Andrew Darrell Krystal
Professor Emeritus of Psychiatry and Behavioral Sciences
My research is focused on better understanding the pathophysiology of sleep disorders and mood disorders and developing improved treatments for these conditions. My primary research tools are: electroencepahlography (EEG), polysomnography (PSG), computer signal analysis and modeling, functional magnetic resonance imaging (fMRI), and positron emission tomograophy (PET). Nearly all of my projects have been carried out with humans, however, projects are ongoing with gene knock-out models in mice, and lemurs in collaboration with the Duke Primate Center. A few representative current studies are: 1) Defining physiologic (EEG, PSG, PET, fMRI) correlates of sleep complaints and subtyping insomnia on the basis of the associated pathophysiology, 2) Studying the relationship of EEG data recorded during non-REM sleep, daytime function, and insomnia treatment response, 3) Developing new pharmacologic and non-pharmacologic treatments for insomnia, 4) Studying the relationship of natural sleep and hibernation-like phenomena (torpor), 5) Predicting depression treatment response on the basis of pre-treatment EEG and structural MRI data.
Current Appointments & Affiliations
- Professor Emeritus of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2017
- Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2014
Contact Information
- 54221 Hosp South, Durham, NC 27710
- Box 3309 Med Ctr, Durham, NC 27710
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andrew.krystal@duke.edu
(919) 681-8742
- Background
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Education, Training, & Certifications
- M.D., Duke University 1987
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Previous Appointments & Affiliations
- Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2016 - 2017
- Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2008 - 2016
- Chief, Division of Brain Stimulation and Neurophysiology, Psychiatry & Behavioral Sciences, Clinical Science Departments 2015 - 2016
- Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2003 - 2008
- Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2000 - 2003
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 1993 - 2000
- Clinical Associate in the Department of Psychiatry, Psychiatry & Behavioral Sciences, Clinical Science Departments 1993
- Recognition
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In the News
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JUL 21, 2016 Duke Today -
JAN 21, 2016 The Hollywood Reporter -
MAY 8, 2014 New Scientist -
NOV 26, 2013 The Washington Post -
NOV 25, 2013 The New York Times -
NOV 19, 2013 The New York Times -
SEP 4, 2013
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Awards & Honors
- Research
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Selected Grants
- Obstructive Sleep Apnea Screening in Pregnant Women with Chronic Hypertension awarded by Society for Obstetric Anesthesia and Perinatology 2017 - 2020
- KOR Phase 2A Study - Mod 3 (Advanced Understanding) awarded by National Institutes of Health 2014 - 2017
- Modified KOR Phase 2A Study awarded by National Institutes of Health 2014 - 2017
- Study to Evaulate the Kappa Opioid Receptor as a Target for the Treatment of Mood and Anxiety Spectrum Disorders by Evaluating Whether LY2456302 Engages Reward-related Neural Circuitry. awarded by National Institutes of Health 2013 - 2017
- Janssen OBSERVEMDD0001 awarded by Janssen Research & Development, LLC 2015 - 2017
- 2/3 Reducing Suicide Ideation Through Insomnia Treatment (REST-IT) awarded by National Institutes of Health 2012 - 2017
- Multicenter Study of the Safety and Efficacy of JZP-110 awarded by Jazz Pharmaceuticals 2015 - 2017
- Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear awarded by National Institutes of Health 2015 - 2017
- The Duke Multidisciplinary Training Program in Pediatric Lung Disease awarded by National Institutes of Health 2010 - 2016
- An Open-Label and Double-Blind Study to Investigate Evoked Potentials as Markers of Ketamine-Induced Cortical Plasticity awarded by Janssen Research & Development, LLC 2013 - 2015
- FAST- MAS Administrative Task Year 3 awarded by National Institutes of Health 2014 - 2015
- Fast-Fail Trials in Mood and Anxiety Spectrum Disorders (FAST-MAS) awarded by National Institutes of Health 2012 - 2015
- An Exploratory Phase II Study to Determine the Safety, Tolerability, and Activity of a Novel Vasopressin 1a Receptor Antagonist (SRX246) in Adults with DSM-5 Intermittent Explosive Disorder (IED) awarded by Azevan Pharmaceuticals, Inc. 2014 - 2015
- A Phase I Study of the Kappa Opiate Receptor Occupancy and Clinical Mu Opiate Receptor Effects Associated with Repeated Dosing of LY2456302 Trial awarded by National Institutes of Health 2013 - 2015
- Effect of SEP-363856 in Narcolepsy awarded by Sunovion Pharmaceuticals, Inc 2015
- A Multicenter, Double-blind, Randomized, Parallel-group, Pilot Study to Assess the Short-term Safety and Tolerability of Lorcaserin Plus Two Doses of Immediate-Release Phentermine-HCl Compared With Lorcaserin Alone in Overweight and Obese Adults awarded by Eisai, Inc. 2013 - 2014
- FAST- MAS Administrative Task Year 2 awarded by National Institutes of Health 2013 - 2014
- Nocturnal Deterusor Overactivity In Overactive Bladder Syndrome awarded by National Institutes of Health 2010 - 2014
- Sleep EEG and Genetic Biomarkers of the Response to CBT for Insomnia in Major Depression awarded by National Institutes of Health 2009 - 2014
- 3/3: Improving Depression Outcome by Adding CBT for Insomnia to Antidepressants awarded by National Institutes of Health 2008 - 2014
- Behavioral Insomnia Therapy for those with Insomnia and Depression awarded by National Institutes of Health 2008 - 2012
- 1/2 Sequenced therapies for comorbid and primary insomnias awarded by National Institutes of Health 2011 - 2012
- Behavioral Insomnia Therapy with Fibromyalgia awarded by National Institutes of Health 2005 - 2012
- Behavioral Insomnia Treatment in Chronic Fatigue Syndrome awarded by National Institutes of Health 2007 - 2009
- Classifying Psychiatric, Medical, and Primary Insomnias awarded by National Institutes of Health 2003 - 2009
- Combined Behavioral/Pharmacological Therapy for Insomnia awarded by National Institutes of Health 2001 - 2007
- Sleep EEG Spectral Measures of Insomnia awarded by National Institutes of Health 2003 - 2006
- same awarded by National Institutes of Health 1998 - 2004
- Behavioral Insomnia Therapy for Fibromyalgia Patients awarded by National Institutes of Health 1999 - 2003
- Improving Ect Effectiveness Through Total Eeg Analysis awarded by National Institutes of Health 1994 - 1999
- Improving Ect Effectivness Through Ictal Eeg Analysis awarded by National Institutes of Health 1994 - 1999
- Improving Effectiveness Through Ictal Eeg Anaysis awarded by National Institutes of Health 1994 - 1999
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Watson, Nathaniel F., Suzanne M. Bertisch, Charles M. Morin, Rafael Pelayo, John W. Winkelman, Phyllis C. Zee, and Andrew D. Krystal. “Do Insomnia Treatments Improve Daytime Function?” J Clin Med 12, no. 9 (April 24, 2023). https://doi.org/10.3390/jcm12093089.Full Text Link to Item
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Pelayo, Rafael, Suzanne M. Bertisch, Charles M. Morin, John W. Winkelman, Phyllis C. Zee, and Andrew D. Krystal. “Should Trazodone Be First-Line Therapy for Insomnia? A Clinical Suitability Appraisal.” J Clin Med 12, no. 8 (April 18, 2023). https://doi.org/10.3390/jcm12082933.Full Text Link to Item
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Sellers, Kristin K., Noah Stapper, Daniela A. Astudillo Maya, Catherine Henderson, Ankit N. Khambhati, Joline M. Fan, Vikram R. Rao, Katherine W. Scangos, Edward F. Chang, and Andrew D. Krystal. “Changes in intracranial neurophysiology associated with acute COVID-19 infection.” Clin Neurophysiol 148 (April 2023): 29–31. https://doi.org/10.1016/j.clinph.2023.01.012.Full Text Link to Item
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Benca, Ruth M., Suzanne M. Bertisch, Ajay Ahuja, Robin Mandelbaum, and Andrew D. Krystal. “Wake Up America: National Survey of Patients' and Physicians' Views and Attitudes on Insomnia Care.” J Clin Med 12, no. 7 (March 25, 2023). https://doi.org/10.3390/jcm12072498.Full Text Link to Item
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Watson, Nathaniel F., Ruth M. Benca, Andrew D. Krystal, William V. McCall, and David N. Neubauer. “Alliance for Sleep Clinical Practice Guideline on Switching or Deprescribing Hypnotic Medications for Insomnia.” J Clin Med 12, no. 7 (March 25, 2023). https://doi.org/10.3390/jcm12072493.Full Text Link to Item
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Morin, Charles M., Suzanne M. Bertisch, Rafael Pelayo, Nathaniel F. Watson, John W. Winkelman, Phyllis C. Zee, and Andrew D. Krystal. “What Should Be the Focus of Treatment When Insomnia Disorder Is Comorbid with Depression or Anxiety Disorder?” J Clin Med 12, no. 5 (March 2, 2023). https://doi.org/10.3390/jcm12051975.Full Text Link to Item
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Zee, Phyllis C., Suzanne M. Bertisch, Charles M. Morin, Rafael Pelayo, Nathaniel F. Watson, John W. Winkelman, and Andrew D. Krystal. “Long-Term Use of Insomnia Medications: An Appraisal of the Current Clinical and Scientific Evidence.” J Clin Med 12, no. 4 (February 17, 2023). https://doi.org/10.3390/jcm12041629.Full Text Link to Item
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Benca, Ruth M., Andrew Krystal, Craig Chepke, and Karl Doghramji. “Recognition and Management of Obstructive Sleep Apnea in Psychiatric Practice.” J Clin Psychiatry 84, no. 2 (January 23, 2023). https://doi.org/10.4088/JCP.22r14521.Full Text Link to Item
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Ohayon, Maurice M., Maggie McCue, Andrew Krystal, Katherine J. Selzler, Lambros Chrones, Debra Lawrence, and Marie-Lise Côté. “Longitudinal study to assess antidepressant treatment patterns and outcomes in individuals with depression in the general population.” J Affect Disord 321 (January 15, 2023): 272–78. https://doi.org/10.1016/j.jad.2022.10.034.Full Text Link to Item
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Epperson, C Neill, David R. Rubinow, Samantha Meltzer-Brody, Kristina M. Deligiannidis, Robert Riesenberg, Andrew D. Krystal, Kemi Bankole, et al. “Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program.” J Affect Disord 320 (January 1, 2023): 353–59. https://doi.org/10.1016/j.jad.2022.09.143.Full Text Link to Item
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Fan, Joline M., Ankit N. Khambhati, Kristin K. Sellers, Noah Stapper, Daniela Astudillo Maya, Elysha Kunwar, Catherine Henderson, et al. “Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations.” Brain Stimul 16, no. 2 (2023): 462–65. https://doi.org/10.1016/j.brs.2023.02.006.Full Text Link to Item
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Krystal, Andrew D., Ruth M. Benca, Russell Rosenberg, Paula K. Schweitzer, Atul Malhotra, Kimberly Babson, Lawrence Lee, Shay Bujanover, and Kingman P. Strohl. “Solriamfetol treatment of excessive daytime sleepiness in participants with narcolepsy or obstructive sleep apnea with a history of depression.” J Psychiatr Res 155 (November 2022): 202–10. https://doi.org/10.1016/j.jpsychires.2022.08.018.Full Text Link to Item
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Scangos, Katherine W., Ghassan S. Makhoul, Leo P. Sugrue, Edward F. Chang, and Andrew D. Krystal. “Publisher Correction: State-dependent responses to intracranial brain stimulation in a patient with depression.” Nat Med 28, no. 10 (October 2022): 2218. https://doi.org/10.1038/s41591-022-01950-9.Full Text Link to Item
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Chang, Jolie L., Andrew N. Goldberg, Jeremiah A. Alt, Alzoubaidi Mohammed, Liza Ashbrook, Dennis Auckley, Indu Ayappa, et al. “International Consensus Statement on Obstructive Sleep Apnea.” Int Forum Allergy Rhinol, September 6, 2022. https://doi.org/10.1002/alr.23079.Full Text Link to Item
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Culpepper, Larry, Andrew D. Krystal, Kate Pinner, and Margaret Moline. “Post Hoc Analysis of the Impact of Lemborexant on Patient-Reported Sleep and Insomnia Severity in Adults with Insomnia and Depression Histories.” Cns Spectr 27, no. 2 (April 2022): 243. https://doi.org/10.1017/S1092852922000499.Full Text Link to Item
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Felder, J. N., R. Mirchandaney, J. Harrison, R. Manber, J. Cuneo, A. Krystal, E. Epel, and F. Hecht. “Examining Experiences of Poor Sleep During Pregnancy: A Qualitative Study to Inform the Development of a Prenatal Sleep Intervention.” Global Advances in Health and Medicine 11 (March 16, 2022). https://doi.org/10.1177/2164957X221087655.Full Text
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Sforzini, Luca, Courtney Worrell, Melisa Kose, Ian M. Anderson, Bruno Aouizerate, Volker Arolt, Michael Bauer, et al. “A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials.” Mol Psychiatry 27, no. 3 (March 2022): 1286–99. https://doi.org/10.1038/s41380-021-01381-x.Full Text Link to Item
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Whitehurst, Lauren N., Anjana Subramoniam, Andrew Krystal, and Aric A. Prather. “Links between the brain and body during sleep: implications for memory processing.” Trends Neurosci 45, no. 3 (March 2022): 212–23. https://doi.org/10.1016/j.tins.2021.12.007.Full Text Link to Item
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Felder, Jennifer N., Elissa S. Epel, John Neuhaus, Andrew D. Krystal, and Aric A. Prather. “Randomized controlled trial of digital cognitive behavior therapy for prenatal insomnia symptoms: effects on postpartum insomnia and mental health.” Sleep 45, no. 2 (February 14, 2022). https://doi.org/10.1093/sleep/zsab280.Full Text Link to Item
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Arnedt, J Todd, M Elizabeth Cardoni, Deirdre A. Conroy, Mandilyn Graham, Sajni Amin, Kipling M. Bohnert, Andrew D. Krystal, and Mark A. Ilgen. “Telemedicine-delivered cognitive-behavioral therapy for insomnia in alcohol use disorder (AUD): study protocol for a randomized controlled trial.” Trials 23, no. 1 (January 20, 2022): 59. https://doi.org/10.1186/s13063-021-05898-y.Full Text Link to Item
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Wickwire, Emerson M., Jennifer S. Albrecht, Vincent F. Capaldi, Sonia O. Jain, Raquel C. Gardner, J Kent Werner, Pratik Mukherjee, et al. “Trajectories of Insomnia in Adults After Traumatic Brain Injury.” Jama Netw Open 5, no. 1 (January 4, 2022): e2145310. https://doi.org/10.1001/jamanetworkopen.2021.45310.Full Text Link to Item
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Lunsford-Avery, Jessica R., Jack D. Edinger, and Andrew D. Krystal. “Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.” Nat Sci Sleep 14 (2022): 217–30. https://doi.org/10.2147/NSS.S330939.Full Text Link to Item
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Krystal, Andrew D., Liza H. Ashbrook, and Aric A. Prather. “What Is Insomnia?” Jama 326, no. 23 (December 21, 2021): 2444. https://doi.org/10.1001/jama.2021.19283.Full Text Link to Item
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McCall, William V., Ben Porter, Ashley R. Pate, Courtney J. Bolstad, Christopher W. Drapeau, Andrew D. Krystal, Ruth M. Benca, Meredith E. Rumble, and Michael R. Nadorff. “Examining suicide assessment measures for research use: Using item response theory to optimize psychometric assessment for research on suicidal ideation in major depressive disorder.” Suicide Life Threat Behav 51, no. 6 (December 2021): 1086–94. https://doi.org/10.1111/sltb.12791.Full Text Link to Item
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Pizzagalli, Diego A., Moria Smoski, Yuen-Siang Ang, Alexis E. Whitton, Gerard Sanacora, Sanjay J. Mathew, John Nurnberger, et al. “Correction to: Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).” Neuropsychopharmacology 46, no. 12 (November 2021): 2224. https://doi.org/10.1038/s41386-021-01145-9.Full Text Link to Item
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Krystal, John H., Bruce Chow, Jennifer Vessicchio, Adam M. Henrie, Thomas C. Neylan, Andrew D. Krystal, Brian P. Marx, et al. “Design of the National Adaptive Trial for PTSD-related Insomnia (NAP Study), VA Cooperative Study Program (CSP) #2016.” Contemp Clin Trials 109 (October 2021): 106540. https://doi.org/10.1016/j.cct.2021.106540.Full Text Link to Item
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Scangos, Katherine W., Ankit N. Khambhati, Patrick M. Daly, Ghassan S. Makhoul, Leo P. Sugrue, Hashem Zamanian, Tony X. Liu, et al. “Closed-loop neuromodulation in an individual with treatment-resistant depression.” Nat Med 27, no. 10 (October 2021): 1696–1700. https://doi.org/10.1038/s41591-021-01480-w.Full Text Link to Item
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Rosenberg, Russell P., and Andrew D. Krystal. “Diagnosing and Treating Insomnia in Adults and Older Adults.” J Clin Psychiatry 82, no. 6 (September 28, 2021). https://doi.org/10.4088/JCP.EI20008AH5C.Full Text Link to Item
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Krystal, Andrew D. “Optimizing Treatment for Insomnia.” J Clin Psychiatry 82, no. 4 (July 13, 2021). https://doi.org/10.4088/JCP.EI20008BR4C.Full Text Link to Item
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Insel, Philip S., Brian S. Mohlenhoff, Thomas C. Neylan, Andrew D. Krystal, and R Scott Mackin. “Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults.” Jama Netw Open 4, no. 7 (July 1, 2021): e2117573. https://doi.org/10.1001/jamanetworkopen.2021.17573.Full Text Link to Item
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Zammit, Gary, and Andrew Krystal. “Evaluating lemborexant for the treatment of insomnia.” Expert Opinion on Pharmacotherapy 22, no. 10 (July 2021): 1235–43. https://doi.org/10.1080/14656566.2021.1902987.Full Text
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Krystal, Andrew D. “Challenges in Managing Insomnia in Older People.” J Clin Psychiatry 82, no. 4 (June 29, 2021). https://doi.org/10.4088/JCP.EI20008BR3C.Full Text Link to Item
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Darden, Michael, Colin A. Espie, Jenna R. Carl, Alasdair L. Henry, Jennifer C. Kanady, Andrew D. Krystal, and Christopher B. Miller. “Cost-effectiveness of digital cognitive behavioral therapy (Sleepio) for insomnia: a Markov simulation model in the United States.” Sleep 44, no. 4 (April 9, 2021). https://doi.org/10.1093/sleep/zsaa223.Full Text Link to Item
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Ohayon, Maurice M., Maggie McCue, Andrew Krystal, Lambros Chrones, Maelys Touya, Debra Lawrence, Sheetal Patel, and Marie Lise Cote. “A Longitudinal Study to Assess Antidepressant Treatment Patterns and Outcomes in Individuals with Depression in the General Population.” Cns Spectr 26, no. 2 (April 2021): 180. https://doi.org/10.1017/S1092852920002965.Full Text Link to Item
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Lunsford-Avery, Jessica R., Jack D. Edinger, and Andrew D. Krystal. “Optimizing computation of overnight decline in delta power: Evidence for slower rate of decline in delta power in insomnia patients.” Clin Neurophysiol 132, no. 2 (February 2021): 545–53. https://doi.org/10.1016/j.clinph.2020.12.004.Full Text Link to Item
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Scangos, Katherine W., Ghassan S. Makhoul, Leo P. Sugrue, Edward F. Chang, and Andrew D. Krystal. “State-dependent responses to intracranial brain stimulation in a patient with depression.” Nat Med 27, no. 2 (February 2021): 229–31. https://doi.org/10.1038/s41591-020-01175-8.Full Text Link to Item
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Shi, Guangsen, Chen Yin, Zenghua Fan, Lijuan Xing, Yulia Mostovoy, Pui-Yan Kwok, Liza H. Ashbrook, Andrew D. Krystal, Louis J. Ptáček, and Ying-Hui Fu. “Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.” Curr Biol 31, no. 1 (January 11, 2021): 13-24.e4. https://doi.org/10.1016/j.cub.2020.09.071.Full Text Link to Item
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Krystal, Andrew D., Aurélia Mittoux, Annika Lindsten, and Ross A. Baker. “Chronobiologic parameter changes in patients with major depressive disorder and sleep disturbance treated with adjunctive brexpiprazole: An open-label, flexible-dose, exploratory substudy.” J Affect Disord 278 (January 1, 2021): 288–95. https://doi.org/10.1016/j.jad.2020.09.026.Full Text Link to Item
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McCall, William V., Ruth M. Benca, Meredith E. Rumble, and Andrew D. Krystal. “Blinding and bias in a hypnotic clinical trial.” Hum Psychopharmacol 36, no. 1 (January 2021): 1–5. https://doi.org/10.1002/hup.2757.Full Text Link to Item
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Scangos, Katherine Wilson, Ankit N. Khambhati, Patrick M. Daly, Lucy W. Owen, Jeremy R. Manning, Josiah B. Ambrose, Everett Austin, Heather E. Dawes, Andrew D. Krystal, and Edward F. Chang. “Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology.” Front Hum Neurosci 15 (2021): 746499. https://doi.org/10.3389/fnhum.2021.746499.Full Text Link to Item
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Dias-Barbosa, C., R. Matos, M. Vernon, C. E. Carney, A. Krystal, and J. Puelles. “Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis.” Journal of Patient Reported Outcomes 4, no. 1 (December 1, 2020). https://doi.org/10.1186/s41687-020-00265-y.Full Text
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Dias-Barbosa, C., R. Matos, M. Vernon, C. E. Carney, A. Krystal, and J. Puelles. “Correction to: Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis (Journal of Patient-Reported Outcomes, (2020), 4, 1, (100), 10.1186/s41687-020-00265-y).” Journal of Patient Reported Outcomes 4, no. 1 (December 1, 2020). https://doi.org/10.1186/s41687-020-00279-6.Full Text
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Hatch, Guy M., Liza Ashbrook, Aric A. Prather, and Andrew D. Krystal. “Is cellular energy monitoring more responsive to hypoxia than pulse oximetry?” Sleep Breath 24, no. 4 (December 2020): 1633–43. https://doi.org/10.1007/s11325-020-02104-2.Full Text Link to Item
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Morin, Charles M., Jack D. Edinger, Simon Beaulieu-Bonneau, Hans Ivers, Andrew D. Krystal, Bernard Guay, Lynda Bélanger, et al. “Effectiveness of Sequential Psychological and Medication Therapies for Insomnia Disorder: A Randomized Clinical Trial.” Jama Psychiatry 77, no. 11 (November 1, 2020): 1107–15. https://doi.org/10.1001/jamapsychiatry.2020.1767.Full Text Link to Item
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Lunsford-Avery, Jessica R., Casey Keller, Scott H. Kollins, Andrew D. Krystal, Leah Jackson, and Matthew M. Engelhard. “Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study.” Jmir Mhealth Uhealth 8, no. 10 (October 1, 2020): e20590. https://doi.org/10.2196/20590.Full Text Link to Item
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Pizzagalli, Diego A., Moria Smoski, Yuen-Siang Ang, Alexis E. Whitton, Gerard Sanacora, Sanjay J. Mathew, John Nurnberger, et al. “Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).” Neuropsychopharmacology 45, no. 10 (September 2020): 1656–63. https://doi.org/10.1038/s41386-020-0738-4.Full Text Link to Item
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Rumble, Meredith E., William V. McCall, Daniel A. Dickson, Andrew D. Krystal, Peter B. Rosenquist, and Ruth M. Benca. “An exploratory analysis of the association of circadian rhythm dysregulation and insomnia with suicidal ideation over the course of treatment in individuals with depression, insomnia, and suicidal ideation.” J Clin Sleep Med 16, no. 8 (August 15, 2020): 1311–19. https://doi.org/10.5664/jcsm.8508.Full Text Link to Item
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Krystal, Andrew D. “Omitted Conflict of Interest Disclosures.” Jama Psychiatry 77, no. 7 (July 1, 2020): 768. https://doi.org/10.1001/jamapsychiatry.2020.0616.Full Text Link to Item
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Lunsford-Avery, Jessica R., Casey Keller, Scott H. Kollins, Andrew D. Krystal, Leah Jackson, and Matthew M. Engelhard. “Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study (Preprint),” May 25, 2020. https://doi.org/10.2196/preprints.20590.Full Text
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Felder, Jennifer N., Elissa S. Epel, John Neuhaus, Andrew D. Krystal, and Aric A. Prather. “Efficacy of Digital Cognitive Behavioral Therapy for the Treatment of Insomnia Symptoms Among Pregnant Women: A Randomized Clinical Trial.” Jama Psychiatry 77, no. 5 (May 1, 2020): 484–92. https://doi.org/10.1001/jamapsychiatry.2019.4491.Full Text Link to Item
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Krystal, Andrew D., Diego A. Pizzagalli, Moria Smoski, Sanjay J. Mathew, John Nurnberger, Sarah H. Lisanby, Dan Iosifescu, et al. “A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.” Nat Med 26, no. 5 (May 2020): 760–68. https://doi.org/10.1038/s41591-020-0806-7.Full Text Link to Item
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Aluisio, Leah, Lynn Yieh, Ewa Wajs, Allitia DiBernardo, Andrew Krystal, Wayne Drevets, Yun Wu, et al. “142 Withdrawal Symptom Assessment in an Esketamine Safety Study in Patients with Treatment-resistant Depression.” Cns Spectrums 25, no. 2 (April 2020): 290. https://doi.org/10.1017/s1092852920000589.Full Text
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Ashbrook, Liza H., Andrew D. Krystal, Ying-Hui Fu, and Louis J. Ptáček. “Genetics of the human circadian clock and sleep homeostat.” Neuropsychopharmacology 45, no. 1 (January 2020): 45–54. https://doi.org/10.1038/s41386-019-0476-7.Full Text Link to Item
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Krystal, Andrew D. “Sleep therapeutics and neuropsychiatric illness.” Neuropsychopharmacology 45, no. 1 (January 2020): 166–75. https://doi.org/10.1038/s41386-019-0474-9.Full Text Link to Item
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Scangos, Katherine W., Hasan S. Ahmad, Alia Shafi, Kristin K. Sellers, Heather E. Dawes, Andrew Krystal, and Edward F. Chang. “Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy.” J Neuropsychiatry Clin Neurosci 32, no. 2 (2020): 185–90. https://doi.org/10.1176/appi.neuropsych.19030081.Full Text Link to Item
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McCall, William V., Ruth M. Benca, Peter B. Rosenquist, Nagy A. Youssef, Laryssa McCloud, Jill C. Newman, Doug Case, et al. “Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.” Am J Psychiatry 176, no. 11 (November 1, 2019): 957–65. https://doi.org/10.1176/appi.ajp.2019.19030267.Full Text Link to Item
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Krystal, Andrew D., Aric A. Prather, and Liza H. Ashbrook. “The assessment and management of insomnia: an update.” World Psychiatry 18, no. 3 (October 2019): 337–52. https://doi.org/10.1002/wps.20674.Full Text Link to Item
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Shi, Guangsen, Lijuan Xing, David Wu, Bula J. Bhattacharyya, Christopher R. Jones, Thomas McMahon, SY Christin Chong, et al. “A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors.” Neuron 103, no. 6 (September 25, 2019): 1044-1055.e7. https://doi.org/10.1016/j.neuron.2019.07.026.Full Text Link to Item
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Krystal, Andrew D., and Aric A. Prather. “Sleep Pharmacogenetics: The Promise of Precision Medicine.” Sleep Med Clin 14, no. 3 (September 2019): 317–31. https://doi.org/10.1016/j.jsmc.2019.05.003.Full Text Link to Item
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McCall, William V., Ruth M. Benca, Meredith E. Rumble, Doug Case, Peter B. Rosenquist, and Andrew D. Krystal. “Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder.” J Psychiatr Res 116 (September 2019): 147–50. https://doi.org/10.1016/j.jpsychires.2019.06.015.Full Text Link to Item
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Wilson, Sue, Kirstie Anderson, David Baldwin, Derk-Jan Dijk, Audrey Espie, Colin Espie, Paul Gringras, et al. “British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update.” J Psychopharmacol 33, no. 8 (August 2019): 923–47. https://doi.org/10.1177/0269881119855343.Full Text Link to Item
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Scangos, Katherine W., Richard D. Weiner, Edward C. Coffey, and Andrew D. Krystal. “An Electrophysiological Biomarker That May Predict Treatment Response to ECT.” J Ect 35, no. 2 (June 2019): 95–102. https://doi.org/10.1097/YCT.0000000000000557.Full Text Link to Item
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Asarnow, Lauren D., Bei Bei, Andrew Krystal, Daniel J. Buysse, Michael E. Thase, Jack D. Edinger, and Rachel Manber. “Circadian Preference as a Moderator of Depression Outcome Following Cognitive Behavioral Therapy for Insomnia Plus Antidepressant Medications: A Report From the TRIAD Study.” J Clin Sleep Med 15, no. 4 (April 15, 2019): 573–80. https://doi.org/10.5664/jcsm.7716.Full Text Link to Item
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Herring, W Joseph, Thomas Roth, Andrew D. Krystal, and David Michelson. “Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications.” J Sleep Res 28, no. 2 (April 2019): e12782. https://doi.org/10.1111/jsr.12782.Full Text Link to Item
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Strollo, Patrick J., Jan Hedner, Nancy Collop, Daniel G. Lorch, Dan Chen, Lawrence P. Carter, Yuan Lu, et al. “Solriamfetol for the Treatment of Excessive Sleepiness in OSA: A Placebo-Controlled Randomized Withdrawal Study.” Chest 155, no. 2 (February 2019): 364–74. https://doi.org/10.1016/j.chest.2018.11.005.Full Text Link to Item
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La, Alice L., Christine M. Walsh, Thomas C. Neylan, Keith A. Vossel, Kristine Yaffe, Andrew D. Krystal, Bruce L. Miller, and Elissaios Karageorgiou. “Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers.” J Alzheimers Dis 67, no. 3 (2019): 911–21. https://doi.org/10.3233/JAD-181145.Full Text Link to Item
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Ohayon, Maurice M., Jed Black, Andrew D. Krystal, Colin M. Shapiro, Todd J. Swick, Richard Bogan, and Charles C. Wells. “Longitudinal study of narcolepsy symptoms in first, second, and third-degree relatives of simplex and multiplex narcolepsy families.” Sleep Med 53 (January 2019): 88–93. https://doi.org/10.1016/j.sleep.2018.06.015.Full Text Link to Item
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Krystal, Andrew D., Diego A. Pizzagalli, Sanjay J. Mathew, Gerard Sanacora, Richard Keefe, Allen Song, Joseph Calabrese, et al. “The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.” Nat Rev Drug Discov 18, no. 1 (December 28, 2018): 82–84. https://doi.org/10.1038/nrd.2018.222.Full Text Link to Item
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Dominguez, Jennifer E., Ashraf S. Habib, and Andrew D. Krystal. “A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease.” Sleep Med Rev 42 (December 2018): 37–46. https://doi.org/10.1016/j.smrv.2018.05.004.Full Text Link to Item
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Dominguez, Jennifer E., Chad A. Grotegut, Mary Cooter, Andrew D. Krystal, and Ashraf S. Habib. “Screening extremely obese pregnant women for obstructive sleep apnea.” Am J Obstet Gynecol 219, no. 6 (December 2018): 613.e1-613.e10. https://doi.org/10.1016/j.ajog.2018.09.001.Full Text Link to Item
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Szabo, Steven T., Kelly Kandra, and Andrew D. Krystal. “Effect of γ-hydroxybutyrate (Xyrem) on locus coeruleus activity as measured by pupillometry in a patient with narcolepsy.” Int J Clin Pharmacol Ther 56, no. 12 (December 2018): 620–22. https://doi.org/10.5414/CP202661.Full Text Link to Item
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Dominguez, Jennifer E., Andrew D. Krystal, and Ashraf S. Habib. “Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management.” Anesth Analg 127, no. 5 (November 2018): 1167–77. https://doi.org/10.1213/ANE.0000000000003335.Full Text Link to Item
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Lundeen, J., W. V. McCall, A. Krystal, and S. Looney. “Validating functional data analysis measures from 24-h actigraphy data.” Biological Rhythm Research 49, no. 5 (September 3, 2018): 797–810. https://doi.org/10.1080/09291016.2018.1424771.Full Text
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Beppler, Eric C., James Dieffenderfer, Tanner Songkakul, Andrew Krystal, and Alper Bozkurt. “An Ultra-miniaturized Near Infrared Spectroscopy System to Assess Sleep Apnea in Children with Down Syndrome.” Annu Int Conf Ieee Eng Med Biol Soc 2018 (July 2018): 2877–80. https://doi.org/10.1109/EMBC.2018.8513038.Full Text Link to Item
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Bei, Bei, Lauren D. Asarnow, Andrew Krystal, Jack D. Edinger, Daniel J. Buysse, and Rachel Manber. “Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories.” J Consult Clin Psychol 86, no. 3 (March 2018): 282–93. https://doi.org/10.1037/ccp0000282.Full Text Link to Item
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Rumble, Meredith E., Daniel Dickson, W Vaughn McCall, Andrew D. Krystal, Doug Case, Peter B. Rosenquist, and Ruth M. Benca. “The relationship of person-specific eveningness chronotype, greater seasonality, and less rhythmicity to suicidal behavior: A literature review.” J Affect Disord 227 (February 2018): 721–30. https://doi.org/10.1016/j.jad.2017.11.078.Full Text Link to Item
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Valero-Sarmiento, J. M., J. Reynolds, A. Krystal, and A. Bozkurt. “In vitro evaluation of an injectable EEG/ECG sensor for wireless monitoring of hibernation in endangered animal species.” Ieee Sensors Journal 18, no. 2 (January 15, 2018): 798–808. https://doi.org/10.1109/JSEN.2017.2772844.Full Text
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Loo, Colleen K., Mustafa M. Husain, William M. McDonald, Scott Aaronson, John P. O’Reardon, Angelo Alonzo, Cynthia Shannon Weickert, et al. “International randomized-controlled trial of transcranial Direct Current Stimulation in depression.” Brain Stimul 11, no. 1 (2018): 125–33. https://doi.org/10.1016/j.brs.2017.10.011.Full Text Link to Item
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McClintock, Shawn M., Irving M. Reti, Linda L. Carpenter, William M. McDonald, Marc Dubin, Stephan F. Taylor, Ian A. Cook, et al. “Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression.” J Clin Psychiatry 79, no. 1 (2018). https://doi.org/10.4088/JCP.16cs10905.Full Text Link to Item
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McClintock, Shawn M., Irving M. Reti, Linda L. Carpenter, William M. McDonald, Marc Dubin, Stephan F. Taylor, Ian A. Cook, et al. “Dr McClintock and Colleagues Reply.” J Clin Psychiatry 79, no. 1 (2018). https://doi.org/10.4088/JCP.17lr11851a.Full Text Link to Item
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Connor, Kathryn M., Paulette Ceesay, Jill Hutzelmann, Duane Snavely, Andrew D. Krystal, Madhukar H. Trivedi, Michael Thase, Christopher Lines, W Joseph Herring, and David Michelson. “Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder.” Int J Neuropsychopharmacol 20, no. 8 (August 1, 2017): 613–18. https://doi.org/10.1093/ijnp/pyx033.Full Text Link to Item
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Evans, Joanna L., Jacob W. Nadler, Xavier A. Preud’homme, Eric Fang, Rommie L. Daughtry, Joseph B. Chapman, David Attarian, Samuel Wellman, and Andrew D. Krystal. “Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium.” Clin Neurophysiol 128, no. 8 (August 2017): 1421–25. https://doi.org/10.1016/j.clinph.2017.05.004.Full Text Link to Item
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Goucher Miranda, Haley, Andrew D. Krystal, and Michael A. Fierro. “Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation?” Anesthesiology 127, no. 2 (August 2017): 397–98. https://doi.org/10.1097/ALN.0000000000001721.Full Text Link to Item
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Samson, David R., Melissa B. Manus, Andrew D. Krystal, Efe Fakir, James J. Yu, and Charles L. Nunn. “Segmented sleep in a nonelectric, small-scale agricultural society in Madagascar.” Am J Hum Biol 29, no. 4 (July 8, 2017). https://doi.org/10.1002/ajhb.22979.Full Text Link to Item
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Herring, W Joseph, Kathryn M. Connor, Ellen Snyder, Duane B. Snavely, Ying Zhang, Jill Hutzelmann, Deborah Matzura-Wolfe, et al. “Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials.” Am J Geriatr Psychiatry 25, no. 7 (July 2017): 791–802. https://doi.org/10.1016/j.jagp.2017.03.004.Full Text Link to Item
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Sateia, Michael J., Daniel J. Buysse, Andrew D. Krystal, and David N. Neubauer. “Adverse Effects of Hypnotic Medications.” J Clin Sleep Med 13, no. 6 (June 15, 2017): 839. https://doi.org/10.5664/jcsm.6634.Full Text Link to Item
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Herring, W Joseph, Kathryn M. Connor, Ellen Snyder, Duane B. Snavely, Ying Zhang, Jill Hutzelmann, Deborah Matzura-Wolfe, et al. “Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data.” Psychopharmacology (Berl) 234, no. 11 (June 2017): 1703–11. https://doi.org/10.1007/s00213-017-4573-1.Full Text Link to Item
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Nadler, J. W., J. L. Evans, E. Fang, X. A. Preud’Homme, R. L. Daughtry, J. B. Chapman, M. P. Bolognesi, D. E. Attarian, S. S. Wellman, and A. D. Krystal. “A randomised trial of peri-operative positive airway pressure for postoperative delirium in patients at risk for obstructive sleep apnoea after regional anaesthesia with sedation or general anaesthesia for joint arthroplasty.” Anaesthesia 72, no. 6 (June 2017): 729–36. https://doi.org/10.1111/anae.13833.Full Text Link to Item
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Carney, Colleen E., Jack D. Edinger, Maragatha Kuchibhatla, Angela M. Lachowski, Olya Bogouslavsky, Andrew D. Krystal, and Colin M. Shapiro. “Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial.” Sleep 40, no. 4 (April 1, 2017). https://doi.org/10.1093/sleep/zsx019.Full Text Link to Item
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Edinger, Jack D., Rachel Manber, Daniel J. Buysse, Andrew D. Krystal, Michael E. Thase, Phillip Gehrman, Christopher P. Fairholme, James Luther, and Stephen Wisniewski. “Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study.” J Clin Sleep Med 13, no. 2 (February 15, 2017): 205–13. https://doi.org/10.5664/jcsm.6448.Full Text Link to Item
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Sateia, Michael J., Daniel J. Buysse, Andrew D. Krystal, David N. Neubauer, and Jonathan L. Heald. “Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.” J Clin Sleep Med 13, no. 2 (February 15, 2017): 307–49. https://doi.org/10.5664/jcsm.6470.Full Text Link to Item
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Ohayon, Maurice, Emerson M. Wickwire, Max Hirshkowitz, Steven M. Albert, Alon Avidan, Frank J. Daly, Yves Dauvilliers, et al. “National Sleep Foundation's sleep quality recommendations: first report.” Sleep Health 3, no. 1 (February 2017): 6–19. https://doi.org/10.1016/j.sleh.2016.11.006.Full Text Link to Item
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Bathgate, Christina J., Jack D. Edinger, and Andrew D. Krystal. “Insomnia Patients With Objective Short Sleep Duration Have a Blunted Response to Cognitive Behavioral Therapy for Insomnia.” Sleep 40, no. 1 (January 1, 2017). https://doi.org/10.1093/sleep/zsw012.Full Text Link to Item
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Krystal, Andrew D., and Aric A. Prather. “Should Internet Cognitive Behavioral Therapy for Insomnia Be the Primary Treatment Option for Insomnia?: Toward Getting More SHUTi.” Jama Psychiatry 74, no. 1 (January 1, 2017): 15–16. https://doi.org/10.1001/jamapsychiatry.2016.3431.Full Text Link to Item
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Krystal, Andrew D., and Xavier A. Preud’homme. “Double-Blind, Placebo-Controlled, Crossover Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia.” Sleep 40, no. 1 (January 1, 2017). https://doi.org/10.1093/sleep/zsw020.Full Text Link to Item
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McCall, W Vaughn, Ruth M. Benca, Peter B. Rosenquist, Mary Anne Riley, Laryssa McCloud, Jill C. Newman, Doug Case, Meredith Rumble, and Andrew D. Krystal. “Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA.” Am J Psychiatry 174, no. 1 (January 1, 2017): 18–25. https://doi.org/10.1176/appi.ajp.2016.16030336.Full Text Link to Item
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Krystal, A., and H. Attarian. “Sleep Medications and Women: a Review of Issues to Consider for Optimizing the Care of Women with Sleep Disorders.” Current Sleep Medicine Reports 2, no. 4 (December 1, 2016): 218–22. https://doi.org/10.1007/s40675-016-0060-1.Full Text
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Lunsford-Avery, Jessica R., Andrew D. Krystal, and Scott H. Kollins. “Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research.” Clin Psychol Rev 50 (December 2016): 159–74. https://doi.org/10.1016/j.cpr.2016.10.004.Full Text Link to Item
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Ptáǒek, Louis J., Ying-Hui Fu, and Andrew D. Krystal. “Sleep and Mood: Chicken or Egg?” Biol Psychiatry 80, no. 11 (December 1, 2016): 810–11. https://doi.org/10.1016/j.biopsych.2016.09.012.Full Text Link to Item
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Jacobsen, Jacob P. R., Andrew D. Krystal, K Ranga R. Krishnan, and Marc G. Caron. “Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.” Trends Pharmacol Sci 37, no. 11 (November 2016): 933–44. https://doi.org/10.1016/j.tips.2016.09.001.Full Text Link to Item
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Carlezon, William A., and Andrew D. Krystal. “Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials.” Depress Anxiety 33, no. 10 (October 2016): 895–906. https://doi.org/10.1002/da.22500.Full Text Link to Item
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Herring, W Joseph, Kathleen M. Connor, Ellen Snyder, Duane B. Snavely, Ying Zhang, Jill Hutzelmann, Deborah Matzura-Wolfe, et al. “Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials.” J Clin Sleep Med 12, no. 9 (September 15, 2016): 1215–25. https://doi.org/10.5664/jcsm.6116.Full Text Link to Item
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Bathgate, Christina J., Jack D. Edinger, and Andrew D. Krystal. “Insomnia Patients with Objective Short Sleep Duration have a Blunted Response to Cognitive Behavioral Therapy for Insomnia.” Sleep, September 9, 2016.Link to Item
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Krystal, Andrew D., and Xavier A. Preud’homme. “DOUBLE-BLIND, PLACEBO-CONTROLLED, CROSS-OVER, STUDY OF ARMODAFINIL TREATMENT OF DAYTIME SLEEPINESS ASSOCIATED WITH TREATED NOCTURIA.” Sleep, September 9, 2016.Link to Item
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Krystal, Andrew D., Aurélia Mittoux, Peter Meisels, and Ross A. Baker. “Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study.” Prim Care Companion Cns Disord 18, no. 5 (September 8, 2016). https://doi.org/10.4088/PCC.15m01914.Full Text Link to Item
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Blanco, Marina B., Kathrin H. Dausmann, Sheena L. Faherty, Peter Klopfer, Andrew D. Krystal, Robert Schopler, and Anne D. Yoder. “Hibernation in a primate: does sleep occur?” R Soc Open Sci 3, no. 8 (August 2016): 160282. https://doi.org/10.1098/rsos.160282.Full Text Link to Item
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Krystal, John H., Anissa Abi-Dargham, Schahram Akbarian, Amy F. T. Arnsten, Deanna M. Barch, Carrie E. Bearden, David L. Braff, et al. “Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.” Biol Psychiatry 80, no. 2 (July 15, 2016): 84–86. https://doi.org/10.1016/j.biopsych.2016.05.004.Full Text Link to Item
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Bathgate, Christina J., Jack D. Edinger, James K. Wyatt, and Andrew D. Krystal. “Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia.” Sleep 39, no. 5 (May 1, 2016): 1037–45. https://doi.org/10.5665/sleep.5748.Full Text Link to Item
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Krystal, Andrew D., and Gary Zammit. “The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia.” Hum Psychopharmacol 31, no. 3 (May 2016): 206–16. https://doi.org/10.1002/hup.2533.Full Text Link to Item
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Krystal, Andrew D., and Adam J. Sorscher. “Recognizing and managing insomnia in primary care and specialty settings.” J Clin Psychiatry 77, no. 4 (April 2016): e471. https://doi.org/10.4088/JCP.15029wc1c.Full Text Link to Item
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Krystal, John H., Robert H. Pietrzak, Robert A. Rosenheck, Joyce A. Cramer, Jennifer Vessicchio, Karen M. Jones, Grant D. Huang, et al. “Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504.” J Clin Psychiatry 77, no. 4 (April 2016): 483–91. https://doi.org/10.4088/JCP.14m09585.Full Text Link to Item
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Morin, Charles M., Jack D. Edinger, Andrew D. Krystal, Daniel J. Buysse, Simon Beaulieu-Bonneau, and Hans Ivers. “Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial.” Trials 17, no. 1 (March 3, 2016): 118. https://doi.org/10.1186/s13063-016-1242-3.Full Text Open Access Copy Link to Item
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Herring, W Joseph, Kathryn M. Connor, Neely Ivgy-May, Ellen Snyder, Ken Liu, Duane B. Snavely, Andrew D. Krystal, et al. “Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials.” Biol Psychiatry 79, no. 2 (January 15, 2016): 136–48. https://doi.org/10.1016/j.biopsych.2014.10.003.Full Text Link to Item
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Nunn, Charles L., David R. Samson, and Andrew D. Krystal. “Shining evolutionary light on human sleep and sleep disorders.” Evol Med Public Health 2016, no. 1 (2016): 227–43. https://doi.org/10.1093/emph/eow018.Full Text Link to Item
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Krystal, Andrew D. “New Developments in Insomnia Medications of Relevance to Mental Health Disorders.” Psychiatr Clin North Am 38, no. 4 (December 2015): 843–60. https://doi.org/10.1016/j.psc.2015.08.001.Full Text Link to Item
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Morin, Charles M., Christopher L. Drake, Allison G. Harvey, Andrew D. Krystal, Rachel Manber, Dieter Riemann, and Kai Spiegelhalder. “Insomnia disorder.” Nat Rev Dis Primers 1 (September 3, 2015): 15026. https://doi.org/10.1038/nrdp.2015.26.Full Text Link to Item
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Krystal, Andrew D. “Current, emerging, and newly available insomnia medications.” J Clin Psychiatry 76, no. 8 (August 2015): e1045. https://doi.org/10.4088/JCP.14046tx2c.Full Text Link to Item
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Peterchev, Angel V., Andrew D. Krystal, Moacyr A. Rosa, and Sarah H. Lisanby. “Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy.” Neuropsychopharmacology 40, no. 9 (August 2015): 2076–84. https://doi.org/10.1038/npp.2015.122.Full Text Link to Item
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Ivgy-May, Neely, Frank Ruwe, Andrew Krystal, and Thomas Roth. “Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial.” Sleep Med 16, no. 7 (July 2015): 838–44. https://doi.org/10.1016/j.sleep.2015.04.001.Full Text Link to Item
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Krystal, John H., Scott Stossel, and Andrew D. Krystal. “Restricting Benzodiazepines to Short-Term Prescription.” Jama Psychiatry 72, no. 7 (July 2015): 734–35. https://doi.org/10.1001/jamapsychiatry.2015.0351.Full Text Link to Item
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McCall, William Vaughn, Ruth M. Benca, Peter B. Rosenquist, Mary Anne Riley, Chelsea Hodges, Brittany Gubosh, Laryssa McCloud, et al. “A multi-site randomized clinical trial to reduce suicidal ideation in suicidal adult outpatients with Major Depressive Disorder: Development of a methodology to enhance safety.” Clin Trials 12, no. 3 (June 2015): 189–98. https://doi.org/10.1177/1740774515573958.Full Text Link to Item
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Szabo, S. T., B. J. Kinon, S. K. Brannan, A. K. Krystal, J. M. A. van Gerven, A. Mahableshwarkar, and G. S. Sachs. “Lessons learned and potentials for improvement in cns drug development: Isctm section on designing the right series of experiments.” Innovations in Clinical Neuroscience 12, no. 3–4 (March 1, 2015): 11S-25S.
