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Closed-loop neurostimulation for the treatment of psychiatric disorders.

Publication ,  Journal Article
Sellers, KK; Cohen, JL; Khambhati, AN; Fan, JM; Lee, AM; Chang, EF; Krystal, AD
Published in: Neuropsychopharmacology
January 2024

Despite increasing prevalence and huge personal and societal burden, psychiatric diseases still lack treatments which can control symptoms for a large fraction of patients. Increasing insight into the neurobiology underlying these diseases has demonstrated wide-ranging aberrant activity and functioning in multiple brain circuits and networks. Together with varied presentation and symptoms, this makes one-size-fits-all treatment a challenge. There has been a resurgence of interest in the use of neurostimulation as a treatment for psychiatric diseases. Initial studies using continuous open-loop stimulation, in which clinicians adjusted stimulation parameters during patient visits, showed promise but also mixed results. Given the periodic nature and fluctuations of symptoms often observed in psychiatric illnesses, the use of device-driven closed-loop stimulation may provide more effective therapy. The use of a biomarker, which is correlated with specific symptoms, to deliver stimulation only during symptomatic periods allows for the personalized therapy needed for such heterogeneous disorders. Here, we provide the reader with background motivating the use of closed-loop neurostimulation for the treatment of psychiatric disorders. We review foundational studies of open- and closed-loop neurostimulation for neuropsychiatric indications, focusing on deep brain stimulation, and discuss key considerations when designing and implementing closed-loop neurostimulation.

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Published In

Neuropsychopharmacology

DOI

EISSN

1740-634X

Publication Date

January 2024

Volume

49

Issue

1

Start / End Page

163 / 178

Location

England

Related Subject Headings

  • Psychiatry
  • Mental Disorders
  • Humans
  • Deep Brain Stimulation
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Sellers, K. K., Cohen, J. L., Khambhati, A. N., Fan, J. M., Lee, A. M., Chang, E. F., & Krystal, A. D. (2024). Closed-loop neurostimulation for the treatment of psychiatric disorders. Neuropsychopharmacology, 49(1), 163–178. https://doi.org/10.1038/s41386-023-01631-2
Sellers, Kristin K., Joshua L. Cohen, Ankit N. Khambhati, Joline M. Fan, A Moses Lee, Edward F. Chang, and Andrew D. Krystal. “Closed-loop neurostimulation for the treatment of psychiatric disorders.Neuropsychopharmacology 49, no. 1 (January 2024): 163–78. https://doi.org/10.1038/s41386-023-01631-2.
Sellers KK, Cohen JL, Khambhati AN, Fan JM, Lee AM, Chang EF, et al. Closed-loop neurostimulation for the treatment of psychiatric disorders. Neuropsychopharmacology. 2024 Jan;49(1):163–78.
Sellers, Kristin K., et al. “Closed-loop neurostimulation for the treatment of psychiatric disorders.Neuropsychopharmacology, vol. 49, no. 1, Jan. 2024, pp. 163–78. Pubmed, doi:10.1038/s41386-023-01631-2.
Sellers KK, Cohen JL, Khambhati AN, Fan JM, Lee AM, Chang EF, Krystal AD. Closed-loop neurostimulation for the treatment of psychiatric disorders. Neuropsychopharmacology. 2024 Jan;49(1):163–178.

Published In

Neuropsychopharmacology

DOI

EISSN

1740-634X

Publication Date

January 2024

Volume

49

Issue

1

Start / End Page

163 / 178

Location

England

Related Subject Headings

  • Psychiatry
  • Mental Disorders
  • Humans
  • Deep Brain Stimulation
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences