Andrew Darrell Krystal

Journal Article J Psychopharmacol · August 9, 2024 BACKGROUND: There are limited data regarding gamma-aminobutyric acid (GABA) allosteric modulator sleep-aid medications in persons with depression, insomnia, and suicidal ideation (SI). AIMS: This secondary analysis examined the relationship of age to insom ... Full text Link to item Cite

Comparative short-term safety and efficacy of hypnotics: A quantitative risk-benefit analysis.

Journal Article J Sleep Res · August 2024 Several professional societies have provided recommendations for prescribing medications for insomnia. None has provided an integrative analysis that concurrently quantifies safety and efficacy (e.g., risk-benefit ratios). This represents an important gap ... Full text Link to item Cite

Association of Biomarkers of Neuronal Injury and Inflammation With Insomnia Trajectories After Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article Neurology · April 23, 2024 BACKGROUND AND OBJECTIVES: Insomnia affects about one-third of patients with traumatic brain injury and is associated with worsened outcomes after injury. We hypothesized that higher levels of plasma neuroinflammation biomarkers at the time of TBI would be ... Full text Link to item Cite

Sleep Physiology and Neurocognition Among Adolescents With Attention-Deficit/Hyperactivity Disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · March 12, 2024 OBJECTIVE: Few studies have characterized the nature of sleep problems among adolescents with attention-deficit/hyperactivity disorder (ADHD) using polysomnography (PSG). Additionally, although adolescents with ADHD and adolescents with sleep disturbances ... Full text Link to item Cite

Cognitive behavioural therapy for insomnia reduces actigraphy and diary measured sleep discrepancy for individuals with comorbid insomnia and major depressive disorder: A report from the TRIAD study.

Journal Article Sleep Med · February 2024 OBJECTIVE/BACKGROUND: Discrepancies between sleep diaries and actigraphy occur among individuals with insomnia. Cognitive behavioural therapy for insomnia (CBT-I) improves insomnia but the impact on discrepancy is unclear. This study examined CBT-I's effec ... Full text Link to item Cite

Closed-loop neurostimulation for the treatment of psychiatric disorders.

Journal Article Neuropsychopharmacology · January 2024 Despite increasing prevalence and huge personal and societal burden, psychiatric diseases still lack treatments which can control symptoms for a large fraction of patients. Increasing insight into the neurobiology underlying these diseases has demonstrated ... Full text Link to item Cite

Intracranial beta activity is a biomarker of circadian and stimulation-induced arousal in obsessive compulsive disorder.

Journal Article Brain Stimul · 2024 Full text Link to item Cite

Proceedings of the 11th Annual Deep Brain Stimulation Think Tank: pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemmas, AI-guided neuromodulation, and translational advancements.

Journal Article Front Hum Neurosci · 2024 The Deep Brain Stimulation (DBS) Think Tank XI was held on August 9-11, 2023 in Gainesville, Florida with the theme of "Pushing the Forefront of Neuromodulation". The keynote speaker was Dr. Nico Dosenbach from Washington University in St. Louis, Missouri. ... Full text Link to item Cite

Feasibility and Acceptability of Mindfulness-based Stress Reduction and Prenatal Sleep Classes for Poor Prenatal Sleep Quality: Pilot Randomized Controlled Trial.

Journal Article Behav Sleep Med · 2024 OBJECTIVES: The main objectives of the current paper were to examine the feasibility, acceptability, and adherence of a remotely delivered intervention consisting of mindfulness-based stress reduction plus prenatal sleep classes (MBSR+PS) compared with tre ... Full text Link to item Cite

Hyperarousal features in the sleep architecture of individuals with and without insomnia

Journal Article Journal of Sleep Research · January 1, 2024 Sleep architecture encodes relevant information on the structure of sleep and has been used to assess hyperarousal in insomnia. This study investigated whether polysomnography-derived sleep architecture displays signs of hyperarousal in individuals with in ... Full text Cite

The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned.

Journal Article Psychiatry Res · December 2023 The REST-IT study found the addition of zolpidem-controlled release (CR) provided a significant reduction in observer-rated measurement of suicidal ideation (the Columbia Suicide Severity Rating Scale) in 103 depressed outpatients with insomnia and suicida ... Full text Link to item Cite

Insomnia medications: History, characteristics, and guidelines for optimal use in clinical practice.

Journal Article J Sleep Res · December 2023 This article reviews the history of insomnia pharmacotherapy, documenting the evolution that has occurred over time in the increasing availability of medications with novel mechanisms of action that more specifically target the neural systems that modulate ... Full text Link to item Cite

Effect of Psychological and Medication Therapies for Insomnia on Daytime Functions: A Randomized Clinical Trial.

Journal Article JAMA Netw Open · December 1, 2023 IMPORTANCE: Daytime functional impairments are the primary reasons for patients with insomnia to seek treatment, yet little is known about what the optimal treatment is for improving daytime functions and how best to proceed with treatment for patients who ... Full text Link to item Cite

Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep.

Journal Article J Neurosci · November 29, 2023 Sleep is a highly stereotyped phenomenon, requiring robust spatiotemporal coordination of neural activity. Understanding how the brain coordinates neural activity with sleep onset can provide insights into the physiological functions subserved by sleep and ... Full text Link to item Cite

Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study.

Journal Article J Affect Disord · October 15, 2023 BACKGROUND: Growing evidence indicates that anhedonia is a multifaceted construct. This study examined the possibility of identifying subgroups of people with anhedonia using multiple reward-related measures to provide greater understanding the Research Do ... Full text Link to item Cite

Association Between Insomnia and Mental Health and Neurocognitive Outcomes Following Traumatic Brain Injury.

Journal Article J Neurotrauma · October 11, 2023 We previously described five trajectories of insomnia (each defined by a distinct pattern of insomnia severity over 12 months following traumatic brain injury [TBI]). Our objective in the present study was to estimate the association between insomnia traje ... Full text Link to item Cite

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder.

Journal Article J Vis Exp · July 7, 2023 Deep brain stimulation involves the administration of electrical stimulation to targeted brain regions for therapeutic benefit. In the context of major depressive disorder (MDD), most studies to date have administered continuous or open-loop stimulation wi ... Full text Link to item Cite

International Consensus Statement on Obstructive Sleep Apnea.

Journal Article Int Forum Allergy Rhinol · July 2023 BACKGROUND: Evaluation and interpretation of the literature on obstructive sleep apnea (OSA) allows for consolidation and determination of the key factors important for clinical management of the adult OSA patient. Toward this goal, an international collab ... Full text Link to item Cite

Objective sleep duration and response to combined pharmacotherapy and cognitive behavioral insomnia therapy among patients with comorbid depression and insomnia: a report from the TRIAD study.

Journal Article J Clin Sleep Med · June 1, 2023 STUDY OBJECTIVES: Several studies have shown that patients with short sleep duration show a poor response to cognitive behavioral therapy for insomnia (CBT-I), but such studies have not included patients with comorbid conditions. The current study was cond ... Full text Link to item Cite

Thalamic transcranial ultrasound stimulation in treatment resistant depression.

Journal Article Brain Stimul · August 22, 2024 Full text Link to item Cite

Insomnia and the effect of zolpidem-extended-release on the sleep items of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia, and suicidal ideation: Relationship to patient age.

Comparative short-term safety and efficacy of hypnotics: A quantitative risk-benefit analysis.

Association of Biomarkers of Neuronal Injury and Inflammation With Insomnia Trajectories After Traumatic Brain Injury: A TRACK-TBI Study.

Sleep Physiology and Neurocognition Among Adolescents With Attention-Deficit/Hyperactivity Disorder.

Cognitive behavioural therapy for insomnia reduces actigraphy and diary measured sleep discrepancy for individuals with comorbid insomnia and major depressive disorder: A report from the TRIAD study.

Closed-loop neurostimulation for the treatment of psychiatric disorders.

Intracranial beta activity is a biomarker of circadian and stimulation-induced arousal in obsessive compulsive disorder.

Journal Article Brain Stimul · 2024 Full text Link to item Cite

Proceedings of the 11th Annual Deep Brain Stimulation Think Tank: pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemmas, AI-guided neuromodulation, and translational advancements.

Feasibility and Acceptability of Mindfulness-based Stress Reduction and Prenatal Sleep Classes for Poor Prenatal Sleep Quality: Pilot Randomized Controlled Trial.

Hyperarousal features in the sleep architecture of individuals with and without insomnia

The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned.

Insomnia medications: History, characteristics, and guidelines for optimal use in clinical practice.

Effect of Psychological and Medication Therapies for Insomnia on Daytime Functions: A Randomized Clinical Trial.

Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep.

Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study.

Association Between Insomnia and Mental Health and Neurocognitive Outcomes Following Traumatic Brain Injury.

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder.

International Consensus Statement on Obstructive Sleep Apnea.

Objective sleep duration and response to combined pharmacotherapy and cognitive behavioral insomnia therapy among patients with comorbid depression and insomnia: a report from the TRIAD study.

Do Insomnia Treatments Improve Daytime Function?

Journal Article J Clin Med · April 24, 2023 A scientific advisory panel of seven U.S. and Canadian sleep experts performed a clinical appraisal by comparing general medical opinion, assessed via a survey of practicing clinicians, regarding insomnia treatment, with the available scientific evidence. ... Full text Link to item Cite

Should Trazodone Be First-Line Therapy for Insomnia? A Clinical Suitability Appraisal.

Journal Article J Clin Med · April 18, 2023 Trazodone is one of the most commonly used prescription medications for insomnia; however, some recent clinical guidelines do not recommend its use for treating insomnia. This clinical appraisal critically reviews the scientific literature on trazodone as ... Full text Link to item Cite

Changes in intracranial neurophysiology associated with acute COVID-19 infection.

