Current, emerging, and newly available insomnia medications.


Journal Article (Review)

Research into the sleep-wake cycle has provided new treatment targets for patients with insomnia as well as a better understanding of how medications affect sleep processes. Current insomnia medications, including benzodiazepines and nonbenzodiazepines, focus on enhancing sleep-promoting systems through broad antagonism of GABA. Other medications that promote sleep by blocking wake-promoting systems include antidepressants, antipsychotics, and antihistamines, but adverse effects and nonspecific therapeutic effects limit their use. New and emerging insomnia medications are focusing on blocking wake-promoting systems via more selective antagonism of orexin, serotonin, and norepinephrine. These medications may offer improved efficacy with fewer adverse effects.

Full Text

Duke Authors

Cited Authors

  • Krystal, AD

Published Date

  • August 2015

Published In

Volume / Issue

  • 76 / 8

Start / End Page

  • e1045 -

PubMed ID

  • 26335094

Pubmed Central ID

  • 26335094

Electronic International Standard Serial Number (EISSN)

  • 1555-2101

Digital Object Identifier (DOI)

  • 10.4088/JCP.14046tx2c


  • eng

Conference Location

  • United States