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The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned.

Publication ,  Journal Article
McCall, WV; Mercado, K; Dzurny, TN; McCloud, LL; Krystal, AD; Benca, RM; Rosenquist, PB; Looney, SW
Published in: Psychiatry Res
December 2023

The REST-IT study found the addition of zolpidem-controlled release (CR) provided a significant reduction in observer-rated measurement of suicidal ideation (the Columbia Suicide Severity Rating Scale) in 103 depressed outpatients with insomnia and suicidal ideation, but without significant change in a self-report measure of suicidal ideation (the Scale for Suicide Ideation). This secondary analysis of the REST-IT data examined the suicide item of another observer-rated scale, the Hamilton Rating Scale for Depression (HRSD), further clarifying the impact of insomnia-focused treatment on suicidal ideation. This analysis established a significant advantage for zolpidem-CR compared with placebo on the HRSD suicide item.

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Published In

Psychiatry Res

DOI

EISSN

1872-7123

Publication Date

December 2023

Volume

330

Start / End Page

115576

Location

Ireland

Related Subject Headings

  • Zolpidem
  • Suicidal Ideation
  • Sleep Initiation and Maintenance Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Outpatients
  • Humans
  • Depression
  • 5203 Clinical and health psychology
  • 3202 Clinical sciences
 

Citation

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McCall, W. V., Mercado, K., Dzurny, T. N., McCloud, L. L., Krystal, A. D., Benca, R. M., … Looney, S. W. (2023). The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned. Psychiatry Res, 330, 115576. https://doi.org/10.1016/j.psychres.2023.115576
McCall, William V., Kayla Mercado, Tess N. Dzurny, Laryssa L. McCloud, Andrew D. Krystal, Ruth M. Benca, Peter B. Rosenquist, and Stephen W. Looney. “The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned.Psychiatry Res 330 (December 2023): 115576. https://doi.org/10.1016/j.psychres.2023.115576.
McCall, William V., et al. “The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned.Psychiatry Res, vol. 330, Dec. 2023, p. 115576. Pubmed, doi:10.1016/j.psychres.2023.115576.
McCall WV, Mercado K, Dzurny TN, McCloud LL, Krystal AD, Benca RM, Rosenquist PB, Looney SW. The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned. Psychiatry Res. 2023 Dec;330:115576.
Journal cover image

Published In

Psychiatry Res

DOI

EISSN

1872-7123

Publication Date

December 2023

Volume

330

Start / End Page

115576

Location

Ireland

Related Subject Headings

  • Zolpidem
  • Suicidal Ideation
  • Sleep Initiation and Maintenance Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Outpatients
  • Humans
  • Depression
  • 5203 Clinical and health psychology
  • 3202 Clinical sciences