Christopher Bang Newgard

Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) Development of methods for protection of β-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies on the mechanisms involved in lipid-induced impairment of insulin secretion and action in diabetes.

Current Appointments & Affiliations

W. David and Sarah W. Stedman Distinguished Professor of Nutrition in the School of Medicine · 2002 - Present Pharmacology & Cancer Biology, Basic Science Departments

Professor of Pharmacology and Cancer Biology · 2002 - Present Pharmacology & Cancer Biology, Basic Science Departments

Director, Sarah W. Stedman Nutrition and Metabolism Center · 2002 - Present Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute

Professor in Medicine · 2020 - Present Medicine, Endocrinology, Metabolism, and Nutrition, Medicine

Member of the Duke Cancer Institute · 2002 - Present Duke Cancer Institute, Institutes and Centers

Affiliate, Duke Global Health Institute · 2009 - Present Duke Global Health Institute, University Institutes and Centers

In the News

Published August 13, 2024

New Use of an Old Hormone Leads to First Drug for a Type of Liver Disease

Published November 16, 2023

Which Duke Scholars Made the Most Cited List?

Published March 28, 2023

The Case of the Mysterious $11 Million Benefactor

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Recent Publications

Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC.

Journal Article bioRxiv · March 19, 2026 Exercise induces widespread health benefits across multiple tissues, yet the acute molecular responses in human adipose tissue remain poorly defined. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) profiled temporal molecular changes in ... Full text Link to item Cite

Integrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).

Journal Article bioRxiv · March 6, 2026 The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to systematically characterize the molecular basis of the health benefits of exercise. Here, we present the integrative, multi-omics response of human skeletal muscle to ac ... Full text Link to item Cite

Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia.

Journal Article Am J Physiol Endocrinol Metab · March 1, 2026 Hyperaminoacidemia is an early hallmark of insulin resistance, with aromatic and branched chain amino acids particularly associated with insulin resistance and type 2 diabetes. We previously showed that healthy adults with obesity exposed to acute hypergly ... Full text Link to item Cite

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Education

University of Texas, Dallas · 1984 Ph.D.

Christopher Bang Newgard

Overview

Current Appointments & Affiliations

In the News

Recent Publications

Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC.

Integrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).

Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia.

Recent Grants

Mechanisms of microbial regulation of postnatal growth and lipid metabolism

Pharmacological Sciences Training Program

Fibro/Adipogenic Progenitor Metabolic Reprogramming for Age-Related Muscle Fibrosis

Education