Journal Article Clin Neurophysiol · April 2023 Full text Link to item Cite

Alliance for Sleep Clinical Practice Guideline on Switching or Deprescribing Hypnotic Medications for Insomnia.

Journal Article J Clin Med · March 25, 2023 Determining the most effective insomnia medication for patients may require therapeutic trials of different medications. In addition, medication side effects, interactions with co-administered medications, and declining therapeutic efficacy can necessitate ... Full text Link to item Cite

Wake Up America: National Survey of Patients' and Physicians' Views and Attitudes on Insomnia Care.

Journal Article J Clin Med · March 25, 2023 While both patients and physicians consider sleep to be important, sleep health may not receive appropriate consideration during patient visits with health care professionals (HCPs). We completed the first large-scale survey of people with trouble sleeping ... Full text Link to item Cite

What Should Be the Focus of Treatment When Insomnia Disorder Is Comorbid with Depression or Anxiety Disorder?

Journal Article J Clin Med · March 2, 2023 Insomnia is a significant, highly prevalent, persistent public health problem but often remains undiagnosed and untreated. Current treatment practices are not always evidence-based. When insomnia is comorbid with anxiety or depression, treatment often targ ... Full text Link to item Cite

Long-Term Use of Insomnia Medications: An Appraisal of the Current Clinical and Scientific Evidence.

Journal Article J Clin Med · February 17, 2023 While evidence supports the benefits of medications for the treatment of chronic insomnia, there is ongoing debate regarding their appropriate duration of use. A panel of sleep experts conducted a clinical appraisal regarding the use of insomnia medication ... Full text Link to item Cite

Recognition and Management of Obstructive Sleep Apnea in Psychiatric Practice.

Journal Article J Clin Psychiatry · January 23, 2023 Objective: The aims of this review were to describe the relationship between obstructive sleep apnea (OSA) and psychiatric disorders and provide an overview of how to recognize/manage OSA in psychiatric practice. Data Sources: A literature search of PubMed ... Full text Link to item Cite

Longitudinal study to assess antidepressant treatment patterns and outcomes in individuals with depression in the general population.

Journal Article J Affect Disord · January 15, 2023 BACKGROUND: Major depressive disorder (MDD) is largely managed in primary care, but physicians vary widely in their understanding of symptoms and treatments. This study aims to better understand the evolution of depression from initial diagnosis over a 3-y ... Full text Link to item Cite

Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program.

Journal Article J Affect Disord · January 1, 2023 BACKGROUND: Brexanolone is currently the only treatment specifically approved for postpartum depression (PPD) in the United States, based on the results from one Phase 2 and two Phase 3 double-blind, randomized, controlled trials in the HUMMINGBIRD program ... Full text Link to item Cite

Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations.

Journal Article Brain Stimul · 2023 Full text Link to item Cite

Identification of Neural Biomarkers of Major Depressive Disorder Symptom Severity Using Computerized Linguistic Analysis

Conference International IEEE/EMBS Conference on Neural Engineering, NER · January 1, 2023 Although numerous treatments are available for major depressive disorder (MDD), patients can be refractory to sequential treatment regimens. Experimental studies have demonstrated promising results implementing deep brain stimulation (DBS) as a therapy for ... Full text Cite

Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans.

Journal Article Brain Stimul · 2023 BACKGROUND: Humans routinely shift their sleepiness and wakefulness levels in response to emotional factors. The diversity of emotional factors that modulates sleep-wake levels suggests that the ascending arousal network may be intimately linked with netwo ... Full text Link to item Cite

Solriamfetol treatment of excessive daytime sleepiness in participants with narcolepsy or obstructive sleep apnea with a history of depression.

Journal Article J Psychiatr Res · November 2022 Given the high rate of depression associated with narcolepsy or obstructive sleep apnea (OSA), this analysis compared effects of solriamfetol treatment of excessive daytime sleepiness (EDS) in participants with/without a history of depression (DHx+/DHx-). ... Full text Link to item Cite

Publisher Correction: State-dependent responses to intracranial brain stimulation in a patient with depression.

Journal Article Nat Med · October 2022 Full text Link to item Cite

Post Hoc Analysis of the Impact of Lemborexant on Patient-Reported Sleep and Insomnia Severity in Adults with Insomnia and Depression Histories.

Journal Article CNS Spectr · April 2022 INTRODUCTION: The dual orexin receptor antagonist lemborexant (LEM) is approved in multiple countries including the United States, Japan, Canada, and Australia for insomnia treatment in adults. In phase 3 study E2006-G000-303 (Study 303; SUNRISE-2; NCT0295 ... Full text Link to item Cite

Examining Experiences of Poor Sleep During Pregnancy: A Qualitative Study to Inform the Development of a Prenatal Sleep Intervention

Journal Article Global Advances In Health and Medicine · March 16, 2022 Background: Poor sleep is common during pregnancy and is associated with increased risk of negative health outcomes. Research indicates that physical discomfort and having an active mind are primary factors for prenatal sleep disturbances. Mindfulness-base ... Full text Cite

A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials.

Journal Article Mol Psychiatry · March 2022 Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD ... Full text Link to item Cite

Links between the brain and body during sleep: implications for memory processing.

Journal Article Trends Neurosci · March 2022 Sleep is intimately related to memory processes. The established view is that the transformation of experiences into long-term memories is linked to sleep-related CNS function. However, there is increasing evidence that the autonomic nervous system (ANS), ... Full text Link to item Cite

Randomized controlled trial of digital cognitive behavior therapy for prenatal insomnia symptoms: effects on postpartum insomnia and mental health.

Journal Article Sleep · February 14, 2022 STUDY OBJECTIVES: To evaluate the effects of digital cognitive behavior therapy for insomnia (dCBT-I) delivered during pregnancy on subjective sleep outcomes, depressive symptoms, and anxiety symptoms through 6 months postpartum. METHODS: People up to 28 w ... Full text Link to item Cite

Telemedicine-delivered cognitive-behavioral therapy for insomnia in alcohol use disorder (AUD): study protocol for a randomized controlled trial.

Journal Article Trials · January 20, 2022 BACKGROUND: Alcohol use disorder (AUD) is a leading preventable cause of morbidity and mortality, but relapse rates are high even with available treatments. Insomnia is a robust predictor of relapse and pilot studies have shown that CBT for insomnia improv ... Full text Link to item Cite

Trajectories of Insomnia in Adults After Traumatic Brain Injury.

Journal Article JAMA Netw Open · January 4, 2022 IMPORTANCE: Insomnia is common after traumatic brain injury (TBI) and contributes to morbidity and long-term sequelae. OBJECTIVE: To identify unique trajectories of insomnia in the 12 months after TBI. DESIGN, SETTING, AND PARTICIPANTS: In this prospective ... Full text Link to item Cite

Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.

Journal Article Nat Sci Sleep · 2022 PURPOSE: Sleep is vital to cognition, yet underlying mechanisms remain unclear. Although sleep duration and continuity are two well-established contributors, additional factors-including homeostatic sleep drive processes-may also underlie cognition-related ... Full text Link to item Cite

What Is Insomnia?

Journal Article JAMA · December 21, 2021 Full text Link to item Cite

Examining suicide assessment measures for research use: Using item response theory to optimize psychometric assessment for research on suicidal ideation in major depressive disorder.

Journal Article Suicide & life-threatening behavior · December 2021 IntroductionProgress reducing suicide death will require randomized clinical trials (RCTs) specifically targeting suicide risk. Even large RCTs may not stipulate suicide death as the primary outcome, as suicide death is relatively uncommon. Theref ... Full text Cite

Correction to: Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).

Journal Article Neuropsychopharmacology · November 2021 Full text Link to item Cite

Design of the National Adaptive Trial for PTSD-related Insomnia (NAP Study), VA Cooperative Study Program (CSP) #2016.

Journal Article Contemp Clin Trials · October 2021 There are currently no validated pharmacotherapies for posttraumatic stress disorder (PTSD)-related insomnia. The purpose of the National Adaptive Trial for PTSD-Related Insomnia (NAP Study) is to efficiently compare to placebo the effects of three insomni ... Full text Link to item Cite

Closed-loop neuromodulation in an individual with treatment-resistant depression.

Journal Article Nat Med · October 2021 Deep brain stimulation is a promising treatment for neuropsychiatric conditions such as major depression. It could be optimized by identifying neural biomarkers that trigger therapy selectively when symptom severity is elevated. We developed an approach th ... Full text Link to item Cite

Diagnosing and Treating Insomnia in Adults and Older Adults.

Journal Article J Clin Psychiatry · September 28, 2021 Insomnia, the most prevalent sleep-wake disorder, affects 6% to 10% of adults. It may result in interpersonal and occupational problems and has a deleterious effect on quality of life. Patients may experience difficulty with sleep onset, sleep maintenance, ... Full text Link to item Cite

Optimizing Treatment for Insomnia.

Journal Article J Clin Psychiatry · July 13, 2021 By tailoring the mechanism of action and effects of therapy to the specific nature of each patient's insomnia and other conditions, clinicians can offer personalized care in an attempt to achieve an improved risk-benefit ratio compared to that of a "one-si ... Full text Link to item Cite

Evaluating lemborexant for the treatment of insomnia.

Journal Article Expert Opin Pharmacother · July 2021 INTRODUCTION: Insomnia is a complex sleep disorder that compromises quality of life and affects approximately 10% of the general population. Insomnia, defined as trouble initiating or maintaining sleep associated with impaired daytime function or distress, ... Full text Link to item Cite

Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults.

