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Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.

Publication ,  Journal Article
McClintock, SM; Choi, J; Deng, Z-D; Appelbaum, LG; Krystal, AD; Lisanby, SH
Published in: J ECT
June 2014

For many patients with neuropsychiatric illnesses, standard psychiatric treatments with mono or combination pharmacotherapy, psychotherapy, and transcranial magnetic stimulation are ineffective. For these patients with treatment-resistant neuropsychiatric illnesses, a main therapeutic option is electroconvulsive therapy (ECT). Decades of research have found ECT to be highly effective; however, it can also result in adverse neurocognitive effects. Specifically, ECT results in disorientation after each session, anterograde amnesia for recently learned information, and retrograde amnesia for previously learned information. Unfortunately, the neurocognitive effects and underlying mechanisms of action of ECT remain poorly understood. The purpose of this paper was to synthesize the multiple moderating and mediating factors that are thought to underlie the neurocognitive effects of ECT into a coherent model. Such factors include demographic and neuropsychological characteristics, neuropsychiatric symptoms, ECT technical parameters, and ECT-associated neurophysiological changes. Future research is warranted to evaluate and test this model, so that these findings may support the development of more refined clinical seizure therapy delivery approaches and efficacious cognitive remediation strategies to improve the use of this important and widely used intervention tool for neuropsychiatric diseases.

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Published In

J ECT

DOI

EISSN

1533-4112

Publication Date

June 2014

Volume

30

Issue

2

Start / End Page

165 / 176

Location

United States

Related Subject Headings

  • Risk Factors
  • Psychiatry
  • Neuropsychological Tests
  • Mental Disorders
  • Humans
  • Electroconvulsive Therapy
  • Cognition Disorders
  • 5203 Clinical and health psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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McClintock, S. M., Choi, J., Deng, Z.-D., Appelbaum, L. G., Krystal, A. D., & Lisanby, S. H. (2014). Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy. J ECT, 30(2), 165–176. https://doi.org/10.1097/YCT.0000000000000137
McClintock, Shawn M., Jimmy Choi, Zhi-De Deng, Lawrence G. Appelbaum, Andrew D. Krystal, and Sarah H. Lisanby. “Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.J ECT 30, no. 2 (June 2014): 165–76. https://doi.org/10.1097/YCT.0000000000000137.
McClintock SM, Choi J, Deng Z-D, Appelbaum LG, Krystal AD, Lisanby SH. Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy. J ECT. 2014 Jun;30(2):165–76.
McClintock, Shawn M., et al. “Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.J ECT, vol. 30, no. 2, June 2014, pp. 165–76. Pubmed, doi:10.1097/YCT.0000000000000137.
McClintock SM, Choi J, Deng Z-D, Appelbaum LG, Krystal AD, Lisanby SH. Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy. J ECT. 2014 Jun;30(2):165–176.

Published In

J ECT

DOI

EISSN

1533-4112

Publication Date

June 2014

Volume

30

Issue

2

Start / End Page

165 / 176

Location

United States

Related Subject Headings

  • Risk Factors
  • Psychiatry
  • Neuropsychological Tests
  • Mental Disorders
  • Humans
  • Electroconvulsive Therapy
  • Cognition Disorders
  • 5203 Clinical and health psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences