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Neoadjuvant radiation therapy does not increase perioperative morbidity among patients undergoing gastrectomy for gastric cancer.

Publication ,  Journal Article
Sun, Z; Nussbaum, DP; Speicher, PJ; Czito, BG; Tyler, DS; Blazer, DG
Published in: J Surg Oncol
July 2015

BACKGROUND: Neoadjuvant radiation therapy (RT) as a component of the multimodality treatment of gastric cancer has demonstrated promising results. Data regarding its effect on perioperative safety are limited. METHODS: Adults undergoing gastrectomy for gastric cancer in the 2005-2011 National Surgical Quality Improvement Program were included. Groups were defined by neoadjuvant RT use, and then propensity-matched based on preoperative variables. Multivariable logistic regression was performed to assess neoadjuvant RT as an independent predictor of outcomes. RESULTS: Among 2,764 patients identified, 55 (2.0%) were treated with neoadjuvant RT. Patients who received neoadjuvant RT were more likely to have received preoperative chemotherapy and steroids, and experienced weight loss (all P < 0.01). After matching, however, there were no preoperative differences. At time of surgery, total (vs. partial) gastrectomy was more common among patients who underwent neoadjuvant RT (70.9 vs. 46.7%, P < 0.01), and operative time was longer (290 vs. 236 min, P < 0.01). There were no differences in overall complications (23.6 vs. 29.7%, P = 0.49) or 30-day mortality (3.6 vs. 3.6%, P = 0.99). CONCLUSIONS: Neoadjuvant RT was not associated with increased morbidity or mortality following resection for gastric cancer. These findings support the ongoing investigation of neoadjuvant RT as part of the multidisciplinary management of resectable gastric cancer.

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Published In

J Surg Oncol

DOI

EISSN

1096-9098

Publication Date

July 2015

Volume

112

Issue

1

Start / End Page

46 / 50

Location

United States

Related Subject Headings

  • Survival Rate
  • Stomach Neoplasms
  • Retrospective Studies
  • Radiotherapy
  • Prognosis
  • Perioperative Period
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Morbidity
 

Citation

APA
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MLA
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Sun, Z., Nussbaum, D. P., Speicher, P. J., Czito, B. G., Tyler, D. S., & Blazer, D. G. (2015). Neoadjuvant radiation therapy does not increase perioperative morbidity among patients undergoing gastrectomy for gastric cancer. J Surg Oncol, 112(1), 46–50. https://doi.org/10.1002/jso.23957
Sun, Zhifei, Daniel P. Nussbaum, Paul J. Speicher, Brian G. Czito, Douglas S. Tyler, and Dan G. Blazer. “Neoadjuvant radiation therapy does not increase perioperative morbidity among patients undergoing gastrectomy for gastric cancer.J Surg Oncol 112, no. 1 (July 2015): 46–50. https://doi.org/10.1002/jso.23957.
Sun Z, Nussbaum DP, Speicher PJ, Czito BG, Tyler DS, Blazer DG. Neoadjuvant radiation therapy does not increase perioperative morbidity among patients undergoing gastrectomy for gastric cancer. J Surg Oncol. 2015 Jul;112(1):46–50.
Sun, Zhifei, et al. “Neoadjuvant radiation therapy does not increase perioperative morbidity among patients undergoing gastrectomy for gastric cancer.J Surg Oncol, vol. 112, no. 1, July 2015, pp. 46–50. Pubmed, doi:10.1002/jso.23957.
Sun Z, Nussbaum DP, Speicher PJ, Czito BG, Tyler DS, Blazer DG. Neoadjuvant radiation therapy does not increase perioperative morbidity among patients undergoing gastrectomy for gastric cancer. J Surg Oncol. 2015 Jul;112(1):46–50.
Journal cover image

Published In

J Surg Oncol

DOI

EISSN

1096-9098

Publication Date

July 2015

Volume

112

Issue

1

Start / End Page

46 / 50

Location

United States

Related Subject Headings

  • Survival Rate
  • Stomach Neoplasms
  • Retrospective Studies
  • Radiotherapy
  • Prognosis
  • Perioperative Period
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Morbidity