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Christopher Bang Newgard

W. David and Sarah W. Stedman Distinguished Professor of Nutrition in the School of Medicine
Pharmacology & Cancer Biology
Duke Box 104775, Durham, NC 27710
300 North Duke Street, Durham, NC 27701

Selected Grants


Duke KURe Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2013 - 2028

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2028

Targeting alpha-cell GPCRs to stimulate glucagon and counter hypoglycemia

ResearchCo-Mentor · Awarded by National Institutes of Health · 2022 - 2027

ABL kinase inhibition sensitizes SCLC to dysregulation of metabolic pathways leading to cell death

FellowshipCollaborator · Awarded by National Institutes of Health · 2024 - 2026

Duke Center for Advancement of Child Health (CAtCH).

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Duke KURe Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2013 - 2028

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2028

Targeting alpha-cell GPCRs to stimulate glucagon and counter hypoglycemia

ResearchCo-Mentor · Awarded by National Institutes of Health · 2022 - 2027

ABL kinase inhibition sensitizes SCLC to dysregulation of metabolic pathways leading to cell death

FellowshipCollaborator · Awarded by National Institutes of Health · 2024 - 2026

Duke Center for Advancement of Child Health (CAtCH).

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Engineered Glucose Metabolism in Insulin Secreting Cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2026

Zone-specific mitochondrial functions in regulation of hepatic metabolism

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2025

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Kallyope SRA

ResearchPrincipal Investigator · Awarded by Kallyope, Inc · 2021 - 2025

Role of Muscle Ketone Metabolism in Mediating the Metabolic Benefits of Weight Loss

ResearchCo-Mentor · Awarded by National Institutes of Health · 2020 - 2025

Metabolomics and Clinical Assay Core (MCAC)

ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2022 - 2024

Studies on the impact of acetyl-cysteine on metabolism

ResearchCollaborator · Awarded by National Institute on Aging · 2022 - 2024

Endocrinology and Metabolism Training Program (Summer 2024)

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2024

Metabolomic Signature of beta cell dysfunction and cardiovascular disease risk in youth with type 2 diabetes

ResearchPrincipal Investigator · Awarded by Baylor College of Medicine · 2023 - 2024

BMMI 4 Subaward to Dr. Newgard/Duke University

ResearchPrincipal Investigator · Awarded by Washington University in St. Louis · 2022 - 2024

Univ of Chicago sub to Duke

ResearchPrincipal Investigator · Awarded by University of Chicago · 2022 - 2024

Understanding metabolic vulnerabilities in cancer and the impact the tumor microenvironment has on cancer progression

ResearchCo-Mentor · Awarded by National Institutes of Health · 2020 - 2024

Studies on the Mechanisms by which SIRT5 Regulates Aging and Disease

ResearchCollaborator · Awarded by National Institutes of Health · 2019 - 2024

NCDRC P&F

ResearchInvestigator · Awarded by Wake Forest University Health Sciences · 2023 - 2024

Profiling of the gut microbiome in children with Prader-Willi Syndrome: a fiber intervention to target hyperphagia

ResearchPrincipal Investigator · Awarded by University of Alberta - Edmonton · 2023 - 2023

Quantifying Enteric Metabolism of Branched-chain Amino Acids in Relation to Other Dietary and Microbiota Nutrients

ResearchAdvisor · Awarded by National Institutes of Health · 2022 - 2023

Tellus Therapeutics (MGC Core)

ResearchPrincipal Investigator · Awarded by Tellus Therapeutics Inc. · 2023 - 2023

Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic disease

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2023

Postdoctoral Training in Genomic Medicine Research

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2017 - 2023

Duke Training Grant in Nephrology

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1995 - 2023

Center for Atypical Diabetes Research and Evaluation (CADRE)

ResearchPrincipal Investigator · Awarded by Baylor College of Medicine · 2018 - 2023

Mechanisms of lipid-induced bioenergetic stress in muscle

ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2023

Multidisciplinary Heart and Vascular Diseases

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2023

VA Contract for MBX analyses, Chris Marx

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2022 - 2023

Serotonin as a Novel Biomarker for Progression to Type 2 Diabetes in Obese Adolescents

ResearchMentor · Awarded by National Institutes of Health · 2018 - 2023

Development of small molecules for islet beta-cell regeneration and diabetes therapy

