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Myogenic transcription factors regulate pro-metastatic miR-182.

Publication ,  Journal Article
Dodd, RD; Sachdeva, M; Mito, JK; Eward, WC; Brigman, BE; Ma, Y; Dodd, L; Kim, Y; Lev, D; Kirsch, DG
Published in: Oncogene
April 7, 2016

Approximately 30% of patients with soft-tissue sarcoma die from pulmonary metastases. The mechanisms that drive sarcoma metastasis are not well understood. Recently, we identified miR-182 as a driver of sarcoma metastasis in a primary mouse model of soft-tissue sarcoma. We also observed elevated miR-182 in a subset of primary human sarcomas that metastasized to the lungs. Here, we show that myogenic differentiation factors regulate miR-182 levels to contribute to metastasis in mouse models. We find that MyoD directly binds the miR-182 promoter to increase miR-182 expression. Furthermore, mechanistic studies revealed that Pax7 can promote sarcoma metastasis in vivo through MyoD-dependent regulation of pro-metastatic miR-182. Taken together, these results suggest that sarcoma metastasis can be partially controlled through Pax7/MyoD-dependent activation of miR-182 and provide insight into the role that myogenic transcription factors have in sarcoma progression.

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Published In

Oncogene

DOI

EISSN

1476-5594

Publication Date

April 7, 2016

Volume

35

Issue

14

Start / End Page

1868 / 1875

Location

England

Related Subject Headings

  • Sarcoma
  • Promoter Regions, Genetic
  • PAX7 Transcription Factor
  • Oncology & Carcinogenesis
  • MyoD Protein
  • Muscle Development
  • MicroRNAs
  • Mice
  • Lung Neoplasms
  • Humans
 

Citation

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Dodd, R. D., Sachdeva, M., Mito, J. K., Eward, W. C., Brigman, B. E., Ma, Y., … Kirsch, D. G. (2016). Myogenic transcription factors regulate pro-metastatic miR-182. Oncogene, 35(14), 1868–1875. https://doi.org/10.1038/onc.2015.252
Dodd, R. D., M. Sachdeva, J. K. Mito, W. C. Eward, B. E. Brigman, Y. Ma, L. Dodd, Y. Kim, D. Lev, and D. G. Kirsch. “Myogenic transcription factors regulate pro-metastatic miR-182.Oncogene 35, no. 14 (April 7, 2016): 1868–75. https://doi.org/10.1038/onc.2015.252.
Dodd RD, Sachdeva M, Mito JK, Eward WC, Brigman BE, Ma Y, et al. Myogenic transcription factors regulate pro-metastatic miR-182. Oncogene. 2016 Apr 7;35(14):1868–75.
Dodd, R. D., et al. “Myogenic transcription factors regulate pro-metastatic miR-182.Oncogene, vol. 35, no. 14, Apr. 2016, pp. 1868–75. Pubmed, doi:10.1038/onc.2015.252.
Dodd RD, Sachdeva M, Mito JK, Eward WC, Brigman BE, Ma Y, Dodd L, Kim Y, Lev D, Kirsch DG. Myogenic transcription factors regulate pro-metastatic miR-182. Oncogene. 2016 Apr 7;35(14):1868–1875.

Published In

Oncogene

DOI

EISSN

1476-5594

Publication Date

April 7, 2016

Volume

35

Issue

14

Start / End Page

1868 / 1875

Location

England

Related Subject Headings

  • Sarcoma
  • Promoter Regions, Genetic
  • PAX7 Transcription Factor
  • Oncology & Carcinogenesis
  • MyoD Protein
  • Muscle Development
  • MicroRNAs
  • Mice
  • Lung Neoplasms
  • Humans