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Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT.

Publication ,  Journal Article
Krystal, AD; Weiner, RD; Dean, MD; Lindahl, VH; Tramontozzi, LA; Falcone, G; Coffey, CE
Published in: J Neuropsychiatry Clin Neurosci
2003
Published version (DOI) Link to item

The authors retrospectively compared the seizure duration, ictal EEG, and cognitive side effects of ketamine and methohexital anesthesia with ECT. This comparison was carried out with data from consecutive index ECT treatments that occurred immediately before and after a switch from methohexital to ketamine in 36 patients. Ketamine was well tolerated and prolonged seizure duration overall, but particularly in those who had a seizure duration shorter than 25 seconds with methohexital at the maximum available stimulus intensity. Ketamine also increased midictal EEG slow-wave amplitude. Thus, a switch to ketamine may be useful when it is difficult to elicit a robust seizure. Faster post-treatment reorientation with ketamine may suggest a lower level of associated cognitive side effects.

Duke Scholars

Andrew Darrell Krystal
Author Andrew Darrell Krystal Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
Richard David Weiner
Author Richard David Weiner Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychol ...

Published In

J Neuropsychiatry Clin Neurosci

DOI

10.1176/jnp.15.1.27

ISSN

0895-0172

Publication Date

2003

Volume

15

Issue

1

Start / End Page

27 / 34

Location

United States

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Retrospective Studies
  • Psychotic Disorders
  • Psychiatry
  • Orientation
  • Middle Aged
  • Methohexital
  • Male
  • Ketamine
  • Humans
 

Citation

APA
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ICMJE
MLA
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Krystal, A. D., Weiner, R. D., Dean, M. D., Lindahl, V. H., Tramontozzi, L. A., Falcone, G., & Coffey, C. E. (2003). Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. J Neuropsychiatry Clin Neurosci, 15(1), 27–34. https://doi.org/10.1176/jnp.15.1.27
Krystal, Andrew D., Richard D. Weiner, Margaret D. Dean, Virginia H. Lindahl, Louis A. Tramontozzi, Grace Falcone, and C Edward Coffey. “Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT.” J Neuropsychiatry Clin Neurosci 15, no. 1 (2003): 27–34. https://doi.org/10.1176/jnp.15.1.27.
Krystal AD, Weiner RD, Dean MD, Lindahl VH, Tramontozzi LA, Falcone G, et al. Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. J Neuropsychiatry Clin Neurosci. 2003;15(1):27–34.
Krystal, Andrew D., et al. “Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT.” J Neuropsychiatry Clin Neurosci, vol. 15, no. 1, 2003, pp. 27–34. Pubmed, doi:10.1176/jnp.15.1.27.
Krystal AD, Weiner RD, Dean MD, Lindahl VH, Tramontozzi LA, Falcone G, Coffey CE. Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. J Neuropsychiatry Clin Neurosci. 2003;15(1):27–34.
Journal cover image

Published In

J Neuropsychiatry Clin Neurosci

DOI

10.1176/jnp.15.1.27

ISSN

0895-0172

Publication Date

2003

Volume

15

Issue

1

Start / End Page

27 / 34

Location

United States

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Retrospective Studies
  • Psychotic Disorders
  • Psychiatry
  • Orientation
  • Middle Aged
  • Methohexital
  • Male
  • Ketamine
  • Humans