Overview
Research efforts under my direction have been in electroconvulsive therapy (ECT). First, in a study of unilateral versus bilateral ECT in elderly unilateral ECT non-responders, we have shown that switching to bilateral ECT is associated with a more substantial and enduring response. We have also shown that switching to bilateral ECT is, however, associated with an increase in memory impairment compared to continuing unilateral ECT. Other ECT work has focussed on the effects of various types of stimulus dosing paradigms on therapeutic response, memory impairment, and EEG abnormality. We have also demonstrated an ability to separate EEG seizures produced by various kinds of ECT treatment parameters. This work has led to multiple research efforts to more fully develop electroencephalographic models of treatment adequate with ECT.
Current Appointments & Affiliations
Professor Emeritus of Psychiatry and Behavioral Sciences
·
2021 - Present
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology,
Psychiatry & Behavioral Sciences
Recent Publications
Comparing the Neurocognitive Effects of Right Unilateral Ultra-Brief Pulse Electroconvulsive Therapy and Magnetic Seizure Therapy for the Treatment of Major Depressive Episode.
Journal Article Biol Psychiatry Cogn Neurosci Neuroimaging · February 2025 BACKGROUND: Magnetic seizure therapy (MST) is under investigation as a treatment for adults with major depression. Previous research has suggested that MST has antidepressant efficacy comparable to that of electroconvulsive therapy (ECT), but with greater ... Full text Link to item CiteElectroconvulsive Therapy Changes Immunological Markers in Patients With Major Depressive Disorder: A Scoping Review.
Journal Article J ECT · December 1, 2024 Major depressive disorder (MDD) is a highly prevalent and disabling condition. As such, understanding the causes of and treatment options for MDD is critical. Electroconvulsive therapy (ECT) remains the gold standard depression treatment, but the molecular ... Full text Link to item CiteCognitive effects of electroconvulsive therapy in depressed adolescents.
Journal Article J Affect Disord · July 1, 2024 Full text Link to item CiteRecent Grants
2/8 Prolonging Remission in Depressed Elderly (PRIDE)
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2009 - 2016Long Term Effects Of Electroconvulsive Therapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1991 - 1993Long-Term Effects Of Electroconvulsive Therapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 1988View All Grants
Education, Training & Certifications
Duke University ·
1974
M.D.
Duke University ·
1973
Ph.D.