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Insomnia medications: History, characteristics, and guidelines for optimal use in clinical practice.

Publication ,  Journal Article
Krystal, AD
Published in: J Sleep Res
December 2023

This article reviews the history of insomnia pharmacotherapy, documenting the evolution that has occurred over time in the increasing availability of medications with novel mechanisms of action that more specifically target the neural systems that modulate sleep/wake function. This evolution provides an increasing capacity to improve the effectiveness of insomnia pharmacotherapy by allowing the selection of medications that specifically target the particular type of sleep difficulty present in each patient. As a result, they can achieve a therapeutic effect with fewer effects on aspects of brain function other than those needed to achieve benefit, thereby minimising adverse effects. The accumulated evidence-base is such that it can serve as the basis for a personalised insomnia pharmacotherapy paradigm. Here we outline a set of best-practice recommendations for how to carry out optimised personalised insomnia pharmacotherapy based on that evidence base in the hope that it will improve the treatment delivered to the many individuals suffering from insomnia.

Duke Scholars

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Published In

J Sleep Res

DOI

EISSN

1365-2869

Publication Date

December 2023

Volume

32

Issue

6

Start / End Page

e14084

Location

England

Related Subject Headings

  • Sleep Initiation and Maintenance Disorders
  • Sleep
  • Neurology & Neurosurgery
  • Humans
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

Citation

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Krystal, A. D. (2023). Insomnia medications: History, characteristics, and guidelines for optimal use in clinical practice. J Sleep Res, 32(6), e14084. https://doi.org/10.1111/jsr.14084
Krystal, Andrew D. “Insomnia medications: History, characteristics, and guidelines for optimal use in clinical practice.J Sleep Res 32, no. 6 (December 2023): e14084. https://doi.org/10.1111/jsr.14084.
Krystal, Andrew D. “Insomnia medications: History, characteristics, and guidelines for optimal use in clinical practice.J Sleep Res, vol. 32, no. 6, Dec. 2023, p. e14084. Pubmed, doi:10.1111/jsr.14084.
Journal cover image

Published In

J Sleep Res

DOI

EISSN

1365-2869

Publication Date

December 2023

Volume

32

Issue

6

Start / End Page

e14084

Location

England

Related Subject Headings

  • Sleep Initiation and Maintenance Disorders
  • Sleep
  • Neurology & Neurosurgery
  • Humans
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences