60, no. 3 (March 2017): 518-530. Full Text
  - Reisetter, AC, Muehlbauer, MJ, Bain, JR, Nodzenski, M, Stevens, RD, Ilkayeva, O, Metzger, BE, Newgard, CB, Lowe, WL, and Scholtens, DM. "Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data." Bmc Bioinformatics 18, no. 1 (February 2, 2017): 84-null. Full Text
  - Griffin, NW, Ahern, PP, Cheng, J, Heath, AC, Ilkayeva, O, Newgard, CB, Fontana, L, and Gordon, JI. "Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions." Cell Host & Microbe 21, no. 1 (January 2017): 84-96. Full Text
  - Hayes, HL, Peterson, BS, Haldeman, JM, Newgard, CB, Hohmeier, HE, and Stephens, SB. "Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival." Plos One 12, no. 2 (January 2017): e0172567-null. Full Text
  - Newgard, CB. "Metabolomics and Metabolic Diseases: Where Do We Stand?." Cell Metabolism 25, no. 1 (January 2017): 43-56. (Review) Full Text
  - Bradley, T, Yang, G, Ilkayeva, O, Holl, TM, Zhang, R, Zhang, J, Santra, S, Fox, CB, Reed, SG, Parks, R, Bowman, CM, Bouton-Verville, H, Sutherland, LL, Scearce, RM, Vandergrift, N, Kepler, TB, Moody, MA, Liao, H-X, Alam, SM, McLendon, R, Everitt, JI, Newgard, CB, Verkoczy, L, Kelsoe, G, and Haynes, BF. "HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism." Journal of Immunology (Baltimore, Md. : 1950) 197, no. 12 (December 2016): 4663-4673. Full Text
  - Gurley, JM, Ilkayeva, O, Jackson, RM, Griesel, BA, White, P, Matsuzaki, S, Qaisar, R, Van Remmen, H, Humphries, KM, Newgard, CB, and Olson, AL. "Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism." Diabetes 65, no. 12 (December 2016): 3585-3597. Full Text
  - Hayes, HL, Zhang, L, Becker, TC, Haldeman, JM, Stephens, SB, Arlotto, M, Moss, LG, Newgard, CB, and Hohmeier, HE. "A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation." Molecular and Cellular Biology 36, no. 23 (December 2016): 2918-2930. Full Text
  - Ribel-Madsen, A, Hellgren, LI, Brøns, C, Ribel-Madsen, R, Newgard, CB, and Vaag, AA. "Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding." Physiological Reports 4, no. 23 (December 2016). Full Text
  - Kraus, WE, Pieper, CF, Huffman, KM, Thompson, DK, Kraus, VB, Morey, MC, Cohen, HJ, Ravussin, E, Redman, LM, Bain, JR, Stevens, RD, and Newgard, CB. "Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 71, no. 11 (November 2016): 1507-1513. Full Text
  - Wagner, VE, Dey, N, Guruge, J, Hsiao, A, Ahern, PP, Semenkovich, NP, Blanton, LV, Cheng, J, Griffin, N, Stappenbeck, TS, Ilkayeva, O, Newgard, CB, Petri, W, Haque, R, Ahmed, T, and Gordon, JI. "Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition." Science Translational Medicine 8, no. 366 (November 2016): 366ra164-null. Full Text
  - Ribel-Madsen, A, Ribel-Madsen, R, Brøns, C, Newgard, CB, Vaag, AA, and Hellgren, LI. "Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men." Physiological Reports 4, no. 19 (October 2016). Full Text
  - Guthrie, G, Kulkarni, M, Vlaardingerbroek, H, Stoll, B, Ng, K, Martin, C, Belmont, J, Hadsell, D, Heird, W, Newgard, CB, Olutoye, O, van Goudoever, J, Lauridsen, C, He, X, Schuchman, EH, and Burrin, D. "Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions." Journal of Lipid Research 57, no. 9 (September 2016): 1696-1711. Full Text
  - Quintana, MT, Parry, TL, He, J, Yates, CC, Sidorova, TN, Murray, KT, Bain, JR, Newgard, CB, Muehlbauer, MJ, Eaton, SC, Hishiya, A, Takayama, S, and Willis, MS. "Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling." The American Journal of Pathology 186, no. 8 (August 2016): 1989-2007. Full Text
  - Hunter, WG, Kelly, JP, McGarrah, RW, Khouri, MG, Craig, D, Haynes, C, Ilkayeva, O, Stevens, RD, Bain, JR, Muehlbauer, MJ, Newgard, CB, Felker, GM, Hernandez, AF, Velazquez, EJ, Kraus, WE, and Shah, SH. "Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure." Journal of the American Heart Association 5, no. 8 (July 29, 2016). Full Text Open Access Copy
  - Kucejova, B, Duarte, J, Satapati, S, Fu, X, Ilkayeva, O, Newgard, CB, Brugarolas, J, and Burgess, SC. "Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity." Cell Reports 16, no. 2 (July 2016): 508-519. Full Text
  - Scholtens, DM, Bain, JR, Reisetter, AC, Muehlbauer, MJ, Nodzenski, M, Stevens, RD, Ilkayeva, O, Lowe, LP, Metzger, BE, Newgard, CB, Lowe, WL, and HAPO Study Cooperative Research Group, . "Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth." Diabetes 65, no. 7 (July 2016): 2039-2050. Full Text
  - White, PJ, Lapworth, AL, An, J, Wang, L, McGarrah, RW, Stevens, RD, Ilkayeva, O, George, T, Muehlbauer, MJ, Bain, JR, Trimmer, JK, Brosnan, MJ, Rolph, TP, and Newgard, CB. "Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export." Molecular Metabolism 5, no. 7 (July 2016): 538-551. Full Text
  - Quinones, QJ, Zhang, Z, Ma, Q, Smith, MP, Soderblom, E, Moseley, MA, Bain, J, Newgard, CB, Muehlbauer, MJ, Hirschey, M, Drew, KL, Barnes, BM, and Podgoreanu, MV. "Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats." Anesthesiology 124, no. 6 (June 2016): 1296-1310. Full Text
  - Ilaiwy, A, Liu, M, Parry, TL, Bain, JR, Newgard, CB, Schisler, JC, Muehlbauer, MJ, Despa, F, and Willis, MS. "Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo." Metabolomics : Official Journal of the Metabolomic Society 12, no. 5 (May 2016). Full Text
  - Marcelo, KL, Ribar, T, Means, CR, Tsimelzon, A, Stevens, RD, Ilkayeva, O, Bain, JR, Hilsenbeck, SG, Newgard, CB, Means, AR, and York, B. "Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism." Molecular endocrinology (Baltimore, Md.) 30, no. 5 (May 2016): 557-572. Full Text
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  - Bustamante-Marin, XM, Cook, MS, Gooding, J, Newgard, C, and Capel, B. "Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites." Biology of reproduction 93, no. 3 (September 2015): 78-. Full Text
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  - Kang, YK, Putluri, N, Maity, S, Tsimelzon, A, Ilkayeva, O, Mo, Q, Lonard, D, Michailidis, G, Sreekumar, A, Newgard, CB, Wang, M, Tsai, SY, Tsai, M-J, and O'Malley, BW. "CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC." Plos Genetics 11, no. 4 (April 2015): e1005116-null. Full Text
  - Shah, SH, and Newgard, CB. "Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease." Circulation. Cardiovascular Genetics 8, no. 2 (April 2015): 410-419. (Review) Full Text
  - Palmer, ND, Stevens, RD, Antinozzi, PA, Anderson, A, Bergman, RN, Wagenknecht, LE, Newgard, CB, and Bowden, DW. "Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study." The Journal of clinical endocrinology and metabolism 100, no. 3 (March 2015): E463-E468. Full Text
  - Guo, C, Ludvik, AE, Arlotto, ME, Hayes, MG, Armstrong, LL, Scholtens, DM, Brown, CD, Newgard, CB, Becker, TC, Layden, BT, Lowe, WL, and Reddy, TE. "Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1." Nature communications 6 (February 4, 2015): 6069-. Full Text
  - Ali, S, Ussher, JR, Baggio, LL, Kabir, MG, Charron, MJ, Ilkayeva, O, Newgard, CB, and Drucker, DJ. "Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction." Molecular Metabolism 4, no. 2 (February 2015): 132-143. Full Text
  - Ali, S, Ussher, JR, Baggio, LL, Kabir, MG, Charron, MJ, Ilkayeva, O, Newgard, CB, and Drucker, DJ. "Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction." Molecular Metabolism 4, no. 2 (January 1, 2015): 132-143. Full Text
  - Gerriets, VA, Kishton, RJ, Nichols, AG, Macintyre, AN, Inoue, M, Ilkayeva, O, Winter, PS, Liu, X, Priyadharshini, B, Slawinska, ME, Haeberli, L, Huck, C, Turka, LA, Wood, KC, Hale, LP, Smith, PA, Schneider, MA, MacIver, NJ, Locasale, JW, Newgard, CB, Shinohara, ML, and Rathmell, JC. "Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation." The Journal of Clinical Investigation 125, no. 1 (January 2015): 194-207. Full Text Open Access Copy
  - Li, LO, Grevengoed, TJ, Paul, DS, Ilkayeva, O, Koves, TR, Pascual, F, Newgard, CB, Muoio, DM, and Coleman, RA. "Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis." Diabetes 64, no. 1 (January 2015): 23-35. Full Text
  - Morgan, PG, Higdon, R, Kolker, N, Bauman, AT, Ilkayeva, O, Newgard, CB, Kolker, E, Steele, LM, and Sedensky, MM. "Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans." Mitochondrion 20 (January 2015): 95-102. Full Text
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  - Shin, AC, Fasshauer, M, Filatova, N, Grundell, LA, Zielinski, E, Zhou, J-Y, Scherer, T, Lindtner, C, White, PJ, Lapworth, AL, Ilkayeva, O, Knippschild, U, Wolf, AM, Scheja, L, Grove, KL, Smith, RD, Qian, W-J, Lynch, CJ, Newgard, CB, and Buettner, C. "Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism." Cell Metabolism 20, no. 5 (November 2014): 898-909. Full Text
  - Tannour-Louet, M, York, B, Tang, K, Stashi, E, Bouguerra, H, Zhou, S, Yu, H, Wong, L-JC, Stevens, RD, Xu, J, Newgard, CB, O'Malley, BW, and Louet, J-F. "Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis." Molecular endocrinology (Baltimore, Md.) 28, no. 10 (October 2014): 1707-1718. Full Text
  - Tripathy, S, Lytle, KA, Stevens, RD, Bain, JR, Newgard, CB, Greenberg, AS, Huang, L-S, and Jump, DB. "Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice." Journal of Lipid Research 55, no. 7 (July 2014): 1448-1464. Full Text
  - Bartz, S, Mody, A, Hornik, C, Bain, J, Muehlbauer, M, Kiyimba, T, Kiboneka, E, Stevens, R, Bartlett, J, St Peter, JV, Newgard, CB, and Freemark, M. "Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality." The Journal of Clinical Endocrinology and Metabolism 99, no. 6 (June 2014): 2128-2137. Full Text
  - Gupte, AA, Hamilton, DJ, Cordero-Reyes, AM, Youker, KA, Yin, Z, Estep, JD, Stevens, RD, Wenner, B, Ilkayeva, O, Loebe, M, Peterson, LE, Lyon, CJ, Wong, STC, Newgard, CB, Torre-Amione, G, Taegtmeyer, H, and Hsueh, WA. "Mechanical unloading promotes myocardial energy recovery in human heart failure." Circulation. Cardiovascular Genetics 7, no. 3 (June 2014): 266-276. Full Text
  - Newgard, CB, and Pessin, JE. "Recent progress in metabolic signaling pathways regulating aging and life span." The journals of gerontology. Series A, Biological sciences and medical sciences 69 Suppl 1 (June 2014): S21-S27. (Review) Full Text
  - Khoo, CM, Muehlbauer, MJ, Stevens, RD, Pamuklar, Z, Chen, J, Newgard, CB, and Torquati, A. "Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction." Annals of Surgery 259, no. 4 (April 2014): 687-693. Full Text
  - Seiler, SE, Martin, OJ, Noland, RC, Slentz, DH, DeBalsi, KL, Ilkayeva, OR, An, J, Newgard, CB, Koves, TR, and Muoio, DM. "Obesity and lipid stress inhibit carnitine acetyltransferase activity." Journal of Lipid Research 55, no. 4 (April 2014): 635-644. Full Text
  - Sinha, RA, Farah, BL, Singh, BK, Siddique, MM, Li, Y, Wu, Y, Ilkayeva, OR, Gooding, J, Ching, J, Zhou, J, Martinez, L, Xie, S, Bay, B-H, Summers, SA, Newgard, CB, and Yen, PM. "Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice." Hepatology (Baltimore, Md.) 59, no. 4 (April 2014): 1366-1380. Full Text
  - Tessem, JS, Moss, LG, Chao, LC, Arlotto, M, Lu, D, Jensen, MV, Stephens, SB, Tontonoz, P, Hohmeier, HE, and Newgard, CB. "Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors." Proceedings of the National Academy of Sciences of the United States of America 111, no. 14 (April 2014): 5242-5247. Full Text
  - Thalacker-Mercer, AE, Ingram, KH, Guo, F, Ilkayeva, O, Newgard, CB, and Garvey, WT. "BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans." Diabetes 63, no. 2 (February 2014): 791-800. Full Text Link to Item
  - Bhattacharya, S, Granger, CB, Craig, D, Haynes, C, Bain, J, Stevens, RD, Hauser, ER, Newgard, CB, Kraus, WE, Newby, LK, and Shah, SH. "Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization." Atherosclerosis 232, no. 1 (January 2014): 191-196. Full Text Link to Item
  - Hivert, MF, Perng, W, Watkins, SM, Newgard, CS, Kenny, LC, Kristal, BS, Patti, ME, Isganaitis, E, DeMeo, DL, Oken, E, and Gillman, MW. "Metabolomics in the developmental origins of obesity and its cardiometabolic consequences." Journal of Developmental Origins of Health and Disease 6, no. 2 (2014): 65-78. Full Text
  - Khoo, CM, Muehlbauer, MJ, Stevens, RD, Pamuklar, Z, Chen, J, Newgard, CB, and Torquati, A. "Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction." Annals of Surgery 259, no. 4 (January 1, 2014): 687-693. Full Text
  - Mody, A, Bartz, S, Hornik, CP, Kiyimba, T, Bain, J, Muehlbauer, M, Kiboneka, E, Stevens, R, St Peter, JV, Newgard, CB, Bartlett, J, and Freemark, M. "Effects of HIV infection on the metabolic and hormonal status of children with severe acute malnutrition." PLoS ONE 9, no. 7 (January 2014): e102233-. Full Text
  - Scholtens, DM, Muehlbauer, MJ, Daya, NR, Stevens, RD, Dyer, AR, Lowe, LP, Metzger, BE, Newgard, CB, Bain, JR, Lowe, WL, and HAPO Study Cooperative Research Group, . "Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy." Diabetes Care 37, no. 1 (January 2014): 158-166. Full Text
  - Shin, AC, Fasshauer, M, Filatova, N, Grundell, LA, Zielinski, E, Zhou, JY, Scherer, T, Lindtner, C, White, PJ, Lapworth, AL, Ilkayeva, O, Knippschild, U, Wolf, AM, Scheja, L, Grove, KL, Smith, RD, Qian, WJ, Lynch, CJ, Newgard, CB, and Buettner, C. "Brain insulin lowers circulating bcaa levels by inducing hepatic bcaa catabolism." Cell Metabolism 20, no. 5 (January 1, 2014): 898-909. Full Text
  - Sinha, RA, Farah, BL, Singh, BK, Siddique, MM, Li, Y, Wu, Y, Ilkayeva, OR, Gooding, J, Ching, J, Zhou, J, Martinez, L, Xie, S, Bay, BH, Summers, SA, Newgard, CB, and Yen, PM. "Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice." Hepatology 59, no. 4 (January 1, 2014): 1366-1380. Full Text
  - Patel, MJ, Batch, BC, Svetkey, LP, Bain, JR, Turer, CB, Haynes, C, Muehlbauer, MJ, Stevens, RD, Newgard, CB, and Shah, SH. "Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults." Omics : a Journal of Integrative Biology 17, no. 12 (December 2013): 627-635. Full Text
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  - Peek, CB, Affinati, AH, Ramsey, KM, Kuo, H-Y, Yu, W, Sena, LA, Ilkayeva, O, Marcheva, B, Kobayashi, Y, Omura, C, Levine, DC, Bacsik, DJ, Gius, D, Newgard, CB, Goetzman, E, Chandel, NS, Denu, JM, Mrksich, M, and Bass, J. "Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice." Science (New York, N.Y.) 342, no. 6158 (November 2013): 1243417-null. Full Text
  - Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 Activates Islet - and -Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2." Molecular and Cellular Biology 33, no. 20 (October 15, 2013): 4017-4029. Full Text
  - Hayes, HL, Moss, LG, Schisler, JC, Haldeman, JM, Zhang, Z, Rosenberg, PB, Newgard, CB, and Hohmeier, HE. "Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2." Molecular and Cellular Biology 33, no. 20 (October 2013): 4017-4029. Full Text
  - Jing, E, O'Neill, BT, Rardin, MJ, Kleinridders, A, Ilkeyeva, OR, Ussar, S, Bain, JR, Lee, KY, Verdin, EM, Newgard, CB, Gibson, BW, and Kahn, CR. "Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation." Diabetes 62, no. 10 (October 2013): 3404-3417. Full Text
  - Ridaura, VK, Faith, JJ, Rey, FE, Cheng, J, Duncan, AE, Kau, AL, Griffin, NW, Lombard, V, Henrissat, B, Bain, JR, Muehlbauer, MJ, Ilkayeva, O, Semenkovich, CF, Funai, K, Hayashi, DK, Lyle, BJ, Martini, MC, Ursell, LK, Clemente, JC, Van Treuren, W, Walters, WA, Knight, R, Newgard, CB, Heath, AC, and Gordon, JI. "Gut microbiota from twins discordant for obesity modulate metabolism in mice." Science (New York, N.Y.) 341, no. 6150 (September 2013): 1241214-null. Full Text
  - Jensen, MV, Haldeman, JM, Zhang, H, Lu, D, Huising, MO, Vale, WW, Hohmeier, HE, Rosenberg, P, and Newgard, CB. "Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion." The Journal of Biological Chemistry 288, no. 32 (August 2013): 23128-23140. Full Text
  - Magkos, F, Bradley, D, Schweitzer, GG, Finck, BN, Eagon, JC, Ilkayeva, O, Newgard, CB, and Klein, S. "Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism." Diabetes 62, no. 8 (August 2013): 2757-2761. Full Text
  - Batch, BC, Shah, SH, Newgard, CB, Turer, CB, Haynes, C, Bain, JR, Muehlbauer, M, Patel, MJ, Stevens, RD, Appel, LJ, Newby, LK, and Svetkey, LP. "Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness." Metabolism: Clinical and Experimental 62, no. 7 (July 2013): 961-969. Full Text
  - Klett, EL, Chen, S, Edin, ML, Li, LO, Ilkayeva, O, Zeldin, DC, Newgard, CB, and Coleman, RA. "Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion." The Journal of Biological Chemistry 288, no. 30 (July 2013): 21618-21629. Full Text
  - Kurland, IJ, Accili, D, Burant, C, Fischer, SM, Kahn, BB, Newgard, CB, Ramagiri, S, Ronnett, GV, Ryals, JA, Sanders, M, Shambaugh, J, Shockcor, J, and Gross, SS. "Application of combined omics platforms to accelerate biomedical discovery in diabesity." Annals of the New York Academy of Sciences 1287 (May 9, 2013): 1-16. Full Text
  - Johnson, ES, Lindblom, KR, Robeson, A, Stevens, RD, Ilkayeva, OR, Newgard, CB, Kornbluth, S, and Andersen, JL. "Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis." The Journal of Biological Chemistry 288, no. 20 (May 2013): 14463-14475. Full Text
  - Newgard, CB, and Sharpless, NE. "Coming of age: molecular drivers of aging and therapeutic opportunities." The Journal of Clinical Investigation 123, no. 3 (March 2013): 946-950. Full Text
  - Patel, SG, Hsu, JW, Jahoor, F, Coraza, I, Bain, JR, Stevens, RD, Iyer, D, Nalini, R, Ozer, K, Hampe, CS, Newgard, CB, and Balasubramanyam, A. "Pathogenesis of A⁻β⁺ ketosis-prone diabetes." Diabetes 62, no. 3 (March 2013): 912-922. Full Text
  - Coppola, A, Wenner, BR, Ilkayeva, O, Stevens, RD, Maggioni, M, Slotkin, TA, Levin, ED, and Newgard, CB. "Branched-chain amino acids alter neurobehavioral function in rats." Am J Physiol Endocrinol Metab 304, no. 4 (February 15, 2013): E405-E413. Full Text Link to Item
  - Li, XN, Herrington, J, Petrov, A, Ge, L, Eiermann, G, Xiong, Y, Jensen, MV, Hohmeier, HE, Newgard, CB, Garcia, ML, Wagner, M, Zhang, BB, Thornberry, NA, Howard, AD, Kaczorowski, GJ, and Zhou, Y-P. "The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets." The Journal of Pharmacology and Experimental Therapeutics 344, no. 2 (February 2013): 407-416. Full Text
  - York, B, Sagen, JV, Tsimelzon, A, Louet, J-F, Chopra, AR, Reineke, EL, Zhou, S, Stevens, RD, Wenner, BR, Ilkayeva, O, Bain, JR, Xu, J, Hilsenbeck, SG, Newgard, CB, and O'Malley, BW. "Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family." Mol Endocrinol 27, no. 2 (February 2013): 366-380. Full Text Link to Item
  - Shimazu, T, Hirschey, MD, Newman, J, He, W, Shirakawa, K, Le Moan, N, Grueter, CA, Lim, H, Saunders, LR, Stevens, RD, Newgard, CB, Farese, RV, de Cabo, R, Ulrich, S, Akassoglou, K, and Verdin, E. "Suppression of Oxidative Stress by -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor." Science 339, no. 6116 (January 11, 2013): 211-214. Full Text
  - Batch, BC, Shah, SH, Newgard, CB, Turer, CB, Haynes, C, Bain, JR, Muehlbauer, M, Patel, MJ, Stevens, RD, Appel, LJ, Newby, LK, and Svetkey, LP. "Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness." Metabolism: Clinical and Experimental 62, no. 7 (2013): 961-969. Full Text
  - Gregory, JF, Park, Y, Lamers, Y, Bandyopadhyay, N, Chi, Y-Y, Lee, K, Kim, S, da Silva, V, Hove, N, Ranka, S, Kahveci, T, Muller, KE, Stevens, RD, Newgard, CB, Stacpoole, PW, and Jones, DP. "Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects." Plos One 8, no. 6 (January 2013): e63544-null. Full Text
  - Kurland, IJ, Accili, D, Burant, C, Fischer, SM, Kahn, BB, Newgard, CB, Ramagiri, S, Ronnett, GV, Ryals, JA, Sanders, M, Shambaugh, J, Shockcor, J, and Gross, SS. "Application of combined omics platforms to accelerate biomedical discovery in diabesity." Annals of the New York Academy of Sciences 1287, no. 1 (2013): 1-16. Full Text
  - Magkos, F, Bradley, D, Schweitzer, GG, Finck, BN, Eagon, JC, Ilkayeva, O, Newgard, CB, and Klein, S. "Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism." Diabetes 62, no. 8 (2013): 2757-2761. Full Text
  - Shimazu, T, Hirschey, MD, Newman, J, He, W, Shirakawa, K, Le Moan, N, Grueter, CA, Lim, H, Saunders, LR, Stevens, RD, Newgard, CB, Farese, RV, de Cabo, R, Ulrich, S, Akassoglou, K, and Verdin, E. "Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor." Science (New York, N.Y.) 339, no. 6116 (January 2013): 211-214. Full Text
  - Chao, LC, Wroblewski, K, Ilkayeva, OR, Stevens, RD, Bain, J, Meyer, GA, Schenk, S, Martinez, L, Vergnes, L, Narkar, VA, Drew, BG, Hong, C, Boyadjian, R, Hevener, AL, Evans, RM, Reue, K, Spencer, MJ, Newgard, CB, and Tontonoz, P. "Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization." Journal of Lipid Research 53, no. 12 (December 2012): 2610-2619. Full Text
  - Vernochet, C, Mourier, A, Bezy, O, Macotela, Y, Boucher, J, Rardin, MJ, An, D, Lee, KY, Ilkayeva, OR, Zingaretti, CM, Emanuelli, B, Smyth, G, Cinti, S, Newgard, CB, Gibson, BW, Larsson, N-G, and Kahn, CR. "Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance." Cell Metabolism 16, no. 6 (December 2012): 765-776. Full Text
  - Zhao, M, Lamers, Y, Ralat, MA, Coats, BS, Chi, Y-Y, Muller, KE, Bain, JR, Shankar, MN, Newgard, CB, Stacpoole, PW, and Gregory, JF. "Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women." The Journal of Nutrition 142, no. 10 (October 2012): 1791-1797. Full Text
  - Gaudet, MM, Falk, RT, Stevens, RD, Gunter, MJ, Bain, JR, Pfeiffer, RM, Potischman, N, Lissowska, J, Peplonska, B, Brinton, LA, Garcia-Closas, M, Newgard, CB, and Sherman, ME. "Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study." The Journal of Clinical Endocrinology and Metabolism 97, no. 9 (September 2012): 3216-3223. Full Text
  - Kim, D-H, Sartor, MA, Bain, JR, Sandoval, D, Stevens, RD, Medvedovic, M, Newgard, CB, Woods, SC, and Seeley, RJ. "Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium." Diabetes 61, no. 9 (September 2012): 2299-2310. Full Text Link to Item
  - Shah, SH, Kraus, WE, and Newgard, CB. "Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function." Circulation 126, no. 9 (August 2012): 1110-1120. (Review) Full Text
  - Thompson, DK, Sloane, R, Bain, JR, Stevens, RD, Newgard, CB, Pieper, CF, and Kraus, VB. "Daily Variation of Serum Acylcarnitines and Amino Acids." Metabolomics : Official Journal of the Metabolomic Society 8, no. 4 (August 2012): 556-565. Full Text
  - Sinha, RA, You, S-H, Zhou, J, Siddique, MM, Bay, B-H, Zhu, X, Privalsky, ML, Cheng, S-Y, Stevens, RD, Summers, SA, Newgard, CB, Lazar, MA, and Yen, PM. "Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy." The Journal of Clinical Investigation 122, no. 7 (July 2012): 2428-2438. Full Text
  - Stephens, SB, Schisler, JC, Hohmeier, HE, An, J, Sun, AY, Pitt, GS, and Newgard, CB. "A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function." Cell Metabolism 16, no. 1 (July 2012): 33-43. Full Text
  - Kimple, ME, Moss, JB, Brar, HK, Rosa, TC, Truchan, NA, Pasker, RL, Newgard, CB, and Casey, PJ. "Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass." The Journal of Biological Chemistry 287, no. 24 (June 2012): 20344-20355. Full Text
  - Farese, RV, Zechner, R, Newgard, CB, and Walther, TC. "The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance." Cell Metab 15, no. 5 (May 2, 2012): 570-573. Full Text Link to Item
  - York, B, Reineke, EL, Sagen, JV, Nikolai, BC, Zhou, S, Louet, J-F, Chopra, AR, Chen, X, Reed, G, Noebels, J, Adesina, AM, Yu, H, Wong, L-JC, Tsimelzon, A, Hilsenbeck, S, Stevens, RD, Wenner, BR, Ilkayeva, O, Xu, J, Newgard, CB, and O'Malley, BW. "Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy." Cell Metab 15, no. 5 (May 2, 2012): 752-763. Full Text Link to Item
  - Newgard, CB. "Interplay between lipids and branched-chain amino acids in development of insulin resistance." Cell Metabolism 15, no. 5 (May 2012): 606-614. (Review) Full Text
  - Shah, SH, Sun, J-L, Stevens, RD, Bain, JR, Muehlbauer, MJ, Pieper, KS, Haynes, C, Hauser, ER, Kraus, WE, Granger, CB, Newgard, CB, Califf, RM, and Newby, LK. "Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease." American Heart Journal 163, no. 5 (May 2012): 844-850.e1. Full Text
  - Shah, AA, Craig, DM, Sebek, JK, Haynes, C, Stevens, RC, Muehlbauer, MJ, Granger, CB, Hauser, ER, Newby, LK, Newgard, CB, Kraus, WE, Hughes, GC, and Shah, SH. "Metabolic profiles predict adverse events after coronary artery bypass grafting." The Journal of Thoracic and Cardiovascular Surgery 143, no. 4 (April 2012): 873-878. Full Text
  - Anderson, KA, Lin, F, Ribar, TJ, Stevens, RD, Muehlbauer, MJ, Newgard, CB, and Means, AR. "Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse." Mol Endocrinol 26, no. 2 (February 2012): 281-291. Full Text Link to Item
  - Shah, SH, Crosslin, DR, Haynes, CS, Nelson, S, Turer, CB, Stevens, RD, Muehlbauer, MJ, Wenner, BR, Bain, JR, Laferrère, B, Gorroochurn, P, Teixeira, J, Brantley, PJ, Stevens, VJ, Hollis, JF, Appel, LJ, Lien, LF, Batch, B, Newgard, CB, and Svetkey, LP. "Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss." Diabetologia 55, no. 2 (February 2012): 321-330. Full Text
  - Huffman, KM, Redman, LM, Landerman, LR, Pieper, CF, Stevens, RD, Muehlbauer, MJ, Wenner, BR, Bain, JR, Kraus, VB, Newgard, CB, Ravussin, E, and Kraus, WE. "Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial." PLoS One 7, no. 4 (2012): e28190-. Full Text Open Access Copy Link to Item
  - Ku, BJ, Kim, TH, Lee, JH, Buras, ED, White, LD, Stevens, RD, Ilkayeva, OR, Bain, JR, Newgard, CB, DeMayo, FJ, and Jeong, J-W. "Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis." Plos One 7, no. 8 (January 2012): e42915-null. Full Text
  - Reineke, EL, York, B, Stashi, E, Chen, X, Tsimelzon, A, Xu, J, Newgard, CB, Taffet, GE, Taegtmeyer, H, Entman, ML, and O'Malley, BW. "SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart." PLoS One 7, no. 12 (2012): e53395-. Full Text Link to Item
  - Sampey, BP, Freemerman, AJ, Zhang, J, Kuan, P-F, Galanko, JA, O'Connell, TM, Ilkayeva, OR, Muehlbauer, MJ, Stevens, RD, Newgard, CB, Brauer, HA, Troester, MA, and Makowski, L. "Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation." PLoS One 7, no. 6 (2012): e38812-. Full Text Link to Item
  - Brunner, MP, Shah, SH, Craig, DM, Stevens, RD, Muehlbauer, MJ, Bain, JR, Newgard, CB, Kraus, WE, Granger, CB, Sketch, MH, and Newby, LK. "Effect of heparin administration on metabolomic profiles in samples obtained during cardiac catheterization." Circulation. Cardiovascular Genetics 4, no. 6 (December 2011): 695-700. Full Text
  - Hirschey, MD, Shimazu, T, Jing, E, Grueter, CA, Collins, AM, Aouizerat, B, Stančáková, A, Goetzman, E, Lam, MM, Schwer, B, Stevens, RD, Muehlbauer, MJ, Kakar, S, Bass, NM, Kuusisto, J, Laakso, M, Alt, FW, Newgard, CB, Farese, RV, Kahn, CR, and Verdin, E. "SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome." Molecular Cell 44, no. 2 (October 2011): 177-190. Full Text
  - McNulty, NP, Yatsunenko, T, Hsiao, A, Faith, JJ, Muegge, BD, Goodman, AL, Henrissat, B, Oozeer, R, Cools-Portier, S, Gobert, G, Chervaux, C, Knights, D, Lozupone, CA, Knight, R, Duncan, AE, Bain, JR, Muehlbauer, MJ, Newgard, CB, Heath, AC, and Gordon, JI. "The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins." Science Translational Medicine 3, no. 106 (October 2011): 106ra106-null. Full Text
  - Sampey, BP, Vanhoose, AM, Winfield, HM, Freemerman, AJ, Muehlbauer, MJ, Fueger, PT, Newgard, CB, and Makowski, L. "Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet." Obesity (Silver Spring, Md.) 19, no. 6 (June 2011): 1109-1117. Full Text
  - Lum, H, Sloane, R, Huffman, KM, Kraus, VB, Thompson, DK, Kraus, WE, Bain, JR, Stevens, R, Pieper, CF, Taylor, GA, Newgard, CB, Cohen, HJ, and Morey, MC. "Plasma acylcarnitines are associated with physical performance in elderly men." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 66, no. 5 (May 2011): 548-553. Full Text
  - Shah, SH, Svetkey, LP, and Newgard, CB. "Branching out for detection of type 2 diabetes." Cell Metabolism 13, no. 5 (May 2011): 491-492. Full Text
  - Lemaire, K, Moura, RF, Granvik, M, Igoillo-Esteve, M, Hohmeier, HE, Hendrickx, N, Newgard, CB, Waelkens, E, Cnop, M, and Schuit, F. "Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis." Plos One 6, no. 4 (April 6, 2011): e18517-null. Full Text
  - Horn, SR, Thomenius, MJ, Johnson, ES, Freel, CD, Wu, JQ, Coloff, JL, Yang, C-S, Tang, W, An, J, Ilkayeva, OR, Rathmell, JC, Newgard, CB, and Kornbluth, S. "Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability." Molecular Biology of the Cell 22, no. 8 (April 2011): 1207-1216. Full Text
  - Laferrère, B, Reilly, D, Arias, S, Swerdlow, N, Gorroochurn, P, Bawa, B, Bose, M, Teixeira, J, Stevens, RD, Wenner, BR, Bain, JR, Muehlbauer, MJ, Haqq, A, Lien, L, Shah, SH, Svetkey, LP, and Newgard, CB. "Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss." Science Translational Medicine 3, no. 80 (April 2011): 80re2-null. Full Text
  - Redman, LM, Huffman, KM, Landerman, LR, Pieper, CF, Bain, JR, Muehlbauer, MJ, Stevens, RD, Wenner, BR, Kraus, VB, Newgard, CB, Kraus, WE, and Ravussin, E. "Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women." J Clin Endocrinol Metab 96, no. 2 (February 2011): E312-E321. Full Text Link to Item
  - Haqq, AM, Muehlbauer, MJ, Newgard, CB, Grambow, S, and Freemark, M. "The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index." The Journal of Clinical Endocrinology and Metabolism 96, no. 1 (January 2011): E225-E232. Full Text
  - Huffman, KM, Slentz, CA, Bateman, LA, Thompson, D, Muehlbauer, MJ, Bain, JR, Stevens, RD, Wenner, BR, Kraus, VB, Newgard, CB, and Kraus, WE. "Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity." Diabetes Care 34, no. 1 (January 2011): 174-176. Full Text Open Access Copy Link to Item
  - Monetti, M, Levin, MC, Watt, MJ, Hubbard, BK, Newgard, C, Sr, RVF, Hevener, AL, and Jr, RVF. "Hepatic acyl-CoA:Diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity." Proceedings of the National Academy of Sciences of the United States of America 108, no. 34 (2011): E523-. Full Text
  - Louet, J-F, Chopra, AR, Sagen, JV, An, J, York, B, Tannour-Louet, M, Saha, PK, Stevens, RD, Wenner, BR, Ilkayeva, OR, Bain, JR, Zhou, S, DeMayo, F, Xu, J, Newgard, CB, and O'Malley, BW. "The coactivator SRC-1 is an essential coordinator of hepatic glucose production." Cell Metab 12, no. 6 (December 1, 2010): 606-618. Full Text Link to Item
  - Han, JC, Muehlbauer, MJ, Cui, HN, Newgard, CB, and Haqq, AM. "Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects." The Journal of Clinical Endocrinology and Metabolism 95, no. 7 (July 2010): 3532-3536. Full Text
  - Rey, FE, Faith, JJ, Bain, J, Muehlbauer, MJ, Stevens, RD, Newgard, CB, and Gordon, JI. "Dissecting the in vivo metabolic potential of two human gut acetogens." The Journal of Biological Chemistry 285, no. 29 (July 2010): 22082-22090. Full Text
  - Turer, AT, Malloy, CR, Newgard, CB, and Podgoreanu, MV. "Energetics and metabolism in the failing heart: important but poorly understood." Current Opinion in Clinical Nutrition and Metabolic Care 13, no. 4 (July 2010): 458-465. (Review) Full Text
  - Civitarese, AE, MacLean, PS, Carling, S, Kerr-Bayles, L, McMillan, RP, Pierce, A, Becker, TC, Moro, C, Finlayson, J, Lefort, N, Newgard, CB, Mandarino, L, Cefalu, W, Walder, K, Collier, GR, Hulver, MW, Smith, SR, and Ravussin, E. "Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL." Cell Metabolism 11, no. 5 (May 2010): 412-426. Full Text
  - Kelly, P, Bailey, CL, Fueger, PT, Newgard, CB, Casey, PJ, and Kimple, ME. "Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation." The Journal of Biological Chemistry 285, no. 21 (May 2010): 15777-15785. Full Text
  - Odegaard, ML, Joseph, JW, Jensen, MV, Lu, D, Ilkayeva, O, Ronnebaum, SM, Becker, TC, and Newgard, CB. "The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion." The Journal of Biological Chemistry 285, no. 22 (May 2010): 16530-16537. Full Text
  - Newgard, CB, and Attie, AD. "Getting biological about the genetics of diabetes." Nature Medicine 16, no. 4 (April 2010): 388-391. Full Text
  - Shah, SH, Bain, JR, Muehlbauer, MJ, Stevens, RD, Crosslin, DR, Haynes, C, Dungan, J, Newby, LK, Hauser, ER, Ginsburg, GS, Newgard, CB, and Kraus, WE. "Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events." Circulation. Cardiovascular Genetics 3, no. 2 (April 2010): 207-214. Full Text Open Access Copy
  - Tai, ES, Tan, MLS, Stevens, RD, Low, YL, Muehlbauer, MJ, Goh, DLM, Ilkayeva, OR, Wenner, BR, Bain, JR, Lee, JJM, Lim, SC, Khoo, CM, Shah, SH, and Newgard, CB. "Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men." Diabetologia 53, no. 4 (April 2010): 757-767. Full Text
  - Healy, JA, Nilsson, KR, Hohmeier, HE, Berglund, J, Davis, J, Hoffman, J, Kohler, M, Li, L-S, Berggren, P-O, Newgard, CB, and Bennett, V. "Cholinergic augmentation of insulin release requires ankyrin-B." Science Signaling 3, no. 113 (March 16, 2010): ra19-null. Full Text
  - Wang, M-Y, Chen, L, Clark, GO, Lee, Y, Stevens, RD, Ilkayeva, OR, Wenner, BR, Bain, JR, Charron, MJ, Newgard, CB, and Unger, RH. "Leptin therapy in insulin-deficient type I diabetes." Proc Natl Acad Sci U S A 107, no. 11 (March 16, 2010): 4813-4819. Full Text Link to Item
  - Maynard, JC, Pham, T, Zheng, T, Jockheck-Clark, A, Rankin, HB, Newgard, CB, Spana, EP, and Nicchitta, CV. "Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control." Dev Biol 339, no. 2 (March 15, 2010): 295-306. Full Text Link to Item
  - Hirschey, MD, Shimazu, T, Goetzman, E, Jing, E, Schwer, B, Lombard, DB, Grueter, CA, Harris, C, Biddinger, S, Ilkayeva, OR, Stevens, RD, Li, Y, Saha, AK, Ruderman, NB, Bain, JR, Newgard, CB, Farese, RV, Alt, FW, Kahn, CR, and Verdin, E. "SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation." Nature 464, no. 7285 (March 2010): 121-125. Full Text
  - Zhang, W, Telemaque, S, Augustyniak, RA, Anderson, P, Thomas, GD, An, J, Wang, Z, Newgard, CB, and Victor, RG. "Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity." J Neuroendocrinol 22, no. 3 (March 2010): 175-180. Full Text Link to Item
  - Lavine, JA, Raess, PW, Davis, DB, Rabaglia, ME, Presley, BK, Keller, MP, Beinfeld, MC, Kopin, AS, Newgard, CB, and Attie, AD. "Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note." Mol Endocrinol 24, no. 2 (February 2010): 464-467. Full Text Link to Item
  - Lavine, JA, Raess, PW, Davis, DB, Rabaglia, ME, Presley, BK, Keller, MP, Beinfeld, MC, Kopin, AS, Newgard, CB, and Attie, AD. "Overexpression of pre-pro-cholecystokinin stimulates β-cell proliferation in mouse and human islets with retention of islet function (Molecular Endocrinology (2008) 22, (2716-2728))." Molecular Endocrinology 24, no. 2 (February 1, 2010): 472-null.
  - Newgard, CB, Stevens, RD, Wenner, BR, Burgess, SC, Ilkayeva, O, Muehlbauer, MJ, Dean Sherry, A, and Bain, JR. "Comprehensive Metabolic Analysis for Understanding of Disease." (2010): 97-107. Full Text
  - Chao, LC, Wroblewski, K, Zhang, Z, Pei, L, Vergnes, L, Ilkayeva, OR, Ding, SY, Reue, K, Watt, MJ, Newgard, CB, Pilch, PF, Hevener, AL, and Tontonoz, P. "Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77." Diabetes 58, no. 12 (December 2009): 2788-2796. Full Text
  - Newgard, CB, Stevens, RD, Wenner, BR, Burgess, SC, Ilkayeva, O, Muehlbauer, MJ, Sherry, AD, and Bain, JR. "Comprehensive Metabolic Analysis for Understanding of Disease Mechanisms." (December 1, 2009): 180-192. (Chapter) Full Text
  - Anderson, KR, Torres, CA, Solomon, K, Becker, TC, Newgard, CB, Wright, CV, Hagman, J, and Sussel, L. "Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3." The Journal of Biological Chemistry 284, no. 45 (November 2009): 31236-31248. Full Text
  - Bain, JR, Stevens, RD, Wenner, BR, Ilkayeva, O, Muoio, DM, and Newgard, CB. "Metabolomics applied to diabetes research: moving from information to knowledge." Diabetes 58, no. 11 (November 2009): 2429-2443. Full Text Link to Item
  - Dong, B, Saha, PK, Huang, W, Chen, W, Abu-Elheiga, LA, Wakil, SJ, Stevens, RD, Ilkayeva, O, Newgard, CB, Chan, L, and Moore, DD. "Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease." Proceedings of the National Academy of Sciences of the United States of America 106, no. 44 (November 2009): 18831-18836. Full Text
  - Huffman, KM, Shah, SH, Stevens, RD, Bain, JR, Muehlbauer, M, Slentz, CA, Tanner, CJ, Kuchibhatla, M, Houmard, JA, Newgard, CB, and Kraus, WE. "Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women." Diabetes Care 32, no. 9 (September 2009): 1678-1683. Full Text
  - Grasfeder, LL, Gaillard, S, Hammes, SR, Ilkayeva, O, Newgard, CB, Hochberg, RB, Dwyer, MA, Chang, C-Y, and McDonnell, DP. "Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha." Mol Endocrinol 23, no. 8 (August 2009): 1171-1182. Full Text Link to Item
  - Malakauskas, SM, Kourany, WM, Zhang, XY, Lu, D, Stevens, RD, Koves, TR, Hohmeier, HE, Muoio, DM, Newgard, CB, and Le, TH. "Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha." Molecular Endocrinology (Baltimore, Md.) 23, no. 6 (June 2009): 881-892. Full Text
  - Newgard, CB, An, J, Bain, JR, Muehlbauer, MJ, Stevens, RD, Lien, LF, Haqq, AM, Shah, SH, Arlotto, M, Slentz, CA, Rochon, J, Gallup, D, Ilkayeva, O, Wenner, BR, Yancy, WS, Eisenson, H, Musante, G, Surwit, R, Millington, DS, Butler, MD, and Svetkey, LP. "A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance (DOI:10.1016/j.cmet.2009.02.002)." Cell Metabolism 9, no. 6 (May 14, 2009): 565-566. Full Text
  - Rathmell, JC, and Newgard, CB. "Biochemistry. A glucose-to-gene link." Science (New York, N.Y.) 324, no. 5930 (May 2009): 1021-1022. Full Text
  - Newgard, CB, An, J, Bain, JR, Muehlbauer, MJ, Stevens, RD, Lien, LF, Haqq, AM, Shah, SH, Arlotto, M, Slentz, CA, Rochon, J, Gallup, D, Ilkayeva, O, Wenner, BR, Yancy, WS, Eisenson, H, Musante, G, Surwit, RS, Millington, DS, Butler, MD, and Svetkey, LP. "A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance." Cell Metabolism 9, no. 4 (April 2009): 311-326. Full Text
  - Turer, AT, Stevens, RD, Bain, JR, Muehlbauer, MJ, van der Westhuizen, J, Mathew, JP, Schwinn, DA, Glower, DD, Newgard, CB, and Podgoreanu, MV. "Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion." Circulation 119, no. 13 (April 2009): 1736-1746. Full Text
  - Lamers, Y, Williamson, J, Ralat, M, Quinlivan, EP, Gilbert, LR, Keeling, C, Stevens, RD, Newgard, CB, Ueland, PM, Meyer, K, Fredriksen, A, Stacpoole, PW, and Gregory, JF. "Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women." J Nutr 139, no. 3 (March 2009): 452-460. Full Text Link to Item
  - Wardell, SE, Ilkayeva, OR, Wieman, HL, Frigo, DE, Rathmell, JC, Newgard, CB, and McDonnell, DP. "Glucose metabolism as a target of histone deacetylase inhibitors." Mol Endocrinol 23, no. 3 (March 2009): 388-401. Full Text Link to Item
  - Lien, LF, Haqq, AM, Arlotto, M, Slentz, CA, Muehlbauer, MJ, McMahon, RL, Rochon, J, Gallup, D, Bain, JR, Ilkayeva, O, Wenner, BR, Stevens, RD, Millington, DS, Muoio, DM, Butler, MD, Newgard, CB, and Svetkey, LP. "The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain." Omics : a Journal of Integrative Biology 13, no. 1 (February 2009): 21-35. Full Text
  - Moss, LG, and Newgard, CB. "The liver--a potential new player in islet regeneration?." Cell Metab 9, no. 1 (January 7, 2009): 5-6. Full Text Link to Item
  - Shah, SH, Freedman, NJ, Zhang, L, Crosslin, DR, Stone, DH, Haynes, C, Johnson, J, Nelson, S, Wang, L, Connelly, JJ, Muehlbauer, M, Ginsburg, GS, Crossman, DC, Jones, CJH, Vance, J, Sketch, MH, Granger, CB, Newgard, CB, Gregory, SG, Goldschmidt-Clermont, PJ, Kraus, WE, and Hauser, ER. "Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis." Plos Genetics 5, no. 1 (January 2, 2009): e1000318-null. Full Text Open Access Copy
  - Shah, SH, Hauser, ER, Bain, JR, Muehlbauer, MJ, Haynes, C, Stevens, RD, Wenner, BR, Dowdy, ZE, Granger, CB, Ginsburg, GS, Newgard, CB, and Kraus, WE. "High heritability of metabolomic profiles in families burdened with premature cardiovascular disease." Molecular Systems Biology 5 (January 2009): 258-null. Full Text
  - Torres, TP, Catlin, RL, Chan, R, Fujimoto, Y, Sasaki, N, Printz, RL, Newgard, CB, and Shiota, M. "Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats." Diabetes 58, no. 1 (January 2009): 78-86. Full Text Link to Item
  - Haqq, AM, Grambow, SC, Muehlbauer, M, Newgard, CB, Svetkey, LP, Carrel, AL, Yanovski, JA, Purnell, JQ, and Freemark, M. "Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development." Clinical Endocrinology 69, no. 6 (December 2008): 911-920. Full Text
  - Jensen, MV, Joseph, JW, Ronnebaum, SM, Burgess, SC, Sherry, AD, and Newgard, CB. "Metabolic cycling in control of glucose-stimulated insulin secretion." American Journal of Physiology. Endocrinology and Metabolism 295, no. 6 (December 2008): E1287-E1297. (Review) Full Text
  - Lavine, JA, Raess, PW, Davis, DB, Rabaglia, ME, Presley, BK, Keller, MP, Beinfeld, MC, Kopin, AS, Newgard, CB, and Attie, AD. "Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function." Mol Endocrinol 22, no. 12 (December 2008): 2716-2728. Full Text Link to Item
  - Chopra, AR, Louet, J-F, Saha, P, An, J, Demayo, F, Xu, J, York, B, Karpen, S, Finegold, M, Moore, D, Chan, L, Newgard, CB, and O'Malley, BW. "Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease." Science (New York, N.Y.) 322, no. 5906 (November 2008): 1395-1399. Full Text
  - Ronnebaum, SM, Jensen, MV, Hohmeier, HE, Burgess, SC, Zhou, Y-P, Qian, S, MacNeil, D, Howard, A, Thornberry, N, Ilkayeva, O, Lu, D, Sherry, AD, and Newgard, CB. "Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets." The Journal of Biological Chemistry 283, no. 43 (October 2008): 28909-28917. Full Text
  - Muoio, DM, and Newgard, CB. "Fatty acid oxidation and insulin action: when less is more." Diabetes 57, no. 6 (June 2008): 1455-1456. Full Text Link to Item
  - Fueger, PT, Schisler, JC, Lu, D, Babu, DA, Mirmira, RG, Newgard, CB, and Hohmeier, HE. "Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function." Mol Endocrinol 22, no. 5 (May 2008): 1251-1259. Full Text Link to Item
  - Ronnebaum, SM, Joseph, JW, Ilkayeva, O, Burgess, SC, Lu, D, Becker, TC, Sherry, AD, and Newgard, CB. "Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism." The Journal of Biological Chemistry 283, no. 21 (May 2008): 14248-14256. Full Text
  - Schisler, JC, Fueger, PT, Babu, DA, Hohmeier, HE, Tessem, JS, Lu, D, Becker, TC, Naziruddin, B, Levy, M, Mirmira, RG, and Newgard, CB. "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1." Molecular and Cellular Biology 28, no. 10 (May 2008): 3465-3476. Full Text
  - Ferrara, CT, Wang, P, Neto, EC, Stevens, RD, Bain, JR, Wenner, BR, Ilkayeva, OR, Keller, MP, Blasiole, DA, Kendziorski, C, Yandell, BS, Newgard, CB, and Attie, AD. "Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling." Plos Genetics 4, no. 3 (March 14, 2008): e1000034-null. Full Text
  - Muoio, DM, and Newgard, CB. "Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes." Nature Reviews. Molecular Cell Biology 9, no. 3 (March 2008): 193-205. (Review) Full Text
  - Kimple, ME, Joseph, JW, Bailey, CL, Fueger, PT, Hendry, IA, Newgard, CB, and Casey, PJ. "Galphaz negatively regulates insulin secretion and glucose clearance." J Biol Chem 283, no. 8 (February 22, 2008): 4560-4567. Full Text Link to Item
  - Kimple, ME, Joseph, JW, Bailey, CL, Fueger, PT, Hendry, IA, Newgard, CB, and Casey, PJ. "Gαz negatively regulates insulin secretion and glucose clearance." Journal of Biological Chemistry 283, no. 8 (February 22, 2008): 4560-4567. Full Text
  - Koves, TR, Ussher, JR, Noland, RC, Slentz, D, Mosedale, M, Ilkayeva, O, Bain, J, Stevens, R, Dyck, JRB, Newgard, CB, Lopaschuk, GD, and Muoio, DM. "Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance." Cell Metabolism 7, no. 1 (January 2008): 45-56. Full Text
  - Clark, C, and Newgard, CB. "Hepatic regulation of fuel metabolism." (December 1, 2007): 90-109. (Chapter) Full Text
  - Haqq, AM, Muehlbauer, M, Svetkey, LP, Newgard, CB, Purnell, JQ, Grambow, SC, and Freemark, MS. "Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones." Clinical Endocrinology 67, no. 6 (December 2007): 944-951. Full Text
  - Levin, MC, Monetti, M, Watt, MJ, Sajan, MP, Stevens, RD, Bain, JR, Newgard, CB, and Farese, RV. "Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle." American Journal of Physiology. Endocrinology and Metabolism 293, no. 6 (December 2007): E1772-E1781. Full Text
  - Joseph, JW, Odegaard, ML, Ronnebaum, SM, Burgess, SC, Muehlbauer, J, Sherry, AD, and Newgard, CB. "Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion." The Journal of Biological Chemistry 282, no. 43 (October 2007): 31592-31600. Full Text
  - Montori-Grau, M, Guitart, M, Lerin, C, Andreu, AL, Newgard, CB, García-Martínez, C, and Gómez-Foix, AM. "Erratum: Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle (Biochemical Journal (2007) 405, (107-113))." Biochemical Journal 405, no. 3 (August 1, 2007): 625-null.
  - Monetti, M, Levin, MC, Watt, MJ, Sajan, MP, Marmor, S, Hubbard, BK, Stevens, RD, Bain, JR, Newgard, CB, Farese, RV, and Hevener, AL. "Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver." Cell Metabolism 6, no. 1 (July 2007): 69-78. Full Text
  - Montori-Grau, M, Guitart, M, Lerin, C, Andreu, AL, Newgard, CB, García-Martínez, C, and Gómez-Foix, AM. "Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle." The Biochemical Journal 405, no. 1 (July 2007): 107-113. Full Text
  - Nagle, CA, An, J, Shiota, M, Torres, TP, Cline, GW, Liu, Z-X, Wang, S, Catlin, RL, Shulman, GI, Newgard, CB, and Coleman, RA. "Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance." The Journal of Biological Chemistry 282, no. 20 (May 2007): 14807-14815. Full Text
  - Gleason, CE, Lu, D, Witters, LA, Newgard, CB, and Birnbaum, MJ. "The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells." The Journal of Biological Chemistry 282, no. 14 (April 2007): 10341-10351. Full Text
  - Hardy, OT, Hohmeier, HE, Becker, TC, Manduchi, E, Doliba, NM, Gupta, RK, White, P, Stoeckert, CJ, Matschinsky, FM, Newgard, CB, and Kaestner, KH. "Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents." Molecular Endocrinology (Baltimore, Md.) 21, no. 3 (March 2007): 765-773. Full Text
  - Pedersen, KB, Zhang, P, Doumen, C, Charbonnet, M, Lu, D, Newgard, CB, Haycock, JW, Lange, AJ, and Scott, DK. "The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions." Am J Physiol Endocrinol Metab 292, no. 3 (March 2007): E788-E801. Full Text Link to Item
  - Zhang, Y-M, Chohnan, S, Virga, KG, Stevens, RD, Ilkayeva, OR, Wenner, BR, Bain, JR, Newgard, CB, Lee, RE, Rock, CO, and Jackowski, S. "Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis." Chemistry & Biology 14, no. 3 (March 2007): 291-302. Full Text
  - Li, LO, Mashek, DG, An, J, Doughman, SD, Newgard, CB, and Coleman, RA. "Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes." The Journal of Biological Chemistry 281, no. 48 (December 2006): 37246-37255. Full Text
  - Joseph, JW, Jensen, MV, Ilkayeva, O, Palmieri, F, Alárcon, C, Rhodes, CJ, and Newgard, CB. "The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion." The Journal of Biological Chemistry 281, no. 47 (November 2006): 35624-35632. Full Text
  - Ronnebaum, SM, Ilkayeva, O, Burgess, SC, Joseph, JW, Lu, D, Stevens, RD, Becker, TC, Sherry, AD, Newgard, CB, and Jensen, MV. "A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion." The Journal of Biological Chemistry 281, no. 41 (October 2006): 30593-30602. Full Text
  - Jensen, MV, Joseph, JW, Ilkayeva, O, Burgess, S, Lu, D, Ronnebaum, SM, Odegaard, M, Becker, TC, Sherry, AD, and Newgard, CB. "Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion." The Journal of Biological Chemistry 281, no. 31 (August 2006): 22342-22351. Full Text
  - Raum, JC, Gerrish, K, Artner, I, Henderson, E, Guo, M, Sussel, L, Schisler, JC, Newgard, CB, and Stein, R. "FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site." Molecular and Cellular Biology 26, no. 15 (August 2006): 5735-5743. Full Text
  - Qi, L, Heredia, JE, Altarejos, JY, Screaton, R, Goebel, N, Niessen, S, Macleod, IX, Liew, CW, Kulkarni, RN, Bain, J, Newgard, C, Nelson, M, Evans, RM, Yates, J, and Montminy, M. "TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism." Science (New York, N.Y.) 312, no. 5781 (June 2006): 1763-1766. Full Text
  - Chen, S, Ding, J-H, Bekeredjian, R, Yang, B-Z, Shohet, RV, Johnston, SA, Hohmeier, HE, Newgard, CB, and Grayburn, PA. "Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology." Proceedings of the National Academy of Sciences of the United States of America 103, no. 22 (May 18, 2006): 8469-8474. Full Text
  - Collier, JJ, Fueger, PT, Hohmeier, HE, and Newgard, CB. "Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines." Diabetes 55, no. 5 (May 2006): 1398-1406. Full Text
  - Muoio, DM, and Newgard, CB. "Obesity-related derangements in metabolic regulation." Annual Review of Biochemistry 75 (January 2006): 367-401. (Review) Full Text
  - Haqq, AM, Lien, LF, Boan, J, Arlotto, M, Slentz, CA, Muehlbauer, MJ, Rochon, J, Gallup, D, McMahon, RL, Bain, JR, Stevens, R, Millington, D, Butler, MD, Newgard, CB, and Svetkey, LP. "The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design." Contemporary Clinical Trials 26, no. 6 (December 2005): 616-625. Full Text
  - Hohmeier, HE, and Newgard, CB. "Islets for all?." Nature Biotechnology 23, no. 10 (October 2005): 1231-1232. Full Text
  - Koves, TR, Li, P, An, J, Akimoto, T, Slentz, D, Ilkayeva, O, Dohm, GL, Yan, Z, Newgard, CB, and Muoio, DM. "Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency." The Journal of Biological Chemistry 280, no. 39 (September 2005): 33588-33598. Full Text
  - De, J, Chang, Y-C, Samli, KN, Schisler, JC, Newgard, CB, Johnston, SA, and Brown, KC. "Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library." Molecular Biosystems 1, no. 2 (July 2005): 149-157. Full Text
  - Muoio, DM, and Newgard, CB. "Metabolism: A is for adipokine." Nature 436, no. 7049 (July 2005): 337-338. Full Text
  - Samli, KN, McGuire, MJ, Newgard, CB, Johnston, SA, and Brown, KC. "Peptide-mediated targeting of the islets of Langerhans." Diabetes 54, no. 7 (July 2005): 2103-2108. Full Text
  - Schisler, JC, Jensen, PB, Taylor, DG, Becker, TC, Knop, FK, Takekawa, S, German, M, Weir, GC, Lu, D, Mirmira, RG, and Newgard, CB. "The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells." Proceedings of the National Academy of Sciences of the United States of America 102, no. 20 (May 9, 2005): 7297-7302. Full Text
  - Iype, T, Francis, J, Garmey, JC, Schisler, JC, Nesher, R, Weir, GC, Becker, TC, Newgard, CB, Griffen, SC, and Mirmira, RG. "Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes." The Journal of Biological Chemistry 280, no. 17 (April 2005): 16798-16807. Full Text
  - Lin, J, Yang, R, Tarr, PT, Wu, P-H, Handschin, C, Li, S, Yang, W, Pei, L, Uldry, M, Tontonoz, P, Newgard, CB, and Spiegelman, BM. "Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP." Cell 120, no. 2 (January 2005): 261-273. Full Text
  - Hohmeier, HE, and Newgard, CB. "Cell lines derived from pancreatic islets." Mol Cell Endocrinol 228, no. 1-2 (December 30, 2004): 121-128. (Review) Full Text Link to Item
