Dynamics-based amplification of RNA function and its characterization by using NMR spectroscopy.

Published

Journal Article (Review)

The ever-increasing cellular roles ascribed to RNA raise fundamental questions regarding how a biopolymer composed of only four chemically similar building-block nucleotides achieves such functional diversity. Here, I discuss how RNA achieves added mechanistic and chemical complexity by undergoing highly controlled conformational changes in response to a variety of cellular signals. I examine pathways for achieving selectivity in these conformational changes that rely to different extents on the structure and dynamics of RNA. Finally, I review solution-state NMR techniques that can be used to characterize RNA structural dynamics and its relationship to function.

Full Text

Duke Authors

Cited Authors

  • Al-Hashimi, HM

Published Date

  • September 2005

Published In

Volume / Issue

  • 6 / 9

Start / End Page

  • 1506 - 1519

PubMed ID

  • 16138302

Pubmed Central ID

  • 16138302

International Standard Serial Number (ISSN)

  • 1439-4227

Digital Object Identifier (DOI)

  • 10.1002/cbic.200500002

Language

  • eng

Conference Location

  • Germany