ResearchPrincipal Investigator · Awarded by University of Michigan · 2019 - 2023

Small molecules with pleiotropic positive effects on beta-cell health

ResearchInvestigator · Awarded by Eli Lilly and Company · 2019 - 2022

Research Collaboration, Icagen and Duke University

ResearchPrincipal Investigator · Awarded by Icagen, Inc · 2022 - 2022

Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism

ResearchCollaborator · Awarded by National Institutes of Health · 2018 - 2022

Understanding methionine metabolism and its therapeutic potential in cancer

ResearchMentor · Awarded by National Institutes of Health · 2019 - 2021

Core Laboratory - Flux analysis of lipid oxidation

ResearchPrincipal Investigator · Awarded by Axcella Health · 2020 - 2021

IPA MIRECC - Michael Hauser

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2019 - 2021

AHA Career Development Award

ResearchCo-Mentor · Awarded by American Heart Association · 2018 - 2021

Metagenomic Studies of the Gut Microbiomes of Obese and Lean Twins

ResearchCo Investigator · Awarded by Washington University in St. Louis · 2014 - 2021

IPA MVP - Michael Hauser

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2019 - 2021

IPA - Michael Hauser

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2019 - 2021

Networks of nutritional stress in human pancreatic islet cells

ResearchPrincipal Investigator · Awarded by Merck Sharp & Dohme · 2018 - 2020

Statin-induced Increases in HMG-CoA lead to HMG-modified Fatty Acid Synthase

FellowshipCo-Mentor · Awarded by National Institutes of Health · 2017 - 2020

EED Project

ResearchPrincipal Investigator · Awarded by Washington University in St. Louis · 2017 - 2020

Metagenomic Studies of the Gut Microbiomes of Obese and Lean Twins

ResearchPrincipal Investigator · Awarded by Washington University in St. Louis · 2014 - 2020

Reversible Mitochondrial Protein Acetylation and Metabolic Regulation

ResearchPrincipal Investigator · Awarded by Buck Institute for Research on Aging · 2017 - 2020

Pharmacological Sciences Training Program

Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by National Institutes of Health · 1975 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Core Laboratory - metabolomics analysis-healthy baseline

ResearchPrincipal Investigator · Awarded by Axcella Health · 2019 - 2019

13C-Metabolic Flux Analysis for Understanding Cardiac Energy Homeostasis

FellowshipCo-Mentor · Awarded by National Institutes of Health · 2017 - 2019

Pharmacology Industry Internships for Ph.D. Students

Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by American Society for Pharmacology and Experimental Therapeutics · 2017 - 2019

Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer

EquipmentMajor User · Awarded by National Institutes of Health · 2018 - 2019

Metabolomic Biomarkers Predictores of Long-term Success Following Bariatric Surgery

ResearchPrincipal Investigator · Awarded by Columbia University · 2015 - 2019

Core Laboratory - targeted metabolomics study

ResearchPrincipal Investigator · Awarded by Axcella Health · 2019 - 2019

Biomarkers of Mental Stress Induced Myocardial Ischemia and CHD Prognosis

ResearchCollaborator · Awarded by National Institutes of Health · 2014 - 2019

Metabolic fate of orally-administered isopentanol in wild-type Black 6 mice

ResearchPrincipal Investigator · Awarded by Synlogic · 2018 - 2019

Biochemical Mechanisms of NNMT Inhibitors

ResearchPrincipal Investigator · Awarded by Eli Lilly and Company · 2017 - 2018

Collaborative Study on Biomarkers of Fatty Liver Diseases

ResearchPrincipal Investigator · Awarded by Pfizer, Inc. · 2017 - 2018

Growth Failure in Extremely Preterm Infants: Microbiomic and Metabolomic Analysis

ResearchCollaborator · Awarded by Gerber Foundation · 2014 - 2018

Duke Research Training Program for Pediatricians

Inst. Training Prgm or CMETraining Faculty · Awarded by National Institutes of Health · 2002 - 2018

Manipulation of BCAA Metabolism for Therapy of Diabetes and its Co-morbidities

ResearchPrincipal Investigator · Awarded by Eli Lilly and Company · 2017 - 2018

HIRN UCSD

ResearchPrincipal Investigator · Awarded by University of California - San Diego · 2017 - 2018