  - Muoio, DM, and Newgard, CB. "Biomedicine. Insulin resistance takes a trip through the ER." Science (New York, N.Y.) 306, no. 5695 (October 2004): 425-426. Full Text
  - Bain, JR, Schisler, JC, Takeuchi, K, Newgard, CB, and Becker, TC. "An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans." Diabetes 53, no. 9 (September 2004): 2190-2194. Link to Item
  - Boucher, A, Lu, D, Burgess, SC, Telemaque-Potts, S, Jensen, MV, Mulder, H, Wang, M-Y, Unger, RH, Sherry, AD, and Newgard, CB. "Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue." The Journal of Biological Chemistry 279, no. 26 (June 2004): 27263-27271. Full Text
  - An, J, Muoio, DM, Shiota, M, Fujimoto, Y, Cline, GW, Shulman, GI, Koves, TR, Stevens, R, Millington, D, and Newgard, CB. "Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance." Nature Medicine 10, no. 3 (March 2004): 268-274. Full Text
  - Newgard, CB, Hohmeier, HE, Lu, D, Jensen, MV, Tran, VV, Chen, G, Burgess, S, and Sherry, AD. "Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies." Cell Biochemistry and Biophysics 40, no. 3 Suppl (January 2004): 159-168. (Review) Full Text
  - Hohmeier, HE, Tran, VV, Chen, G, Gasa, R, and Newgard, CB. "Inflammatory mechanisms in diabetes: lessons from the beta-cell." Int J Obes Relat Metab Disord 27 Suppl 3 (December 2003): S12-S16. (Review) Full Text Link to Item
  - Ramanadham, S, Song, H, Hsu, F-F, Zhang, S, Crankshaw, M, Grant, GA, Newgard, CB, Bao, S, Ma, Z, and Turk, J. "Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript." Biochemistry 42, no. 47 (December 2003): 13929-13940. Full Text
  - Lerín, C, Montell, E, Nolasco, T, Clark, C, Brady, MJ, Newgard, CB, and Gómez-Foix, AM. "Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content." Diabetes 52, no. 9 (September 2003): 2221-2226. Link to Item
  - Lin, J, Tarr, PT, Yang, R, Rhee, J, Puigserver, P, Newgard, CB, and Spiegelman, BM. "PGC-1beta in the regulation of hepatic glucose and energy metabolism." The Journal of Biological Chemistry 278, no. 33 (August 2003): 30843-30848. Full Text
  - St-Pierre, J, Lin, J, Krauss, S, Tarr, PT, Yang, R, Newgard, CB, and Spiegelman, BM. "Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells." The Journal of Biological Chemistry 278, no. 29 (July 2003): 26597-26603. Full Text
  - Yoon, JC, Xu, G, Deeney, JT, Yang, S-N, Rhee, J, Puigserver, P, Levens, AR, Yang, R, Zhang, C-Y, Lowell, BB, Berggren, P-O, Newgard, CB, Bonner-Weir, S, Weir, G, and Spiegelman, BM. "Suppression of beta cell energy metabolism and insulin release by PGC-1alpha." Developmental Cell 5, no. 1 (July 2003): 73-83. Full Text
  - Yang, R, and Newgard, CB. "Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression." J Biol Chem 278, no. 26 (June 27, 2003): 23418-23425. Full Text Link to Item
  - Tran, VV, Chen, G, Newgard, CB, and Hohmeier, HE. "Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy." Diabetes 52, no. 6 (June 2003): 1423-1432. Link to Item
  - Newgard, CB, Lu, D, Jensen, MV, Schissler, J, Boucher, A, Burgess, S, and Sherry, AD. "Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach." Diabetes 51 Suppl 3 (December 2002): S389-S393. (Review) Full Text
  - Newgard, CB. "While tinkering with the beta-cell...metabolic regulatory mechanisms and new therapeutic strategies: American Diabetes Association Lilly Lecture, 2001." Diabetes 51, no. 11 (November 2002): 3141-3150. Full Text
  - Guan, H-P, Li, Y, Jensen, MV, Newgard, CB, Steppan, CM, and Lazar, MA. "A futile metabolic cycle activated in adipocytes by antidiabetic agents." Nature Medicine 8, no. 10 (October 2002): 1122-1128. Full Text
  - Antinozzi, PA, Ishihara, H, Newgard, CB, and Wollheim, CB. "Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues." The Journal of Biological Chemistry 277, no. 14 (April 2002): 11746-11755. Full Text
  - Lu, D, Mulder, H, Zhao, P, Burgess, SC, Jensen, MV, Kamzolova, S, Newgard, CB, and Sherry, AD. "13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)." Proceedings of the National Academy of Sciences of the United States of America 99, no. 5 (March 2002): 2708-2713. Full Text
  - Gasa, R, Clark, C, Yang, R, DePaoli-Roach, AA, and Newgard, CB. "Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1." J Biol Chem 277, no. 2 (January 11, 2002): 1524-1530. Full Text Link to Item
  - Jiménez-Chillarón, JC, Telemaque-Potts, S, Gómez-Valadés, AG, Anderson, P, Newgard, CB, and Gómez-Foix, AM. "Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake." Metabolism 51, no. 1 (January 2002): 121-126. Link to Item
  - Montell, E, Lerín, C, Newgard, CB, and Gómez-Foix, AM. "Effects of modulation of glycerol kinase expression on lipid and carbohydrate metabolism in human muscle cells." The Journal of Biological Chemistry 277, no. 4 (January 2002): 2682-2686. Full Text
  - Wu, C, Okar, DA, Newgard, CB, and Lange, AJ. "Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes." Am J Physiol Endocrinol Metab 282, no. 1 (January 2002): E38-E45. Full Text Link to Item
  - Yang, R, Cao, L, Gasa, R, Brady, MJ, Sherry, AD, and Newgard, CB. "Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes." The Journal of Biological Chemistry 277, no. 2 (January 2002): 1514-1523. Full Text
  - Yoon, JC, Puigserver, P, Chen, G, Donovan, J, Wu, Z, Rhee, J, Adelmant, G, Stafford, J, Kahn, CR, Granner, DK, Newgard, CB, and Spiegelman, BM. "Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1." Nature 413, no. 6852 (September 2001): 131-138. Full Text
  - Sonenberg, N, and Newgard, CB. "Protein synthesis. The perks of balancing glucose." Science 293, no. 5531 (August 3, 2001): 818-819. Full Text Link to Item
  - An, J, Li, Y, van De Werve, G, and Newgard, CB. "Overexpression of the P46 (T1) translocase component of the glucose-6-phosphatase complex in hepatocytes impairs glycogen accumulation via hydrolysis of glucose 1-phosphate." J Biol Chem 276, no. 14 (April 6, 2001): 10722-10729. Full Text Link to Item
  - Mulder, H, Lu, D, Finley, J, An, J, Cohen, J, Antinozzi, PA, McGarry, JD, and Newgard, CB. "Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells." The Journal of Biological Chemistry 276, no. 9 (March 2001): 6479-6484. Full Text
  - Chen, G, Hohmeier, HE, and Newgard, CB. "Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines." The Journal of Biological Chemistry 276, no. 1 (January 2001): 766-772. Full Text
  - Wu, C, Okar, DA, Newgard, CB, and Lange, AJ. "Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production." J Clin Invest 107, no. 1 (January 2001): 91-98. Full Text Link to Item
  - Bandyopadhyay, G, Sajan, MP, Kanoh, Y, Standaert, ML, Burke, TR, Quon, MJ, Reed, BC, Dikic, I, Noel, LE, Newgard, CB, and Farese, R. "Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter." J Biol Chem 275, no. 52 (December 29, 2000): 40817-40826. Full Text Link to Item
  - Lerín, C, Montell, E, Berman, HK, Newgard, CB, and Gómez-Foix, AM. "Overexpression of protein targeting to glycogen in cultured human muscle cells stimulates glycogen synthesis independent of glycogen and glucose 6-phosphate levels." J Biol Chem 275, no. 51 (December 22, 2000): 39991-39995. Full Text Link to Item
  - Newgard, CB, Brady, MJ, O'Doherty, RM, and Saltiel, AR. "Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1." Diabetes 49, no. 12 (December 2000): 1967-1977. (Review) Link to Item
  - Roduit, R, Morin, J, Massé, F, Segall, L, Roche, E, Newgard, CB, Assimacopoulos-Jeannet, F, and Prentki, M. "Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell." The Journal of Biological Chemistry 275, no. 46 (November 2000): 35799-35806. Full Text
  - Gasa, R, Jensen, PB, Berman, HK, Brady, MJ, DePaoli-Roach, AA, and Newgard, CB. "Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in hepatocytes." J Biol Chem 275, no. 34 (August 25, 2000): 26396-26403. Full Text Link to Item
  - Chen, G, Hohmeier, HE, Gasa, R, Tran, VV, and Newgard, CB. "Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity." Diabetes 49, no. 4 (April 2000): 562-570. Link to Item
  - Buettner, R, Newgard, CB, Rhodes, CJ, and O'Doherty, RM. "Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia." Am J Physiol Endocrinol Metab 278, no. 3 (March 2000): E563-E569. Full Text Link to Item
  - Buettner, R, Newgard, CB, Rhodes, CJ, and O'Doherty, RM. "Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia." American Journal of Physiology Endocrinology and Metabolism 278, no. 3 41-3 (March 1, 2000).
  - Hohmeier, HE, Mulder, H, Chen, G, Henkel-Rieger, R, Prentki, M, and Newgard, CB. "Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion." Diabetes 49, no. 3 (March 2000): 424-430. Full Text
  - O'Doherty, RM, Jensen, PB, Anderson, P, Jones, JG, Berman, HK, Kearney, D, and Newgard, CB. "Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen." J Clin Invest 105, no. 4 (February 2000): 479-488. Full Text Link to Item
  - Werve, GVD, Lange, A, Newgard, C, Méchin, M-C, Li, Y, and Berteloot, A. "New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system." European Journal of Biochemistry 267, no. 6 (2000): 1533-1549. Full Text
  - Jiménez-Chillarón, JC, Newgard, CB, and Gómez-Foix, AM. "Increased glucose disposal induced by adenovirus-mediated transfer of glucokinase to skeletal muscle in vivo." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 13, no. 15 (December 1999): 2153-2160. Full Text
  - Seoane, J, Barberà, A, Télémaque-Potts, S, Newgard, CB, and Guinovart, JJ. "Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats." The Journal of Biological Chemistry 274, no. 45 (November 1999): 31833-31838. Full Text
  - O'Doherty, RM, Lehman, DL, Télémaque-Potts, S, and Newgard, CB. "Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia." Diabetes 48, no. 10 (October 1999): 2022-2027. Link to Item
  - O'Doherty, RM, Anderson, PR, Zhao, AZ, Bornfeldt, KE, and Newgard, CB. "Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition." The American Journal of Physiology 277, no. 3 (September 1999): E544-E550. Full Text
  - O'Doherty, RM, Anderson, PR, Zhao, AZ, Bornfeldt, KE, and Newgard, CB. "Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition." American Journal of Physiology Endocrinology and Metabolism 277, no. 3 40-3 (September 1, 1999).