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Rapp, P. E., D. O. Keyser, A. Albano, R. Hernandez, D. B. Gibson, R. A. Zambon, W. David Hairston, J. D. Hughes, A. Krystal, and A. S. Nichols. “Traumatic brain injury detection using electrophysiological methods.” Frontiers in Human Neuroscience 9, no. FEB (February 4, 2015). https://doi.org/10.3389/fnhum.2015.00011.Full Text
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Leuchter, Andrew F., Ian A. Cook, David Feifel, John W. Goethe, Mustafa Husain, Linda L. Carpenter, Michael E. Thase, et al. “Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression.” Brain Stimul 8, no. 4 (2015): 787–94. https://doi.org/10.1016/j.brs.2015.05.005.Full Text Link to Item
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Tek, Cenk, Laura B. Palmese, Andrew D. Krystal, Vinod H. Srihari, Pamela C. DeGeorge, Erin L. Reutenauer, and Sinan Guloksuz. “The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial.” Schizophr Res 160, no. 1–3 (December 2014): 180–85. https://doi.org/10.1016/j.schres.2014.10.002.Full Text Link to Item
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Calabrese, Joseph R., Maurizio Fava, George Garibaldi, Heinz Grunze, Andrew D. Krystal, Thomas Laughren, Wayne Macfadden, Robert Marin, Andrew A. Nierenberg, and Mauricio Tohen. “Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders.” J Affect Disord 168 (October 2014): 439–51. https://doi.org/10.1016/j.jad.2014.06.056.Full Text Link to Item
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Goforth, Harold W., Xavier A. Preud’homme, and Andrew D. Krystal. “A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain.” Sleep 37, no. 6 (June 1, 2014): 1053–60. https://doi.org/10.5665/sleep.3760.Full Text Link to Item
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McClintock, Shawn M., Jimmy Choi, Zhi-De Deng, Lawrence G. Appelbaum, Andrew D. Krystal, and Sarah H. Lisanby. “Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.” J Ect 30, no. 2 (June 2014): 165–76. https://doi.org/10.1097/YCT.0000000000000137.Full Text Open Access Copy Link to Item
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Krystal, Andrew D., Wei Zhang, Jonathan R. T. Davidson, and Kathryn M. Connor. “The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks.” J Psychopharmacol 28, no. 5 (May 2014): 457–65. https://doi.org/10.1177/0269881113509903.Full Text Open Access Copy Link to Item
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Michelson, David, Ellen Snyder, Erin Paradis, Mary Chengan-Liu, Duane B. Snavely, Jill Hutzelmann, James K. Walsh, et al. “Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial.” Lancet Neurol 13, no. 5 (May 2014): 461–71. https://doi.org/10.1016/S1474-4422(14)70053-5.Full Text Link to Item
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Mirrakhimov, Aibek E., Carey L. Brewbaker, Andrew D. Krystal, and Madan M. Kwatra. “Obstructive sleep apnea and delirium: exploring possible mechanisms.” Sleep Breath 18, no. 1 (March 2014): 19–29. https://doi.org/10.1007/s11325-013-0846-z.Full Text Link to Item
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Greve, Douglas N., Stephen P. Duntley, Linda Larson-Prior, Andrew D. Krystal, Michele T. Diaz, Sean P. A. Drummond, Stephen G. Thein, Clete A. Kushida, Ronghua Yang, and Robert J. Thomas. “Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study.” J Clin Sleep Med 10, no. 2 (February 15, 2014): 143–53. https://doi.org/10.5664/jcsm.3440.Full Text Link to Item
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Wang, Xiaoming, Alexandra L. Bey, Leeyup Chung, Andrew D. Krystal, and Yong-Hui Jiang. “Therapeutic approaches for shankopathies.” Dev Neurobiol 74, no. 2 (February 2014): 123–35. https://doi.org/10.1002/dneu.22084.Full Text Link to Item
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Low, Yinghui, Harold Goforth, Xavier Preud’homme, Jack Edinger, and Andrew Krystal. “Insomnia in HIV-infected patients: pathophysiologic implications.” Aids Rev 16, no. 1 (2014): 3–13.Link to Item
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Minkel, Jared, and Andrew D. Krystal. “Optimizing the Pharmacologic Treatment of Insomnia: Current Status and Future Horizons.” Sleep Med Clin 8, no. 3 (September 1, 2013): 333–50. https://doi.org/10.1016/j.jsmc.2013.06.002.Full Text Link to Item
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Krystal, Andrew D., Elliott Richelson, and Thomas Roth. “Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications.” Sleep Med Rev 17, no. 4 (August 2013): 263–72. https://doi.org/10.1016/j.smrv.2012.08.001.Full Text Link to Item
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Edinger, Jack D., Melanie K. Means, and Andrew D. Krystal. “Does physiological hyperarousal enhance error rates among insomnia sufferers?” Sleep 36, no. 8 (August 1, 2013): 1179–86. https://doi.org/10.5665/sleep.2882.Full Text Link to Item
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Preud’homme, Xavier A., Cindy L. Amundsen, George D. Webster, and Andrew D. Krystal. “Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls.” Int Urogynecol J 24, no. 3 (March 2013): 501–8. https://doi.org/10.1007/s00192-012-1890-0.Full Text Link to Item
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Roth, Thomas, Andrew Krystal, Frank J. Steinberg, Nikhilesh N. Singh, and Margaret Moline. “Novel sublingual low-dose zolpidem tablet reduces latency to sleep onset following spontaneous middle-of-the-night awakening in insomnia in a randomized, double-blind, placebo-controlled, outpatient study.” Sleep 36, no. 2 (February 1, 2013): 189–96. https://doi.org/10.5665/sleep.2370.Full Text Link to Item
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Rosenquist, Peter B., Andrew Krystal, Karen L. Heart, Mark A. Demitrack, and W Vaughn McCall. “Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder.” Psychiatry Res 205, no. 1–2 (January 30, 2013): 67–73. https://doi.org/10.1016/j.psychres.2012.09.011.Full Text Link to Item
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Krystal, Andrew D., Bobby Schopler, Susanne Kobbe, Cathy Williams, Hajanirina Rakatondrainibe, Anne D. Yoder, and Peter Klopfer. “The relationship of sleep with temperature and metabolic rate in a hibernating primate.” Plos One 8, no. 9 (2013): e69914. https://doi.org/10.1371/journal.pone.0069914.Full Text Open Access Copy Link to Item
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Krystal, Andrew D., Ruth M. Benca, and Thomas S. Kilduff. “Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.” J Clin Psychiatry 74 Suppl 1 (2013): 3–20. https://doi.org/10.4088/JCP.13011su1c.Full Text Link to Item
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Krystal, A. D. “Sleep in Mood Disorders,” December 1, 2012, 675–81. https://doi.org/10.1016/B978-1-4377-1703-7.10054-4.Full Text
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Low, Yinghui, Harold W. Goforth, Toma Omonuwa, Xavier Preud’homme, Jack Edinger, and Andrew Krystal. “Comparison of polysomnographic data in age-, sex- and Axis I psychiatric diagnosis matched HIV-seropositive and HIV-seronegative insomnia patients.” Clin Neurophysiol 123, no. 12 (December 2012): 2402–5. https://doi.org/10.1016/j.clinph.2012.05.004.Full Text Link to Item
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Krystal, Andrew D. “Psychiatric disorders and sleep.” Neurol Clin 30, no. 4 (November 2012): 1389–1413. https://doi.org/10.1016/j.ncl.2012.08.018.Full Text Link to Item
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Krystal, Andrew D., Thomas Roth, and Richard D. Simon. “Shift work disorder case studies: applying management principles in clinical practice.” The Journal of Clinical Psychiatry 73, no. 8 (August 2012): e25. https://doi.org/10.4088/jcp.11073br4.Full Text
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Krystal, Andrew D., Holly Huang, Jacqueline Zummo, Todd Grinnell, and Randall D. Marshall. “A WASO sub-group analysis of a 6-month study of eszopiclone 3 mg.” Sleep Med 13, no. 6 (June 2012): 691–96. https://doi.org/10.1016/j.sleep.2012.01.010.Full Text Link to Item
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Ohayon, M. M., M. W. Mahowald, Y. Dauvilliers, A. D. Krystal, and D. Léger. “Prevalence and comorbidity of nocturnal wandering in the U.S. adult general population.” Neurology 78, no. 20 (May 15, 2012): 1583–89. https://doi.org/10.1212/WNL.0b013e3182563be5.Full Text Link to Item
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Flink, Benjamin J., Sarah K. Rivelli, Elizabeth A. Cox, William D. White, Grace Falcone, Thomas P. Vail, Christopher C. Young, et al. “Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly.” Anesthesiology 116, no. 4 (April 2012): 788–96. https://doi.org/10.1097/ALN.0b013e31824b94fc.Full Text Link to Item
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Carney, Colleen E., Daniel J. Buysse, Sonia Ancoli-Israel, Jack D. Edinger, Andrew D. Krystal, Kenneth L. Lichstein, and Charles M. Morin. “The consensus sleep diary: standardizing prospective sleep self-monitoring.” Sleep 35, no. 2 (February 1, 2012): 287–302. https://doi.org/10.5665/sleep.1642.Full Text Link to Item
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Krystal, Andrew D. “How the circadian rhythm affects sleep, wakefulness, and overall health: background for understanding shift work disorder.” The Journal of Clinical Psychiatry 73, no. 2 (February 2012): e05. https://doi.org/10.4088/jcp.11073br1.Full Text
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Krystal, Andrew D., W Vaughn McCall, Maurizio Fava, Hadine Joffe, Claudio N. Soares, Holly Huang, Todd Grinell, Jacqueline Zummo, William Spalding, and Randall Marshall. “Eszopiclone treatment for insomnia: effect size comparisons in patients with primary insomnia and insomnia with medical and psychiatric comorbidity.” Prim Care Companion Cns Disord 14, no. 4 (2012). https://doi.org/10.4088/PCC.11m01296.Full Text Link to Item
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Ulmer, C. S., M. Sutherland, J. D. Edinger, J. Davidson, K. M. Connor, W. Zhang, and A. Krystal. “REM sleep bout duration and frequency in PTSD.” Journal of Aggression, Maltreatment and Trauma 21, no. 1 (January 1, 2012): 67–76. https://doi.org/10.1080/10926771.2012.630339.Full Text
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Krystal, Andrew D., Janice Sutherland, and Daryl W. Hochman. “Loop diuretics have anxiolytic effects in rat models of conditioned anxiety.” Plos One 7, no. 4 (2012): e35417. https://doi.org/10.1371/journal.pone.0035417.Full Text Link to Item
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Low, Yinghui, Xavier Preud’homme, Harold W. Goforth, Toma Omonuwa, and Andrew D. Krystal. “The association of fatigue with depression and insomnia in HIV-seropositive patients: a pilot study.” Sleep 34, no. 12 (December 1, 2011): 1723–26. https://doi.org/10.5665/sleep.1446.Full Text Link to Item
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Palmese, Laura B., Pamela C. DeGeorge, Joseph C. Ratliff, Vinod H. Srihari, Bruce E. Wexler, Andrew D. Krystal, and Cenk Tek. “Insomnia is frequent in schizophrenia and associated with night eating and obesity.” Schizophr Res 133, no. 1–3 (December 2011): 238–43. https://doi.org/10.1016/j.schres.2011.07.030.Full Text Link to Item
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Rose, Jed E., F Joseph McClernon, Brett Froeliger, Frédérique M. Behm, Xavier Preud’homme, and Andrew D. Krystal. “Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes.” Biol Psychiatry 70, no. 8 (October 15, 2011): 794–99. https://doi.org/10.1016/j.biopsych.2011.05.031.Full Text Link to Item
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Edinger, Jack D., James K. Wyatt, Edward J. Stepanski, Maren K. Olsen, Karen M. Stechuchak, Colleen E. Carney, Ambrose Chiang, et al. “Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis.” Arch Gen Psychiatry 68, no. 10 (October 2011): 992–1002. https://doi.org/10.1001/archgenpsychiatry.2011.64.Full Text Link to Item
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Krystal, Andrew D., Alan Lankford, H Heith Durrence, Elizabeth Ludington, Philip Jochelson, Roberta Rogowski, and Thomas Roth. “Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia.” Sleep 34, no. 10 (October 1, 2011): 1433–42. https://doi.org/10.5665/SLEEP.1294.Full Text Link to Item
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Carney, Colleen E., Taryn G. Moss, Andrea L. Harris, Jack D. Edinger, and Andrew D. Krystal. “Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients?” J Psychiatr Res 45, no. 9 (September 2011): 1243–49. https://doi.org/10.1016/j.jpsychires.2011.03.011.Full Text Link to Item
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Krystal, A. D. “A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression (Journal of Clinical Psychiatry (2010) 71, 1 (32-40)).” Journal of Clinical Psychiatry 72, no. 8 (August 1, 2011): 1157. https://doi.org/10.4088/JCP.11lr07077a.Full Text
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“Recognition and assessment of shift work disorder.” J Clin Psychiatry 72, no. 2 (February 2011): 248–57. https://doi.org/10.4088/JCP.10062ah1.Full Text Link to Item
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Richey, Sarah M., and Andrew D. Krystal. “Pharmacological advances in the treatment of insomnia.” Curr Pharm Des 17, no. 15 (2011): 1471–75. https://doi.org/10.2174/138161211796197052.Full Text Link to Item
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Krystal, Andrew D. “Antidepressant and Antipsychotic Drugs.” Sleep Med Clin 5, no. 4 (December 1, 2010): 571–89. https://doi.org/10.1016/j.jsmc.2010.08.010.Full Text Link to Item
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Krystal, Andrew D., H Heith Durrence, Martin Scharf, Philip Jochelson, Roberta Rogowski, Elizabeth Ludington, and Thomas Roth. “Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia.” Sleep 33, no. 11 (November 2010): 1553–61. https://doi.org/10.1093/sleep/33.11.1553.Full Text Link to Item
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Wilson, S. J., D. J. Nutt, C. Alford, S. V. Argyropoulos, D. S. Baldwin, A. N. Bateson, T. C. Britton, et al. “British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders.” J Psychopharmacol 24, no. 11 (November 2010): 1577–1601. https://doi.org/10.1177/0269881110379307.Full Text Link to Item
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Flynn, Kathryn E., Rebecca A. Shelby, Sandra A. Mitchell, Maria R. Fawzy, N Chantelle Hardy, Aatif M. Husain, Francis J. Keefe, et al. “Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®)).” Psychooncology 19, no. 10 (October 2010): 1086–93. https://doi.org/10.1002/pon.1664.Full Text Link to Item
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Janicak, Philip G., Ziad Nahas, Sarah H. Lisanby, H Brent Solvason, Shirlene M. Sampson, William M. McDonald, Lauren B. Marangell, et al. “Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study.” Brain Stimul 3, no. 4 (October 2010): 187–99. https://doi.org/10.1016/j.brs.2010.07.003.Full Text Link to Item
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McCall, W Vaughn, Jill N. Blocker, Ralph D’Agostino, James Kimball, Niki Boggs, Barbara Lasater, Roger Haskett, Andrew Krystal, William M. McDonald, and Peter B. Rosenquist. “Treatment of insomnia in depressed insomniacs: effects on health-related quality of life, objective and self-reported sleep, and depression.” J Clin Sleep Med 6, no. 4 (August 15, 2010): 322–29.Link to Item
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Krystal, Andrew D., Gary K. Zammit, James K. Wyatt, Stuart F. Quan, Jack D. Edinger, David P. White, Richard P. Chiacchierini, and Atul Malhotra. “The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia.” J Clin Sleep Med 6, no. 4 (August 15, 2010): 315–21.Link to Item
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Krystal, Andrew D., Xavier A. Preud’homme, Cindy L. Amundsen, and George D. Webster. “Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study.” J Urol 184, no. 2 (August 2010): 623–28. https://doi.org/10.1016/j.juro.2010.03.148.Full Text Link to Item
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Krystal, Andrew D. “In vivo evidence of the specificity of effects of GABA(A) receptor modulating medications.” Sleep 33, no. 7 (July 2010): 859–60. https://doi.org/10.1093/sleep/33.7.859.Full Text Link to Item
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Krystal, Andrew D., and Jack D. Edinger. “Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia.” Sleep 33, no. 5 (May 2010): 669–77. https://doi.org/10.1093/sleep/33.5.669.Full Text Link to Item
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Ohayon, Maurice M., Andrew Krystal, Timothy A. Roehrs, Thomas Roth, and Michael V. Vitiello. “Using difficulty resuming sleep to define nocturnal awakenings.” Sleep Med 11, no. 3 (March 2010): 236–41. https://doi.org/10.1016/j.sleep.2009.11.004.Full Text Link to Item
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Ancoli-Israel, Sonia, Andrew D. Krystal, W Vaughn McCall, Kendyl Schaefer, Amy Wilson, Raymond Claus, Robert Rubens, and Thomas Roth. “A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia.” Sleep 33, no. 2 (February 2010): 225–34. https://doi.org/10.1093/sleep/33.2.225.Full Text Link to Item
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Ancoli-Lsrael, S., and A. D. Krystal. “Insomnia: A health care (gap that is growing).” Psychiatric Times 27, no. SUPPL. APRIL (January 1, 2010): 1–4.
