Scholars@Duke
Hashim Al-Hashimi

Hashim Al-Hashimi

Adjunct Professor in the Department of Biochemistry
Biochemistry

Current Appointments & Affiliations

Adjunct Professor in the Department of Biochemistry · 2022 - Present Biochemistry, Basic Science Departments

In the News

Published October 21, 2020
Transcription Factors May Inadvertently Lock in DNA Mistakes
Published January 22, 2020
Al-Hashimi Receives Prestigious National Academy of Sciences Award in Molecular Biology
Published July 18, 2018
Foundation Funds an 'Expedition' to Map Novel Structures in the Human Genome

View All News

Recent Publications

Revealing hidden protonated conformational states in RNA dynamic ensembles.

Journal Article Nucleic Acids Res · November 26, 2025 Identifying protonated states within RNA ensembles, quantifying their pKas, and elucidating the kinetic mechanisms by which they form is essential for understanding protonation-coupled biochemical reactions and how RNAs sense and adapt to pH fluctuations. ... Full text Link to item Cite

Insight into the Conformational Ensembles Formed by U-U and T-T Mismatches in RNA and DNA Duplexes From a Structure-based Survey, NMR, and Molecular Dynamics Simulations.

Journal Article J Mol Biol · September 1, 2025 Nucleic acid base pairs interconvert between alternative conformations on a free energy landscape, and these dynamics play critical roles in recognition, folding, and catalysis. U-U and T-T mismatches can adopt two nearly isoenergetic wobble conformations, ... Full text Link to item Cite

Probing rare and short-lived conformational states in nucleic acids using off-resonance carbonyl and guanidino carbon R1ρ relaxation dispersion.

Journal Article J Magn Reson · August 2025 Chemical exchange-based NMR techniques provide powerful approaches for characterizing lowly-populated and short-lived conformational states in nucleic acids. Among possible probes, the nucleobase carbonyl and guanidino carbons stand out due to the sensitiv ... Full text Link to item Cite
View All Publications

Recent Grants

The Center for HIV RNA Studies (CRNA)

ResearchPrincipal Investigator · Awarded by Regents of the University of Michigan · 2014 - 2022

Deep Topological Sampling of Protein Structures - non-competing renewal for Year 4

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2017 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

View All Grants

Education, Training & Certifications

Yale University · 2000 Ph.D.