Scholars@Duke
Sarah Hollingsworth Lisanby

Sarah Hollingsworth Lisanby

Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
lisan001@win.duke.edu
DUMC Box 3620, Durham, NC 27710
Room 5-4232. Red Zone, Box 3620 DUMC, Durham, NC 27710

Selected Publications

NIMH perspectives on future directions in neuroimaging for mental health.

Journal Article Neuropsychopharmacology · November 2024 NIMH's mission is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. New imaging techniques hold great promise for improving our understanding of the path ... Full text Link to item Cite

Computational Models of High-Definition Electroconvulsive Therapy for Focal or Multitargeting Treatment.

Journal Article J ECT · August 26, 2024 Attempts to dissociate electroconvulsive therapy (ECT) therapeutic efficacy from cognitive side effects of ECT include modifying electrode placement, but traditional electrode placements employing 2 large electrodes are inherently nonfocal, limiting the ab ... Full text Link to item Cite

Site- and frequency-specific enhancement of visual search performance with online individual alpha frequency (IAF) repetitive transcranial magnetic stimulation (rTMS) to the inferior frontal junction.

Journal Article Cereb Cortex · July 25, 2024 In this study, repetitive transcranial magnetic stimulation was applied to either the right inferior frontal junction or the right inferior parietal cortex during a difficult aerial reconnaissance search task to test its capacity to improve search performa ... Full text Link to item Cite

Electroconvulsive Therapy Across Nations: A 2022 Survey of Practice.

Journal Article J ECT · June 1, 2024 OBJECTIVES: We aimed to characterize worldwide electroconvulsive therapy (ECT) practice and compare practice across nations and global regions. METHOD: Our anonymous survey was open on SurveyMonkey.com from January to June 2022. We sent invitations to prov ... Full text Link to item Cite

Electroconvulsive Therapy in the United States: A 2022 Survey of Practice.

Journal Article J ECT · June 1, 2024 OBJECTIVES: This study aimed to describe current US electroconvulsive therapy (ECT) practice, identify practice changes over time, and inform discussion of practice. METHOD: Our anonymous survey was open on SurveyMonkey.com from January to June 2022. We se ... Full text Link to item Cite

The Use of Cognitive Paired Associative Stimulation (C-PAS) in Investigating and Remediating the Effects of Sleep Deprivation on Working Memory in Humans: The Importance of State-Dependency

Journal Article Current Sleep Medicine Reports · June 1, 2024 Purpose of Review: Sleep deprivation is a global health issue, and the resultant cognitive deficits can be debilitating. A series of studies reported success with individually neuronavigated transcranial magnetic stimulation (TMS), coupled with online task ... Full text Cite

Electric Field Characteristics of Rotating Permanent Magnet Stimulation.

Journal Article Bioengineering (Basel) · March 6, 2024 Neurostimulation devices that use rotating permanent magnets are being explored for their potential therapeutic benefits in patients with psychiatric and neurological disorders. This study aims to characterize the electric field (E-field) for ten configura ... Full text Link to item Cite

Clinical Outcomes of Magnetic Seizure Therapy vs Electroconvulsive Therapy for Major Depressive Episode: A Randomized Clinical Trial.

Journal Article JAMA Psychiatry · March 1, 2024 IMPORTANCE: Electroconvulsive therapy (ECT) is highly effective and rapid in treating depression, but it carries a risk of significant cognitive adverse effects. Magnetic seizure therapy (MST), an investigational antidepressant treatment, may maintain the ... Full text Link to item Cite

How electroconvulsive therapy works in the treatment of depression: is it the seizure, the electricity, or both?

Journal Article Neuropsychopharmacology · January 2024 We have known for nearly a century that triggering seizures can treat serious mental illness, but what we do not know is why. Electroconvulsive Therapy (ECT) works faster and better than conventional pharmacological interventions; however, those benefits c ... Full text Link to item Cite

The use of noninvasive brain stimulation techniques in autism spectrum disorder.

Journal Article Autism Res · January 2024 Noninvasive brain stimulation (NIBS) techniques, including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), have recently emerged as alternative, nonpharmacological interventions for a variety of psych ... Full text Link to item Cite

Design and methodology for a proof of mechanism study of individualized neuronavigated continuous Theta burst stimulation for auditory processing in adolescents with autism spectrum disorder.

Journal Article Front Psychiatry · 2024 It has been suggested that aberrant excitation/inhibition (E/I) balance and dysfunctional structure and function of relevant brain networks may underlie the symptoms of autism spectrum disorder (ASD). However, the nomological network linking these construc ... Full text Link to item Cite

Lessons learned from an fMRI-guided rTMS study on performance in a numerical Stroop task.

Journal Article PLoS One · 2024 The Stroop task is a well-established tool to investigate the influence of competing visual categories on decision making. Neuroimaging as well as rTMS studies have demonstrated the involvement of parietal structures, particularly the intraparietal sulcus ... Full text Link to item Cite

Educating the next generation of psychiatrists in the use of clinical neuromodulation therapies: what should all psychiatry residents know?

Journal Article Front Psychiatry · 2024 A variety of neuromodulation treatments are available today and more are on the way, but are tomorrow's psychiatrists prepared to incorporate these tools into their patients' care plans? This article addresses the need for training in clinical neuromodulat ... Full text Link to item Cite

Distinguishing Convulsive Syncope From Seizure Induced by Repetitive Transcranial Magnetic Stimulation: A Case Report.

Journal Article J ECT · December 1, 2023 Repetitive transcranial magnetic stimulation (rTMS) is Food and Drug Administration cleared for clinical use in treatment-resistant depression and a growing list of other disorders. The clinical uptake of rTMS has been facilitated by its relatively benign ... Full text Link to item Cite

Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study.

Journal Article J Affect Disord · October 15, 2023 BACKGROUND: Growing evidence indicates that anhedonia is a multifaceted construct. This study examined the possibility of identifying subgroups of people with anhedonia using multiple reward-related measures to provide greater understanding the Research Do ... Full text Link to item Cite

Network-level dynamics underlying a combined rTMS and psychotherapy treatment for major depressive disorder: An exploratory network analysis.

Journal Article Int J Clin Health Psychol · 2023 BACKGROUND: Despite the growing use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for depression, there is a limited understanding of the mechanisms of action and how potential treatment-related brain changes help to characterize tr ... Full text Open Access Link to item Cite

Future directions in psychiatric neurosurgery: Proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical neuromodulation for psychiatric disorders.

Journal Article Brain Stimul · 2023 OBJECTIVE: Despite advances in the treatment of psychiatric diseases, currently available therapies do not provide sufficient and durable relief for as many as 30-40% of patients. Neuromodulation, including deep brain stimulation (DBS), has emerged as a po ... Full text Link to item Cite

Recent advances in electroconvulsive therapy in clinical practice and research.

