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A comparison of placebo and no-treatment during a hypnotic clinical trial.

Publication ,  Journal Article
Mccall, WV; Perlis, ML; Tu, X; Groman, AE; Krystal, A; Walsh, JK
Published in: Int J Clin Pharmacol Ther
August 2005

OBJECTIVE: Sleep parameters commonly improve during placebo treatment in insomnia clinical trials. We examined whether the improvement seen with placebo was related to taking pills or other non-specific factors. METHOD: 95 insomniacs took either a placebo pill (pill+) or no pill (pill-) on nights of their choosing over 12 weeks. RESULTS: Pills were consumed on about half of the nights. Consistent improvement was seen with reduced reported sleep latency, wakefulness after sleep onset, number of awakenings, and total sleep time over the 12 weeks for both the pill+ and pill condition. A difference between pill+ and pill- was detected only for total sleep time, and this difference favored pill+. CONCLUSIONS: This study suggests that improvement seen during placebo treatment is more related to non-specific factors of participating in clinical trial than to pill taking behavior.

Duke Scholars

Published In

Int J Clin Pharmacol Ther

DOI

ISSN

0946-1965

Publication Date

August 2005

Volume

43

Issue

8

Start / End Page

355 / 359

Location

Germany

Related Subject Headings

  • Time Factors
  • Sleep Stages
  • Sleep Initiation and Maintenance Disorders
  • Randomized Controlled Trials as Topic
  • Placebos
  • Placebo Effect
  • Pharmacology & Pharmacy
  • Middle Aged
  • Male
  • Hypnotics and Sedatives
 

Citation

APA
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ICMJE
MLA
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Mccall, W. V., Perlis, M. L., Tu, X., Groman, A. E., Krystal, A., & Walsh, J. K. (2005). A comparison of placebo and no-treatment during a hypnotic clinical trial. Int J Clin Pharmacol Ther, 43(8), 355–359. https://doi.org/10.5414/cpp43355
Mccall, W. V., M. L. Perlis, X. Tu, A. E. Groman, A. Krystal, and J. K. Walsh. “A comparison of placebo and no-treatment during a hypnotic clinical trial.Int J Clin Pharmacol Ther 43, no. 8 (August 2005): 355–59. https://doi.org/10.5414/cpp43355.
Mccall WV, Perlis ML, Tu X, Groman AE, Krystal A, Walsh JK. A comparison of placebo and no-treatment during a hypnotic clinical trial. Int J Clin Pharmacol Ther. 2005 Aug;43(8):355–9.
Mccall, W. V., et al. “A comparison of placebo and no-treatment during a hypnotic clinical trial.Int J Clin Pharmacol Ther, vol. 43, no. 8, Aug. 2005, pp. 355–59. Pubmed, doi:10.5414/cpp43355.
Mccall WV, Perlis ML, Tu X, Groman AE, Krystal A, Walsh JK. A comparison of placebo and no-treatment during a hypnotic clinical trial. Int J Clin Pharmacol Ther. 2005 Aug;43(8):355–359.

Published In

Int J Clin Pharmacol Ther

DOI

ISSN

0946-1965

Publication Date

August 2005

Volume

43

Issue

8

Start / End Page

355 / 359

Location

Germany

Related Subject Headings

  • Time Factors
  • Sleep Stages
  • Sleep Initiation and Maintenance Disorders
  • Randomized Controlled Trials as Topic
  • Placebos
  • Placebo Effect
  • Pharmacology & Pharmacy
  • Middle Aged
  • Male
  • Hypnotics and Sedatives