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Edinger, J. D., J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. A. Chiang, A. D. Krystal, M. D. Lineberger, M. K. Means, and R. A. Radtke. “UTILITY, VALIDITY, AND METHODOLOGICAL FACTORS INFLUENCING ASSIGNMENT OF DSM-IV-TR INSOMNIA DIAGNOSES: CONSIDERATIONS FOR DSM-V.” Sleep 33 (January 1, 2010): A191–A191.Link to Item
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Edinger, J. D., M. R. Green, A. A. Prather, J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. A. Chiang, A. D. Krystal, and R. A. Radtke. “VALIDITY AND RELIABILITY OF THE DSM-IV-TR AND ICSD-2 INSOMNIA NOSOLOGIES AMONG CAUCASIANS AND AFRICAN-AMERICANS.” Sleep 33 (January 1, 2010): A209–A209.Link to Item
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Krystal, A. D., J. Harsh, R. Yang, G. A. Rippon, and A. Lankford. “EFFECT OF ARMODAFINIL ON PATIENT FUNCTIONING AND FATIGUE: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY IN PATIENTS WITH RESIDUAL EXCESSIVE SLEEPINESS ASSOCIATED WITH TREATED OBSTRUCTIVE SLEEP APNEA AND A COMORBID DEPRESSIVE DISORDER.” Sleep 33 (January 1, 2010): A7–8.Link to Item
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Krystal, A. D., X. A. Preud’homme, C. L. Amundsen, and G. D. Webster. “NOCTURNAL DETRUSOR OVERACTIVITY IN OVERACTIVE BLADDER SYNDROME: A NOCTURNAL CYSTOMETROGRAPHIC AND POLYSOMNOGRAPHIC STUDY.” Sleep 33 (January 1, 2010): A293–A293.Link to Item
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Low, Y., E. C. Suarez, T. Omonuwa, H. W. Goforth, and A. D. Krystal. “A PILOT STUDY: IMPROVEMENT IN INSOMNIA SEVERITY IS ASSOCIATED WITH DECREASED SOLUBLE CD4-LIGAND IN HIV-SEROPOSITIVE PATIENTS.” Sleep 33 (January 1, 2010): A26–27.Link to Item
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Low, Y., T. Omonuwa, H. W. Goforth, and A. D. Krystal. “INSOMNIA SEVERITY IN HIV-SEROPOSITIVE PATIENTS IS ASSOCIATED WITH INCREASED FATIGUE.” Sleep 33 (January 1, 2010): A194–A194.Link to Item
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Preud’homme, X. A., C. L. Amundsen, G. D. Webster, and A. D. Krystal. “SELF-REPORTED SLEEP: HOW DO PATIENTS WITH OAB COMPARE TO INSOMNIACS AND NORMAL SUBJECTS?” Sleep 33 (January 1, 2010): A292–A292.Link to Item
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Preud’homme, X. A., C. L. Amundsen, G. D. Webster, and A. D. Krystal. “MONITORED NIGHTTIME BLADDER FUNCTION: COMPARISONS BETWEEN PATIENTS WITH INSOMNIA AND THOSE WITH OVERACTIVE BLADDER SYNDROME.” Sleep 33 (January 1, 2010): A293–A293.Link to Item
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Krystal, Andrew D., John R. Harsh, Ronghua Yang, Gregory A. Rippon, and D Alan Lankford. “A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression.” J Clin Psychiatry 71, no. 1 (January 2010): 32–40. https://doi.org/10.4088/JCP.09m05536gry.Full Text Link to Item
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Krystal, Andrew D. “The treatment of primary insomnia.” Cns Spectr 14, no. 12 Suppl 13 (December 2009): 6–10. https://doi.org/10.1017/s1092852900003953.Full Text Link to Item
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Krystal, Andrew D. “A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice.” Sleep Med Rev 13, no. 4 (August 2009): 265–74. https://doi.org/10.1016/j.smrv.2008.08.001.Full Text Link to Item
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Omonuwa, Toma S., Harold W. Goforth, Xavier Preud’homme, and Andrew D. Krystal. “The pharmacologic management of insomnia in patients with HIV.” J Clin Sleep Med 5, no. 3 (June 15, 2009): 251–62.Link to Item
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Carney, Colleen E., Christi Ulmer, Jack D. Edinger, Andrew D. Krystal, and Faye Knauss. “Assessing depression symptoms in those with insomnia: an examination of the beck depression inventory second edition (BDI-II).” J Psychiatr Res 43, no. 5 (February 2009): 576–82. https://doi.org/10.1016/j.jpsychires.2008.09.002.Full Text Link to Item
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Carney, C. E., J. D. Edinger, J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, A. Chiang, A. D. Krystal, M. D. Lineberger, M. K. Means, and R. A. Radtke. “SHOULD DSM-IV-TR PRIMARY INSOMNIA BE DIVIDED INTO SPECIFIC SUBTYPES?” Sleep 32 (January 1, 2009): A264–65.Link to Item
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Edinger, J. D., J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. Chiang, A. D. Krystal, M. D. Lineberger, M. K. Means, and R. A. Radtke. “COMPARATIVE VALIDITY OF THE DSM-IV-TR AND ICSD-2 INSOMNIA NOSOLOGIES: HOW MANY WAYS SHOULD WE SLICE THE INSOMNIA PIE?” Sleep 32 (January 1, 2009): A263–A263.Link to Item
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Edinger, J. D., J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. Chiang, A. D. Krystal, M. D. Lineberger, M. K. Means, and R. A. Radtke. “RELIABILITY AND VALIDITY OF THE DUKE STRUCTURED INTERVIEW FOR SLEEP DISORDERS FOR INSOMNIA SCREENING.” Sleep 32 (January 1, 2009): A265–A265.Link to Item
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Kane, J. M., A. D. Krystal, J. E. McKenzie, R. Yang, J. Tiller, and J. M. Youakim. “SLEEP IN SCHIZOPHRENIA: A NIGHT- AND DAYTIME ACTIGRAPHY STUDY IN PATIENTS WITH TREATED WITH ORAL RISPERIDONE, OLANZAPINE OR PALIPERIDONE.” Sleep 32 (January 1, 2009): A355–A355.Link to Item
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Sutherland, M. E., J. D. Edinger, C. Carney, X. Preud’homme, and A. D. Krystal. “EFFECTS OF MANUAL ARTIFACT-REJECTION ON NON-REM SLEEP EEG SPECTRAL ANALYSIS.” Sleep 32 (January 1, 2009): A374–A374.Link to Item
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Lisanby, Sarah H., Mustafa M. Husain, Peter B. Rosenquist, Daniel Maixner, Rosben Gutierrez, Andrew Krystal, William Gilmer, et al. “Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial.” Neuropsychopharmacology 34, no. 2 (January 2009): 522–34. https://doi.org/10.1038/npp.2008.118.Full Text Link to Item
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Preud’homme, Xavier A., Jean-Pol Lanquart, Andrew D. Krystal, Philippe Bogaerts, and Paul Linkowski. “Modeling slow-wave activity dynamics: does an exponentially dampened periodic function really fit a single night of normal human sleep?” Clin Neurophysiol 119, no. 12 (December 2008): 2753–61. https://doi.org/10.1016/j.clinph.2008.09.016.Full Text Link to Item
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Krystal, A. D. “Non-REM sleep EEG spectral analysis in insomnia.” Psychiatric Annals 38, no. 9 (September 1, 2008): 615–20.
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Krystal, Andrew D., and Jack D. Edinger. “Measuring sleep quality.” Sleep Med 9 Suppl 1 (September 2008): S10–17. https://doi.org/10.1016/S1389-9457(08)70011-X.Full Text Link to Item
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Edinger, Jack D., Melanie K. Means, Colleen E. Carney, and Andrew D. Krystal. “Psychomotor performance deficits and their relation to prior nights' sleep among individuals with primary insomnia.” Sleep 31, no. 5 (May 2008): 599–607. https://doi.org/10.1093/sleep/31.5.599.Full Text Link to Item
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Krystal, Andrew D., Harold W. Goforth, and Thomas Roth. “Effects of antipsychotic medications on sleep in schizophrenia.” Int Clin Psychopharmacol 23, no. 3 (May 2008): 150–60. https://doi.org/10.1097/YIC.0b013e3282f39703.Full Text Link to Item
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Pollack, Mark, Gustavo Kinrys, Andrew Krystal, W Vaughn McCall, Thomas Roth, Kendyl Schaefer, Robert Rubens, James Roach, Holly Huang, and Ranga Krishnan. “Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder.” Arch Gen Psychiatry 65, no. 5 (May 2008): 551–62. https://doi.org/10.1001/archpsyc.65.5.551.Full Text Link to Item
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Chiang, Ambrose, and Andrew Krystal. “Report of two cases where sleep related eating behavior occurred with the extended-release formulation but not the immediate-release formulation of a sedative-hypnotic agent.” J Clin Sleep Med 4, no. 2 (April 15, 2008): 155–56.Link to Item
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Krystal, John H., Cameron S. Carter, Daniel Geschwind, Husseini K. Manji, John S. March, Eric J. Nestler, Jon-Kar Zubieta, et al. “It is time to take a stand for medical research and against terrorism targeting medical scientists.” Biol Psychiatry 63, no. 8 (April 15, 2008): 725–27. https://doi.org/10.1016/j.biopsych.2008.03.005.Full Text Link to Item
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Krystal, Andrew D., Milton Erman, Gary K. Zammit, C. Soubrane, Thomas Roth, and Thomas ZOLONG Study Group. “Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per week for 24 weeks, in patients with chronic primary insomnia: a 6-month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study.” Sleep 31, no. 1 (January 2008): 79–90. https://doi.org/10.1093/sleep/31.1.79.Full Text Link to Item
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Krystal, Andrew D., Mugdha Thakur, and Thomas Roth. “Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia.” Ann Clin Psychiatry 20, no. 1 (2008): 39–46. https://doi.org/10.1080/10401230701844661.Full Text Link to Item
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Walsh, James K., Andrew D. Krystal, David A. Amato, Robert Rubens, Judy Caron, Thomas C. Wessel, Kendyl Schaefer, James Roach, Gene Wallenstein, and Thomas Roth. “Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations.” Sleep 30, no. 8 (August 2007): 959–68. https://doi.org/10.1093/sleep/30.8.959.Full Text Link to Item
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Roth, T., A. D. Krystal, and J. A. Lieberman. “Long-term issues in the treatment of sleep disorders.” Primary Psychiatry 14, no. 7 (July 1, 2007): 1–14.
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Roth, Thomas, Andrew D. Krystal, and Joseph A. Lieberman. “Long-term issues in the treatment of sleep disorders.” Cns Spectr 12, no. 7 Suppl 10 (July 2007): 1–14.Link to Item
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Lim, Leslie, and Andrew Krystal. “Psychotic disorder in a patient with central and extrapontine myelinolysis.” Psychiatry Clin Neurosci 61, no. 3 (June 2007): 320–22. https://doi.org/10.1111/j.1440-1819.2007.01648.x.Full Text Link to Item
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Brummett, Beverly H., Andrew D. Krystal, Ilene C. Siegler, Cynthia Kuhn, Richard S. Surwit, Stephan Züchner, Allison Ashley-Koch, John C. Barefoot, and Redford B. Williams. “Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.” Psychosom Med 69, no. 5 (June 2007): 396–401. https://doi.org/10.1097/PSY.0b013e31806d040b.Full Text Link to Item
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Krystal, A. D., M. E. Thase, V. L. Tucker, and E. P. Goodale. “Bupropion HCL and sleep in patients with depression.” Current Psychiatry Reviews 3, no. 2 (May 1, 2007): 123–28. https://doi.org/10.2174/157340007780599096.Full Text
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Krystal, Andrew D., and Jonathan R. T. Davidson. “The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder.” Biol Psychiatry 61, no. 8 (April 15, 2007): 925–27. https://doi.org/10.1016/j.biopsych.2007.02.020.Full Text Link to Item
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Montgomery, S., G. Kinrys, A. Krystal, W. V. McCall, T. Roth, R. Rubens, K. Schaefer, et al. “Evaluation of eszopiclone and escitalopram oxalate co-therapy in patients with generalized anxiety disorder and insomnia.” European Psychiatry 22 (March 2007): S238–39. https://doi.org/10.1016/j.eurpsy.2007.01.798.Full Text
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Krystal, Andrew D. “Treating the health, quality of life, and functional impairments in insomnia.” J Clin Sleep Med 3, no. 1 (February 15, 2007): 63–72.Link to Item
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Krystal, Andrew, Maurizio Fava, Robert Rubens, Thomas Wessel, Judy Caron, Phebe Wilson, Thomas Roth, and W Vaughn McCall. “Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression.” J Clin Sleep Med 3, no. 1 (February 15, 2007): 48–55.Link to Item
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Carney, Colleen E., Zindel V. Segal, Jack D. Edinger, and Andrew D. Krystal. “A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorder.” J Clin Psychiatry 68, no. 2 (February 2007): 254–60. https://doi.org/10.4088/jcp.v68n0211.Full Text Link to Item
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Krystal, A. D. “The Morbidity of Insomnia.” Cns Spectrums 12, no. S10 (January 1, 2007): 6–8. https://doi.org/10.1017/S1092852900026110.Full Text
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Brummett, Beverly H., Andrew D. Krystal, Allison Ashley-Koch, Cynthia M. Kuhn, Stephan Züchner, Ilene C. Siegler, John C. Barefoot, Edna L. Ballard, Lisa P. Gwyther, and Redford B. Williams. “Sleep quality varies as a function of 5-HTTLPR genotype and stress.” Psychosom Med 69, no. 7 (2007): 621–24. https://doi.org/10.1097/PSY.0b013e31814b8de6.Full Text Link to Item
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Krystal, Andrew D. “Sleep and psychiatric disorders: future directions.” Psychiatr Clin North Am 29, no. 4 (December 2006): 1115–30. https://doi.org/10.1016/j.psc.2006.09.001.Full Text Link to Item
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Zammit, Gary K., Bruce Corser, Karl Doghramji, June M. Fry, Steven James, Andrew Krystal, and Richard M. Mangano. “Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening.” J Clin Sleep Med 2, no. 4 (October 15, 2006): 417–23.Link to Item
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Krystal, A. D. “Psychiatric Comorbidity: The Case for Treating Insomnia.” Sleep Medicine Clinics 1, no. 3 (September 1, 2006): 359–65. https://doi.org/10.1016/j.jsmc.2006.06.007.Full Text
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McCall, W Vaughn, Milton Erman, Andrew D. Krystal, Russell Rosenberg, Martin Scharf, Gary K. Zammit, and Thomas Wessel. “A polysomnography study of eszopiclone in elderly patients with insomnia.” Curr Med Res Opin 22, no. 9 (September 2006): 1633–42. https://doi.org/10.1185/030079906X112741.Full Text Link to Item
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Fava, Maurizio, W Vaughn McCall, Andrew Krystal, Thomas Wessel, Robert Rubens, Judy Caron, David Amato, and Thomas Roth. “Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder.” Biol Psychiatry 59, no. 11 (June 1, 2006): 1052–60. https://doi.org/10.1016/j.biopsych.2006.01.016.Full Text Link to Item
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Walsh, James K., Michael Perlis, Murray Rosenthal, Andrew Krystal, John Jiang, and Thomas Roth. “Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia.” J Clin Sleep Med 2, no. 1 (January 15, 2006): 35–41.Link to Item
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Ancoli-Israel, S., D. G. Folks, A. D. Krystal, and W. V. McCall. “Response to Dr. Finucane [2].” Journal of the American Geriatrics Society 54, no. 1 (January 1, 2006): 170–72. https://doi.org/10.1111/j.1532-5415.2005.00575_1.x.Full Text
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Ancoli-Israel, S., D. G. Folks, A. D. Krystal, and W. V. McCall. “Advertising the new hypnotics - Response to Dr. Finucane.” Journal of the American Geriatrics Society 54, no. 1 (January 1, 2006): 170–72.Link to Item
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Krystal, A. D., S. Rogers, and M. A. Fitzgerald. “Long-Term Pharmacotherapy in the Management of Chronic Insomnia.” Journal for Nurse Practitioners 2, no. 9 (January 1, 2006). https://doi.org/10.1016/j.nurpra.2006.08.003.Full Text
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Edinger, Jack D., William K. Wohlgemuth, Andrew D. Krystal, and John R. Rice. “Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial.” Arch Intern Med 165, no. 21 (November 28, 2005): 2527–35. https://doi.org/10.1001/archinte.165.21.2527.Full Text Link to Item
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Roth, Thomas, James K. Walsh, Andrew Krystal, Thomas Wessel, and Timothy A. Roehrs. “An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia.” Sleep Med 6, no. 6 (November 2005): 487–95. https://doi.org/10.1016/j.sleep.2005.06.004.Full Text Link to Item
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Mccall, W. V., M. L. Perlis, X. Tu, A. E. Groman, A. Krystal, and J. K. Walsh. “A comparison of placebo and no-treatment during a hypnotic clinical trial.” Int J Clin Pharmacol Ther 43, no. 8 (August 2005): 355–59. https://doi.org/10.5414/cpp43355.Full Text Link to Item
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Krystal, Andrew D. “The effect of insomnia definitions, terminology, and classifications on clinical practice.” J Am Geriatr Soc 53, no. 7 Suppl (July 2005): S258–63. https://doi.org/10.1111/j.1532-5415.2005.53391.x.Full Text Link to Item
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Wohlgemuth, William K., and Andrew D. Krystal. “Hypnotics should be considered for the initial treatment of chronic insomnia. Pro.” Journal of Clinical Sleep Medicine : Jcsm : Official Publication of the American Academy of Sleep Medicine 1, no. 2 (April 2005): 120–24.