  - Aiston, S, Trinh, KY, Lange, AJ, Newgard, CB, and Agius, L. "Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase." J Biol Chem 274, no. 35 (August 27, 1999): 24559-24566. Link to Item
  - Gaisano, HY, Huang, X, Sheu, L, Ghai, M, Newgard, CB, Trinh, KY, and Trimble, WS. "Snare protein expression and adenoviral transfection of amphicrine AR42J." Biochem Biophys Res Commun 260, no. 3 (July 14, 1999): 781-784. Full Text Link to Item
  - Seijffers, R, Ben-David, O, Cohen, Y, Karasik, A, Berezin, M, Newgard, CB, and Ferber, S. "Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells." Endocrinology 140, no. 7 (July 1999): 3311-3317. Full Text
  - Gasa, R, Trinh, KY, Yu, K, Wilkie, TM, and Newgard, CB. "Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion." Diabetes 48, no. 5 (May 1999): 1035-1044. Full Text
  - Wang, MY, Shimabukuro, M, Lee, Y, Trinh, KY, Chen, JL, Newgard, CB, and Unger, RH. "Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function." Diabetes 48, no. 5 (May 1999): 1020-1025. Link to Item
  - Zhou, YT, Wang, ZW, Higa, M, Newgard, CB, and Unger, RH. "Reversing adipocyte differentiation: implications for treatment of obesity." Proceedings of the National Academy of Sciences of the United States of America 96, no. 5 (March 1999): 2391-2395. Full Text
  - Antinozzi, PA, Berman, HK, O'Doherty, RM, and Newgard, CB. "Metabolic engineering with recombinant adenoviruses." Annu Rev Nutr 19 (1999): 511-544. (Review) Full Text Link to Item
  - Shimabukuro, M, Higa, M, Zhou, YT, Wang, MY, Newgard, CB, and Unger, RH. "Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression." The Journal of Biological Chemistry 273, no. 49 (December 1998): 32487-32490. Full Text
  - Trinh, KY, O'Doherty, RM, Anderson, P, Lange, AJ, and Newgard, CB. "Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats." J Biol Chem 273, no. 47 (November 20, 1998): 31615-31620. Link to Item
  - Berman, HK, O'Doherty, RM, Anderson, P, and Newgard, CB. "Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms." J Biol Chem 273, no. 41 (October 9, 1998): 26421-26425. Link to Item
  - Scott, DK, O'Doherty, RM, Stafford, JM, Newgard, CB, and Granner, DK. "The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism." J Biol Chem 273, no. 37 (September 11, 1998): 24145-24151. Link to Item
  - Baqué, S, Montell, E, Guinovart, JJ, Newgard, CB, and Gómez-Foix, AM. "Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage." Diabetes 47, no. 9 (September 1998): 1392-1398. Link to Item
  - Wang, MY, Koyama, K, Shimabukuro, M, Mangelsdorf, D, Newgard, CB, and Unger, RH. "Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion." Proceedings of the National Academy of Sciences of the United States of America 95, no. 20 (September 1998): 11921-11926. Full Text
  - Koyama, K, Shimabukuro, M, Chen, G, Wang, MY, Lee, Y, Kalra, PS, Dube, MG, Kalra, SP, Newgard, CB, and Unger, RH. "Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors." J Clin Invest 102, no. 4 (August 15, 1998): 728-733. Full Text Link to Item
  - Shimabukuro, M, Wang, MY, Zhou, YT, Newgard, CB, and Unger, RH. "Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression." Proc Natl Acad Sci U S A 95, no. 16 (August 4, 1998): 9558-9561. Link to Item
  - Zhou, YT, Shimabukuro, M, Wang, MY, Lee, Y, Higa, M, Milburn, JL, Newgard, CB, and Unger, RH. "Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells." Proc Natl Acad Sci U S A 95, no. 15 (July 21, 1998): 8898-8903. Link to Item
  - Antinozzi, PA, Segall, L, Prentki, M, McGarry, JD, and Newgard, CB. "Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis." The Journal of Biological Chemistry 273, no. 26 (June 1998): 16146-16154. Full Text
  - Hohmeier, HE, Thigpen, A, Tran, VV, Davis, R, and Newgard, CB. "Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production." J Clin Invest 101, no. 9 (May 1, 1998): 1811-1820. Full Text Link to Item
  - Berman, HK, and Newgard, CB. "Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression." Biochemistry 37, no. 13 (March 31, 1998): 4543-4552. Full Text Link to Item
  - Wang, MY, Koyama, K, Shimabukuro, M, Newgard, CB, and Unger, RH. "OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype." Proc Natl Acad Sci U S A 95, no. 2 (January 20, 1998): 714-718. Link to Item
  - Seoane, J, Trinh, K, O'Doherty, RM, Gómez-Foix, AM, Lange, AJ, Newgard, CB, and Guinovart, JJ. "Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes." The Journal of Biological Chemistry 272, no. 43 (October 1997): 26972-26977. Full Text
  - Trinh, K, Minassian, C, Lange, AJ, O'Doherty, RM, and Newgard, CB. "Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion." The Journal of Biological Chemistry 272, no. 40 (October 1997): 24837-24842. Full Text
  - Antinozzi, PA, Ramanathan M., J, and Newgard, CB. "Evidence that potentiation of insulin secretion is mediated by free rather than CoA-activated fatty acids." Experimental and Clinical Endocrinology and Diabetes 105, no. 4 (September 24, 1997).
  - Koyama, K, Chen, G, Wang, MY, Lee, Y, Shimabukuro, M, Newgard, CB, and Unger, RH. "beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy." Diabetes 46, no. 8 (August 1997): 1276-1280. Link to Item
  - Newgard, CB, Clark, S, BeltrandelRio, H, Hohmeier, HE, Quaade, C, and Normington, K. "Engineered cell lines for insulin replacement in diabetes: current status and future prospects." Diabetologia 40 Suppl 2 (July 1997): S42-S47. (Review) Full Text
  - Noel, RJ, Antinozzi, PA, McGarry, JD, and Newgard, CB. "Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling." The Journal of Biological Chemistry 272, no. 30 (July 1997): 18621-18627. Full Text
  - Clark, SA, Quaade, C, Constandy, H, Hansen, P, Halban, P, Ferber, S, Newgard, CB, and Normington, K. "Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression." Diabetes 46, no. 6 (June 1997): 958-967. Full Text
  - Hohmeier, HE, BeltrandelRio, H, Clark, SA, Henkel-Rieger, R, Normington, K, and Newgard, CB. "Regulation of insulin secretion from novel engineered insulinoma cell lines." Diabetes 46, no. 6 (June 1997): 968-977. Full Text
  - Zhou, YT, Shimabukuro, M, Koyama, K, Lee, Y, Wang, MY, Trieu, F, Newgard, CB, and Unger, RH. "Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation." Proceedings of the National Academy of Sciences of the United States of America 94, no. 12 (June 1997): 6386-6390. Full Text
  - Argaud, D, Kirby, TL, Newgard, CB, and Lange, AJ. "Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate." J Biol Chem 272, no. 19 (May 9, 1997): 12854-12861. Link to Item
  - Noel, LE, and Newgard, CB. "Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras." Biochemistry 36, no. 18 (May 6, 1997): 5465-5475. Full Text Link to Item
  - Shimabukuro, M, Koyama, K, Chen, G, Wang, MY, Trieu, F, Lee, Y, Newgard, CB, and Unger, RH. "Direct antidiabetic effect of leptin through triglyceride depletion of tissues." Proceedings of the National Academy of Sciences of the United States of America 94, no. 9 (April 1997): 4637-4641. Full Text
  - Newgard, CB, Becker, TC, Berman, HK, and O'Doherty, RM. "Regulation of overexpressed hexokinases in liver and islet cells." Biochem Soc Trans 25, no. 1 (February 1997): 118-122. (Review) Link to Item
  - Chen, G, Koyama, K, Yuan, X, Lee, Y, Zhou, YT, O'Doherty, R, Newgard, CB, and Unger, RH. "Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy." Proc Natl Acad Sci U S A 93, no. 25 (December 10, 1996): 14795-14799. Link to Item
  - O'Doherty, RM, Lehman, DL, and Newgard, CB. "Adenoviral-mediated glucokinase overexpression in rat primary hepatocytes increases the efficiency of glycogen accumulation and lactate production at physiologic glucose concentrations." Faseb Journal 10, no. 3 (December 1, 1996).
  - Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "Insulinsezernierende Zellen zur Therapie des Diabetes mellitus." Naturwissenschaften 83, no. 1 (December 1, 1996): 1-5.
  - Agius, L, Peak, M, Newgard, CB, Gomez-Foix, AM, and Guinovart, JJ. "Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis." J Biol Chem 271, no. 48 (November 29, 1996): 30479-30486. Link to Item
  - Seoane, J, Gómez-Foix, AM, O'Doherty, RM, Gómez-Ara, C, Newgard, CB, and Guinovart, JJ. "Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase." The Journal of Biological Chemistry 271, no. 39 (September 1996): 23756-23760. Full Text
  - Wang, MY, Zhou, YT, Newgard, CB, and Unger, RH. "A novel leptin receptor isoform in rat." FEBS Lett 392, no. 2 (August 26, 1996): 87-90. Link to Item
  - O'Doherty, RM, Lehman, DL, Seoane, J, Gómez-Foix, AM, Guinovart, JJ, and Newgard, CB. "Differential metabolic effects of adenovirus-mediated glucokinase and hexokinase I overexpression in rat primary hepatocytes." The Journal of Biological Chemistry 271, no. 34 (August 1996): 20524-20530. Full Text
  - Becker, TC, Noel, RJ, Johnson, JH, Lynch, RM, Hirose, H, Tokuyama, Y, Bell, GI, and Newgard, CB. "Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes." The Journal of Biological Chemistry 271, no. 1 (January 1996): 390-394. Full Text
  - Newgard, CB. "Regulatory role of glucose transport and phosphorylation in pancreatic islet β-cells." Diabetes Reviews 4, no. 2 (January 1, 1996): 191-206.
  - Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "[Insulin producing cells as therapy in diabetes mellitus]." Die Naturwissenschaften 83, no. 1 (January 1996): 1-5. (Review) Full Text
  - Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "Insulin secretory cells for the therapy of diabetes mellitus." Naturwissenschaften 83, no. 1 (1996): 1-5. Full Text
  - Schnedl, WJ, Hohmeier, HE, and Newgard, CB. "Insulinsezernierende Zellen zur Therapie des Diabetes mellitus." Naturwissenschaften 83, no. 1 (January 1, 1996): 1-5. Full Text
  - Wang, MY, Zhou, YT, Newgard, CB, and Unger, RH. "Erratum: A novel leptin receptor isoform in rat (FEBS Letters 392 (1996) (87-90)) (PII S0014579396007909)." Febs Letters 398, no. 2-3 (January 1, 1996): 344-null.
  - Argaud, D, Lange, AJ, Becker, TC, Okar, DA, el-Maghrabi, MR, Newgard, CB, and Pilkis, SJ. "Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels." J Biol Chem 270, no. 41 (October 13, 1995): 24229-24236. Link to Item
  - Milburn, JL, Hirose, H, Lee, YH, Nagasawa, Y, Ogawa, A, Ohneda, M, BeltrandelRio, H, Newgard, CB, Johnson, JH, and Unger, RH. "Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids." The Journal of Biological Chemistry 270, no. 3 (January 1995): 1295-1299. Full Text
  - Newgard, CB, and McGarry, JD. "Metabolic coupling factors in pancreatic beta-cell signal transduction." Annual Review of Biochemistry 64 (January 1995): 689-719. (Review) Full Text
  - Baqué, S, Newgard, CB, Gerard, RD, Guinovart, JJ, and Gómez-Foix, AM. "Adenovirus-mediated delivery into myocytes of muscle glycogen phosphorylase, the enzyme deficient in patients with glycogen-storage disease type V." Biochem J 304 ( Pt 3) (December 15, 1994): 1009-1014. Link to Item
  - Cassidy, LE, and Newgard, CB. "Glucose-stimulated insulin secretion in cell lines." Diabetes, Nutrition and Metabolism Clinical and Experimental 7, no. 4 (December 1, 1994): 189-195.
