Sleep quality varies as a function of 5-HTTLPR genotype and stress.
OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.
Duke Scholars
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Related Subject Headings
- Stress, Psychological
- Sleep Wake Disorders
- Severity of Illness Index
- Serotonin Plasma Membrane Transport Proteins
- Serotonin
- Psychiatry
- Polymorphism, Genetic
- Middle Aged
- Male
- Humans
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Stress, Psychological
- Sleep Wake Disorders
- Severity of Illness Index
- Serotonin Plasma Membrane Transport Proteins
- Serotonin
- Psychiatry
- Polymorphism, Genetic
- Middle Aged
- Male
- Humans