Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents.
Journal Article (Journal Article)
In this pilot study, amygdala connectivity related to trauma symptoms was explored using resting-state functional magnetic resonance imaging (R-fMRI) in 23 healthy adolescents ages 13-17 years with no psychiatric diagnoses. Adolescents completed a self-report trauma symptom checklist and a R-fMRI scan. We examined the relationship of trauma symptoms to resting-state functional connectivity of the amygdala. Increasing self-report of trauma symptoms by adolescents was associated with increasing functional connectivity with the right amygdala and a local limbic cluster and decreasing functional connectivity with the amygdala and a long-range frontoparietal cluster to the left amygdala, which can be a hallmark of immaturity. These pilot findings in adolescents provide preliminary evidence that even mild trauma symptoms can be linked to the configuration of brain networks associated with the amygdala.
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Duke Authors
Cited Authors
- Nooner, KB; Mennes, M; Brown, S; Castellanos, FX; Leventhal, B; Milham, MP; Colcombe, SJ
Published Date
- December 2013
Published In
Volume / Issue
- 26 / 6
Start / End Page
- 784 - 787
PubMed ID
- 24343754
Pubmed Central ID
- PMC4073800
Electronic International Standard Serial Number (EISSN)
- 1573-6598
Digital Object Identifier (DOI)
- 10.1002/jts.21873
Language
- eng
Conference Location
- United States