Ethanol-induced Protein Acylation Regulates Metabolism

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2013 - 2018

Gene expression programs of lactic acidosis in human cancers

ResearchCollaborator · Awarded by National Institutes of Health · 2007 - 2018

Mitochondrial Protein Acetylation and Energy Metabolism in Muscle

FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2015 - 2018

Center for Molecular & Cellular Studies of Ped Disease

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2018

Microbiome engineering to affect host nitrogen/amino acid metabolism

ResearchPrincipal Investigator · Awarded by Synlogic · 2017 - 2018

Role of Protein Malonylation in Regulating Mitochondrial Function

FellowshipMentor · Awarded by National Institutes of Health · 2015 - 2017

Supplement - A Biochemical Roadmap of Exercise Signaling

ResearchPrincipal Investigator · Awarded by Broad Institute · 2017 - 2017

Development of Novel Therapies for NIDDM

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1984 - 2017

Reversible Mitochondrial Protein Acetylation and Metabolic Regulation

ResearchPrincipal Investigator · Awarded by Gladstone · 2010 - 2017

Sponsored Research Agreement

ResearchPrincipal Investigator · Awarded by Eli Lilly and Company · 2015 - 2017

Beta cell development and type 2 diabetes: the role of lactogen signaling

ResearchConsultant · Awarded by American Diabetes Association · 2014 - 2016

The Breast Milk, Gut Microbiome and Immunity Project

ResearchPrincipal Investigator · Awarded by Washington University in St. Louis · 2013 - 2016

VA268-15-J-0133

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2015 - 2016

Regulation of Islet Beta-Cell Function via Islet-Derived VGF Peptides

ResearchMentor · Awarded by National Institutes of Health · 2013 - 2016

Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD

ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2016

Iron homeostasis in mammalian muscle

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2016

Exploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory

ResearchCollaborator · Awarded by National Institutes of Health · 2015 - 2015

Metabolic Regulators of Insulin Secretion and Insulin Resistance

ResearchMentor · Awarded by National Institutes of Health · 2013 - 2015

T cell metabolism as a determinant of differentiation in allergic asthma

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2015

Multi-Disciplinary Approaches to Driving Therapeutic Human Beta Cell Replication

ResearchPrincipal Investigator · Awarded by Mount Sinai School of Medicine · 2013 - 2015

Multidisciplinary Neonatal Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2015

Fat Oxidation, Redox Stress and Insulin Resistance in Skeletal Muscle

FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2011 - 2014

Glucose Transport in Regulation of T Cell Activation and Inflammation

ResearchCollaborator · Awarded by National Institutes of Health · 2012 - 2014

Glucose metabolism and cell death in cancer

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2007 - 2014

Hormonal regulation of a Ca2+/AMPK signaling pathway

ResearchCollaborator · Awarded by National Institutes of Health · 1984 - 2011

Integration of Oncogenic Networks in Cancer Phenotypes

ResearchInvestigator · Awarded by National Institutes of Health · 2004 - 2011

G(alpha)Z signaling in insulin secretion and glucose tolerance

ResearchMentor · Awarded by National Institutes of Health · 2008 - 2010

Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance & Obesity

ResearchCo-Mentor · Awarded by National Institutes of Health · 2007 - 2010

Regulation and metabolic impact of mitochondrial CD36 in skeletal muscle

FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2006 - 2009

Mechanisms to Induce Islet Proliferation

ResearchMentor · Awarded by National Institutes of Health · 2007 - 2009

Molecular Genetics of Muscle Specialization

ResearchConsultant · Awarded by National Institutes of Health · 2001 - 2009

Developmental, nutritional and hormonal regulation of Ghrelin in children with Prader-Willi Syndrome

Clinical TrialCollaborator · Awarded by National Institutes of Health · 2005 - 2009

Engineering of Immunoprotection in B-Cell Lines

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2007

External Relationships


  • AstraZeneca
  • Boehringer Ingleheim
  • Kallyope
  • Lilly (Eli Lilly)
  • Novo Nordisk
  • AstraZeneca
  • Boehringer Ingleheim
  • Kallyope
  • Lilly (Eli Lilly)
  • Novo Nordisk
  • Sigilon
  • axcella health

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.