Journal Article Fac Rev · 2023 Electroconvulsive therapy (ECT), the oldest somatic therapy still in use in psychiatry today, remains one of the most effective therapeutic interventions for a wide variety of psychiatric disorders. In this article, we review some of the recent advances in ... Full text Link to item Cite

New directions in psychiatric drug development: promising therapeutics in the pipeline.

Journal Article Expert Opin Drug Discov · 2023 INTRODUCTION: Psychiatric disorders are a leading cause of disability worldwide, calling for an urgent need for new treatments, early detection, early intervention, and precision medicine. Drug discovery and development in psychiatry continues to expand in ... Full text Link to item Cite

Digitalized transcranial electrical stimulation: A consensus statement.

Journal Article Clin Neurophysiol · November 2022 OBJECTIVE: Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, comb ... Full text Link to item Cite

Promising Strategies for Treatment-Resistant Depression

Journal Article Psychiatric Times · May 1, 2022 Cite

Using diffusion tensor imaging to effectively target TMS to deep brain structures

Conference NeuroImage · April 1, 2022 TMS has become a powerful tool to explore cortical function, and in parallel has proven promising in the development of therapies for various psychiatric and neurological disorders. Unfortunately, much of the inference of the direct effects of TMS has been ... Full text Cite

Using diffusion tensor imaging to effectively target TMS to deep brain structures.

Journal Article Neuroimage · April 1, 2022 TMS has become a powerful tool to explore cortical function, and in parallel has proven promising in the development of therapies for various psychiatric and neurological disorders. Unfortunately, much of the inference of the direct effects of TMS has been ... Full text Link to item Cite

Longitudinal Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Pharmacotherapy in Major Depressive Disorder in Older Adults: Phase 2 of the PRIDE Study.

Journal Article The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · January 2022 ObjectiveThere is limited information regarding neurocognitive outcomes of right unilateral ultrabrief pulse width electroconvulsive therapy (RUL-UB ECT) combined with pharmacotherapy in older adults with major depressive disorder. We report longi ... Full text Cite

Noninvasive neuromodulation of the prefrontal cortex in mental health disorders.

Journal Article Neuropsychopharmacology · January 2022 More than any other brain region, the prefrontal cortex (PFC) gives rise to the singularity of human experience. It is therefore frequently implicated in the most distinctly human of all disorders, those of mental health. Noninvasive neuromodulation, inclu ... Full text Link to item Cite

Enhancing Cognitive Restructuring with Concurrent Repetitive Transcranial Magnetic Stimulation: A Transdiagnostic Randomized Controlled Trial.

Journal Article Psychother Psychosom · 2022 INTRODUCTION: Emotional dysregulation constitutes a serious public health problem in need of novel transdiagnostic treatments. OBJECTIVE: To this aim, we developed and tested a one-time intervention that integrates behavioral skills training with concurren ... Full text Link to item Cite

Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary Study.

Journal Article Front Hum Neurosci · 2022 Transcranial magnetic stimulation (TMS) was used to test the functional role of parietal and prefrontal cortical regions activated during a playing card Guilty Knowledge Task (GKT). Single-pulse TMS was applied to 15 healthy volunteers at each of three tar ... Full text Link to item Cite

Network-based rTMS to modulate working memory: The difficult choice of effective parameters for online interventions.

Journal Article Brain Behav · November 2021 BACKGROUND: Online repetitive transcranialmagnetic stimulation (rTMS) has been shown to modulate working memory (WM) performance in a site-specific manner, with behavioral improvements due to stimulation of the dorsolateral prefrontal cortex (DLPFC), and i ... Full text Link to item Cite

Non-invasive brain stimulation and psychiatric symptoms in neurological disorders

Conference Journal of the Neurological Sciences · October 2021 Full text Cite

Training in the practice of noninvasive brain stimulation: Recommendations from an IFCN committee.

Journal Article Clin Neurophysiol · March 2021 As the field of noninvasive brain stimulation (NIBS) expands, there is a growing need for comprehensive guidelines on training practitioners in the safe and effective administration of NIBS techniques in their various research and clinical applications. Th ... Full text Link to item Cite

Next-generation seizure therapy

Chapter · February 10, 2021 Electroconvulsive therapy (ECT) is highly effective in treating severe psychiatric conditions, but its cognitive side effects have been a limiting factor in its clinical use. Fortunately, decades of research have led to improvements in ECT technique that h ... Full text Cite

The oxford handbook of transcranial stimulation: Second edition

Book · February 10, 2021 Transcranial stimulation encompasses noninvasive methods that transmit physical fields-such as magnetic, electric, ultrasound, and light-to the brain to modulate its function. The most widespread approach, transcranial magnetic stimulation (TMS), has emerg ... Full text Cite

Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.

Journal Article Clin Neurophysiol · January 2021 This article is based on a consensus conference, promoted and supported by the International Federation of Clinical Neurophysiology (IFCN), which took place in Siena (Italy) in October 2018. The meeting intended to update the ten-year-old safety guidelines ... Full text Link to item Cite

Enhancing Cognitive Restructuring with Concurrent Repetitive Transcranial Magnetic Stimulation: A Transdiagnostic Randomized Controlled Trial

Journal Article · 2021 Introduction Emotional dysregulation constitutes a serious public health problem in need of novel transdiagnostic treatments. Objective To this aim, we developed and tested a one-time intervention that integrates behavioral skills trainin ... Full text Cite

Repetitive Transcranial Magnetic Stimulation for Adolescent Major Depressive Disorder: A Focus on Neurodevelopment.

Journal Article Front Psychiatry · 2021 Adolescent depression is a potentially lethal condition and a leading cause of disability for this age group. There is an urgent need for novel efficacious treatments since half of adolescents with depression fail to respond to current therapies and up to ... Full text Link to item Cite

A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation.

Journal Article Nat Protoc · November 2020 Transcranial magnetic stimulation (TMS) is a noninvasive method to stimulate the cerebral cortex that has applications in psychiatry, such as in the treatment of depression and anxiety. Although many TMS targeting methods that use figure-8 coils exist, man ... Full text Link to item Cite

5.6 NEUROMODULATION IN CHILDREN AND ADOLESCENTS: THE DEVIL IS IN THE DOSING

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2020 Full text Cite

Neurocognitive subgroups in major depressive disorder.

Journal Article Neuropsychology · September 2020 BACKGROUND: Major depressive disorder (MDD) is commonly associated with neurocognitive dysfunction. However, there remains substantial heterogeneity between patients and inconsistent findings regarding the magnitude and prevalence of specific neurocognitiv ... Full text Link to item Cite

Older adults benefit from more widespread brain network integration during working memory.