Journal Article JAMA Netw Open · July 1, 2021 IMPORTANCE: Disrupted sleep commonly occurs with progressing neurodegenerative disease. Large, well-characterized neuroimaging studies of cognitively unimpaired adults are warranted to clarify the magnitude and onset of the association between sleep and em ... Full text Link to item Cite

Challenges in Managing Insomnia in Older People.

Journal Article The Journal of clinical psychiatry · June 2021 Older people often experience insomnia, whether it is difficulty initiating or maintaining sleep. These sleep disturbances have a negative impact on quality of life and functioning. This report offers general considerations as well as specific data related ... Full text Cite

Cost-effectiveness of digital cognitive behavioral therapy (Sleepio) for insomnia: a Markov simulation model in the United States.

Journal Article Sleep · April 9, 2021 STUDY OBJECTIVES: To examine the cost-effectiveness and potential net monetary benefit (NMB) of a fully automated digital cognitive behavioral therapy (CBT) intervention for insomnia compared with no insomnia treatment in the United States (US). Similar re ... Full text Link to item Cite

A Longitudinal Study to Assess Antidepressant Treatment Patterns and Outcomes in Individuals with Depression in the General Population.

Journal Article CNS Spectr · April 2021 STUDY OBJECTIVES: Depression is an important cause of disability in the United States (US). The care experience of major depressive disorder (MDD) is highly variable and has only been documented to a limited degree. This study examines the prevalence incid ... Full text Link to item Cite

State-dependent responses to intracranial brain stimulation in a patient with depression.

Journal Article Nat Med · February 2021 Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematic ... Full text Link to item Cite

Optimizing computation of overnight decline in delta power: Evidence for slower rate of decline in delta power in insomnia patients.

Journal Article Clin Neurophysiol · February 2021 OBJECTIVE: To determine the best of commonly used methods for computing the rate of decline in non-rapid eye movement (NREM) sleep EEG delta power overnight (Delta Decline) in terms of vulnerability to missing data and to evaluate whether this rate is slow ... Full text Link to item Cite

Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.

Journal Article Curr Biol · January 11, 2021 Sufficient and efficient sleep is crucial for our health. Natural short sleepers can sleep significantly shorter than the average population without a desire for more sleep and without any obvious negative health consequences. In searching for genetic vari ... Full text Link to item Cite

Blinding and bias in a hypnotic clinical trial.

Journal Article Hum Psychopharmacol · January 2021 OBJECTIVES: Information is lacking regarding how commonly unblinding of treatment assignment occurs in hypnotic randomized clinic trials (RCTs). We now report the "best guesses" of clinical trial participants, versus study coordinators, versus study physic ... Full text Link to item Cite

Chronobiologic parameter changes in patients with major depressive disorder and sleep disturbance treated with adjunctive brexpiprazole: An open-label, flexible-dose, exploratory substudy.

Journal Article J Affect Disord · January 1, 2021 BACKGROUND: Circadian rhythm disturbances have been reported in patients with major depressive disorder (MDD). Among these is an increased phase angle between peak cortisol concentration and dim-light melatonin onset (DLMO). The aim of this study was to ev ... Full text Link to item Cite

Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology.

Journal Article Front Hum Neurosci · 2021 Major depressive disorder is a common and disabling disorder with high rates of treatment resistance. Evidence suggests it is characterized by distributed network dysfunction that may be variable across patients, challenging the identification of quantitat ... Full text Link to item Cite

Is cellular energy monitoring more responsive to hypoxia than pulse oximetry?

Journal Article Sleep Breath · December 2020 PURPOSE: Pulse oximetry is the current standard for detecting drops in arterial blood oxygen saturation (SpO2) associated with obstructive sleep apnea and hypopnea events in polysomnographic (PSG) testing. However, cellular energy monitoring (CE monitoring ... Full text Link to item Cite

Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis

Journal Article Journal of Patient-Reported Outcomes · December 1, 2020 Background: The intense itching associated with atopic dermatitis (AD) often causes patients to experience severe sleep disturbance. Here, we describe the results of a two-phase concept elicitation and cognitive interview study to establish the content val ... Full text Cite

Correction to: Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis (Journal of Patient-Reported Outcomes, (2020), 4, 1, (100), 10.1186/s41687-020-00265-y)

Journal Article Journal of Patient-Reported Outcomes · December 1, 2020 Following publication of the original article [1], the authors identified an error in the listed corresponding author. She should be identified as Carla Dias-Barbosa and not as Rodolfo Matos. ... Full text Cite

Effectiveness of Sequential Psychological and Medication Therapies for Insomnia Disorder: A Randomized Clinical Trial.

Journal Article JAMA Psychiatry · November 1, 2020 IMPORTANCE: Despite evidence of efficacious psychological and pharmacologic therapies for insomnia, there is little information about what first-line treatment should be and how best to proceed when initial treatment fails. OBJECTIVE: To evaluate the compa ... Full text Link to item Cite

Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study.

Journal Article JMIR Mhealth Uhealth · October 1, 2020 BACKGROUND: Adolescence is an important life stage for the development of healthy behaviors, which have a long-lasting impact on health across the lifespan. Sleep undergoes significant changes during adolescence and is linked to physical and psychiatric he ... Full text Link to item Cite

Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).

Journal Article Neuropsychopharmacology · September 2020 Anhedonia remains a major clinical issue for which there is few effective interventions. Untreated or poorly controlled anhedonia has been linked to worse disease course and increased suicidal behavior across disorders. Taking a proof-of-mechanism approach ... Full text Link to item Cite

An exploratory analysis of the association of circadian rhythm dysregulation and insomnia with suicidal ideation over the course of treatment in individuals with depression, insomnia, and suicidal ideation.

Journal Article J Clin Sleep Med · August 15, 2020 STUDY OBJECTIVES: Sleep disturbance is significantly associated with suicidal ideation. However, the majority of past research has examined the relationship between insomnia and suicidality. The current exploratory study examined the relationship of circad ... Full text Link to item Cite

Omitted Conflict of Interest Disclosures.

Journal Article JAMA Psychiatry · July 1, 2020 Full text Link to item Cite

Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study (Preprint)

Journal Article · May 25, 2020 BACKGROUNDAdolescence is an important life stage for the development of healthy behaviors, which have a long-lasting impact on health across the lifespan. Sleep undergoes significant chan ... Full text Cite

Efficacy of Digital Cognitive Behavioral Therapy for the Treatment of Insomnia Symptoms Among Pregnant Women: A Randomized Clinical Trial.

Journal Article JAMA Psychiatry · May 1, 2020 IMPORTANCE: Despite the prevalence and adverse consequences of prenatal insomnia, a paucity of research is available regarding interventions to improve insomnia symptoms during pregnancy. OBJECTIVE: To test the efficacy of digital cognitive behavioral ther ... Full text Link to item Cite

A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.

Journal Article Nat Med · May 2020 The National Institute of Mental Health (NIMH) 'fast-fail' approach seeks to improve too-often-misleading early-phase drug development methods by incorporating biomarker-based proof-of-mechanism (POM) testing in phase 2a. This first comprehensive applicati ... Full text Link to item Cite

142 Withdrawal Symptom Assessment in an Esketamine Safety Study in Patients with Treatment-resistant Depression.

Journal Article CNS Spectr · April 2020 BACKGROUND: SUSTAIN-2 (NCT02497287) was an open-label, phase III trial evaluating the safety of esketamine (ESK) nasal spray plus a newly initiated oral antidepressant (AD) for up to 1 year in adults with treatment-resistant depression (TRD). ESK is a sche ... Full text Link to item Cite

Sleep therapeutics and neuropsychiatric illness.

Journal Article Neuropsychopharmacology · January 2020 Alterations in sleep are extremely common in patients with neuropsychiatric illness. In addition, sleep disorders such as insomnia, obstructive sleep apnea, rapid eye movement sleep behavior disorder, and circadian rhythm disorders commonly occur at a rate ... Full text Link to item Cite

Genetics of the human circadian clock and sleep homeostat.

Journal Article Neuropsychopharmacology · January 2020 Timing and duration of sleep are controlled by the circadian system, which keeps an ~24-h internal rhythm that entrains to environmental stimuli, and the sleep homeostat, which rises as a function of time awake. There is a normal distribution across the po ... Full text Link to item Cite

Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy.

Journal Article J Neuropsychiatry Clin Neurosci · 2020 OBJECTIVES: Adult patients with epilepsy have an increased prevalence of major depressive disorder (MDD). Intracranial EEG (iEEG) captured during extended inpatient monitoring of patients with treatment-resistant epilepsy offers a particularly promising me ... Full text Link to item Cite

SLEEP ASSOCIATED WITH EXECUTIVE FUNCTIONING AMONG ADOLESCENTS ACROSS THE ADHD CONTINUUM

Conference SLEEP · 2020 Cite

DO THE SUBJECTIVE EFFECTS OF HYPNOTIC MEDICATIONS RESULT IN UNBLINDING OF TREATMENT ASSIGNMENT IN HYPNOTIC RANDOMIZED CLINICAL TRIALS?

Conference SLEEP · 2020 Cite

FACTORS ASSOCIATED WITH THE CONTINUOUS USE OF PSYCHOTROPIC TREATMENTS FOR NARCOLEPSY

Conference SLEEP · 2020 Cite

Corticocortical Evoked Potentials and Patient Response Reveal Networks Underlying Depression

Conference BIOLOGICAL PSYCHIATRY · 2020 Cite

Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.

