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Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders.

Publication ,  Journal Article
Calabrese, JR; Fava, M; Garibaldi, G; Grunze, H; Krystal, AD; Laughren, T; Macfadden, W; Marin, R; Nierenberg, AA; Tohen, M
Published in: J Affect Disord
October 2014

BACKGROUND: There is growing research interest in studying motivational deficits in different neuropsychiatric disorders because these symptoms appear to be more common than originally reported and negatively impact long-term functional outcomes. However, there is considerable ambiguity in the terminology used to describe motivational deficits in the scientific literature. For the purposes of this manuscript, the term "amotivation" will be utilised in the context of mood disorders, since this is considered a more inclusive/appropriate term for this patient population. Other challenges impacting the study of amotivation in mood disorders, include: appropriate patient population selection; managing or controlling for potential confounding factors; the lack of gold-standard diagnostic criteria and assessment scales; and determination of the most appropriate study duration. METHODS: This paper summarises the search for a consensus by a group of experts in the optimal approach to studying amotivation in mood disorders. RESULTS: The consensus of this group is that amotivation in mood disorders is a legitimate therapeutic target, given the magnitude of the associated unmet needs, and that proof-of-concept studies should be conducted in order to facilitate subsequent larger investigations. The focus of this manuscript is to consider the study of amotivation, as a residual symptom of major depressive disorder (MDD) or bipolar depression (BD), following adequate treatment with a typical antidepressant or mood stabiliser/antipsychotic, respectively. DISCUSSION: There is a paucity of data studying amotivation in mood disorders. This manuscript provides general guidance on the most appropriate study design(s) and methodology to assess potential therapeutic options for the management of residual amotivation in mood disorders.

Duke Scholars

Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

October 2014

Volume

168

Start / End Page

439 / 451

Location

Netherlands

Related Subject Headings

  • Research Design
  • Psychiatry
  • Motivation
  • Humans
  • Depressive Disorder, Major
  • Bipolar Disorder
  • Apathy
  • Antipsychotic Agents
  • Antidepressive Agents
  • 52 Psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Calabrese, J. R., Fava, M., Garibaldi, G., Grunze, H., Krystal, A. D., Laughren, T., … Tohen, M. (2014). Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders. J Affect Disord, 168, 439–451. https://doi.org/10.1016/j.jad.2014.06.056
Calabrese, Joseph R., Maurizio Fava, George Garibaldi, Heinz Grunze, Andrew D. Krystal, Thomas Laughren, Wayne Macfadden, Robert Marin, Andrew A. Nierenberg, and Mauricio Tohen. “Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders.J Affect Disord 168 (October 2014): 439–51. https://doi.org/10.1016/j.jad.2014.06.056.
Calabrese JR, Fava M, Garibaldi G, Grunze H, Krystal AD, Laughren T, et al. Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders. J Affect Disord. 2014 Oct;168:439–51.
Calabrese, Joseph R., et al. “Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders.J Affect Disord, vol. 168, Oct. 2014, pp. 439–51. Pubmed, doi:10.1016/j.jad.2014.06.056.
Calabrese JR, Fava M, Garibaldi G, Grunze H, Krystal AD, Laughren T, Macfadden W, Marin R, Nierenberg AA, Tohen M. Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders. J Affect Disord. 2014 Oct;168:439–451.
Journal cover image

Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

October 2014

Volume

168

Start / End Page

439 / 451

Location

Netherlands

Related Subject Headings

  • Research Design
  • Psychiatry
  • Motivation
  • Humans
  • Depressive Disorder, Major
  • Bipolar Disorder
  • Apathy
  • Antipsychotic Agents
  • Antidepressive Agents
  • 52 Psychology