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McCall, W. V., M. L. Perlis, X. Tu, A. E. Groman, A. Krystal, and J. K. Walsh. “A comparison of placebo and no-treatment during a hypnotic clinical trial.” International Journal of Clinical Pharmacology and Therapeutics 43, no. 8 (2005): 355–59.
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Krystal, Andrew D. “The possibility of preventing functional impairment due to sleep loss by pharmacologically enhancing sleep.” Sleep 28, no. 1 (January 2005): 16–17.
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Krystal, A. D., and T. Roth. “Definitions, measurements, and management in insomnia.” Journal of Clinical Psychiatry 65, no. SUPPL. 8 (December 1, 2004): 5–7.
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Perlis, Michael L., W Vaughn McCall, Andrew D. Krystal, and James K. Walsh. “Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia.” J Clin Psychiatry 65, no. 8 (August 2004): 1128–37. https://doi.org/10.4088/jcp.v65n0816.Full Text Link to Item
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Singh, Jaskaran, Carlos A. Zarate, and Andrew D. Krystal. “Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine.” Psychopharmacology (Berl) 173, no. 1–2 (April 2004): 227–28. https://doi.org/10.1007/s00213-003-1756-8.Full Text Link to Item
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Krystal, Andrew D., James K. Walsh, Eugene Laska, Judy Caron, David A. Amato, Thomas C. Wessel, and Thomas Roth. “The Sustained 6-Month Efficacy of Eszopiclone in the Treatment of Chronic Insomnia.” Sleep 27, no. 2 (March 2004): 346–47. https://doi.org/10.1093/sleep/27.2.346.Full Text
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Ancoli-Israel, S., R. M. Benca, J. D. Edinger, A. D. Krystal, W. Mendelson, H. Moldofsky, J. Petrie, T. Roth, J. K. Walsh, and J. Winkelman. “Changing how we think about insomnia.” Journal of Clinical Psychiatry 65 (January 1, 2004): 44–46.Link to Item
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Ancoli-Israel, Sonia, Ruth M. Benca, Jack D. Edinger, Andrew D. Krystal, Wallace Mendelson, Harvey Moldofsky, Justine Petrie, et al. “Panel discussion: changing how we think about insomnia.” J Clin Psychiatry 65 Suppl 8 (2004): 44–46.Link to Item
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Krystal, Andrew D. “The changing perspective on chronic insomnia management.” J Clin Psychiatry 65 Suppl 8 (2004): 20–25.Link to Item
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Krystal, Andrew D. “Depression and insomnia in women.” Clin Cornerstone 6 Suppl 1B (2004): S19–28. https://doi.org/10.1016/s1098-3597(04)80022-x.Full Text Link to Item
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Krystal, Andrew D., and Thomas Roth. “Introduction: Definitions, measurements, and management in insomnia.” The Journal of Clinical Psychiatry 65 Suppl 8 (January 2004): 5–7.
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Krystal, Andrew D., James K. Walsh, Eugene Laska, Judy Caron, David A. Amato, Thomas C. Wessel, and Thomas Roth. “Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia.” Sleep 26, no. 7 (November 1, 2003): 793–99. https://doi.org/10.1093/sleep/26.7.793.Full Text Link to Item
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Edinger, Jack D., and Andrew D. Krystal. “Subtyping primary insomnia: is sleep state misperception a distinct clinical entity?” Sleep Med Rev 7, no. 3 (June 2003): 203–14. https://doi.org/10.1053/smrv.2002.0253.Full Text Link to Item
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Cellucci, C. J., A. M. Albano, P. E. Rapp, and A. D. Krystal. “Quantitative determination of abrupt changes in dynamical systems: Illustration via identification of seizure termination in generalized tonic-clonic seizure EEG data.” International Journal of Bifurcation and Chaos in Applied Sciences and Engineering 13, no. 9 (January 1, 2003): 2641–55. https://doi.org/10.1142/S0218127403008132.Full Text
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Krystal, Andrew D. “Insomnia in women.” Clin Cornerstone 5, no. 3 (2003): 41–50. https://doi.org/10.1016/s1098-3597(03)90034-2.Full Text Link to Item
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Krystal, Andrew D., Richard D. Weiner, Margaret D. Dean, Virginia H. Lindahl, Louis A. Tramontozzi, Grace Falcone, and C Edward Coffey. “Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT.” J Neuropsychiatry Clin Neurosci 15, no. 1 (2003): 27–34. https://doi.org/10.1176/jnp.15.1.27.Full Text Link to Item
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Krystal, Andrew D., Jack D. Edinger, William K. Wohlgemuth, and Gail R. Marsh. “NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes.” Sleep 25, no. 6 (September 15, 2002): 630–40.Link to Item
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Krystal, A. D., J. D. Edinger, W. K. Wohlgemuth, and C. Michaels. “A within-subject study of the relationship of non-REM EEG spectral amplitude and the agreement between subjective and objective assessments of sleep time.” Sleep 25 (April 15, 2002): A33–34.Link to Item
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Krystal, A. D., M. L. Perlis, W. V. McCall, G. Zammit, and M. Hirshkowitz. “Three-month non-nightly use of zolpidem for the treatment of primary insomnia.” Sleep 25 (April 15, 2002): A68–A68.Link to Item
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Wohlgemuth, W. K., J. D. Edinger, A. D. Krystal, and J. R. Rice. “Behavioral insomnia therapy for patients with fibromyalgia.” Sleep 25 (April 15, 2002): A384–A384.Link to Item
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Wohlgemuth, W. K., J. D. Edinger, and A. D. Krystal. “The best of both: Brief hypnotic use to enhance behavioral insomnia therapy.” Sleep 25 (April 15, 2002): A360–61.Link to Item
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Rossler, I. B., R. C. Johnson, A. D. Krystal, R. D. Weiner, E. D. Levin, P. Logue, C. E. Coffey, and C. L. Edwards. “A naturalistic study of the effects of smoking on the cognitive side effects of ECT.” Journal of Ect 18, no. 1 (March 1, 2002): 64–64.Link to Item
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Vidal, F., A. D. Krystal, J. D. Edinger, and W. K. Wohlgemuth. “Changes in sleep architecture and the sleep EEG with aging.” American Journal of Geriatric Psychiatry 10, no. 2 (March 1, 2002): 96–97.Link to Item
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Krystal, A. D., and I. Ressler. “The use of valerian in neuropsychiatry.” Cns Spectrums 6, no. 10 (October 2001): 841–47. https://doi.org/10.1017/s1092852900001668.Full Text
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Sackeim, H. A., D. P. Devanand, S. H. Lisanby, M. S. Nobler, J. Prudic, E. J. Heyer, E. Ornstein, et al. “Treatment of the modal patient: does one size fit nearly all?” J Ect 17, no. 3 (September 2001): 219–22. https://doi.org/10.1097/00124509-200109000-00015.Full Text Link to Item
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Krystal, A. D., and R. D. Weiner. “ECT failure rate among specific devices - Drs. Krystal and Weiner reply.” American Journal of Psychiatry 158, no. 6 (June 1, 2001): 974–974.Link to Item
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Swartz, C. M. “ECT failure rate among specific devices.” Am J Psychiatry 158, no. 6 (June 2001): 973–74. https://doi.org/10.1176/appi.ajp.158.6.973.Full Text Link to Item
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Krystal, A. D., J. D. Edinger, W. K. Wohlgemuth, and G. R. Marsh. “A pilot study of the sleep EEG power spectral effects of behavioral therapy in primary insomniacs.” Sleep 24 (April 15, 2001): A62–A62.Link to Item
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Krystal, A. D., T. Holsinger, R. D. Weiner, D. C. Steffens, and C. E. Coffey. “A naturalistic study of maintenance ECT: Implications for optimizing the inter-treatment interval.” Journal of Ect 17, no. 1 (March 1, 2001): 79–79.Link to Item
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Prado, R., M. West, and A. D. Krystal. “Multichannel electroencephalographic analyses via dynamic regression models with time-varying lag-lead structure.” Journal of the Royal Statistical Society. Series C: Applied Statistics 50, no. 1 (January 1, 2001): 95–109. https://doi.org/10.1111/1467-9876.00222.Full Text
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Krystal, A. D., R. D. Weiner, V. Lindahl, and R. Massie. “The development and retrospective testing of an electroencephalographic seizure quality-based stimulus dosing paradigm with ECT.” J Ect 16, no. 4 (December 2000): 338–49. https://doi.org/10.1097/00124509-200012000-00003.Full Text Link to Item
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Krystal, A. D., T. Holsinger, R. D. Weiner, and C. E. Coffey. “Prediction of the utility of a switch from unilateral to bilateral ECT in the elderly using treatment 2 ictal EEG indices.” J Ect 16, no. 4 (December 2000): 327–37. https://doi.org/10.1097/00124509-200012000-00002.Full Text Link to Item
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Krystal, A. D., M. D. Dean, R. D. Weiner, L. A. Tramontozzi, K. M. Connor, V. H. Lindahl, and R. W. Massie. “ECT stimulus intensity: are present ECT devices too limited?” Am J Psychiatry 157, no. 6 (June 2000): 963–67. https://doi.org/10.1176/appi.ajp.157.6.963.Full Text Link to Item
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Krystal, A. D., R. D. Weiner, B. Luber, J. Prudic, D. P. Devanand, and H. A. Sackeim. “The role of the ictal EEG in ECT stimulus dosing.” Journal of Ect 16, no. 1 (March 1, 2000): 74–74.Link to Item
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Krystal, A. D., M. West, R. Prado, H. Greenside, S. Zoldi, and R. D. Weiner. “EEG effects of ECT: implications for rTMS.” Depress Anxiety 12, no. 3 (2000): 157–65. https://doi.org/10.1002/1520-6394(2000)12:3<157::AID-DA7>3.0.CO;2-R.Full Text Link to Item
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Zoldi, S. M., A. Krystal, and H. S. Greenside. “Stationarity and redundancy of multichannel EEG data recorded during generalized tonic-clonic seizures.” Brain Topogr 12, no. 3 (2000): 187–200. https://doi.org/10.1023/a:1023489807177.Full Text Link to Item
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Krystal, A. D., R. Prado, and M. West. “New methods of time series analysis of non-stationary EEG data: eigenstructure decompositions of time varying autoregressions.” Clin Neurophysiol 110, no. 12 (December 1999): 2197–2206. https://doi.org/10.1016/s1388-2457(99)00165-0.Full Text Link to Item
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West, M., R. Prado, and A. D. Krystal. “Evaluation and Comparison of EEG Traces: Latent Structure in Nonstationary Time Series.” Journal of the American Statistical Association 94, no. 448 (December 1, 1999): 1083–95. https://doi.org/10.1080/01621459.1999.10473861.Full Text
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Asnis, G. M., A. Chakraburtty, E. A. DuBoff, A. Krystal, P. D. Londborg, R. Rosenberg, B. Roth-Schechter, M. B. Scharf, and J. K. Walsh. “Zolpidem for persistent insomnia in SSRI-treated depressed patients.” J Clin Psychiatry 60, no. 10 (October 1999): 668–76. https://doi.org/10.4088/jcp.v60n1005.Full Text Link to Item
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West, M., R. Prado, and A. D. Krystal. “Evaluation and Comparison of EEG Traces: Latent Structure in Nonstationary Time Series.” Journal of the American Statistical Association 94, no. 446 (June 1, 1999): 375–87. https://doi.org/10.1080/01621459.1999.10474128.Full Text
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Krystal, A. D., and R. D. Weiner. “EEG correlates of the response to ECT: a possible antidepressant role of brain-derived neurotrophic factor.” J Ect 15, no. 1 (March 1999): 27–38.Link to Item
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Krystal, Andrew D., Richard D. Weiner, and K Ranga R. Krishnan. “3. Magnetic Resonance Spectroscopic Correlates of the Response to ECT.” The Journal of Ect 15, no. 1 (March 1999): 103–103. https://doi.org/10.1097/00124509-199903000-00011.Full Text
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Weiner, Richard D., and Andrew D. Krystal. “2. ECT and Anticonvulsant Medications.” The Journal of Ect 15, no. 1 (March 1999): 104–104. https://doi.org/10.1097/00124509-199903000-00014.Full Text
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Krystal, A. D., J. Edinger, W. Wohlgemuth, and G. R. Marsh. “Sleep in peri-menopausal and post-menopausal women.” Sleep Med Rev 2, no. 4 (November 1998): 243–53. https://doi.org/10.1016/s1087-0792(98)90011-9.Full Text Link to Item
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Krystal, A. D., H. S. Greenside, A. Gottschalk, M. S. Bauer, and P. C. Whybrow. “Low-dimensional chaos in bipolar disorder [1] (multiple letters).” Archives of Internal Medicine 158, no. 5 (March 9, 1998): 275.