Journal Article Am J Psychiatry · November 1, 2019 OBJECTIVE: The authors sought to determine whether targeted treatment of insomnia with controlled-release zolpidem (zolpidem-CR) in suicidal adults with insomnia would provide a reduction in suicidal ideation superior to placebo. METHODS: Reducing Suicidal ... Full text Link to item Cite

The assessment and management of insomnia: an update.

Journal Article World Psychiatry · October 2019 Insomnia poses significant challenges to public health. It is a common condition associated with marked impairment in function and quality of life, psychiatric and physical morbidity, and accidents. As such, it is important that effective treatment is prov ... Full text Link to item Cite

Narcolepsy Symptoms are Highly Persistent over Time Despite Treatment

Conference ANNALS OF NEUROLOGY · October 1, 2019 Link to item Cite

Longitudinal Assessment of Psychotropic Treatments for Narcolepsy

Conference ANNALS OF NEUROLOGY · October 1, 2019 Link to item Cite

A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors.

Journal Article Neuron · September 25, 2019 Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and alleviate diseases associated with poor sleep, a greater understanding of sleep regulation is ... Full text Link to item Cite

Sleep Pharmacogenetics: The Promise of Precision Medicine.

Journal Article Sleep Med Clin · September 2019 Pharmacogenetics is the branch of personalized medicine concerned with the variability in drug response occurring because of heredity. Advances in genetics research, and decreasing costs of gene sequencing, are promoting tremendous growth in pharmacogeneti ... Full text Link to item Cite

Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder.

Journal Article J Psychiatr Res · September 2019 In this paper, we report the rate of previously undiagnosed obstructive sleep apnea (OSA) in a randomized clinical trial (RCT) of suicidal patients with major depressive disorder (MDD). One hundred and twenty-five suicidal adults with MDD were recruited in ... Full text Link to item Cite

British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update.

Journal Article J Psychopharmacol · August 2019 This British Association for Psychopharmacology guideline replaces the original version published in 2010, and contains updated information and recommendations. A consensus meeting was held in London in October 2017 attended by recognised experts and advoc ... Full text Link to item Cite

An Electrophysiological Biomarker That May Predict Treatment Response to ECT.

Journal Article J ECT · June 2019 OBJECTIVE: Electroconvulsive therapy (ECT) is the most effective treatment for major depression but also carries risk of cognitive side effects. The ability to predict whether treatment will be effective before initiation of treatment could significantly i ... Full text Link to item Cite

Circadian Preference as a Moderator of Depression Outcome Following Cognitive Behavioral Therapy for Insomnia Plus Antidepressant Medications: A Report From the TRIAD Study.

Journal Article J Clin Sleep Med · April 15, 2019 STUDY OBJECTIVES: We previously presented results from a randomized controlled trial that examined the effects of antidepressant medication plus cognitive behavioral therapy for insomnia (CBT-I) among patients with major depressive disorder (MDD) and insom ... Full text Link to item Cite

Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications.

Journal Article J Sleep Res · April 2019 In this review, we outline the role of orexin receptor antagonists in disorders of sleep/wake and other potential neuropsychiatric conditions, with a focus on suvorexant, which is currently the only approved agent in this class. The efficacy of suvorexant ... Full text Link to item Cite

PITOLISANT IN COMBINATION WITH OTHER MEDICATIONS FOR THE MANAGEMENT OF NARCOLEPSY

Conference SLEEP · April 1, 2019 Link to item Cite

Solriamfetol for the Treatment of Excessive Sleepiness in OSA: A Placebo-Controlled Randomized Withdrawal Study.

Journal Article Chest · February 2019 BACKGROUND: Excessive sleepiness (ES) is a common symptom of OSA, which often persists despite primary OSA therapy. This phase III randomized withdrawal trial evaluated solriamfetol (JZP-110) for the treatment of ES in adults with OSA. METHODS: After 2 wee ... Full text Link to item Cite

Longitudinal study of narcolepsy symptoms in first, second, and third-degree relatives of simplex and multiplex narcolepsy families.

Journal Article Sleep Med · January 2019 OBJECTIVE: To assess the evolution of narcolepsy symptoms in first-, second, and third-degree relatives and to compare multiplex and simplex families. METHODS: A total of 4045 family members and 362 narcoleptic individuals were entered in the study; with 3 ... Full text Link to item Cite

Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers.

Journal Article J Alzheimers Dis · 2019 BACKGROUND: Recent studies reveal an association between slow-wave sleep (SWS), amyloid-β aggregation, and cognition. OBJECTIVE: This retrospective study examines whether long-term use of trazodone, an SWS enhancer, is associated with delayed cognitive dec ... Full text Link to item Cite

SLEEP IMPACTS OF NOCTURIA IN A LONGITUDINAL STUDY

Conference SLEEP MEDICINE · 2019 Cite

The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.

Journal Article Nat Rev Drug Discov · December 28, 2018 Full text Link to item Cite

A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease.

Journal Article Sleep Med Rev · December 2018 Obesity is prevalent among pregnant women in the United States; 15-20% of obese pregnant women have obstructive sleep apnea. The prevalence of obstructive sleep apnea increases along with body mass index, age and in the presence of other co-morbidities. Un ... Full text Link to item Cite

Effect of γ-hydroxybutyrate (Xyrem) on locus coeruleus activity as measured by pupillometry in a patient with narcolepsy.

Journal Article Int J Clin Pharmacol Ther · December 2018 Full text Link to item Cite

Screening extremely obese pregnant women for obstructive sleep apnea.

Journal Article Am J Obstet Gynecol · December 2018 BACKGROUND: Obesity is prevalent among pregnant women in the United States; obstructive sleep apnea is highly comorbid with obesity and is associated with adverse pregnancy outcomes. Screening for obstructive sleep apnea in pregnant women has remained a ch ... Full text Link to item Cite

Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management.

Journal Article Anesth Analg · November 2018 Among obese pregnant women, 15%-20% have obstructive sleep apnea (OSA) and this prevalence increases along with body mass index and in the presence of other comorbidities. Prepregnancy obesity and pregnancy-related weight gain are certainly risk factors fo ... Full text Link to item Cite

Longitudinal Evolution of Narcolepsy Symptoms in Simplex and Multiplex Families

Conference ANNALS OF NEUROLOGY · October 1, 2018 Link to item Cite

Validating functional data analysis measures from 24-h actigraphy data

Journal Article Biological Rhythm Research · September 3, 2018 The timing of sleep and wakefulness are under the influence of the circadian pacemaker in the suprachiasmatic nucleus, and the set-point for the circadian pacemaker is revealed by the time of onset of the secretion of melatonin under dim light conditions ( ... Full text Cite

Weekly changes in sleep and insomnia symptoms during acute treatment of persistent insomnia with behavioural or pharmacological therapy

Conference JOURNAL OF SLEEP RESEARCH · September 1, 2018 Link to item Cite

An Ultra-miniaturized Near Infrared Spectroscopy System to Assess Sleep Apnea in Children with Down Syndrome.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · July 2018 Down syndrome is one of the health disorders that interferes with regular and healthy sleep. Most children with Down syndrome are referred to a sleep clinic for the assessment of the severity of their apnea. Regular polysomnography based assessment of apne ... Full text Link to item Cite

0762 Sleeping at Home: Feasibility and Tolerability of Ambulatory Polysomnography for Use with Adolescents with Attention-Deficit/Hyperactivity Disorder

Conference Sleep · April 27, 2018 Full text Cite

0639 A Preliminary Report from the “REST-IT” Study: Self-reported Eveningness and Actigraphic Delayed Sleep Timing Correlate with Suicidal Ideation in Individuals with Depression and Insomnia

Conference Sleep · April 27, 2018 Full text Cite

To arouse or not to arouse: physiological responses from active thermogenesis versus thermoconforming in hibernating dwarf lemurs

Conference AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY · April 1, 2018 Link to item Cite

Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories.

Journal Article J Consult Clin Psychol · March 2018 OBJECTIVE: Insomnia and major depressive disorders (MDD) often co-occur, and such comorbidity has been associated with poorer outcomes for both conditions. However, individual differences in depressive symptom trajectories during and after treatment are po ... Full text Link to item Cite

The relationship of person-specific eveningness chronotype, greater seasonality, and less rhythmicity to suicidal behavior: A literature review.

Journal Article J Affect Disord · February 2018 BACKGROUND: Epidemiological data have demonstrated seasonal and circadian patterns of suicidal deaths. Several reviews and meta-analyses have confirmed the relationship between sleep disturbance and suicidality. However, these reviews/meta-analyses have no ... Full text Link to item Cite

In vitro evaluation of an injectable EEG/ECG sensor for wireless monitoring of hibernation in endangered animal species

Journal Article IEEE Sensors Journal · January 15, 2018 Hibernation is a unique metabolic adaptation employed by several animal species for survival where its study would further enhance our understanding of metabolic disorders, such as diabetes and obesity. As a primate animal with close genetic ties to humans ... Full text Cite

Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression.

Journal Article J Clin Psychiatry · 2018 OBJECTIVE: To provide expert recommendations for the safe and effective application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive disorder (MDD). PARTICIPANTS: Participants included a group of 17 expert clinici ... Full text Link to item Cite

International randomized-controlled trial of transcranial Direct Current Stimulation in depression.

Journal Article Brain Stimul · 2018 BACKGROUND: Evidence suggests that transcranial Direct Current Stimulation (tDCS) has antidepressant effects in unipolar depression, but there is limited information for patients with bipolar depression. Additionally, prior research suggests that brain der ... Full text Link to item Cite

Dr McClintock and Colleagues Reply.

Journal Article J Clin Psychiatry · 2018 Full text Link to item Cite

Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder.

