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A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors.

Publication ,  Journal Article
Shi, G; Xing, L; Wu, D; Bhattacharyya, BJ; Jones, CR; McMahon, T; Chong, SYC; Chen, JA; Coppola, G; Geschwind, D; Krystal, A; Ptáček, LJ; Fu, Y-H
Published in: Neuron
September 25, 2019

Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and alleviate diseases associated with poor sleep, a greater understanding of sleep regulation is necessary. We have identified a mutation in the β1-adrenergic receptor gene in humans who require fewer hours of sleep than most. In vitro, this mutation leads to decreased protein stability and dampened signaling in response to agonist treatment. In vivo, the mice carrying the same mutation demonstrated short sleep behavior. We found that this receptor is highly expressed in the dorsal pons and that these ADRB1+ neurons are active during rapid eye movement (REM) sleep and wakefulness. Activating these neurons can lead to wakefulness, and the activity of these neurons is affected by the mutation. These results highlight the important role of β1-adrenergic receptors in sleep/wake regulation.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

September 25, 2019

Volume

103

Issue

6

Start / End Page

1044 / 1055.e7

Location

United States

Related Subject Headings

  • Wakefulness
  • Sleep, REM
  • Sleep Wake Disorders
  • Sleep
  • Receptors, Adrenergic, beta-1
  • Pontine Tegmentum
  • Pedigree
  • Neurons
  • Neurology & Neurosurgery
  • Mutation
 

Citation

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Shi, G., Xing, L., Wu, D., Bhattacharyya, B. J., Jones, C. R., McMahon, T., … Fu, Y.-H. (2019). A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors. Neuron, 103(6), 1044-1055.e7. https://doi.org/10.1016/j.neuron.2019.07.026
Shi, Guangsen, Lijuan Xing, David Wu, Bula J. Bhattacharyya, Christopher R. Jones, Thomas McMahon, SY Christin Chong, et al. “A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors.Neuron 103, no. 6 (September 25, 2019): 1044-1055.e7. https://doi.org/10.1016/j.neuron.2019.07.026.
Shi G, Xing L, Wu D, Bhattacharyya BJ, Jones CR, McMahon T, et al. A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors. Neuron. 2019 Sep 25;103(6):1044-1055.e7.
Shi, Guangsen, et al. “A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors.Neuron, vol. 103, no. 6, Sept. 2019, pp. 1044-1055.e7. Pubmed, doi:10.1016/j.neuron.2019.07.026.
Shi G, Xing L, Wu D, Bhattacharyya BJ, Jones CR, McMahon T, Chong SYC, Chen JA, Coppola G, Geschwind D, Krystal A, Ptáček LJ, Fu Y-H. A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors. Neuron. 2019 Sep 25;103(6):1044-1055.e7.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

September 25, 2019

Volume

103

Issue

6

Start / End Page

1044 / 1055.e7

Location

United States

Related Subject Headings

  • Wakefulness
  • Sleep, REM
  • Sleep Wake Disorders
  • Sleep
  • Receptors, Adrenergic, beta-1
  • Pontine Tegmentum
  • Pedigree
  • Neurons
  • Neurology & Neurosurgery
  • Mutation