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Sarah Hollingsworth Lisanby

Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
DUMC Box 3620, Durham, NC 27710
Room 5-4232. Red Zone, Box 3620 DUMC, Durham, NC 27710

Overview


Sarah Hollingsworth “Holly” Lisanby, MD, is an experienced translational researcher and innovator of neuromodulation technologies to study and treat psychiatric disorders. Dr. Lisanby is Director of the Division of Translational Research at NIMH, which funds research on the discovery of preventions, treatments, and cures for mental illness across the lifespan.  She is Founder and Director of the Noninvasive Neuromodulation Unit in the NIMH Intramural Research Program, a multi-disciplinary clinical research program specializing in the innovation of new brain stimulation tools to measure and modulate neuroplasticity to improve mental health.  Dr. Lisanby is former Chair of the Duke Department of Psychiatry & Behavioral Sciences, and JP Gibbons Endowed Professor at Duke University.  She founded and directed both the Duke and the Columbia University Divisions of Brain Stimulation, where she built interdisciplinary research programs specializing in the convergence of Psychiatry, Neuroscience and Engineering. She co-led the NIH BRAIN Initiative Team focused on large-scale neural recording and modulation devices. Dr. Lisanby has been principal investigator on a series of federally funded grants on the development of novel neuromodulation technologies, including the rational design of magnetic and electrical seizure therapies.  Her team pioneered magnetic seizure therapy (MST) as a novel depression treatment from the stages of animal testing, first-in-human, and international clinical trials.  She led a series of studies involving transcranial magnetic stimulation, electroconvulsive therapy (ECT), MST, vagus nerve stimulation, and deep brain stimulation. She has received numerous international recognitions, including the Max Hamilton Memorial Prize of the Collegium Internationale Neuro-Psychopharmacologicum, the Gerald Klerman Award from the National Depression and Manic Depression Association, and the Eva King Killam Research Award from the American College of Neuropsychopharmacology.  She has been a member of the NIMH Board of Scientific Counselors. Dr. Lisanby served on the FDA Neurological Devices Advisory Panel and has held key leadership positions with numerous professional associations, including serving as President for the Association for Convulsive Therapy/International Society of Neurostimulation, and the International Society for Transcranial Stimulation, and Chair of the American Psychiatric Association Task Force to Revise the Practice on ECT. 

Current Appointments & Affiliations


Professor Emeritus of Psychiatry and Behavioral Sciences · 2020 - Present Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences
Faculty Network Member of the Duke Institute for Brain Sciences · 2011 - Present Duke Institute for Brain Sciences, University Institutes and Centers

In the News


Published May 13, 2018
Anderson Cooper: Is Shock Therapy Making a Comeback?
Published November 18, 2015
Dr. Sarah Lisanby: The return of electroshock therapy
Published March 4, 2015
Lisanby named Director of Translational Research for NIMH

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Recent Publications


Computational Models of High-Definition Electroconvulsive Therapy for Focal or Multitargeting Treatment.

Journal Article J ECT · December 1, 2025 Attempts to dissociate electroconvulsive therapy (ECT) therapeutic efficacy from cognitive side effects of ECT include modifying electrode placement, but traditional electrode placements employing 2 large electrodes are inherently nonfocal, limiting the ab ... Full text Link to item Cite

Resting-State and Task-Based Functional Connectivity Reveal Distinct mPFC and Hippocampal Network Alterations in Major Depressive Disorder.

Journal Article Brain Sci · October 22, 2025 Background: Resting-state functional connectivity (RSFC) is widely used to identify abnormal brain function associated with depression. Resting-state functional magnetic resonance imaging (fMRI) scans have many potential confounds, and task-based FC might ... Full text Link to item Cite
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Recent Grants


Neuromodulation Enhanced Cognitive Restructuring for Emotion Dysregulation: A Proof of Concept Study

ResearchMentor · Awarded by Brain and Behavior Research Foundation · 2016 - 2019

FAST-MAS Phase 2A - Duke Site

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2017

Janssen Resident Psychiatric Research Scholars Program

FellowshipPrincipal Investigator · Awarded by American Psychiatric Association · 2015 - 2016

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Education, Training & Certifications


Duke University, School of Medicine · 1991 M.D.