Journal Article Int J Neuropsychopharmacol · August 1, 2017 BACKGROUND: We evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with major depressive disorder. METHODS: We conducted a 6-week, double-blind, placebo-controlled, parallel-group, Phase II, proof-of-concept ... Full text Link to item Cite

Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium.

Journal Article Clin Neurophysiol · August 2017 OBJECTIVE: Delirium is a common post-operative complication associated with significant costs, morbidity, and mortality. We sought sleep/EEG predictors of delirium present prior to delirium symptoms to facilitate developing and targeting therapies. METHODS ... Full text Link to item Cite

Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation?

Journal Article Anesthesiology · August 2017 Full text Link to item Cite

Segmented sleep in a nonelectric, small-scale agricultural society in Madagascar.

Journal Article Am J Hum Biol · July 8, 2017 OBJECTIVES: We studied sleep in a rural population in Madagascar to (i) characterize sleep in an equatorial small-scale agricultural population without electricity, (ii) assess whether sleep is linked to noise levels in a dense population, and (iii) examin ... Full text Link to item Cite

Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials.

Journal Article Am J Geriatr Psychiatry · July 2017 OBJECTIVE: Suvorexant is an orexin receptor antagonist approved for treating insomnia at doses of 10-20 mg. Previously reported phase III results showed that suvorexant was effective and well-tolerated in a combined-age population (elderly and nonelderly a ... Full text Link to item Cite

Adverse Effects of Hypnotic Medications.

Journal Article J Clin Sleep Med · June 15, 2017 Full text Link to item Cite

A randomised trial of peri-operative positive airway pressure for postoperative delirium in patients at risk for obstructive sleep apnoea after regional anaesthesia with sedation or general anaesthesia for joint arthroplasty.

Journal Article Anaesthesia · June 2017 Previous pilot work has established an association between obstructive sleep apnoea and the development of acute postoperative delirium , but it remains unclear to what extent this risk factor is modifiable in the 'real world' peri-operative setting. In a ... Full text Link to item Cite

Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data.

Journal Article Psychopharmacology (Berl) · June 2017 RATIONALE: Sex-related differences in the clinical profiles of some insomnia medications have been previously reported. OBJECTIVE: To evaluate the clinical profile of suvorexant, a novel orexin receptor antagonist approved for treating insomnia at doses up ... Full text Link to item Cite

0341 SEQUENTIAL THERAPIES FOR COMORBID AND PRIMARY INSOMNIA: A RANDOMIZED CONTROLLED TRIAL

Conference Sleep · April 28, 2017 Full text Cite

0335 DOES OBJECTIVE SLEEP DURATION MODERATE TREATMENT RESPONSE IN PATIENT WITH COMORBID DEPRESSION AND INSOMNIA? A REPORT FROM THE TRIAD STUDY

Conference Sleep · April 28, 2017 Full text Cite

0395 CLINICAL PRACTICE GUIDELINE FOR THE PHARMACOLOGIC TREATMENT OF CHRONIC INSOMNIA IN ADULTS: AN AMERICAN ACADEMY OF SLEEP MEDICINE CLINICAL PRACTICE GUIDELINE

Conference Sleep · April 28, 2017 Full text Cite

Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial.

Journal Article Sleep · April 1, 2017 STUDY OBJECTIVE: To compare cognitive behavioral therapy for insomnia (CBT-I) + antidepressant medication (AD) against treatments that target solely depression or solely insomnia. DESIGN: A blinded, randomized split-plot experimental study. SETTING: Two ur ... Full text Link to item Cite

Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study.

Journal Article J Clin Sleep Med · February 15, 2017 STUDY OBJECTIVES: To determine if patients with childhood onsets (CO) of both major depression and insomnia disorder show blunted depression and insomnia treatment responses to concurrent interventions for both disorders compared to those with adult onsets ... Full text Link to item Cite

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.

Journal Article J Clin Sleep Med · February 15, 2017 INTRODUCTION: The purpose of this guideline is to establish clinical practice recommendations for the pharmacologic treatment of chronic insomnia in adults, when such treatment is clinically indicated. Unlike previous meta-analyses, which focused on broad ... Full text Link to item Cite

National Sleep Foundation's sleep quality recommendations: first report.

Journal Article Sleep Health · February 2017 OBJECTIVES: To provide evidence-based recommendations and guidance to the public regarding indicators of good sleep quality across the life-span. METHODS: The National Sleep Foundation assembled a panel of experts from the sleep community and representativ ... Full text Link to item Cite

Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA.

Journal Article Am J Psychiatry · January 1, 2017 OBJECTIVE: Insomnia is associated with increased risk for suicide. The Food and Drug Administration (FDA) has mandated that warnings regarding suicide be included in the prescribing information for hypnotic medications. The authors conducted a review of th ... Full text Link to item Cite

Should Internet Cognitive Behavioral Therapy for Insomnia Be the Primary Treatment Option for Insomnia?: Toward Getting More SHUTi.

Journal Article JAMA Psychiatry · January 1, 2017 Full text Link to item Cite

Insomnia Patients With Objective Short Sleep Duration Have a Blunted Response to Cognitive Behavioral Therapy for Insomnia.

Journal Article Sleep · January 1, 2017 STUDY OBJECTIVES: This study examined whether individuals with insomnia and objective short sleep duration <6 h, a subgroup with greater risks of adverse health outcomes, differ in their response to cognitive-behavioral therapy for insomnia (CBT-I) when co ... Full text Link to item Cite

Double-Blind, Placebo-Controlled, Crossover Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia.

Journal Article Sleep · January 1, 2017 STUDY OBJECTIVES: Nocturia, voids which disturb sleep, is the most common cause of awakenings and is associated with daytime sleepiness. Because the standard treatments for the most common causes of nocturia are relatively ineffective, many treated patient ... Full text Link to item Cite

Shedding light to sleep studies

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2017 This paper presents our efforts in the development of a small wireless, flexible bandage sized near-infrared spectroscopy (NIRS) system for sleep analysis. The current size of the system is 2.8 cm × 1.7 cm × 0.6 cm. It is capable of performing NIRS with 66 ... Full text Cite

Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research.

Journal Article Clin Psychol Rev · December 2016 BACKGROUND: Biological mechanisms underlying symptom and prognostic heterogeneity in Attention-Deficit/Hyperactivity Disorder (ADHD) are unclear. Sleep impacts neurocognition and daytime functioning and is disrupted in ADHD, yet little is known about sleep ... Full text Link to item Cite

Sleep and Mood: Chicken or Egg?

Journal Article Biol Psychiatry · December 1, 2016 Full text Link to item Cite

Sleep Medications and Women: a Review of Issues to Consider for Optimizing the Care of Women with Sleep Disorders

Journal Article Current Sleep Medicine Reports · December 1, 2016 Certain medications exhibit sex-specific pharmacological profiles. It is, therefore, imperative to understand their unique pharmacokinetic properties to optimize women’s health. Two such medications that are commonly used in sleep medicine are zolpidem and ... Full text Cite

Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.

Journal Article Trends Pharmacol Sci · November 2016 Serotonin transporter (SERT) inhibitors treat depression by elevating brain extracellular 5-hydroxytryptamine (5-HTExt). However, only one-third of patients respond adequately. Treatment-resistant depression (TRD) is a major unmet need. Interestingly, elev ... Full text Link to item Cite

Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials.

Journal Article Depress Anxiety · October 2016 Kappa-opioid receptor (KOR) antagonists are currently being considered for the treatment of a variety of neuropsychiatric conditions, including depressive, anxiety, and substance abuse disorders. A general ability to mitigate the effects of stress, which c ... Full text Link to item Cite

Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial.

Conference J Clin Psychiatry · October 2016 OBJECTIVES: The Treatment of Insomnia and Depression (TRIAD) study evaluated the efficacy of combining depression pharmacotherapy (using MED, an ecologically valid and generalizable antidepressant medication algorithm) with cognitive-behavioral therapy for ... Full text Link to item Cite

Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials.

Journal Article J Clin Sleep Med · September 15, 2016 STUDY OBJECTIVES: Suvorexant is an orexin receptor antagonist approved for treating insomnia at a maximum dose of 20 mg. Phase-3 trials evaluated two age-adjusted (non-elderly/elderly) dose-regimes of 40/30 mg and 20/15 mg with the primary focus on 40/30 m ... Full text Link to item Cite

Insomnia Patients with Objective Short Sleep Duration have a Blunted Response to Cognitive Behavioral Therapy for Insomnia.

Journal Article Sleep · September 9, 2016 STUDY OBJECTIVES: This study examined whether individuals with insomnia and objective short sleep duration <6h, a subgroup with greater risks of adverse health outcomes, differ in their response to cognitive behavioral therapy for insomnia (CBT-I) when com ... Link to item Cite

DOUBLE-BLIND, PLACEBO-CONTROLLED, CROSS-OVER, STUDY OF ARMODAFINIL TREATMENT OF DAYTIME SLEEPINESS ASSOCIATED WITH TREATED NOCTURIA.

Journal Article Sleep · September 9, 2016 STUDY OBJECTIVES: Nocturia, voids which disturb sleep, is the most common cause of awakenings and is associated with daytime sleepiness. Because the standard treatments for the most common causes of nocturia are relatively ineffective, many treated patient ... Link to item Cite

Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study.

Journal Article Prim Care Companion CNS Disord · September 8, 2016 BACKGROUND: Brexpiprazole is a serotonin-dopamine activity modulator. We evaluated the effects of adjunctive treatment with brexpiprazole on sleep disturbances in patients with DSM-IV-TR major depressive disorder (MDD) and inadequate response to antidepres ... Full text Link to item Cite

Hibernation in a primate: does sleep occur?

Journal Article R Soc Open Sci · August 2016 During hibernation, critical physiological processes are downregulated and thermogenically induced arousals are presumably needed periodically to fulfil those physiological demands. Among the processes incompatible with a hypome tabolic state is sleep. How ... Full text Link to item Cite

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Journal Article Biol Psychiatry · July 15, 2016 Full text Link to item Cite

Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia.

Journal Article Sleep · May 1, 2016 STUDY OBJECTIVES: To examine the relationship between hypertension prevalence in individuals with insomnia who have short total sleep duration < 6 h or sleep duration ≥ 6 h, using both objective and subjective measures of total sleep duration. METHODS: Usi ... Full text Link to item Cite

The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia.

Journal Article Hum Psychopharmacol · May 2016 BACKGROUND: Lurasidone, an atypical antipsychotic, is a potent 5-HT7 antagonist and D2 , 5-HT2A antagonist, and 5-HT1A partial agonist. As such, lurasidone would be expected to modulate sleep and circadian function but there have been no human studies of t ... Full text Link to item Cite

Benzodiazepine receptor agonists: Indications, efficacy, and outcome

Chapter · April 19, 2016 Cite

Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504.

Journal Article J Clin Psychiatry · April 2016 OBJECTIVE: Sleep disturbances are common among veterans with chronic military-related posttraumatic stress disorder (PTSD). This article reports the results of a multicenter clinical trial that explored the clinical correlates of reported sleep impairment ... Full text Link to item Cite

Recognizing and managing insomnia in primary care and specialty settings.

Journal Article J Clin Psychiatry · April 2016 Insomnia is a common feature of both medical and psychiatric disorders. Whether as a symptom of an illness or as a comorbid disorder, insomnia worsens patient outcomes related to quality of life, functioning, workplace productivity, and health care expendi ... Full text Link to item Cite

Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial.

Journal Article Trials · March 3, 2016 BACKGROUND: Chronic insomnia is a prevalent disorder associated with significant psychosocial, health, and economic impacts. Cognitive behavioral therapies (CBTs) and benzodiazepine receptor agonist (BzRA) medications are the most widely supported therapeu ... Full text Open Access Link to item Cite

Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials.

Journal Article Biol Psychiatry · January 15, 2016 BACKGROUND: Suvorexant is an orexin receptor antagonist for treatment of insomnia. We report results from two pivotal phase 3 trials. METHODS: Two randomized, double-blind, placebo-controlled, parallel-group, 3-month trials in nonelderly (18-64 years) and ... Full text Link to item Cite

Shining evolutionary light on human sleep and sleep disorders.

Journal Article Evol Med Public Health · 2016 Sleep is essential to cognitive function and health in humans, yet the ultimate reasons for sleep-i.e. 'why' sleep evolved-remain mysterious. We integrate findings from human sleep studies, the ethnographic record, and the ecology and evolution of mammalia ... Full text Link to item Cite

New Developments in Insomnia Medications of Relevance to Mental Health Disorders.

Journal Article Psychiatr Clin North Am · December 2015 Many insomnia medications with high specificity have become available recently. They provide a window into the clinical effects of modulating specific brain systems and establish a new guiding principal for conceptualizing insomnia medications: "mechanism ... Full text Link to item Cite

Insomnia disorder.

Journal Article Nat Rev Dis Primers · September 3, 2015 Insomnia disorder affects a large proportion of the population on a situational, recurrent or chronic basis and is among the most common complaints in medical practice. The disorder is predominantly characterized by dissatisfaction with sleep duration or q ... Full text Link to item Cite

Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy.

Journal Article Neuropsychopharmacology · August 2015 Electroconvulsive therapy (ECT) at conventional current amplitudes (800-900 mA) is highly effective but carries the risk of cognitive side effects. Lowering and individualizing the current amplitude may reduce side effects by virtue of a less intense and m ... Full text Link to item Cite

Current, emerging, and newly available insomnia medications.

Journal Article J Clin Psychiatry · August 2015 Research into the sleep-wake cycle has provided new treatment targets for patients with insomnia as well as a better understanding of how medications affect sleep processes. Current insomnia medications, including benzodiazepines and nonbenzodiazepines, fo ... Full text Link to item Cite

Restricting Benzodiazepines to Short-Term Prescription.

Journal Article JAMA Psychiatry · July 2015 Full text Link to item Cite

Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial.

Journal Article Sleep Med · July 2015 OBJECTIVE: Esmirtazapine (Org 50081), a medication that binds with high affinity to serotonin 5-HT2A and histamine-1 receptors, was evaluated as a potential treatment for insomnia. METHODS: Adults with primary insomnia were treated with esmirtazapine (3.0 ... Full text Link to item Cite

A multi-site randomized clinical trial to reduce suicidal ideation in suicidal adult outpatients with Major Depressive Disorder: Development of a methodology to enhance safety.

Journal Article Clin Trials · June 2015 BACKGROUND/AIMS: Suicide is a major public health concern, yet there are very few randomized clinical trials that have been conducted to reduce suicidal ideation in patients at risk of suicide. We describe the rationale and refinements of such a trial that ... Full text Link to item Cite

Can We Use Brain Oscillations to Guide Treatment of MDD?

Conference BIOLOGICAL PSYCHIATRY · May 1, 2015 Link to item Cite

Lessons learned and potentials for improvement in cns drug development: Isctm section on designing the right series of experiments

Journal Article Innovations in Clinical Neuroscience · March 1, 2015 Once a molecule has been characterized as engaging an identified target at the appropriate location (affinity and potency), the next step involves designing experiments that will determine its pharmacodynamic activities both for efficacy (on target) and sa ... Cite

Traumatic brain injury detection using electrophysiological methods

Journal Article Frontiers in Human Neuroscience · February 4, 2015 Measuring neuronal activity with electrophysiological methods may be useful in detecting neurological dysfunctions, such as mild traumatic brain injury (mTBI).This approach may be particularly valuable for rapid detection in at-risk populations including m ... Full text Cite

Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression.

Journal Article Brain Stimul · 2015 BACKGROUND: Transcranial Magnetic Stimulation (TMS) customarily uses high-field electromagnets to achieve therapeutic efficacy in Major Depressive Disorder (MDD). Low-field magnetic stimulation also may be useful for treatment of MDD, with fewer treatment- ... Full text Link to item Cite

Towards injectable biophotonic sensors for physiological monitoring of animals

Conference Proceedings of IEEE Sensors · December 12, 2014 We present a novel subcutaneous biophotonics sensor system for continuous monitoring of hemodynamic parameters in animals. This sensor incorporates surface-mount light sources and photodetectors in the form factors of glass capsules used for microchip impl ... Full text Cite

The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial.

Journal Article Schizophr Res · December 2014 BACKGROUND: Insomnia is frequent in schizophrenia and may contribute to cognitive impairment as well as overuse of weight inducing sedative antipsychotics. We investigated the effects of eszopiclone on sleep and cognition for patients with schizophrenia-re ... Full text Link to item Cite

Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders.

Journal Article J Affect Disord · October 2014 BACKGROUND: There is growing research interest in studying motivational deficits in different neuropsychiatric disorders because these symptoms appear to be more common than originally reported and negatively impact long-term functional outcomes. However, ... Full text Link to item Cite

Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.

Journal Article J ECT · June 2014 For many patients with neuropsychiatric illnesses, standard psychiatric treatments with mono or combination pharmacotherapy, psychotherapy, and transcranial magnetic stimulation are ineffective. For these patients with treatment-resistant neuropsychiatric ... Full text Open Access Link to item Cite

A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain.

Journal Article Sleep · June 1, 2014 STUDY OBJECTIVES: Insomnia, which is very common in patients with chronic low back pain (LBP), has long been viewed as a pain symptom that did not merit specific treatment. Recent data suggest that adding insomnia therapy to pain-targeted treatment should ... Full text Link to item Cite

The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks.

Journal Article J Psychopharmacol · May 2014 INTRODUCTION: We sought to test the hypothesis that improvements in sleep might mediate treatment-related improvements in daytime symptoms of post-traumatic stress disorder (PTSD). We evaluated whether changes in sleep occurring on the first night of tiaga ... Full text Open Access Link to item Cite

Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial.

Journal Article Lancet Neurol · May 2014 BACKGROUND: Suvorexant (MK-4305) is an orexin receptor antagonist shown to be efficacious for insomnia over 3 months. We aimed to assess its clinical profile during and after 1 year of treatment. METHODS: We did a randomised, placebo-controlled, parallel-g ... Full text Link to item Cite

The Impact of Eszopiclone Insomnia Treatment on Cognition in Schizophrenia: A Double-blind, Randomized, Placebo-controlled Trial

Conference BIOLOGICAL PSYCHIATRY · May 1, 2014 Link to item Cite

Obstructive sleep apnea and delirium: exploring possible mechanisms.

Journal Article Sleep Breath · March 2014 INTRODUCTION: Obstructive sleep apnea (OSA) is a medical disorder strongly associated with multiple comorbidities and postoperative complications. Current evidence suggests that OSA disturbs fundamental biochemical processes, leading to low-grade systemic ... Full text Link to item Cite

Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study.

Journal Article J Clin Sleep Med · February 15, 2014 STUDY OBJECTIVE: To assess the effect of armodafinil on task-related prefrontal cortex activation using functional magnetic resonance imaging (fMRI) in patients with obstructive sleep apnea (OSA) and excessive sleepiness despite continuous positive airway ... Full text Link to item Cite

Therapeutic approaches for shankopathies.