Journal Article Neuroimage · September 2020 Neuroimaging evidence suggests that the aging brain relies on a more distributed set of cortical regions than younger adults in order to maintain successful levels of performance during demanding cognitive tasks. However, it remains unclear how task demand ... Full text Open Access Link to item Cite

Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).

Journal Article Neuropsychopharmacology · September 2020 Anhedonia remains a major clinical issue for which there is few effective interventions. Untreated or poorly controlled anhedonia has been linked to worse disease course and increased suicidal behavior across disorders. Taking a proof-of-mechanism approach ... Full text Link to item Cite

Electroconvulsive therapy (ECT) for moderate-severity major depression among the elderly: Data from the pride study.

Journal Article J Affect Disord · September 1, 2020 BACKGROUND: Electroconvulsive therapy (ECT) is usually reserved for treatment of severe major depressive disorder (MDD), but may be equally effective in the treatment of moderate-severity MDD. This possibility, however, has only been studied to a very limi ... Full text Link to item Cite

Structural Controllability Predicts Functional Patterns and Brain Stimulation Benefits Associated with Working Memory.

Journal Article J Neurosci · August 26, 2020 The brain is an inherently dynamic system, and much work has focused on the ability to modify neural activity through both local perturbations and changes in the function of global network ensembles. Network controllability is a recent concept in network n ... Full text Link to item Cite

A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.

Journal Article Nat Med · May 2020 The National Institute of Mental Health (NIMH) 'fast-fail' approach seeks to improve too-often-misleading early-phase drug development methods by incorporating biomarker-based proof-of-mechanism (POM) testing in phase 2a. This first comprehensive applicati ... Full text Link to item Cite

Site-Specific Effects of Online rTMS during a Working Memory Task in Healthy Older Adults.

Journal Article Brain Sci · April 27, 2020 The process of manipulating information within working memory is central to many cognitive functions, but also declines rapidly in old age. Improving this process could markedly enhance the health-span in older adults. The current pre-registered, randomize ... Full text Open Access Link to item Cite

Efficacy and acceptability of transcranial direct current stimulation (tDCS) for major depressive disorder: An individual patient data meta-analysis.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · April 20, 2020 We evaluated the efficacy and acceptability of transcranial direct current stimulation (tDCS) for treating acute depressive episodes using individual patient data that provide more precise estimates than aggregate data meta-analysis. A systematic review of ... Full text Link to item Cite

Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Venlafaxine in Geriatric Depression: Phase 1 of the PRIDE Study.

Journal Article Am J Geriatr Psychiatry · March 2020 OBJECTIVE: There is limited information regarding the tolerability of electroconvulsive therapy (ECT) combined with pharmacotherapy in elderly adults with major depressive disorder (MDD). Addressing this gap, we report acute neurocognitive outcomes from Ph ... Full text Open Access Link to item Cite

Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects.

Journal Article Neuropsychopharmacology · March 2020 Much of the mechanistic research on anxiety focuses on subcortical structures such as the amygdala; however, less is known about the distributed cortical circuit that also contributes to anxiety expression. One way to learn about this circuit is to probe c ... Full text Link to item Cite

Neurocognitive effects of transcranial direct current stimulation (tDCS) in unipolar and bipolar depression: Findings from an international randomized controlled trial.

Journal Article Depress Anxiety · March 2020 OBJECTIVE: Transcranial direct current stimulation (tDCS) has been found to have antidepressant effects and may have beneficial neurocognitive effects. However, prior research has produced an unclear understanding of the neurocognitive effects of repeated ... Full text Link to item Cite

Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety.

Journal Article Transl Psychiatry · February 17, 2020 Anxiety disorders are the most prevalent mental disorders, with few effective neuropharmacological treatments, making treatments development critical. While noninvasive neuromodulation can successfully treat depression, few treatment targets have been iden ... Full text Link to item Cite

Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders.

Journal Article Annu Rev Pharmacol Toxicol · January 6, 2020 Device-based neuromodulation of brain circuits is emerging as a promising new approach in the study and treatment of psychiatric disorders. This work presents recent advances in the development of tools for identifying neurocircuits as therapeutic targets ... Full text Link to item Cite

Using Transcranial Magnetic Stimulation to Test a Network Model of Perceptual Decision Making in the Human Brain.

Journal Article Front Hum Neurosci · 2020 Previous research has suggested that the lateral occipital cortex (LOC) is involved with visual decision making, and specifically with the accumulation of information leading to a decision. In humans, this research has been primarily based on imaging and e ... Full text Link to item Cite

Utilizing transcranial direct current stimulation to enhance laparoscopic technical skills training: A randomized controlled trial.

Journal Article Brain Stimul · 2020 BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that delivers constant, low electrical current resulting in changes to cortical excitability. Prior work suggests it may enhance motor learning giving ... Full text Open Access Link to item Cite

Optimizing the Effects of Theta-Burst Stimulation (TBS)

Conference BIOLOGICAL PSYCHIATRY · 2020 Cite

Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies.

Journal Article Neurosci Biobehav Rev · December 2019 Online repetitive transcranial magnetic stimulation (rTMS), applied while subjects are performing a task, is widely used to disrupt brain regions underlying cognition. However, online rTMS has also induced "paradoxical enhancement". Given the rapid prolife ... Full text Open Access Link to item Cite

Ethical Challenges of Risk, Informed Consent, and Posttrial Responsibilities in Human Research With Neural Devices: A Review.

Journal Article JAMA Neurol · December 1, 2019 IMPORTANCE: Developing more and better diagnostic and therapeutic tools for central nervous system disorders is an ethical imperative. Human research with neural devices is important to this effort and a critical focus of the National Institutes of Health ... Full text Link to item Cite

Accuracy of robotic coil positioning during transcranial magnetic stimulation.

Journal Article J Neural Eng · September 17, 2019 OBJECTIVE: Robotic positioning systems for transcranial magnetic stimulation (TMS) promise improved accuracy and stability of coil placement, but there is limited data on their performance. Investigate the usability, accuracy, and limitations of robotic co ... Full text Link to item Cite

Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation Effects on Resting-State Functional Connectivity Between the Postcentral Gyrus and the Insula.

Journal Article Brain Connect · May 2019 The insular cortex supports the conscious awareness of physical and emotional sensations, and the ability to modulate the insula could have important clinical applications in psychiatry. Repetitive transcranial magnetic stimulation (rTMS) uses transient ma ... Full text Open Access Link to item Cite

The Dynamic Duo: Combining noninvasive brain stimulation with cognitive interventions.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · March 8, 2019 Pharmacotherapy, psychotherapy, and non-invasive brain stimulation (NIBS)1 each show efficacy in the treatment of psychiatric disorders; however, more efficacious interventions are needed as reflected by an overall unmet need in mental health care. While e ... Full text Link to item Cite

George Niederehe, Ph.D.: Tribute and Thanks.

Journal Article Am J Geriatr Psychiatry · March 2019 Full text Link to item Cite

Online repetitive transcranial magnetic stimulation during working memory in younger and older adults: A randomized within-subject comparison.

Journal Article PLoS One · 2019 Working memory is the ability to perform mental operations on information that is stored in a flexible, limited capacity buffer. The ability to manipulate information in working memory is central to many aspects of human cognition, but also declines with h ... Full text Open Access Link to item Cite

Accuracy of robotic coil positioning during transcranial magnetic stimulation

Journal Article · 2019 Objective Robotic positioning systems for transcranial magnetic stimulation (TMS) promise improved accuracy and stability of coil placement, but there is limited data on their performance. This text investigates the usability, accuracy, and limita ... Full text Cite

Structural controllability predicts functional patterns and brain stimulation benefits associated with working memory

Journal Article · 2019 Summary The brain is an inherently dynamic system, and much work has focused on the ability to modify neural activity through both local perturbations and changes in the function of global network ensembles. Network controllability is a recent con ... Full text Cite

Magnetic Seizure Therapy: Towards Personalized Seizure Therapy for Major Depression.

Journal Article Pers Med Psychiatry · 2019 Magnetic seizure therapy (MST) is a noninvasive neuromodulation therapy under investigation for the treatment of severe neuropsychiatric disorders. MST involves inducing a therapeutic seizure under anesthesia in a setting similar to electroconvulsive thera ... Full text Link to item Cite

Complementary topology of maintenance and manipulation brain networks in working memory.

Journal Article Sci Rep · December 13, 2018 Working memory (WM) is assumed to consist of a process that sustains memory representations in an active state (maintenance) and a process that operates on these activated representations (manipulation). We examined evidence for two distinct, concurrent co ... Full text Open Access Link to item Cite

On the Concurrent Use of Self-System Therapy and Functional Magnetic Resonance Imaging-Guided Transcranial Magnetic Stimulation as Treatment for Depression.

Journal Article J ECT · December 2018 OBJECTIVES: Despite the growing use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for unipolar depression, its typical effect sizes have been modest, and methodological and conceptual challenges remain regarding how to optimize its ... Full text Open Access Link to item Cite

The State of the NIH BRAIN Initiative.

Journal Article J Neurosci · July 18, 2018 The BRAIN Initiative arose from a grand challenge to "accelerate the development and application of new technologies that will enable researchers to produce dynamic pictures of the brain that show how individual brain cells and complex neural circuits inte ... Full text Link to item Cite

Differences in Seizure Expression Between Magnetic Seizure Therapy and Electroconvulsive Shock.

Journal Article J ECT · June 2018 OBJECTIVE: Evidence suggests that magnetic seizure therapy (MST) results in fewer side effects than electroconvulsive treatment, both in humans treated with electroconvulsive therapy (ECT) as well as in the animal preclinical model that uses electroconvuls ... Full text Link to item Cite

Excitatory TMS Boosts Memory Representations

Journal Article · March 10, 2018 Abstract Brain stimulation technologies have seen increasing application in basic science investigations, specifically towards the goal of improving memory functioning. However, proposals concerning the neural mechanisms underlying cognitive enhancement of ... Full text Cite

Effects of continuation electroconvulsive therapy on quality of life in elderly depressed patients: A randomized clinical trial.

Journal Article J Psychiatr Res · February 2018 We examined whether electroconvulsive therapy (ECT) plus medications ("STABLE + PHARM" group) had superior HRQOL compared with medications alone ("PHARM" group) as continuation strategy after successful acute right unilateral ECT for major depressive disor ... Full text Link to item Cite

Effects of a Course of Right Unilateral Ultrabrief Pulse Electroconvulsive Therapy Combined With Venlafaxine on Insomnia Symptoms in Elderly Depressed Patients.

Conference J Clin Psychiatry · 2018 OBJECTIVE: Antidepressant medications have a variety of effects on sleep, apart from their antidepressant effects. It is unknown whether electroconvulsive therapy (ECT) has effects on perceived sleep in depressed patients. This secondary analysis examines ... Full text Link to item Cite

Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression.

Journal Article J Clin Psychiatry · 2018 OBJECTIVE: To provide expert recommendations for the safe and effective application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive disorder (MDD). PARTICIPANTS: Participants included a group of 17 expert clinici ... Full text Link to item Cite

International randomized-controlled trial of transcranial Direct Current Stimulation in depression.

Journal Article Brain Stimul · 2018 BACKGROUND: Evidence suggests that transcranial Direct Current Stimulation (tDCS) has antidepressant effects in unipolar depression, but there is limited information for patients with bipolar depression. Additionally, prior research suggests that brain der ... Full text Link to item Cite

Rigor and reproducibility in research with transcranial electrical stimulation: An NIMH-sponsored workshop.

Journal Article Brain Stimul · 2018 BACKGROUND: Neuropsychiatric disorders are a leading source of disability and require novel treatments that target mechanisms of disease. As such disorders are thought to result from aberrant neuronal circuit activity, neuromodulation approaches are of inc ... Full text Link to item Cite

Dr McClintock and Colleagues Reply.

Journal Article J Clin Psychiatry · 2018 Full text Link to item Cite

Dr McClintock and Colleagues Reply.

Journal Article J Clin Psychiatry · 2018 Full text Link to item Cite

Excitatory TMS modulates memory representations.

Journal Article Cogn Neurosci · 2018 Brain stimulation technologies have seen increasing application in basic science investigations, specifically toward the goal of improving memory function. However, proposals concerning the neural mechanisms underlying cognitive enhancement often rely on s ... Full text Link to item Cite

Pre-treatment attentional processing speed and antidepressant response to transcranial direct current stimulation: Results from an international randomized controlled trial.

Journal Article Brain Stimul · 2018 BACKGROUND: Transcranial direct current stimulation (tDCS) has promising antidepressant effects, however, clinical trials have shown variable efficacy. Pre-treatment neurocognitive functioning has previously been identified as an inter-individual predictor ... Full text Link to item Cite

A systematic study of repetitive transcranial magnetic stimulation to enhance working memory manipulation abilities

Journal Article · 2018 A core element of human working memory (WM) is the ability to perform mental operations on information that is stored in a flexible, limited capacity buffer. Given the profound importance of such WM manipulation (WM-M) abilities, there is a concerted effor ... Full text Cite

Spatio-temporally specific transcranial magnetic stimulation to test the locus of perceptual decision making in the human brain

Journal Article · 2018 Previous research modeling EEG, fMRI and behavioral data has identified three spatially distributed brain networks that activate in temporal sequence, and are thought to enable perceptual decision-making during face-versus-car categorization. These studies ... Full text Cite

Frequency-specific neuromodulation of local and distant connectivity in aging and episodic memory function.