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Krystal, A. D., B. V. Watts, R. D. Weiner, S. Moore, D. C. Steffens, and V. Lindahl. “The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient.” J Ect 14, no. 1 (March 1998): 5–14.Link to Item
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Krystal, A. D., and H. S. Greenside. “Low-dimensional chaos in bipolar disorder?” Arch Gen Psychiatry 55, no. 3 (March 1998): 275–76. https://doi.org/10.1001/archpsyc.55.3.275.Full Text Link to Item
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Krystal, A. D. “The clinical utility of ictal EEG seizure adequacy models.” Psychiatric Annals 28, no. 1 (January 1, 1998): 30–35. https://doi.org/10.3928/0048-5713-19980101-08.Full Text
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Krystal, A. D., C. E. Coffey, R. D. Weiner, and T. Holsinger. “Changes in seizure threshold over the course of electroconvulsive therapy affect therapeutic response and are detected by ictal EEG ratings.” J Neuropsychiatry Clin Neurosci 10, no. 2 (1998): 178–86. https://doi.org/10.1176/jnp.10.2.178.Full Text Link to Item
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Krystal, A. D., C. Zaidman, H. S. Greenside, R. D. Weiner, and C. E. Coffey. “The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy.” Electroencephalogr Clin Neurophysiol 103, no. 6 (December 1997): 599–606. https://doi.org/10.1016/s0013-4694(97)00062-x.Full Text Link to Item
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Krystal, A. D., C. E. Coffey, R. D. Weiner, P. E. Rapp, A. Albano, H. S. Greenside, M. DeMasi, and C. Cellucci. “EEG correlates of the response to ECT.” Biological Psychiatry 41 (April 1, 1997): 189–189.Link to Item
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Krystal, A. D., R. D. Weiner, B. V. Watts, S. Moore, D. C. Steffens, and V. Lindahl. “The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient.” Convulsive Therapy 13, no. 1 (March 1, 1997): 57–58.Link to Item
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Weiner, R. D., A. D. Krystal, and D. C. Steffens. “Establishing an ambulatory ECT program: Different models.” Convulsive Therapy 13, no. 1 (March 1, 1997): 49–49.Link to Item
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Krystal, A. D., and C. E. Coffey. “Neuropsychiatric considerations in the use of electroconvulsive therapy.” J Neuropsychiatry Clin Neurosci 9, no. 2 (1997): 283–92. https://doi.org/10.1176/jnp.9.2.283.Full Text Link to Item
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Zoldi, S. M., A. D. Krystal, and H. S. Greenside. “Statistical analysis of redundancy and stationarity in multi-channel EEG.” Journal of Mathematical Psychology 40, no. 4 (December 1, 1996): 354–55.Link to Item
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Krystal, A. D., H. S. Greenside, R. D. Weiner, and D. Gassert. “A comparison of EEG signal dynamics in waking, after anesthesia induction and during electroconvulsive therapy seizures.” Electroencephalogr Clin Neurophysiol 99, no. 2 (August 1996): 129–40. https://doi.org/10.1016/0013-4694(96)95090-7.Full Text Link to Item
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Edinger, J. D., A. I. Fins, J. M. Goeke, D. K. McMillan, T. L. Gersh, A. D. Krystal, and W. V. McCall. “The empirical identification of insomnia subtypes: a cluster analytic approach.” Sleep 19, no. 5 (June 1996): 398–411.Link to Item
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Krystal, A. D., R. D. Weiner, C. E. Coffey, and W. V. McCall. “Effect of ECT treatment number on the ictal EEG.” Psychiatry Res 62, no. 2 (May 17, 1996): 179–89. https://doi.org/10.1016/0165-1781(96)02844-2.Full Text Link to Item
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Coffey, C. E., R. D. Weiner, and A. D. Krystal. “The anticonvulsant properties of ECT.” Convulsive Therapy 12, no. 1 (March 1, 1996): 64–64.Link to Item
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Krystal, A. D., R. D. Weiner, D. Gassert, W. V. McCall, C. E. Coffey, T. Sibert, and T. Holsinger. “The relative ability of three ictal EEG frequency bands to differentiate ECT seizures on the basis of electrode placement, stimulus intensity, and therapeutic response.” Convuls Ther 12, no. 1 (March 1996): 13–24.Link to Item
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Steffens, D. C., A. D. Krystal, T. E. Sibert, S. D. Moore, and R. D. Weiner. “Cost effectiveness of maintenance ECT.” Convuls Ther 11, no. 4 (December 1995): 283–84.Link to Item
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Krystal, A. D., and R. D. Weiner. “ECT seizure duration: reliability of manual and computer-automated determinations.” Convuls Ther 11, no. 3 (September 1995): 158–69.Link to Item
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Coffey, C. E., J. Lucke, R. D. Weiner, A. D. Krystal, and M. Aque. “Seizure threshold in electroconvulsive therapy (ECT) II. The anticonvulsant effect of ECT.” Biol Psychiatry 37, no. 11 (June 1, 1995): 777–88. https://doi.org/10.1016/0006-3223(95)00053-J.Full Text Link to Item
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Coffey, C. E., J. Lucke, R. D. Weiner, A. D. Krystal, and M. Aque. “Seizure threshold in electroconvulsive therapy: I. Initial seizure threshold.” Biol Psychiatry 37, no. 10 (May 15, 1995): 713–20. https://doi.org/10.1016/0006-3223(95)00262-F.Full Text Link to Item
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Edinger, J. D., C. W. Erwin, A. I. Fins, G. R. Marsh, and A. D. Krystal. “Ambulatory cassette polysomnography: findings from a large cohort of drug-free insomnia patients.” J Clin Neurophysiol 12, no. 3 (May 1995): 302–9.Link to Item
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Krystal, A. D., R. D. Weiner, and C. E. Coffey. “The ictal EEG as a marker of adequate stimulus intensity with unilateral ECT.” J Neuropsychiatry Clin Neurosci 7, no. 3 (1995): 295–303. https://doi.org/10.1176/jnp.7.3.295.Full Text Link to Item
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Krystal, A. D., and R. D. Weiner. “ECT seizure therapeutic adequacy.” Convuls Ther 10, no. 2 (June 1994): 153–64.Link to Item
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Weiner, R. D., and A. D. Krystal. “The present use of electroconvulsive therapy.” Annual Review of Medicine 45 (January 1994): 273–81. https://doi.org/10.1146/annurev.med.45.1.273.Full Text
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Krystal, A. D., R. D. Weiner, W. V. McCall, F. E. Shelp, R. Arias, and P. Smith. “The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study.” Biol Psychiatry 34, no. 11 (December 1, 1993): 759–67. https://doi.org/10.1016/0006-3223(93)90064-k.Full Text Link to Item
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Krystal, Andrew D., and Richard D. Weiner. “Low-Frequency Ictal EEG Activity and ECT Therapeutic Impact.” Convulsive Therapy 9, no. 3 (January 1993): 220–24.
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Krystal, A. D., R. D. Weiner, C. E. Coffey, P. Smith, R. Arias, and E. Moffett. “EEG evidence of more "intense" seizure activity with bilateral ECT.” Biol Psychiatry 31, no. 6 (March 15, 1992): 617–21. https://doi.org/10.1016/0006-3223(92)90249-y.Full Text Link to Item
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McCall, W. V., C. W. Erwin, J. D. Edinger, A. D. Krystal, and G. R. Marsh. “Ambulatory polysomnography: technical aspects and normative values.” Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society 9, no. 1 (January 1992): 68–77.
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Weiner, R. D., A. D. Krystal, C. E. Coffey, and P. Smith. “The electrophysiology of ECT: relevance to mechanism of action.” Clin Neuropharmacol 15 Suppl 1 Pt A (1992): 671A-672A. https://doi.org/10.1097/00002826-199201001-00347.Full Text Link to Item
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Weiner, R. D., C. E. Coffey, and A. D. Krystal. “The monitoring and management of electrically induced seizures.” Psychiatr Clin North Am 14, no. 4 (December 1991): 845–69.Link to Item
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Krystal, A. D., and J. P. McEvoy. “Shared features of neuroleptic malignant syndrome and alcohol abuse complications.” J Clin Psychiatry 51, no. 12 (December 1990): 523.Link to Item
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Krystal, A., K. R. Krishnan, M. Raitiere, R. Poland, J. C. Ritchie, N. R. Dunnick, K. Hanada, and C. B. Nemeroff. “Differential diagnosis and pathophysiology of Cushing's syndrome and primary affective disorder.” J Neuropsychiatry Clin Neurosci 2, no. 1 (1990): 34–43. https://doi.org/10.1176/jnp.2.1.34.Full Text Link to Item
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Book Sections
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Krystal, A. D. “Benzodiazepine receptor agonists: Indications, efficacy, and outcome.” In Insomnia: Diagnosis and Treatment, 375–86, 2016.
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Krystal, A. D. “Psychiatric disorders and EEG.” In Niedermeyer’s Electroencephalography: Basic Principles, Clinical Applications, and Related Fields: Sixth Edition, 1113–27, 2012.
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Krystal, A. D. “Sleep and psychiatric disorders.” In Handbook of Sleep Medicine, 2011.
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Low, Y., and A. D. Krystal. “Daytime sleepiness in insomnia patients.” In Sleepiness: Causes, Consequences and Treatment, 168–75, 2011. https://doi.org/10.1017/CBO9780511762697.018.Full Text
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Krystal, A. D. “Pharmacologic Treatment: Other Medications.” In Principles and Practice of Sleep Medicine: Fifth Edition, 916–30, 2010. https://doi.org/10.1016/B978-1-4160-6645-3.00082-7.Full Text
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Krystal, A. D. “Geriatric psychopharmacology: An overview.” In Principles and Practice of Geriatric Sleep Medicine, 327–31, 2009. https://doi.org/10.1017/CBO9780511770661.034.Full Text
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Richey, S. M., and A. D. Krystal. “Sleep medications: When to prescribe and rationale for use.” In Sleep Disorders: Diagnosis and Therapeutics, 268–80, 2008.
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Conference Papers
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Lunsford-Avery, J. R., A. D. Krystal, M. A. Carskadon, and S. H. Kollins. “SLEEP ASSOCIATED WITH EXECUTIVE FUNCTIONING AMONG ADOLESCENTS ACROSS THE ADHD CONTINUUM.” In Sleep, 43:A373–A373, 2020.Link to Item
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McCall, W. V., R. M. Benca, M. Rumble, and A. D. Krystal. “DO THE SUBJECTIVE EFFECTS OF HYPNOTIC MEDICATIONS RESULT IN UNBLINDING OF TREATMENT ASSIGNMENT IN HYPNOTIC RANDOMIZED CLINICAL TRIALS?” In Sleep, 43:A181–A181, 2020.Link to Item
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Ohayon, M. M., A. D. Krystal, J. Black, C. M. Shapiro, S. Sullivan, T. J. Swick, and C. C. Wells. “FACTORS ASSOCIATED WITH THE CONTINUOUS USE OF PSYCHOTROPIC TREATMENTS FOR NARCOLEPSY.” In Sleep, 43:A294–A294, 2020.Link to Item
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Scangos, Katherine, Ghassan Makhoul, Ankit N. Khambhati, Kristin K. Sellers, Edward F. Chang, and Andrew D. Krystal. “Corticocortical Evoked Potentials and Patient Response Reveal Networks Underlying Depression.” In Biological Psychiatry, 87:S157–S157, 2020.Link to Item
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Ohayon, Maurice M., Shannon S. Sullivan, Andrew D. Krystal, Jed Black, Todd J. Swick, Colin M. Shapiro, and Charles C. Wells. “Narcolepsy Symptoms are Highly Persistent over Time Despite Treatment.” In Annals of Neurology, 86:S122–S122. WILEY, 2019.Link to Item
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Ohayon, Maurice M., Shannon S. Sullivan, Jed Black, Andrew D. Krystal, Colin M. Shapiro, Todd J. Swick, and Charles C. Wells. “Longitudinal Assessment of Psychotropic Treatments for Narcolepsy.” In Annals of Neurology, 86:S212–S212. WILEY, 2019.Link to Item
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Doghramji, Karl, Craig W. Davis, Albena Patroneva, Jean-Charles Schwartz, Catherine Scart-Gres, Philippe Robert, Stephen P. Wanaski, and Andrew D. Krystal. “PITOLISANT IN COMBINATION WITH OTHER MEDICATIONS FOR THE MANAGEMENT OF NARCOLEPSY.” In Sleep, Vol. 42. OXFORD UNIV PRESS INC, 2019.Link to Item
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Ohayon, M. M., and A. D. Krystal. “SLEEP IMPACTS OF NOCTURIA IN A LONGITUDINAL STUDY.” In Sleep Medicine, 64:S284–85, 2019.Link to Item
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Ohayon, Maurice M., Jed Black, Andrew D. Krystal, Colin M. Shapiro, Todd Swick, Richard Rogan, and Charles C. Well. “Longitudinal Evolution of Narcolepsy Symptoms in Simplex and Multiplex Families.” In Annals of Neurology, 84:S129–30. WILEY, 2018.Link to Item
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Beaulieu-Bonneau, S., J. D. Edinger, H. Ivers, A. D. Krystal, and C. M. Morin. “Weekly changes in sleep and insomnia symptoms during acute treatment of persistent insomnia with behavioural or pharmacological therapy.” In Journal of Sleep Research, Vol. 27. WILEY, 2018.Link to Item
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Lunsford-Avery, J. R., S. H. Kollins, and A. D. Krystal. “0762 Sleeping at Home: Feasibility and Tolerability of Ambulatory Polysomnography for Use with Adolescents with Attention-Deficit/Hyperactivity Disorder.” In Sleep, 41:A283–84. Oxford University Press (OUP), 2018. https://doi.org/10.1093/sleep/zsy061.761.Full Text
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Rumble, M. E., D. Dickson, W. V. McCall, A. D. Krystal, J. C. Newman, S. Notermann, P. B. Rosenquist, and R. M. Benca. “0639 A Preliminary Report from the “REST-IT” Study: Self-reported Eveningness and Actigraphic Delayed Sleep Timing Correlate with Suicidal Ideation in Individuals with Depression and Insomnia.” In Sleep, 41:A237–38. Oxford University Press (OUP), 2018. https://doi.org/10.1093/sleep/zsy061.638.Full Text
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Blanco, Marina B., Peter H. Klopfer, and Andrew D. Krystal. “To arouse or not to arouse: physiological responses from active thermogenesis versus thermoconforming in hibernating dwarf lemurs.” In American Journal of Physical Anthropology, 165:30–30. WILEY, 2018.Link to Item
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Edinger, J. D., R. Manber, A. D. Krystal, and D. J. Buysse. “0335 DOES OBJECTIVE SLEEP DURATION MODERATE TREATMENT RESPONSE IN PATIENT WITH COMORBID DEPRESSION AND INSOMNIA? A REPORT FROM THE TRIAD STUDY.” In Sleep, 40:A124–A124. Oxford University Press (OUP), 2017. https://doi.org/10.1093/sleepj/zsx050.334.Full Text
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Morin, C. M., J. D. Edinger, A. D. Krystal, S. Beaulieu-Bonneau, H. Ivers, B. Guay, A. Cartwright, A. Solano, and M. Busby. “0341 SEQUENTIAL THERAPIES FOR COMORBID AND PRIMARY INSOMNIA: A RANDOMIZED CONTROLLED TRIAL.” In Sleep, 40:A127–A127. Oxford University Press (OUP), 2017. https://doi.org/10.1093/sleepj/zsx050.340.Full Text
