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Sleep quality varies as a function of 5-HTTLPR genotype and stress.

Publication ,  Journal Article
Brummett, BH; Krystal, AD; Ashley-Koch, A; Kuhn, CM; Züchner, S; Siegler, IC; Barefoot, JC; Ballard, EL; Gwyther, LP; Williams, RB
Published in: Psychosom Med
2007

OBJECTIVE: To test the hypothesis that allelic variation in 5HTT gene-linked polymorphic region (5-HTTLPR) genotype was associated with sleep quality (Pittsburgh Sleep Quality Index, PSQI) as a main effect and as moderated by the chronic stress of caregiving. Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. METHODS: Subjects were 142 adult primary caregivers for a spouse or parent with dementia and 146 noncaregiver controls. Subjects underwent genotyping and completed the PSQI. RESULTS: Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect (p > .36). However, there was a caregiver X 5-HTTLPR interaction (p < .009), such that the s allele was associated with poorer sleep quality in caregivers as compared with controls. CONCLUSIONS: Findings suggest that the s allele may moderate sleep disturbance in response to chronic stress.

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Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

2007

Volume

69

Issue

7

Start / End Page

621 / 624

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Sleep Wake Disorders
  • Severity of Illness Index
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Psychiatry
  • Polymorphism, Genetic
  • Middle Aged
  • Male
  • Humans
 

Citation

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Brummett, B. H., Krystal, A. D., Ashley-Koch, A., Kuhn, C. M., Züchner, S., Siegler, I. C., … Williams, R. B. (2007). Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosom Med, 69(7), 621–624. https://doi.org/10.1097/PSY.0b013e31814b8de6
Brummett, Beverly H., Andrew D. Krystal, Allison Ashley-Koch, Cynthia M. Kuhn, Stephan Züchner, Ilene C. Siegler, John C. Barefoot, Edna L. Ballard, Lisa P. Gwyther, and Redford B. Williams. “Sleep quality varies as a function of 5-HTTLPR genotype and stress.Psychosom Med 69, no. 7 (2007): 621–24. https://doi.org/10.1097/PSY.0b013e31814b8de6.
Brummett BH, Krystal AD, Ashley-Koch A, Kuhn CM, Züchner S, Siegler IC, et al. Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosom Med. 2007;69(7):621–4.
Brummett, Beverly H., et al. “Sleep quality varies as a function of 5-HTTLPR genotype and stress.Psychosom Med, vol. 69, no. 7, 2007, pp. 621–24. Pubmed, doi:10.1097/PSY.0b013e31814b8de6.
Brummett BH, Krystal AD, Ashley-Koch A, Kuhn CM, Züchner S, Siegler IC, Barefoot JC, Ballard EL, Gwyther LP, Williams RB. Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosom Med. 2007;69(7):621–624.

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

2007

Volume

69

Issue

7

Start / End Page

621 / 624

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Sleep Wake Disorders
  • Severity of Illness Index
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Psychiatry
  • Polymorphism, Genetic
  • Middle Aged
  • Male
  • Humans