Unconstrained recovery characterization of shape-memory polymer networks for cardiovascular applications.

Journal Article (Journal Article)

Shape-memory materials have been proposed in biomedical device design due to their ability to facilitate minimally invasive surgery and recover to a predetermined shape in vivo. Use of the shape-memory effect in polymers is proposed for cardiovascular stent interventions to reduce the catheter size for delivery and offer highly controlled and tailored deployment at body temperature. Shape-memory polymer networks were synthesized via photopolymerization of tert-butyl acrylate and poly(ethylene glycol) dimethacrylate to provide precise control over the thermomechanical response of the system. The free recovery response of the polymer stents at body temperature was studied as a function of glass transition temperature (T(g)), crosslink density, geometrical perforation, and deformation temperature, all of which can be independently controlled. Room temperature storage of the stents was shown to be highly dependent on T(g) and crosslink density. The pressurized response of the stents is also demonstrated to depend on crosslink density. This polymer system exhibits a wide range of shape-memory and thermomechanical responses to adapt and meet specific needs of minimally invasive cardiovascular devices.

Full Text

Duke Authors

Cited Authors

  • Yakacki, CM; Shandas, R; Lanning, C; Rech, B; Eckstein, A; Gall, K

Published Date

  • May 2007

Published In

Volume / Issue

  • 28 / 14

Start / End Page

  • 2255 - 2263

PubMed ID

  • 17296222

Pubmed Central ID

  • PMC2700024

Electronic International Standard Serial Number (EISSN)

  • 1878-5905

International Standard Serial Number (ISSN)

  • 0142-9612

Digital Object Identifier (DOI)

  • 10.1016/j.biomaterials.2007.01.030


  • eng