Epigenetics and cancer metabolism.

Journal Article (Journal Article;Review)

Cancer cells adapt their metabolism to support proliferation and survival. A hallmark of cancer, this alteration is characterized by dysfunctional metabolic enzymes, changes in nutrient availability, tumor microenvironment and oncogenic mutations. Metabolic rewiring in cancer is tightly connected to changes at the epigenetic level. Enzymes that mediate epigenetic status of cells catalyze posttranslational modifications of DNA and histones and influence metabolic gene expression. These enzymes require metabolites that are used as cofactors and substrates to carry out reactions. This interaction of epigenetics and metabolism constitutes a new avenue of cancer biology and could lead to new insights for the development of anti-cancer therapeutics.

Full Text

Duke Authors

Cited Authors

  • Johnson, C; Warmoes, MO; Shen, X; Locasale, JW

Published Date

  • January 28, 2015

Published In

Volume / Issue

  • 356 / 2 Pt A

Start / End Page

  • 309 - 314

PubMed ID

  • 24125862

Pubmed Central ID

  • PMC3984372

Electronic International Standard Serial Number (EISSN)

  • 1872-7980

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2013.09.043


  • eng

Conference Location

  • Ireland