Journal Article Hum Brain Mapp · December 2017 A growing literature has focused on the brain's ability to augment processing in local regions by recruiting distant communities of neurons in response to neural decline or insult. In particular, both younger and older adult populations recruit bilateral p ... Full text Link to item Cite

Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial.

Journal Article Lancet Psychiatry · November 2017 BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate white matter has shown promise as an intervention for patients with chronic, unremitting depression. To test the safety and efficacy of DBS for treatment-resistant depression, a prospect ... Full text Link to item Cite

Electric field characteristics of low-field synchronized transcranial magnetic stimulation (sTMS).

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · July 2017 Low-field synchronized trancranial magnetic stimulation (sTMS) was hypothesized to have significant therapeutic effects in patients with major depressive disorder by entrainment of neural oscillations. The sTMS device is comprised of neodymium magnets moun ... Full text Link to item Cite

Minimum Electric Field Exposure for Seizure Induction with Electroconvulsive Therapy and Magnetic Seizure Therapy.

Journal Article Neuropsychopharmacology · May 2017 Lowering and individualizing the current amplitude in electroconvulsive therapy (ECT) has been proposed as a means to produce stimulation closer to the neural activation threshold and more focal seizure induction, which could potentially reduce cognitive s ... Full text Link to item Cite

Reprint of ''Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention''.

Journal Article Neuroimage · May 1, 2017 The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than ... Full text Open Access Link to item Cite

New directions in the rational design of electrical and magnetic seizure therapies: individualized Low Amplitude Seizure Therapy (iLAST) and Magnetic Seizure Therapy (MST).

Journal Article Int Rev Psychiatry · April 2017 Electroconvulsive therapy remains a key treatment option for severe cases of depression, but undesirable side-effects continue to limit its use. Innovations in the design of novel seizure therapies seek to improve its risk benefit ratio through enhanced co ... Full text Link to item Cite

Evidence for an Evolutionarily Conserved Memory Coding Scheme in the Mammalian Hippocampus.

Journal Article J Neurosci · March 8, 2017 Decades of research identify the hippocampal formation as central to memory storage and recall. Events are stored via distributed population codes, the parameters of which (e.g., sparsity and overlap) determine both storage capacity and fidelity. However, ... Full text Link to item Cite

Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention.

Journal Article Neuroimage · March 1, 2017 The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than ... Full text Open Access Link to item Cite

P238 Working memory enhancement in young and older adults using rTMS

Journal Article Clinical Neurophysiology · March 2017 Full text Cite

Effects of a right unilateral ultrabrief pulse electroconvulsive therapy course on health related quality of life in elderly depressed patients.

Journal Article J Affect Disord · February 2017 INTRODUCTION: Patients with Major Depressive Disorder (MDD) referred for electroconvulsive therapy (ECT) have poorer Health Related Quality of Life (HRQOL), compared with other patients with MDD, but ECT is associated with significant and durable improveme ... Full text Link to item Cite

A naturalistic, multi-site study of repetitive transcranial magnetic stimulation therapy for depression.

Journal Article J Affect Disord · January 15, 2017 BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) was approved in 2008 in the United States, and there are relatively few studies describing its use in regular clinical practice since approval. METHODS: From April 2011 to October 2014, ten si ... Full text Link to item Cite

Using diffusion tensor imaging to identify corticospinal tract projection patterns in children with unilateral spastic cerebral palsy.

Journal Article Dev Med Child Neurol · January 2017 AIM: To determine whether diffusion tensor imaging (DTI) can be an independent assessment for identifying the corticospinal tract (CST) projecting from the more-affected motor cortex in children with unilateral spastic cerebral palsy (CP). METHOD: Twenty c ... Full text Link to item Cite

Pulse Width Affects Scalp Sensation of Transcranial Magnetic Stimulation.

Journal Article Brain Stimul · 2017 BACKGROUND: Scalp sensation and pain comprise the most common side effect of transcranial magnetic stimulation (TMS), which can reduce tolerability and complicate experimental blinding. OBJECTIVE: We explored whether changing the width of single TMS pulses ... Full text Link to item Cite

A Novel Strategy for Continuation ECT in Geriatric Depression: Phase 2 of the PRIDE Study.

Journal Article Am J Psychiatry · November 1, 2016 OBJECTIVE: The randomized phase (phase 2) of the Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy and tolerability of continuation ECT plus medication compared with medication alone in depressed geriatric patients after a succ ... Full text Link to item Cite

Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study.

Journal Article Am J Psychiatry · November 1, 2016 OBJECTIVE: The Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy of right unilateral ultrabrief pulse electroconvulsive therapy (ECT) combined with venlafaxine for the treatment of geriatric depression. METHOD: PRIDE was a two- ... Full text Link to item Cite

Study design and methodology for a multicentre, randomised controlled trial of transcranial direct current stimulation as a treatment for unipolar and bipolar depression.

Journal Article Contemp Clin Trials · November 2016 Transcranial Direct Current Stimulation (tDCS) is a new, non-invasive neuromodulation approach for treating depression that has shown promising efficacy. The aim of this trial was to conduct the first international, multicentre randomised controlled trial ... Full text Link to item Cite

Skilled Bimanual Training Drives Motor Cortex Plasticity in Children With Unilateral Cerebral Palsy.

Journal Article Neurorehabil Neural Repair · October 2016 Background Intensive bimanual therapy can improve hand function in children with unilateral spastic cerebral palsy (USCP). We compared the effects of structured bimanual skill training versus unstructured bimanual practice on motor outcomes and motor map p ... Full text Link to item Cite

Comparison of electric field strength and spatial distribution of electroconvulsive therapy and magnetic seizure therapy in a realistic human head model.

Journal Article Eur Psychiatry · August 2016 BACKGROUND: This study examines the strength and spatial distribution of the electric field induced in the brain by electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). METHODS: The electric field induced by standard (bilateral, right unilat ... Full text Link to item Cite

Long-Term Efficacy of Repeated Daily Prefrontal Transcranial Magnetic Stimulation (TMS) In Treatmnt-Resistant Depression.

Journal Article Focus (Am Psychiatr Publ) · April 2016 (Reprinted with permission from Depression and Anxiety 2012; 29:833-890). ... Full text Link to item Cite

Magnetic Stimulation for Depression: Subconvulsive and Convulsive Approaches

Chapter · March 5, 2016 Treatment-resistant depression remains an important clinical problem in need of novel treatment solutions. Electro-convulsive therapy and transcranial magnetic stimulation are two neuromodulation techniques with promise in the treatment of severe and chron ... Full text Cite

Enhancement of Neuromodulation with Novel Pulse Shapes Generated by Controllable Pulse Parameter Transcranial Magnetic Stimulation.

Journal Article Brain Stimul · 2016 BACKGROUND: Standard repetitive transcranial magnetic stimulation (rTMS) devices generate bidirectional biphasic sinusoidal pulses that are energy efficient, but may be less effective than monophasic pulses that induce a more unidirectional electric field. ... Full text Link to item Cite

Recent Developments in Noninvasive Neuromodulation for Mood and Anxiety Disorders

Journal Article Current Behavioral Neuroscience Reports · September 1, 2015 Noninvasive neuromodulation refers to a family of device-based interventions that apply electrical or magnetic fields, either at convulsive or subconvulsive levels, to the brain through the intact skull to modulate neural function. This is a rapidly evolvi ... Full text Cite

Electric Field Model of Transcranial Electric Stimulation in Nonhuman Primates: Correspondence to Individual Motor Threshold.

Journal Article IEEE Trans Biomed Eng · September 2015 OBJECTIVE: To develop a pipeline for realistic head models of nonhuman primates (NHPs) for simulations of noninvasive brain stimulation, and use these models together with empirical threshold measurements to demonstrate that the models capture individual a ... Full text Link to item Cite

S.05.04 Prolonging remission in depressed elderly (PRIDE; NCT01028508)

Conference European Neuropsychopharmacology · September 2015 Full text Cite

Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy.

Journal Article Neuropsychopharmacology · August 2015 Electroconvulsive therapy (ECT) at conventional current amplitudes (800-900 mA) is highly effective but carries the risk of cognitive side effects. Lowering and individualizing the current amplitude may reduce side effects by virtue of a less intense and m ... Full text Link to item Cite

Brain network properties in depressed patients receiving seizure therapy: A graph theoretical analysis of peri-treatment resting EEG.

Conference Annu Int Conf IEEE Eng Med Biol Soc · August 2015 Electroconvulsive therapy (ECT), the most efficacious antidepressant therapy for treatment-resistant depression, has been reported to alter functional brain network architecture by down-regulating connectivity in frontotemporal circuitry. Magnetic seizure ... Full text Link to item Cite

Magnetic Seizure Therapy for the Treatment of Depression

Chapter · June 5, 2015 The magnetic approach to seizure therapy is based on the hypothesis that the electrical currents induced in deep brain structures by electroconvulsive therapy (ECT) may contribute to the adverse cognitive side effects. This chapter reviews the rationale fo ... Full text Cite

Can We Use Brain Oscillations to Guide Treatment of MDD?

Conference BIOLOGICAL PSYCHIATRY · May 1, 2015 Link to item Cite

Neuromodulation for mood and memory: from the engineering bench to the patient bedside.

Journal Article Curr Opin Neurobiol · February 2015 Brain stimulation, in the form of electroconvulsive therapy (ECT), has long been a gold standard treatment for depression, but today, the field of neuromodulation is rapidly changing with the advent of newer and more precise tools to alter neuroplasticity ... Full text Link to item Cite

Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial.

Journal Article World Psychiatry · February 2015 Major depressive disorder (MDD) is a prevalent and disabling condition, and many patients do not respond to available treatments. Deep transcranial magnetic stimulation (dTMS) is a new technology allowing non-surgical stimulation of relatively deep brain a ... Full text Link to item Cite

Effect of anatomical variability on electric field characteristics of electroconvulsive therapy and magnetic seizure therapy: a parametric modeling study.

Journal Article IEEE Trans Neural Syst Rehabil Eng · January 2015 Electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) are conventionally applied with a fixed stimulus current amplitude, which may result in differences in the neural stimulation strength and focality across patients due to interindividual an ... Full text Link to item Cite

Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome.

Journal Article Brain Stimul · 2015 BACKGROUND: A small proportion of individuals with Tourette syndrome (TS) have a lifelong course of illness that fails to respond to conventional treatments. Open label studies have suggested that low frequency (1-Hz) repetitive transcranial magnetic stimu ... Full text Link to item Cite

Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression.

Journal Article Brain Stimul · 2015 BACKGROUND: Transcranial Magnetic Stimulation (TMS) customarily uses high-field electromagnets to achieve therapeutic efficacy in Major Depressive Disorder (MDD). Low-field magnetic stimulation also may be useful for treatment of MDD, with fewer treatment- ... Full text Link to item Cite

Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.

Journal Article J ECT · June 2014 For many patients with neuropsychiatric illnesses, standard psychiatric treatments with mono or combination pharmacotherapy, psychotherapy, and transcranial magnetic stimulation are ineffective. For these patients with treatment-resistant neuropsychiatric ... Full text Open Access Link to item Cite

Coil design considerations for deep transcranial magnetic stimulation.

Journal Article Clin Neurophysiol · June 2014 OBJECTIVES: To explore the field characteristics and design tradeoffs of coils for deep transcranial magnetic stimulation (dTMS). METHODS: We simulated parametrically two dTMS coil designs on a spherical head model using the finite element method, and comp ... Full text Link to item Cite

Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS).

Journal Article Neuroimage · January 15, 2014 Here we review the usefulness of transcranial magnetic stimulation (TMS) in modulating cortical networks in ways that might produce performance enhancements in healthy human subjects. To date over sixty studies have reported significant improvements in spe ... Full text Link to item Cite

Improvement in quality of life with left prefrontal transcranial magnetic stimulation in patients with pharmacoresistant major depression: acute and six month outcomes.

Journal Article Brain Stimul · 2014 BACKGROUND: Transcranial magnetic stimulation (TMS) is a safe and effective treatment for major depression. We describe quality of life (QOL) outcomes from acute treatment with TMS, and describe the durability of benefit across 24-weeks. METHODS: Three hun ... Full text Link to item Cite

Coil design considerations for deep transcranial magnetic stimulation

Journal Article Clinical Neurophysiology · 2014 Cite

GABA level, gamma oscillation, and working memory performance in schizophrenia.

Journal Article Neuroimage Clin · 2014 A relationship between working memory impairment, disordered neuronal oscillations, and abnormal prefrontal GABA function has been hypothesized in schizophrenia; however, in vivo GABA measurements and gamma band neural synchrony have not yet been compared ... Full text Link to item Cite

A novel model incorporating two variability sources for describing motor evoked potentials.

Journal Article Brain Stimul · 2014 OBJECTIVE: Motor evoked potentials (MEPs) play a pivotal role in transcranial magnetic stimulation (TMS), e.g., for determining the motor threshold and probing cortical excitability. Sampled across the range of stimulation strengths, MEPs outline an input- ... Full text Link to item Cite

Stimulation strength and focality of electroconvulsive therapy and magnetic seizure therapy in a realistic head model.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2014 This study examines the characteristics of the electric field (E-field) induced in the brain by electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). The electric field induced by five ECT electrode configurations (bilateral, bifrontal, right ... Full text Link to item Cite

Determination of motor threshold using visual observation overestimates transcranial magnetic stimulation dosage: safety implications.

