Novel therapeutics in myocardial infarction: targeting microvascular dysfunction and reperfusion injury.

Published

Journal Article (Review)

Despite the large number of novel therapies under basic scientific investigation, the translation of cardioprotective strategies targeting reperfusion injury to improve patient outcomes following percutaneous coronary intervention (PCI) for myocardial infarction (MI) has been disappointing. The varying susceptibility of an individual to reperfusion injury, as well as the narrow window of opportunity in which to intervene, adds significant complexity. Here, we discuss the unmet need and challenges of translating cardioprotective strategies into clinical practice, review the pathophysiology of microvascular dysfunction and lethal reperfusion as they relate to promising novel therapeutics, and evaluate recent and ongoing clinical trials in the field.

Full Text

Duke Authors

Cited Authors

  • Fordyce, CB; Gersh, BJ; Stone, GW; Granger, CB

Published Date

  • September 2015

Published In

Volume / Issue

  • 36 / 9

Start / End Page

  • 605 - 616

PubMed ID

  • 26148636

Pubmed Central ID

  • 26148636

Electronic International Standard Serial Number (EISSN)

  • 1873-3735

Digital Object Identifier (DOI)

  • 10.1016/j.tips.2015.06.004

Language

  • eng

Conference Location

  • England