  - Schnedl, WJ, Ferber, S, Johnson, JH, and Newgard, CB. "STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells." Diabetes 43, no. 11 (November 1994): 1326-1333. Full Text
  - Becker, TC, BeltrandelRio, H, Noel, RJ, Johnson, JH, and Newgard, CB. "Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels." The Journal of Biological Chemistry 269, no. 33 (August 1994): 21234-21238.
  - Ferber, S, BeltrandelRio, H, Johnson, JH, Noel, RJ, Cassidy, LE, Clark, S, Becker, TC, Hughes, SD, and Newgard, CB. "GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity." The Journal of Biological Chemistry 269, no. 15 (April 1994): 11523-11529.
  - Ferber, S, Schnedl, WJ, BeltrandelRio, H, Irminger, JC, Halban, P, and Newgard, CB. "Molecular strategies for the treatment of diabetes." Transplant Proc 26, no. 2 (April 1994): 363-365. (Review) Link to Item
  - Newgard, CB. "Cellular engineering and gene therapy strategies for insulin replacement in diabetes." Diabetes 43, no. 3 (March 1994): 341-350. (Review) Full Text
  - Becker, TC, Noel, RJ, Coats, WS, Gómez-Foix, AM, Alam, T, Gerard, RD, and Newgard, CB. "Use of recombinant adenovirus for metabolic engineering of mammalian cells." Methods in Cell Biology 43 Pt A (January 1994): 161-189. (Review)
  - Becker, TC, Noel, RJ, Coats, WS, Gómez-Foix, AM, Alam, T, Gerard, RD, and Newgard, CB. "Chapter 8 Use of Recombinant Adenovirus for Metabolic Engineering of Mammalian Cells." Methods in Cell Biology 43, no. C (January 1, 1994): 161-189. Full Text
  - Newgard, CB, Hughes, SD, Quaade, C, Beltrandelrio, H, Gomez-Foix, AM, and Ferber, S. "Molecular engineering of the pancreatic beta-cell." The Journal of Laboratory and Clinical Medicine 122, no. 4 (October 1993): 356-363. (Review)
  - Hughes, SD, Quaade, C, Johnson, JH, Ferber, S, and Newgard, CB. "Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism." The Journal of Biological Chemistry 268, no. 20 (July 1993): 15205-15212.
  - Inman, LR, McAllister, CT, Chen, L, Hughes, S, Newgard, CB, Kettman, JR, Unger, RH, and Johnson, JH. "Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset." Proc Natl Acad Sci U S A 90, no. 4 (February 15, 1993): 1281-1284. Link to Item
  - Gómez-Foix, AM, Coats, WS, Baqué, S, Alam, T, Gerard, RD, and Newgard, CB. "Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism." J Biol Chem 267, no. 35 (December 15, 1992): 25129-25134. Link to Item
  - Newgard, CB. "Cellular engineering for the treatment of metabolic disorders: prospects for therapy in diabetes." Biotechnology (N Y) 10, no. 10 (October 1992): 1112-1120. Link to Item
  - Chen, L, Appel, MC, Alam, T, Miyaura, C, Sestak, A, O'Neil, J, Unger, RH, and Newgard, CB. "Factors regulating islet regeneration in the post-insulinoma NEDH rat." Adv Exp Med Biol 321 (1992): 71-80. (Review) Link to Item
  - Hughes, SD, Johnson, JH, Quaade, C, and Newgard, CB. "Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells." Proceedings of the National Academy of Sciences of the United States of America 89, no. 2 (January 1992): 688-692. Full Text
  - Newgard, CB. "Cellular engineering for the treatment of metabolic disorders: Prospects for therapy in diabetes." Bio/Technology 10, no. 10 (January 1, 1992): 1112-1120. Full Text
  - Newgard, CB, Norkiewicz, B, Hughes, SD, Frenkel, RA, Coats, WS, Martiniuk, F, and Johnston, JM. "Developmental expression of glycogenolytic enzymes in rabbit tissues: possible relationship to fetal lung maturation." Biochim Biophys Acta 1090, no. 3 (November 11, 1991): 333-342. Link to Item
  - Coats, WS, Browner, MF, Fletterick, RJ, and Newgard, CB. "An engineered liver glycogen phosphorylase with AMP allosteric activation." J Biol Chem 266, no. 24 (August 25, 1991): 16113-16119. Link to Item
  - Quaade, C, Hughes, SD, Coats, WS, Sestak, AL, Iynedjian, PB, and Newgard, CB. "Analysis of the protein products encoded by variant glucokinase transcripts via expression in bacteria." FEBS Lett 280, no. 1 (March 11, 1991): 47-52. Link to Item
  - Hughes, SD, Quaade, C, Milburn, JL, Cassidy, L, and Newgard, CB. "Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells." The Journal of Biological Chemistry 266, no. 7 (March 1991): 4521-4530.
  - Miyaura, C, Chen, L, Appel, M, Alam, T, Inman, L, Hughes, SD, Milburn, JL, Unger, RH, and Newgard, CB. "Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass." Mol Endocrinol 5, no. 2 (February 1991): 226-234. Full Text Link to Item
  - Orci, L, Ravazzola, M, Baetens, D, Inman, L, Amherdt, M, Peterson, RG, Newgard, CB, Johnson, JH, and Unger, RH. "Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia." Proc Natl Acad Sci U S A 87, no. 24 (December 1990): 9953-9957. Link to Item
  - Johnson, JH, Ogawa, A, Chen, L, Orci, L, Newgard, CB, Alam, T, and Unger, RH. "Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes." Science (New York, N.Y.) 250, no. 4980 (October 1990): 546-549. Full Text
  - Newgard, CB, Quaade, C, Hughes, SD, and Milburn, JL. "Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis." Biochem Soc Trans 18, no. 5 (October 1990): 851-853. Link to Item
  - Chen, L, Alam, T, Johnson, JH, Hughes, S, Newgard, CB, and Unger, RH. "Regulation of beta-cell glucose transporter gene expression." Proc Natl Acad Sci U S A 87, no. 11 (June 1990): 4088-4092. Link to Item
  - Johnson, JH, Newgard, CB, Milburn, JL, Lodish, HF, and Thorens, B. "The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence." J Biol Chem 265, no. 12 (April 25, 1990): 6548-6551. Link to Item
  - Johnson, JH, Ogawa, A, Chen, L, Alam, T, Unger, RH, Orci, L, and Newgard, CB. "Erratum: Underexpression of β cell high K(m) glucose transporters in noninsulin-dependent diabetes (Science (26 Oct. 1990) (546))." Science 250, no. 4985 (January 1, 1990): 1195-null. Full Text
  - Iynedjian, PB, Pilot, PR, Nouspikel, T, Milburn, JL, Quaade, C, Hughes, S, Ucla, C, and Newgard, CB. "Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans." Proceedings of the National Academy of Sciences of the United States of America 86, no. 20 (October 1989): 7838-7842. Full Text
  - Leffert, JD, Newgard, CB, Okamoto, H, Milburn, JL, and Luskey, KL. "Rat amylin: cloning and tissue-specific expression in pancreatic islets." Proc Natl Acad Sci U S A 86, no. 9 (May 1989): 3127-3130. Link to Item
  - Newgard, CB, Hwang, PK, and Fletterick, RJ. "The family of glycogen phosphorylases: structure and function." Critical Reviews in Biochemistry and Molecular Biology 24, no. 1 (January 1989): 69-99. (Review) Full Text
  - Newgard, CB, Littman, DR, van Genderen, C, Smith, M, and Fletterick, RJ. "Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes." J Biol Chem 263, no. 8 (March 15, 1988): 3850-3857. Link to Item
  - Newgard, CB, Fletterick, RJ, Anderson, LA, and Lebo, RV. "The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14." Am J Hum Genet 40, no. 4 (April 1987): 351-364. Link to Item
  - McGarry, JD, Kuwajima, M, Newgard, CB, Foster, DW, and Katz, J. "From dietary glucose to liver glycogen: the full circle round." Annu Rev Nutr 7 (1987): 51-73. (Review) Full Text Link to Item
  - Rath, VL, Newgard, CB, Sprang, SR, Goldsmith, EJ, and Fletterick, RJ. "Modeling the biochemical differences between rabbit muscle and human liver phosphorylase." Proteins 2, no. 3 (1987): 225-235. Full Text Link to Item
  - Newgard, CB, Nakano, K, Hwang, PK, and Fletterick, RJ. "Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage." Proc Natl Acad Sci U S A 83, no. 21 (November 1986): 8132-8136. Link to Item
  - Kuwajima, M, Newgard, CB, Foster, DW, and McGarry, JD. "The glucose-phosphorylating capacity of liver as measured by three independent assays. Implications for the mechanism of hepatic glycogen synthesis." J Biol Chem 261, no. 19 (July 5, 1986): 8849-8853. Link to Item
  - Fletterick, RJ, Burke, JA, Hwang, PK, Nakano, K, and Newgard, CB. "Structural relationships in glycogen phosphorylases." Ann N Y Acad Sci 478 (1986): 220-232. (Review) Link to Item
  - NEWGARD, CB, NAKANO, K, HWANG, PK, and FLETTERICK, RJ. "Structure of Mammalian Isozymes of Glycogen Phosphorylase: Implications for Function." Annals of the New York Academy of Sciences 478, no. 1 (January 1, 1986): 298-299. Full Text
  - Newgard, C, Gorin, F, and Fletterick, R. "Structure of yeast and mammalian isozymes of glycogen phosphorylase deduced by molecular cloning." Federation Proceedings 44, no. 4 (January 1, 1985): 3802-null.
  - Kuwajima, M, Newgard, CB, Foster, DW, and McGarry, JD. "Time course and significance of changes in hepatic fructose-2,6-bisphosphate levels during refeeding of fasted rats." J Clin Invest 74, no. 3 (September 1984): 1108-1111. Full Text Link to Item
  - Newgard, CB, Moore, SV, Foster, DW, and McGarry, JD. "Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway." J Biol Chem 259, no. 11 (June 10, 1984): 6958-6963. Link to Item
  - Newgard, CB, Foster, DW, and McGarry, JD. "Evidence for suppression of hepatic glucose-6-phosphatase with carbohydrate feeding." Diabetes 33, no. 2 (February 1984): 192-195. Link to Item
  - Newgard, CB, Hirsch, LJ, Foster, DW, and McGarry, JD. "Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway?." J Biol Chem 258, no. 13 (July 10, 1983): 8046-8052. Link to Item
  - Berelowitz, M, LeRoith, D, Schenk, HV, Newgard, C, Szabo, M, Frohman, LA, Shiloach, J, and Roth, J. "Somatostatin-like immunoactivity and biological activity is present in Tetrahymena pyriformis, a ciliated protozoan." Endocrinology 110, no. 6 (1982): 1939-1944.
  - Newgard, CB, and Holst, JJ. "Heterogeneity of somatostatin like immunoreactivity (SLI) in extracts of porcine, canine and human pancreas." Acta Endocrinologica 98, no. 4 (December 1981): 564-572.
  - Koyama, K, Chen, G, Wang, MY, Lee, Y, Shimabukuro, M, Newgard, CB, and Unger, RH. "β-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy." Diabetes 46, no. 8 (August 7, 1997): 1276-1280.
  - Wu, C, Okar, DA, Newgard, CB, and Lange, AJ. "Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes." American Journal of Physiology Endocrinology and Metabolism 282, no. 1 45-1 (June 29, 2002).
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