Journal Article Clin Neurophysiol · January 2014 OBJECTIVE: While the standard has been to define motor threshold (MT) using EMG to measure motor cortex response to transcranial magnetic stimulation (TMS), another method of determining MT using visual observation of muscle twitch (OM-MT) has emerged in c ... Full text Link to item Cite

Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome.

Journal Article Psychiatry Res · December 30, 2013 Low-frequency repetitive transcranial magnetic stimulation (rTMS) to supplementary motor area (SMA) showed clinical benefit in obsessive-compulsive disorder (OCD). Here we tested whether clinical improvement was associated with enhanced cortical inhibition ... Full text Link to item Cite

Controlling stimulation strength and focality in electroconvulsive therapy via current amplitude and electrode size and spacing: comparison with magnetic seizure therapy.

Journal Article J ECT · December 2013 OBJECTIVES: Understanding the relationship between the stimulus parameters of electroconvulsive therapy (ECT) and the electric field characteristics could guide studies on improving risk/benefit ratio. We aimed to determine the effect of current amplitude ... Full text Link to item Cite

Topography of seizures induced by electroconvulsive therapy and magnetic seizure therapy

Conference International IEEE/EMBS Conference on Neural Engineering, NER · December 1, 2013 We present the first topographical characterization of seizures induced by ultrabrief pulse width right unilateral electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). Topographical electroencephalogram (EEG) was acquired during treatments i ... Full text Cite

Anatomical variability predicts individual differences in transcranial electric stimulation motor threshold.

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · December 1, 2013 We have proposed that the current amplitude in electroconvulsive therapy (ECT) be lowered to produce stimulation closer to the neural activation threshold and individualized to account for anatomical variability across patients. A novel approach to individ ... Cite

Single pulse TMS differentially modulates reward behavior.

Journal Article Neuropsychologia · December 2013 Greater knowledge of cortical brain regions in reward processing may set the stage for using transcranial magnetic stimulation (TMS) as a treatment in patients with avolition, apathy or other drive-related symptoms. This study examined the effects of singl ... Full text Link to item Cite

Controlling Stimulation Strength and Focality in Electroconvulsive Therapy via Current Amplitude and Electrode Size and Spacing: Comparison With Magnetic Seizure Therapy.

Journal Article J ECT · November 7, 2013 Understanding the relationship between the stimulus parameters of electroconvulsive therapy (ECT) and the electric field characteristics could guide studies on improving risk/benefit ratio. We aimed to determine the effect of current amplitude and electrod ... Full text Link to item Cite

The painfulness of active, but not sham, transcranial magnetic stimulation decreases rapidly over time: results from the double-blind phase of the OPT-TMS Trial.

Journal Article Brain Stimul · November 2013 BACKGROUND: Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) over several weeks is an FDA approved treatment for major depression. Although rTMS is generally safe when administered using the FDA guidelines, there are a number of si ... Full text Link to item Cite

Vagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: acute and chronic effects.

Journal Article Brain Stimul · July 2013 BACKGROUND: Major depressive disorder is a prevalent, disabling, and often chronic or recurrent psychiatric condition. About 35% of patients fail to respond to conventional treatment approaches and are considered to have treatment-resistant depression (TRD ... Full text Link to item Cite

Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation.

Journal Article Clin Neurophysiol · July 2013 OBJECTIVE: To demonstrate the use of a novel controllable pulse parameter TMS (cTMS) device to characterize human corticospinal tract physiology. METHODS: Motor threshold and input-output (IO) curve of right first dorsal interosseus were determined in 26 a ... Full text Link to item Cite

Extended remediation of sleep deprived-induced working memory deficits using fMRI-guided transcranial magnetic stimulation.

Journal Article Sleep · June 1, 2013 STUDY OBJECTIVES: We attempted to prevent the development of working memory (WM) impairments caused by sleep deprivation using fMRI-guided repetitive transcranial magnetic stimulation (rTMS). Novel aspects of our fMRI-guided rTMS paradigm included the use ... Full text Link to item Cite

A feasibility study of a new method for electrically producing seizures in man: focal electrically administered seizure therapy [FEAST].

Journal Article Brain Stimul · May 2013 BACKGROUND: Electroconvulsive therapy (ECT) remains the most effective acute treatment for severe major depression, but with significant risk of adverse cognitive effects. Unidirectional electrical stimulation with a novel electrode placement and geometry ... Full text Link to item Cite

Lateralized effects of prefrontal repetitive transcranial magnetic stimulation on emotional working memory.

Journal Article Exp Brain Res · May 2013 Little is known about the neural correlates underlying the integration of working memory and emotion processing. We investigated the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) applied over the left or right dorsolateral pr ... Full text Link to item Cite

Prefrontal rTMS for treating depression: location and intensity results from the OPT-TMS multi-site clinical trial.

Journal Article Brain Stimul · March 2013 BACKGROUND: Motor cortex localization and motor threshold determination often guide Transcranial Magnetic Stimulation (TMS) placement and intensity settings for non-motor brain stimulation. However, anatomic variability results in variability of placement ... Full text Link to item Cite

Applications of transcranial magnetic stimulation and magnetic seizure therapy in the study and treatment of disorders related to cerebral aging.

Journal Article Dialogues Clin Neurosci · March 2013 Transcranial magnetic stimulation (TMS) can be used to probe cortical function and treat neuropsychiatric illnesses. TMS has demonstrated neuroplastic effects akin to long-term potentiation and long-term depression, and therapeutic applications are in deve ... Full text Link to item Cite

Disruption of component processes of spatial working memory by electroconvulsive shock but not magnetic seizure therapy.

Journal Article Int J Neuropsychopharmacol · February 2013 Self-ordered spatial working memory measures provide important information regarding underlying cognitive strategies, such as stereotypy. This strategy is based on repetitive sequential selection of a spatial pattern once a correct sequence has been identi ... Full text Link to item Cite

Randomized sham controlled trial of repetitive transcranial magnetic stimulation to the dorsolateral prefrontal cortex for the treatment of panic disorder with comorbid major depression.

Journal Article J Affect Disord · January 10, 2013 BACKGROUND: In an open-label trial low-frequency repetitive transcranial magnetic stimulation (rTMS) to the right dorsolateral prefrontal cortex (DLPFC) significantly improved symptoms of panic disorder and major depression. Here we present data of a rando ... Full text Link to item Cite

Electric field depth-focality tradeoff in transcranial magnetic stimulation: simulation comparison of 50 coil designs.

Journal Article Brain Stimul · January 2013 BACKGROUND: Various transcranial magnetic stimulation (TMS) coil designs are available or have been proposed. However, key coil characteristics such as electric field focality and attenuation in depth have not been adequately compared. Knowledge of the coi ... Full text Link to item Cite

Electroconvulsive therapy device classification: response to FDA advisory panel hearing and recommendations.