Journal Article Dev Neurobiol · February 2014 Despite recent advances in understanding the molecular mechanisms of autism spectrum disorders (ASD), the current treatments for these disorders are mostly focused on behavioral and educational approaches. The considerable clinical and molecular heterogene ... Full text Link to item Cite

Insomnia in HIV-infected patients: pathophysiologic implications.

Journal Article AIDS Rev · 2014 The prevalence of insomnia in the HIV-seropositive population is estimated to be 29-97%, far greater than the 10% general population prevalence. We carried out a systematic review to assess whether the prevalence of insomnia is indeed higher in HIV-seropos ... Link to item Cite

Topography of seizures induced by electroconvulsive therapy and magnetic seizure therapy

Conference International IEEE/EMBS Conference on Neural Engineering, NER · December 1, 2013 We present the first topographical characterization of seizures induced by ultrabrief pulse width right unilateral electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). Topographical electroencephalogram (EEG) was acquired during treatments i ... Full text Cite

Optimizing the Pharmacologic Treatment of Insomnia: Current Status and Future Horizons.

Journal Article Sleep Med Clin · September 1, 2013 A number of medications are available for treating patients with insomnia. These medications include agents approved as insomnia therapies by the U.S. Food and Drug Administration (FDA), agents approved by the FDA for another condition that are used "off-l ... Full text Link to item Cite

Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications.

Journal Article Sleep Med Rev · August 2013 The pharmacologic management of insomnia has long been dominated by agents that facilitate gamma amino butyric acid inhibition. These agents have served as the clinical model for understanding the pharmacodynamic effects of insomnia agents according to whi ... Full text Link to item Cite

Does physiological hyperarousal enhance error rates among insomnia sufferers?

Journal Article Sleep · August 1, 2013 OBJECTIVE: To examine the association between physiological hyperarousal and response accuracy on reaction time tasks among individuals with insomnia. DESIGN AND SETTING: This study was conducted at affiliated Veterans Administration (VA) and academic medi ... Full text Link to item Cite

Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls.

Journal Article Int Urogynecol J · March 2013 INTRODUCTION AND HYPOTHESIS: Can diary-derived bladder and sleep measurements differentiate individuals with overactive bladder syndrome (OAB) from individuals with primary insomnia and healthy controls? METHODS: Bladder- and sleep-diary data were compared ... Full text Link to item Cite

Novel sublingual low-dose zolpidem tablet reduces latency to sleep onset following spontaneous middle-of-the-night awakening in insomnia in a randomized, double-blind, placebo-controlled, outpatient study.

Journal Article Sleep · February 1, 2013 STUDY OBJECTIVES: To evaluate efficacy and safety of 3.5-mg zolpidem tartrate sublingual tablets (ZST) on latency to sleep onset after middle-of-the-night (MOTN) awakenings in patients with insomnia characterized by difficulty returning to sleep after MOTN ... Full text Link to item Cite

Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder.

Journal Article Psychiatry Res · January 30, 2013 As they alleviate major depressive disorder, antidepressant therapies may improve associated sleep disturbances, but may also have inherent sedating or activating properties. We examined sleep changes during a multicenter, sham-controlled, trial of transcr ... Full text Link to item Cite

The relationship of sleep with temperature and metabolic rate in a hibernating primate.

Journal Article PLoS One · 2013 STUDY OBJECTIVES: It has long been suspected that sleep is important for regulating body temperature and metabolic-rate. Hibernation, a state of acute hypothermia and reduced metabolic-rate, offers a promising system for investigating those relationships. ... Full text Open Access Link to item Cite

Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.

Journal Article J Clin Psychiatry · 2013 Full text Link to item Cite

Comparison of polysomnographic data in age-, sex- and Axis I psychiatric diagnosis matched HIV-seropositive and HIV-seronegative insomnia patients.

Journal Article Clin Neurophysiol · December 2012 OBJECTIVE: There is a high prevalence of insomnia in HIV-seropositive patients. Insomnia is associated with poorer disease outcomes, cognitive impairment and HIV-associated dementia. However there is limited data characterizing the type of sleep disturbanc ... Full text Link to item Cite

Sleep in Mood Disorders

Journal Article · December 1, 2012 Full text Cite

Psychiatric disorders and sleep.

Journal Article Neurol Clin · November 2012 There is growing experimental evidence that the relationship between psychiatric disorders and sleep is complex and includes bidirectional causation. This article provides the evidence that supports this point of view, reviewing data on sleep disturbances ... Full text Link to item Cite

Psychiatric disorders and EEG

Chapter · October 18, 2012 Cite

Shift work disorder case studies: applying management principles in clinical practice.

Journal Article J Clin Psychiatry · August 2012 Shift work disorder (SWD) is a circadian rhythm sleep disorder characterized by insomnia and excessive sleepiness. SWD, which is estimated to affect 10% of people who work night or rotating shifts, can have serious consequences such as accidents, loss of p ... Full text Link to item Cite

A WASO sub-group analysis of a 6-month study of eszopiclone 3 mg.

Journal Article Sleep Med · June 2012 BACKGROUND: Insomnia marked by sleep maintenance difficulty is extremely prevalent. Yet, problems staying asleep have been relatively neglected as a research focus compared to problems falling asleep. Insomnia treatment studies typically have not required ... Full text Link to item Cite

Prevalence and comorbidity of nocturnal wandering in the U.S. adult general population.

Journal Article Neurology · May 15, 2012 OBJECTIVE: To assess the prevalence and comorbid conditions of nocturnal wandering with abnormal state of consciousness (NW) in the American general population. METHODS: Cross-sectional study conducted with a representative sample of 19,136 noninstitutiona ... Full text Link to item Cite

Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly.

Journal Article Anesthesiology · April 2012 BACKGROUND: Postoperative delirium, a common complication in the elderly, can occur following any type of surgery and is associated with increased morbidity and mortality; it may also be associated with subsequent cognitive problems. Effective therapy for ... Full text Link to item Cite

How the circadian rhythm affects sleep, wakefulness, and overall health: background for understanding shift work disorder.

Journal Article J Clin Psychiatry · February 2012 It is estimated that 15 to 25% of the U.S. labor force works night, evening, or rotating shifts. These non-traditional schedules can affect the circadian rhythm, a self-sustained rhythm of biological processes that plays an important role in modulating sle ... Full text Link to item Cite

The consensus sleep diary: standardizing prospective sleep self-monitoring.

Journal Article Sleep · February 1, 2012 STUDY OBJECTIVES: To present an expert consensus, standardized, patient-informed sleep diary. METHODS AND RESULTS: Sleep diaries from the original expert panel of 25 attendees of the Pittsburgh Assessment Conference(1) were collected and reviewed. A smalle ... Full text Link to item Cite

Suvorexant, an orexin receptor antagonist, in preventing symptom return in patients with insomnia after 1 year of treatment: a randomised, double-blind, placebo-controlled study

Conference JOURNAL OF SLEEP RESEARCH · 2012 Cite

Efficacy and safety of suvorexant, an orexin receptor antagonist, in patients with primary insomnia: a 3-month phase 3 trial (trial #1)

Conference JOURNAL OF SLEEP RESEARCH · 2012 Cite

Loop diuretics have anxiolytic effects in rat models of conditioned anxiety.

Journal Article PLoS One · 2012 A number of antiepileptic medications that modulate GABA(A) mediated synaptic transmission are anxiolytic. The loop diuretics furosemide (Lasix) and bumetanide (Bumex) are thought to have antiepileptic properties. These drugs also modulate GABA(A) mediated ... Full text Link to item Cite

REM sleep bout duration and frequency in PTSD

Journal Article Journal of Aggression, Maltreatment and Trauma · January 1, 2012 The few pharmacological treatments shown to be effective in reducing sleep disturbance in posttraumatic stress disorder (PTSD) might work through normalization of rapid eye movement (REM). However, evidence of REM sleep disturbance in PTSD has been inconsi ... Full text Cite

Eszopiclone treatment for insomnia: effect size comparisons in patients with primary insomnia and insomnia with medical and psychiatric comorbidity.

Journal Article Prim Care Companion CNS Disord · 2012 OBJECTIVE: The purpose of this post hoc analysis was to compare the treatment effect size of eszopiclone 3 mg for insomnia in patients with a diagnosis of primary insomnia and in several of the psychiatric and medical conditions that are most commonly como ... Full text Link to item Cite

NOCTURIA IN SUBJECTS WITH OVERACTIVE BLADDER SYNDROME (OAB): WHAT WAKES THEM UP?

Conference SLEEP · January 1, 2012 Link to item Cite

DOES HYPERAROUSAL INCREASE DAYTIME ERROR PRONENESS AMONG INSOMNIA SUFFERERS?

Conference SLEEP · January 1, 2012 Link to item Cite

ARE INSOMNIA SUFFERERS' DAYTIME DEFICITS PRODUCTS OF SUBJECTIVE DISTORTIONS?

Conference SLEEP · January 1, 2012 Link to item Cite

GENDER EFFECTS OF 1.75 MG AND 3.5 MG ZOLPIDEM TARTRATE SUBLINGUAL TABLETS FORMULATED WITH A CARBONATE-BICARBONATE BUFFER ON SLEEP ONSET FOLLOWING MIDDLE-OF-THE-NIGHT AWAKENING AND ON NEXT-DAY RESIDUAL EFFECTS

Conference SLEEP · January 1, 2012 Link to item Cite

EFFICACY AND SAFETY OF ESMIRTAZAPINE IN ELDERLY PATIENTS WITH PRIMARY INSOMNIA IN A 2-WEEK SLEEP LABORATORY TRIAL

Conference SLEEP · January 1, 2012 Link to item Cite

SLEEP AND HEALTH-RELATED FUNCTION IN A CLINICAL SAMPLE AS MEASURED BY PROMIS (PATIENT-REPORTED OUTCOMES MEASUREMENT INFORMATION SYSTEM)

Conference SLEEP · January 1, 2012 Link to item Cite

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ESZOPICLONE FOR THE TREATMENT OF INSOMNIA IN PATIENTS WITH CHRONIC LOW BACK PAIN

Conference SLEEP · January 1, 2012 Link to item Cite

Sleep and psychiatric disorders

Chapter · December 21, 2011 Cite

Insomnia is frequent in schizophrenia and associated with night eating and obesity.

