Current Appointments & Affiliations
Adjunct Professor in the Department of Biochemistry
·
2022 - Present
Biochemistry,
Basic Science Departments
In the News
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Recent Publications
Quantitative and Systematic NMR Measurements of Sequence-Dependent A-T Hoogsteen Dynamics in the DNA Double Helix.
Journal Article Biochemistry · March 4, 2025 The dynamic properties of DNA depend on the sequence, providing an important source of sequence-specificity in biochemical reactions. However, comprehensively measuring how these dynamics vary with sequence is challenging, especially when they involve lowl ... Full text Link to item CiteConformational penalties: New insights into nucleic acid recognition.
Journal Article Curr Opin Struct Biol · December 2024 The energy cost accompanying changes in the structures of nucleic acids when they bind partner molecules is a significant but underappreciated thermodynamic contribution to binding affinity and specificity. This review highlights recent advances in measuri ... Full text Link to item CiteExploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs.
Journal Article RNA · November 18, 2024 Folded RNAs contain tertiary contact motifs whose structures and energetics are conserved across different RNAs. The transferable properties of RNA motifs simplify the RNA folding problem, but measuring energetic and conformational properties of many motif ... Full text Link to item CiteRecent Grants
The Center for HIV RNA Studies (CRNA)
ResearchPrincipal Investigator · Awarded by Regents of the University of Michigan · 2014 - 2022Deep Topological Sampling of Protein Structures - non-competing renewal for Year 4
ResearchSignificant Contributor · Awarded by National Institutes of Health · 2017 - 2022Medical Scientist Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022View All Grants
Education, Training & Certifications
Yale University ·
2000
Ph.D.