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Christopher Bull Granger

Fred Cobb, M.D. Distinguished Professor of Medicine
Medicine, Cardiology
Duke Box 3409, Durham, NC 27710
300 West Morgan Street, Durham, NC 27701

Overview


Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

Current Appointments & Affiliations


Fred Cobb, M.D. Distinguished Professor of Medicine · 2024 - Present Medicine, Cardiology, Medicine
Professor of Medicine · 2007 - Present Medicine, Cardiology, Medicine
Professor in the School of Nursing · 2015 - Present School of Nursing
Member in the Duke Clinical Research Institute · 1988 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published November 16, 2023
Which Duke Scholars Made the Most Cited List?
Published May 4, 2023
Duke Awards 44 Distinguished Professorships
Published November 19, 2019
Global List of Highly Cited Puts Duke in Top Ten

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Recent Publications


Racial and Ethnic Representation and Study Engagement in a Siteless Digital Clinical Trial Using a Smartwatch: Findings From the Apple Heart Study

Journal Article Mayo Clinic Proceedings Digital Health · September 1, 2025 Objective: To evaluate differences in study engagement in diverse racial/ethnic groups that have been significantly underrepresented in atrial fibrillation and digital clinical trials. Patients and Methods: This was a secondary analysis of participants fro ... Full text Cite

Advancement of the implementation of evidence-based therapies for cardiovascular-kidney-metabolic conditions: A multi-stakeholder perspective.

Journal Article Am Heart J · August 2025 Cardiovascular disease remains the leading cause of mortality and healthcare expenditures in the United States. It is also a major contributor to premature mortality, years lived with disability, and rising healthcare costs around the world. Despite the av ... Full text Link to item Cite
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Recent Grants


KARDIA-6 CVOT SUA

Clinical TrialPrincipal Investigator · Awarded by Alnylam Pharmaceuticals · 2025 - 2030

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2018 - 2028

MarTide DMC

ResearchPrincipal Investigator · Awarded by Amgen, Inc. · 2025 - 2027

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Education, Training & Certifications


University of Connecticut · 1984 M.D.