Journal Article Schizophr Res · December 2011 BACKGROUND: Sleep difficulties are common in schizophrenia, however these complaints are often overshadowed by more prominent clinical concerns. The point prevalence of insomnia in this population is not well documented. Poor sleep is associated with lower ... Full text Link to item Cite

The association of fatigue with depression and insomnia in HIV-seropositive patients: a pilot study.

Journal Article Sleep · December 1, 2011 OBJECTIVE: Fatigue is a pervasive symptom associated with HIV, resulting in significant functioning impairment; but little is known about its etiology or treatment. In patients with primary insomnia, data have shown improvement in fatigue following success ... Full text Link to item Cite

Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes.

Journal Article Biol Psychiatry · October 15, 2011 BACKGROUND: Previous functional magnetic resonance imaging studies have shown strong correlations between cue-elicited craving for cigarettes and activation of the superior frontal gyrus (SFG). Repetitive transcranial magnetic stimulation (rTMS) offers a n ... Full text Link to item Cite

Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis.

Journal Article Arch Gen Psychiatry · October 2011 CONTEXT: Distinctive diagnostic classification schemes for insomnia diagnoses are available, but the optimal insomnia nosology has yet to be determined. OBJECTIVES: To test the reliability and validity of insomnia diagnoses listed in the American Psychiatr ... Full text Link to item Cite

Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia.

Journal Article Sleep · October 1, 2011 STUDY OBJECTIVES: To evaluate the efficacy and safety of doxepin (DXP) 3 mg and 6 mg in adults diagnosed with primary insomnia. DESIGN AND METHODS: The study was a randomized, double-blind, parallel-group, placebo-controlled trial. Patients meeting DSM-IV- ... Full text Link to item Cite

Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients?

Journal Article J Psychiatr Res · September 2011 Assessing for clinical levels of anxiety is crucial, as comorbid insomnias far outnumber primary insomnias (PI). Such assessment is complex since those with Anxiety Disorders (AD) and those with PI have overlapping symptoms. Because of this overlap, we nee ... Full text Link to item Cite

A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression (Journal of Clinical Psychiatry (2010) 71, 1 (32-40))

Journal Article Journal of Clinical Psychiatry · August 1, 2011 Full text Cite

Repetitive Transcranial Magnetic Stimulation (rTMS) of the Superior Frontal Gyrus Modulates Craving for Cigarettes

Conference BIOLOGICAL PSYCHIATRY · May 1, 2011 Link to item Cite

SLEEP PATTERNS OF INDIVIDUALS WITH SCHIZOPHRENIA

Conference SCHIZOPHRENIA BULLETIN · March 1, 2011 Link to item Cite

Recognition and assessment of shift work disorder.

Journal Article J Clin Psychiatry · February 2011 Full text Link to item Cite

Daytime sleepiness in insomnia patients

Chapter · January 1, 2011 Introduction Insomnia patients, by definition, have disturbed or non-restorative sleep, and sleep less on average than the general population in terms of both self-reported and objective polysomnographic measures. As a result, it would be expected that ins ... Full text Cite

Pharmacological advances in the treatment of insomnia.

Journal Article Curr Pharm Des · 2011 Insomnia is a highly prevalent condition, and due to ongoing demand from patients suffering with this condition, new pharmacological treatments are actively being sought. As our neurophysiological understanding of insomnia grows, so too do the available tr ... Full text Link to item Cite

PATIENT-REPORTED SYMPTOM IMPROVEMENT IN SLEEP MAINTENANCE ENDPOINTS IN ADULT AND ELDERLY PATIENTS WITH INSOMNIA TREATED WITH DOXEPIN 3 AND 6 MG

Conference SLEEP · January 1, 2011 Link to item Cite

OBSTRUCTIVE SLEEP APNEA (OSA) IN MAJOR DEPRESSIVE DISORDER

Conference SLEEP · January 1, 2011 Link to item Cite

A POSTHOC ANALYSIS OF ESZOPICLONE EFFECTS ON CARDIOMETABOLIC INDICES OF HYPERAROUSAL IN THE TREATMENT OF PRIMARY INSOMNIA

Conference SLEEP · January 1, 2011 Link to item Cite

IMPROVEMENT IN SLEEP MAINTENANCE AND EARLY MORNING AWAKENINGS IN ADULT AND ELDERLY PATIENTS WITH INSOMNIA TREATED WITH DOXEPIN 3 AND 6 MG

Conference SLEEP · January 1, 2011 Link to item Cite

AUTONOMIC NERVOUS SYSTEM ACTIVITY PRECEDING NOCTURIA IN OLDER ADULTS

Conference SLEEP · January 1, 2011 Link to item Cite

Antidepressant and Antipsychotic Drugs.

Journal Article Sleep Med Clin · December 1, 2010 Full text Link to item Cite

British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders.

Journal Article J Psychopharmacol · November 2010 Sleep disorders are common in the general population and even more so in clinical practice, yet are relatively poorly understood by doctors and other health care practitioners. These British Association for Psychopharmacology guidelines are designed to add ... Full text Link to item Cite

Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia.

Journal Article Sleep · November 2010 STUDY OBJECTIVES: to evaluate the efficacy and safety of doxepin 1 mg and 3 mg in elderly subjects with chronic primary insomnia. DESIGN AND METHODS: the study was a randomized, double-blind, parallel-group, placebo-controlled trial. Subjects meeting DSM-I ... Full text Link to item Cite

Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®)).

Journal Article Psychooncology · October 2010 OBJECTIVE: Cancer and its treatments disturb sleep-wake functioning; however, there is little information available on the characteristics and consequences of sleep problems associated with cancer. As part of an effort to improve measurement of sleep-wake ... Full text Link to item Cite

Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study.

Journal Article Brain Stimul · October 2010 BACKGROUND: Although transcranial magnetic stimulation (TMS) can be an effective acute antidepressant treatment, few studies systematically examine persistence of benefit. OBJECTIVE: We assessed the durability of antidepressant effect after acute response ... Full text Link to item Cite

The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia.

Journal Article J Clin Sleep Med · August 15, 2010 STUDY OBJECTIVES: To determine if vestibular stimulation is an effective therapy for transient insomnia in a sleep phase advance model. DESIGN: Multi-site, double-blind, randomized, parallel-group, sham-controlled trial SETTING: This study was carried out ... Link to item Cite

Treatment of insomnia in depressed insomniacs: effects on health-related quality of life, objective and self-reported sleep, and depression.

Journal Article J Clin Sleep Med · August 15, 2010 STUDY OBJECTIVES: Insomnia is associated with poor health related quality of life (HRQOL) in depressed patients. Prior clinical trials of hypnotic treatment of insomnia in depressed patients have shown improvement in HRQOL, but in these studies HRQOL was r ... Link to item Cite

Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study.

Journal Article J Urol · August 2010 PURPOSE: Nocturia, a common symptom of overactive bladder syndrome, is associated with substantial adverse consequences and yet its pathophysiology has hardly been studied and the capacity to treat it remains limited. We established methods to study the ph ... Full text Link to item Cite

In vivo evidence of the specificity of effects of GABA(A) receptor modulating medications.

Journal Article Sleep · July 2010 Full text Link to item Cite

Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia.

Journal Article Sleep · May 2010 STUDY OBJECTIVES: Determine the relationship of non-rapid eye movement (NREM) electroencephalographic (EEG) spectral measures and the response to cognitive behavioral therapy (CBT) in primary insomnia (PI). DESIGN: Patients with PI were randomly assigned t ... Full text Link to item Cite

Using difficulty resuming sleep to define nocturnal awakenings.

Journal Article Sleep Med · March 2010 OBJECTIVE: Nocturnal awakenings are one of the most prevalent sleep disturbances in the general population. Little is known, however, about the frequency of these episodes and how difficulty resuming sleep once awakened affects subjective sleep quality and ... Full text Link to item Cite

A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia.

Journal Article Sleep · February 2010 BACKGROUND: Longer-term pharmacologic studies for insomnia in older individuals are sparse. OBJECTIVE: To evaluate the efficacy and safety of 12 weeks of nightly eszopiclone in elderly outpatients with insomnia. METHODS: Participants (65-85 years) met DSM- ... Full text Link to item Cite

Pharmacologic Treatment: Other Medications

Chapter · January 1, 2010 Full text Cite

Insomnia: A health care (gap that is growing)

Journal Article Psychiatric Times · January 1, 2010 Insomnia is a highly prevalent and costly condition. It is underdiagnosed and many patients remain untreated. All patients should be asked about their sleep-related health. If the patient has sleep difficulties accompanied by impairment in physical or cogn ... Cite

A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression.

Journal Article J Clin Psychiatry · January 2010 OBJECTIVE: Treatment of excessive sleepiness in the context of obstructive sleep apnea (OSA) may be particularly difficult in those with depression because depression and/or antidepressant medications may cause sleepiness and fatigue in addition to that du ... Full text Link to item Cite