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Sateia, M. J., D. Buysse, A. D. Krystal, D. N. Neubauer, and J. L. Heald. “0395 CLINICAL PRACTICE GUIDELINE FOR THE PHARMACOLOGIC TREATMENT OF CHRONIC INSOMNIA IN ADULTS: AN AMERICAN ACADEMY OF SLEEP MEDICINE CLINICAL PRACTICE GUIDELINE.” In Sleep, 40:A147–A147. Oxford University Press (OUP), 2017. https://doi.org/10.1093/sleepj/zsx050.394.Full Text
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Dieffenderfer, J., A. Krystal, and A. Bozkurt. “Shedding light to sleep studies.” In Proceedings of Spie the International Society for Optical Engineering, Vol. 10352, 2017. https://doi.org/10.1117/12.2275625.Full Text
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Manber, Rachel, Daniel J. Buysse, Jack Edinger, Andrew Krystal, James F. Luther, Stephen R. Wisniewski, Mickey Trockel, Helena C. Kraemer, and Michael E. Thase. “Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial.” In J Clin Psychiatry, 77:e1316–23, 2016. https://doi.org/10.4088/JCP.15m10244.Full Text Link to Item
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Leuchter, Andrew F., Ian A. Cook, David Feifel, John W. Goethe, Mustafa Husain, Linda L. Carpenter, Michael E. Thase, et al. “Can We Use Brain Oscillations to Guide Treatment of MDD?” In Biological Psychiatry, 77:37S-38S. ELSEVIER SCIENCE INC, 2015.Link to Item
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Valero-Sarmiento, J. M., S. Bhattacharya, A. Krystal, and A. Bozkurt. “Towards injectable biophotonic sensors for physiological monitoring of animals.” In Proceedings of Ieee Sensors, 2014-December:503–6, 2014. https://doi.org/10.1109/ICSENS.2014.6985045.Full Text
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Tek, Cenk, Laura B. Palmese, Andrew D. Krystal, Pamela C. DeGeorge, Erin L. Reutenauer, and Sinan Guloksuz. “The Impact of Eszopiclone Insomnia Treatment on Cognition in Schizophrenia: A Double-blind, Randomized, Placebo-controlled Trial.” In Biological Psychiatry, 75:341S-342S. ELSEVIER SCIENCE INC, 2014.Link to Item
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Deng, Z. D., A. V. Peterchev, A. D. Krystal, B. Luber, S. M. McClintock, M. M. Husain, and S. H. Lisanby. “Topography of seizures induced by electroconvulsive therapy and magnetic seizure therapy.” In International Ieee/Embs Conference on Neural Engineering, Ner, 577–80, 2013. https://doi.org/10.1109/NER.2013.6696000.Full Text
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Buysse, D. J., A. D. Krystal, K. Johnston, N. Dodds, L. Yu, R. Giang, and P. Pilkonis. “SLEEP AND HEALTH-RELATED FUNCTION IN A CLINICAL SAMPLE AS MEASURED BY PROMIS (PATIENT-REPORTED OUTCOMES MEASUREMENT INFORMATION SYSTEM).” In Sleep, 35:A133–A133. OXFORD UNIV PRESS INC, 2012.Link to Item
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Edinger, J. D., M. K. Means, and A. D. Krystal. “DOES HYPERAROUSAL INCREASE DAYTIME ERROR PRONENESS AMONG INSOMNIA SUFFERERS?” In Sleep, 35:A214–A214. OXFORD UNIV PRESS INC, 2012.Link to Item
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Edinger, J. D., M. K. Means, and A. D. Krystal. “ARE INSOMNIA SUFFERERS' DAYTIME DEFICITS PRODUCTS OF SUBJECTIVE DISTORTIONS?” In Sleep, 35:A230–A230. OXFORD UNIV PRESS INC, 2012.Link to Item
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Krystal, A. D., T. Roth, A. Pong, L. Stet, and N. Ivgy-May. “EFFICACY AND SAFETY OF ESMIRTAZAPINE IN ELDERLY PATIENTS WITH PRIMARY INSOMNIA IN A 2-WEEK SLEEP LABORATORY TRIAL.” In Sleep, 35:A222–A222. OXFORD UNIV PRESS INC, 2012.Link to Item
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Krystal, A. D., X. A. Preud’homme, and H. W. Goforth. “A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ESZOPICLONE FOR THE TREATMENT OF INSOMNIA IN PATIENTS WITH CHRONIC LOW BACK PAIN.” In Sleep, 35:A216–A216. OXFORD UNIV PRESS INC, 2012.Link to Item
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Preud’homme, X. A., J. Lohri, C. L. Amundsen, A. Peterson, G. D. Webster, and A. D. Krystal. “NOCTURIA IN SUBJECTS WITH OVERACTIVE BLADDER SYNDROME (OAB): WHAT WAKES THEM UP?” In Sleep, 35:A309–A309. OXFORD UNIV PRESS INC, 2012.Link to Item
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Roth, T., S. G. Hull, N. N. Singh, F. Steinberg, and A. D. Krystal. “GENDER EFFECTS OF 1.75 MG AND 3.5 MG ZOLPIDEM TARTRATE SUBLINGUAL TABLETS FORMULATED WITH A CARBONATE-BICARBONATE BUFFER ON SLEEP ONSET FOLLOWING MIDDLE-OF-THE-NIGHT AWAKENING AND ON NEXT-DAY RESIDUAL EFFECTS.” In Sleep, 35:A225–26. OXFORD UNIV PRESS INC, 2012.Link to Item
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Connor, K., K. Budd, D. Snavely, K. Liu, J. Hutzel-Mann, R. Benca, A. Krystal, T. Roth, D. Michelson, and W. J. Herring. “Efficacy and safety of suvorexant, an orexin receptor antagonist, in patients with primary insomnia: a 3-month phase 3 trial (trial #1).” In Journal of Sleep Research, 21:97–97, 2012.Link to Item
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Herring, W. J., E. Snyder, E. Paradis, J. Hutzelmann, M. -. C. Liu, D. Snavely, J. Walsh, A. Krystal, T. Roth, and D. Michelson. “Suvorexant, an orexin receptor antagonist, in preventing symptom return in patients with insomnia after 1 year of treatment: a randomised, double-blind, placebo-controlled study.” In Journal of Sleep Research, 21:351–351, 2012.Link to Item
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Rose, Jed E., F Joseph McClernon, Brett Froeliger, Frederique M. Behm, Xavier Preud’homme, and Andrew D. Krystal. “Repetitive Transcranial Magnetic Stimulation (rTMS) of the Superior Frontal Gyrus Modulates Craving for Cigarettes.” In Biological Psychiatry, 69:277S-278S. ELSEVIER SCIENCE INC, 2011.Link to Item
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Palmese, Laura B., P. C. DeGeorge, Vinod H. Srihari, B. E. Wexler, A. D. Krystal, and Cenk Tek. “SLEEP PATTERNS OF INDIVIDUALS WITH SCHIZOPHRENIA.” In Schizophrenia Bulletin, 37:277–277. OXFORD UNIV PRESS, 2011.Link to Item
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Krystal, A. D., A. Lankford, B. Dorsey, R. Rogowski, E. Ludington, H. Durrence, and T. Roth. “IMPROVEMENT IN SLEEP MAINTENANCE AND EARLY MORNING AWAKENINGS IN ADULT AND ELDERLY PATIENTS WITH INSOMNIA TREATED WITH DOXEPIN 3 AND 6 MG.” In Sleep, 34:A182–A182. OXFORD UNIV PRESS INC, 2011.Link to Item
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Krystal, A. D., T. Grinnell, W. Spalding, J. Zummo, E. Schweizer, and R. D. Marshall. “A POSTHOC ANALYSIS OF ESZOPICLONE EFFECTS ON CARDIOMETABOLIC INDICES OF HYPERAROUSAL IN THE TREATMENT OF PRIMARY INSOMNIA.” In Sleep, 34:A175–A175. OXFORD UNIV PRESS INC, 2011.Link to Item
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Lankford, A., A. D. Krystal, B. Dorsey, R. Rogowski, E. Ludington, H. Durrence, C. S. Davis, and T. Roth. “PATIENT-REPORTED SYMPTOM IMPROVEMENT IN SLEEP MAINTENANCE ENDPOINTS IN ADULT AND ELDERLY PATIENTS WITH INSOMNIA TREATED WITH DOXEPIN 3 AND 6 MG.” In Sleep, 34:A175–A175. OXFORD UNIV PRESS INC, 2011.Link to Item
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Manber, R., S. Suh, D. J. Buysse, J. D. Edinger, C. Cardell, J. Cardell, and A. D. Krystal. “OBSTRUCTIVE SLEEP APNEA (OSA) IN MAJOR DEPRESSIVE DISORDER.” In Sleep, 34:A256–57. OXFORD UNIV PRESS INC, 2011.Link to Item
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Preud’homme, X. A., C. L. Amundsen, G. D. Webster, W. Jiang, M. Kuchibhatla, and A. D. Krystal. “AUTONOMIC NERVOUS SYSTEM ACTIVITY PRECEDING NOCTURIA IN OLDER ADULTS.” In Sleep, 34:A241–A241. OXFORD UNIV PRESS INC, 2011.Link to Item
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Moore, P., G. Zammit, M. Yen, D. Lankford, M. Scharf, R. Rosenberg, J. Edinger, and A. Krystal. “THE INFLUENCE OF MORNINGNESS-EVENINGNESS ON LATENCY TO PERSISTENT SLEEP IN A MODEL OF TRANSIENT INSOMNIA.” In Sleep, 32:A60–A60. OXFORD UNIV PRESS INC, 2009.Link to Item
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Sloane, P. D., A. Krystal, J. J. Harrington, and C. Williams. “MR1 abnormalities and circadian rhythm disturbances in persons with dementia.” In Journal of the American Geriatrics Society, 56:S59–S59. BLACKWELL PUBLISHING, 2008.Link to Item
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Carney, C. E., J. D. Edinger, M. K. Olsen, K. M. Stechuchak, A. D. Krystal, and J. K. Wyatt. “Inter-rater reliability for insomnia diagnoses derived from the duke structured interview for sleep disorders.” In Sleep, 31:A250–A250. OXFORD UNIV PRESS INC, 2008.Link to Item
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Edinger, J. D., J. K. Wyatt, M. K. Olsen, K. M. Stechuchak, C. E. Carney, A. Chiang, A. D. Krystal, M. K. Means, and R. A. Radtke. “How valid are the DSM-IV-TR and ICSD-2 insomnia nosologies? Preliminary results from a multi-trait/multi-method diagnostic trial.” In Sleep, 31:A249–A249. OXFORD UNIV PRESS INC, 2008.Link to Item
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Krystal, A. D., M. B. Scharf, C. Mordy, N. Singh, and M. Maytom. “Pharmacokinetics of a low dose, sublingual formulation of zolpidem tartrate in elderly subjects.” In Sleep, 31:A234–35. OXFORD UNIV PRESS INC, 2008.Link to Item
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Krystal, A. D., R. Kahn, Y. Maguire, N. Singh, and M. Maytom. “A pharmacokinetic study of the co-administration of a high fat meal with a low dose, sublingual formulation of zolpidem tartrate.” In Sleep, 31:A34–A34. OXFORD UNIV PRESS INC, 2008.Link to Item
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Ohayon, M. M., C. Guilleminault, J. Black, C. Wells, and A. D. Krystal. “Evolution of narcolepsy symptoms in families.” In Sleep, 31:A213–A213. OXFORD UNIV PRESS INC, 2008.Link to Item
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Richey, S. M., R. D. Weiner, J. D. Edinger, X. Preud’homme, C. E. Carney, and A. D. Krystal. “Change in sleep correlates with change in post-dexamethasone cortisol in patients with refractory depression treated with ECT.” In Sleep, 31:A244–A244. OXFORD UNIV PRESS INC, 2008.Link to Item
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Rosenberg, R., A. D. Krystal, J. Novak, Y. Maguire, C. Mordy, N. Singh, and M. Maytom. “Frequency and timing of middle-of-the-night (MOTN) awakenings as described using an interactive voice response system.” In Sleep, 31:A235–A235. OXFORD UNIV PRESS INC, 2008.Link to Item
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Roth, T., A. D. Krystal, Y. Maguire, N. Singh, and M. Maytom. “Pharmacokinetics of the sublingual zolpidem tartrate 3.5mg lozenge compared to the oral zolpidem tartrate 10 mg tablet.” In Sleep, 31:A235–A235. OXFORD UNIV PRESS INC, 2008.Link to Item
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Krystal, Andrew D., and David F. Dinges. “Modafinil improves performance requiring sustained attention in patients with narcolepsy.” In Annals of Neurology, 62:S80–S80. WILEY-LISS, 2007.Link to Item
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Janicak, Philip G., Ziad Nahas, Sarah Lisanby, H Brent Solvason, Shirlene Sampson, William McDonald, Lauren Marangell, et al. “Durability of acute response to TMS in the treatment of major depression: Relapse during a continuation pharmacotherapy extension study.” In Biological Psychiatry, 61:176S-176S, 2007.Link to Item
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Krystal, Andrew, Maurizio Fava, Mark Pollack, Robert Rubens, Kendyl Schaefer, David Amato, and Thomas Roth. “Sleep outcomes following eszopiclone discontinuation in patients with primary insomnia co-existing with major depressive disorder or generalized anxiety disorder.” In Biological Psychiatry, 61:84S-84S, 2007.Link to Item
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Aaronson, Scott, David Avery, R. Canterbury, Z. J. Daskalakis, Mark A. Demitrack, Paul Fitzgerald, Mark S. George, et al. “Transcranial magnetic stimulation: Effectiveness and safety in a randomized, controlled, multisite clinical trial and an open-label extension study.” In Neuropsychopharmacology, 31:S230–S230. NATURE PUBLISHING GROUP, 2006.Link to Item
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Carney, C. E., J. D. Edinger, A. D. Krystal, E. J. Stepanski, and A. Kirby. “Are insomnia patients pathologically worried or simply worried about sleep?” In Sleep, 29:A234–A234. OXFORD UNIV PRESS INC, 2006.Link to Item
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Carney, C. E., J. D. Edinger, A. D. Krystal, E. J. Stepanski, and A. Kirby. “The contribution of anxiety to sleep quality reporting in insomnia subtypes.” In Sleep, 29:A233–A233. OXFORD UNIV PRESS INC, 2006.Link to Item
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Rubens, R., A. D. Krystal, T. C. Wessel, T. Roth, J. Caron, and D. A. Amato. “Efficacy of eszopiclone in the treatment of sleep maintenance insomnia.” In Neurology, 64:A46–A46. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Wessel, T. C., T. Roth, A. D. Krystal, J. Caron, and D. A. Amato. “Twelve months of nightly eszopiclone treatment in patients with chronic insomnia: Assessment of long-term efficacy and safety.” In Neurology, 64:A46–A46. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Litsch, S., C. Michaels, C. Carney, J. J. Edinger, W. K. Wohlgemuth, and A. D. Krystal. “A pilot study of the sleep EEG power spectral effects of relaxation training in primary insomniacs.” In Sleep, 28:A255–A255. OXFORD UNIV PRESS INC, 2005.Link to Item
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Wohlgemuth, W. K., J. D. Edinger, A. D. Krystal, and J. R. Rice. “Behavioral insomnia therapy for patients with fibromyalgia: An update.” In Sleep, 26:A368–A368. AMER ACADEMY SLEEP MEDICINE, 2003.Link to Item
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Walsh, J. K., D. D. Lankford, A. Krystal, T. Roth, P. Jochelson, M. Garber, T. Alexander, and J. Burke. “Efficacy and tolerability of four doses of indiplon (NBI-34060) modified-release in elderly patients with sleep maintenance insomnia.” In Sleep, 26:A78–A78. AMER ACADEMY SLEEP MEDICINE, 2003.Link to Item
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“Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy Multicenter Study Group.” In Neurology, 54:1166–75, 2000. https://doi.org/10.1212/wnl.54.5.1166.Full Text Link to Item
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Fry, D. A. “Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy.” In Annals of Neurology, 43:88–97. Wiley, 1998. https://doi.org/10.1002/ana.410430115.Full Text
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KRYSTAL, A. D., and R. D. WEINER. “THE LARGEST LYAPUNOV EXPONENT OF THE EEG IN ECT SEIZURES.” In Proceedings of the Conference on Measuring Chaos in the Human Brain, edited by D. W. Duke and W. S. Pritchard, 113. WORLD SCIENTIFIC PUBL CO PTE LTD, 1991.Link to Item
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