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Epigenetics and cancer metabolism.

Publication ,  Journal Article
Johnson, C; Warmoes, MO; Shen, X; Locasale, JW
Published in: Cancer Lett
January 28, 2015

Cancer cells adapt their metabolism to support proliferation and survival. A hallmark of cancer, this alteration is characterized by dysfunctional metabolic enzymes, changes in nutrient availability, tumor microenvironment and oncogenic mutations. Metabolic rewiring in cancer is tightly connected to changes at the epigenetic level. Enzymes that mediate epigenetic status of cells catalyze posttranslational modifications of DNA and histones and influence metabolic gene expression. These enzymes require metabolites that are used as cofactors and substrates to carry out reactions. This interaction of epigenetics and metabolism constitutes a new avenue of cancer biology and could lead to new insights for the development of anti-cancer therapeutics.

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Published In

Cancer Lett

DOI

EISSN

1872-7980

Publication Date

January 28, 2015

Volume

356

Issue

2 Pt A

Start / End Page

309 / 314

Location

Ireland

Related Subject Headings

  • Tumor Microenvironment
  • Protein Processing, Post-Translational
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Glycolysis
  • Glucose
  • Epigenesis, Genetic
  • Energy Metabolism
  • DNA Methylation
 

Citation

APA
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Johnson, C., Warmoes, M. O., Shen, X., & Locasale, J. W. (2015). Epigenetics and cancer metabolism. Cancer Lett, 356(2 Pt A), 309–314. https://doi.org/10.1016/j.canlet.2013.09.043
Johnson, Christelle, Marc O. Warmoes, Xiling Shen, and Jason W. Locasale. “Epigenetics and cancer metabolism.Cancer Lett 356, no. 2 Pt A (January 28, 2015): 309–14. https://doi.org/10.1016/j.canlet.2013.09.043.
Johnson C, Warmoes MO, Shen X, Locasale JW. Epigenetics and cancer metabolism. Cancer Lett. 2015 Jan 28;356(2 Pt A):309–14.
Johnson, Christelle, et al. “Epigenetics and cancer metabolism.Cancer Lett, vol. 356, no. 2 Pt A, Jan. 2015, pp. 309–14. Pubmed, doi:10.1016/j.canlet.2013.09.043.
Johnson C, Warmoes MO, Shen X, Locasale JW. Epigenetics and cancer metabolism. Cancer Lett. 2015 Jan 28;356(2 Pt A):309–314.
Journal cover image

Published In

Cancer Lett

DOI

EISSN

1872-7980

Publication Date

January 28, 2015

Volume

356

Issue

2 Pt A

Start / End Page

309 / 314

Location

Ireland

Related Subject Headings

  • Tumor Microenvironment
  • Protein Processing, Post-Translational
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Glycolysis
  • Glucose
  • Epigenesis, Genetic
  • Energy Metabolism
  • DNA Methylation