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Richard David Weiner

Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
3717 Bluestone Ct., Chapel Hill, NC 27514
3717 Bluestone Ct., Chapel Hill, NC 27514

Overview


Research efforts under my direction have been in electroconvulsive therapy (ECT). First, in a study of unilateral versus bilateral ECT in elderly unilateral ECT non-responders, we have shown that switching to bilateral ECT is associated with a more substantial and enduring response. We have also shown that switching to bilateral ECT is, however, associated with an increase in memory impairment compared to continuing unilateral ECT. Other ECT work has focussed on the effects of various types of stimulus dosing paradigms on therapeutic response, memory impairment, and EEG abnormality. We have also demonstrated an ability to separate EEG seizures produced by various kinds of ECT treatment parameters. This work has led to multiple research efforts to more fully develop electroencephalographic models of treatment adequate with ECT.

Current Appointments & Affiliations


Professor Emeritus of Psychiatry and Behavioral Sciences · 2021 - Present Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology, Psychiatry & Behavioral Sciences

Recent Publications


Comparing the Neurocognitive Effects of Right Unilateral Ultra-Brief Pulse Electroconvulsive Therapy and Magnetic Seizure Therapy for the Treatment of Major Depressive Episode.

Journal Article Biol Psychiatry Cogn Neurosci Neuroimaging · February 2025 BACKGROUND: Magnetic seizure therapy (MST) is under investigation as a treatment for adults with major depression. Previous research has suggested that MST has antidepressant efficacy comparable to that of electroconvulsive therapy (ECT), but with greater ... Full text Link to item Cite

Electroconvulsive Therapy Changes Immunological Markers in Patients With Major Depressive Disorder: A Scoping Review.

Journal Article J ECT · December 1, 2024 Major depressive disorder (MDD) is a highly prevalent and disabling condition. As such, understanding the causes of and treatment options for MDD is critical. Electroconvulsive therapy (ECT) remains the gold standard depression treatment, but the molecular ... Full text Link to item Cite
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Recent Grants


2/8 Prolonging Remission in Depressed Elderly (PRIDE)

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2009 - 2016

Long Term Effects Of Electroconvulsive Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1991 - 1993

Long-Term Effects Of Electroconvulsive Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 1988

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Education, Training & Certifications


Duke University · 1974 M.D.
Duke University · 1973 Ph.D.