Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents.

Journal Article (Journal Article)

In this pilot study, amygdala connectivity related to trauma symptoms was explored using resting-state functional magnetic resonance imaging (R-fMRI) in 23 healthy adolescents ages 13-17 years with no psychiatric diagnoses. Adolescents completed a self-report trauma symptom checklist and a R-fMRI scan. We examined the relationship of trauma symptoms to resting-state functional connectivity of the amygdala. Increasing self-report of trauma symptoms by adolescents was associated with increasing functional connectivity with the right amygdala and a local limbic cluster and decreasing functional connectivity with the amygdala and a long-range frontoparietal cluster to the left amygdala, which can be a hallmark of immaturity. These pilot findings in adolescents provide preliminary evidence that even mild trauma symptoms can be linked to the configuration of brain networks associated with the amygdala.

Full Text

Duke Authors

Cited Authors

  • Nooner, KB; Mennes, M; Brown, S; Castellanos, FX; Leventhal, B; Milham, MP; Colcombe, SJ

Published Date

  • December 2013

Published In

Volume / Issue

  • 26 / 6

Start / End Page

  • 784 - 787

PubMed ID

  • 24343754

Pubmed Central ID

  • PMC4073800

Electronic International Standard Serial Number (EISSN)

  • 1573-6598

Digital Object Identifier (DOI)

  • 10.1002/jts.21873


  • eng

Conference Location

  • United States