Skip to main content

Hashim Al-Hashimi

Adjunct Professor in the Department of Biochemistry
Biochemistry

Current Appointments & Affiliations


Adjunct Professor in the Department of Biochemistry · 2022 - Present Biochemistry, Basic Science Departments

In the News


Published October 21, 2020
Transcription Factors May Inadvertently Lock in DNA Mistakes
Published January 22, 2020
Al-Hashimi Receives Prestigious National Academy of Sciences Award in Molecular Biology
Published July 18, 2018
Foundation Funds an 'Expedition' to Map Novel Structures in the Human Genome

View All News

Recent Publications


Quantitative and Systematic NMR Measurements of Sequence-Dependent A-T Hoogsteen Dynamics in the DNA Double Helix.

Journal Article Biochemistry · March 4, 2025 The dynamic properties of DNA depend on the sequence, providing an important source of sequence-specificity in biochemical reactions. However, comprehensively measuring how these dynamics vary with sequence is challenging, especially when they involve lowl ... Full text Link to item Cite

Conformational penalties: New insights into nucleic acid recognition.

Journal Article Curr Opin Struct Biol · December 2024 The energy cost accompanying changes in the structures of nucleic acids when they bind partner molecules is a significant but underappreciated thermodynamic contribution to binding affinity and specificity. This review highlights recent advances in measuri ... Full text Link to item Cite

Exploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs.

Journal Article RNA · November 18, 2024 Folded RNAs contain tertiary contact motifs whose structures and energetics are conserved across different RNAs. The transferable properties of RNA motifs simplify the RNA folding problem, but measuring energetic and conformational properties of many motif ... Full text Link to item Cite
View All Publications

Recent Grants


The Center for HIV RNA Studies (CRNA)

ResearchPrincipal Investigator · Awarded by Regents of the University of Michigan · 2014 - 2022

Deep Topological Sampling of Protein Structures - non-competing renewal for Year 4

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2017 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

View All Grants

Education, Training & Certifications


Yale University · 2000 Ph.D.