Journal Article J Clin Psychiatry · January 2013 Electroconvulsive therapy (ECT) is a safe and highly effective treatment for management of acute episodes of a variety of serious mental disorders, particularly for major depressive episodes that are resistant to multiple interventions with treatment alter ... Full text Link to item Cite

Electric field characteristics of electroconvulsive therapy with individualized current amplitude: a preclinical study.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2013 This study examines the characteristics of the electric field induced in the brain by electroconvulsive therapy (ECT) with individualized current amplitude. The electric field induced by bilateral (BL), bifrontal (BF), right unilateral (RUL), and frontomed ... Full text Link to item Cite

Anatomical variability predicts individual differences in transcranial electric stimulation motor threshold.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2013 We have proposed that the current amplitude in electroconvulsive therapy (ECT) be lowered to produce stimulation closer to the neural activation threshold and individualized to account for anatomical variability across patients. A novel approach to individ ... Full text Link to item Cite

Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study.

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · December 1, 2012 This study investigates the stimulation strength and focality of electroconvulsive therapy (ECT) with individualized current amplitude in a nonhuman primate (NHP) model. We generated an anatomically realistic finite element model of a NHP head incorporatin ... Cite

How does deep brain stimulation work?

Journal Article Biol Psychiatry · December 1, 2012 Full text Link to item Cite

TMS in the study and treatment of anxiety disorders

Chapter · November 21, 2012 A few studies of transcranial magnetic stimulation (TMS) as an anxiety disorder treatment have been reported. In treatment studies, the focal application of TMS in the treatment of anxiety disorders has been guided by the present understanding of the neuro ... Full text Cite

Therapeutic potential of TMS-induced plasticity in the prefrontal cortex

Chapter · November 21, 2012 This article discusses synaptic plasticity as a potential mechanism of enduring changes in function observed after relatively brief periods of repetitive (r)TMS. Plasticity is a use dependent enduring change in neural structure and function. The characteri ... Full text Cite

Methodological issues in clinical trial design for TMS

Chapter · November 21, 2012 This article explores the emergence of transcranial magnetic stimulation (TMS) as a new therapeutic approach and the implications of this technology for the study and treatment of neuropsychiatric disorders, with a focus on major depression. Relapse, chron ... Full text Cite

Self-enhancement processing in the default network: a single-pulse TMS study.

Journal Article Exp Brain Res · November 2012 Much research has been done on positive self-evaluation and its relationship to mental health. However, little is known about its neural underpinnings. Imaging studies have suggested that the brain's default network is involved with self-related processing ... Full text Link to item Cite

Long-term efficacy of repeated daily prefrontal transcranial magnetic stimulation (TMS) in treatment-resistant depression.

Journal Article Depress Anxiety · October 2012 BACKGROUND: A few studies have examined the durability of transcranial magnetic stimulation (TMS) antidepressant benefit once patients remitted. This study examined the long-term durability of clinical benefit from TMS using a protocol-specified TMS taper ... Full text Link to item Cite

Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices.

Journal Article Brain Stimul · October 2012 BACKGROUND: The growing use of transcranial electric and magnetic (EM) brain stimulation in basic research and in clinical applications necessitates a clear understanding of what constitutes the dose of EM stimulation and how it should be reported. METHODS ... Full text Link to item Cite

ECT use in unipolar and bipolar depression.

Journal Article J ECT · September 2012 BACKGROUND: Few studies have compared response to electroconvulsive therapy (ECT) in depressed patients with unipolar and bipolar disorder. METHODS: We reviewed the charts of inpatients with unipolar or bipolar depression who received open treatment with r ... Full text Link to item Cite

The ethics of research on deep brain stimulation for depression: decisional capacity and therapeutic misconception.

Journal Article Ann N Y Acad Sci · August 2012 Research on deep brain stimulation (DBS) for treatment-resistant depression appears promising, but concerns have been raised about the decisional capacity of severely depressed patients and their potential misconceptions about the research. We assessed 31 ... Full text Link to item Cite

Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy.

Journal Article Arch Gen Psychiatry · May 2012 CONTEXT: Postmortem studies have found evidence of γ-aminobutyric acid (GABA) deficits in fast-spiking, parvalbumin-positive interneurons in the prefrontal cortex in schizophrenia. Magnetic resonance spectroscopy studies in unmedicated patients have report ... Full text Link to item Cite

Dual-tasking alleviated sleep deprivation disruption in visuomotor tracking: an fMRI study.

Journal Article Brain Cogn · April 2012 Effects of dual-responding on tracking performance after 49-h of sleep deprivation (SD) were evaluated behaviorally and with functional magnetic resonance imaging (fMRI). Continuous visuomotor tracking was performed simultaneously with an intermittent colo ... Full text Link to item Cite

Direct injection of noise to the visual cortex decreases accuracy but increases decision confidence.

Journal Article J Neurophysiol · March 2012 The relationship between accuracy and confidence in psychophysical tasks traditionally has been assumed to be mainly positive, i.e., the two typically increase or decrease together. However, recent studies have reported examples of exceptions, where confid ... Full text Link to item Cite

Regional electric field induced by electroconvulsive therapy in a realistic finite element head model: influence of white matter anisotropic conductivity.

Journal Article Neuroimage · February 1, 2012 We present the first computational study investigating the electric field (E-field) strength generated by various electroconvulsive therapy (ECT) electrode configurations in specific brain regions of interest (ROIs) that have putative roles in the therapeu ... Full text Link to item Cite

Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2012 This study investigates the stimulation strength and focality of electroconvulsive therapy (ECT) with individualized current amplitude in a nonhuman primate (NHP) model. We generated an anatomically realistic finite element model of a NHP head incorporatin ... Full text Link to item Cite

Somatic treatments for mood disorders.

Journal Article Neuropsychopharmacology · January 2012 Somatic treatments for mood disorders represent a class of interventions available either as a stand-alone option, or in combination with psychopharmacology and/or psychotherapy. Here, we review the currently available techniques, including those already i ... Full text Link to item Cite

Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study.

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · 2012 Cite

A conceptual introduction to cognitive remediation for memory deficits associated with right unilateral electroconvulsive therapy.

Journal Article J ECT · December 2011 OBJECTIVE: Although electroconvulsive therapy (ECT) is a highly effective treatment for people with severe depression, many patients report that treatment-induced memory problems are the most disturbing and serious adverse effects, affecting quality of lif ... Full text Link to item Cite

Improving the antidepressant efficacy of transcranial magnetic stimulation: maximizing the number of stimulations and treatment location in treatment-resistant depression.

Journal Article Depress Anxiety · November 2011 OBJECTIVE: To assess the efficacy of increasing the number of fast left repetitive transcranial magnetic stimulations (rTMS) (10 Hz @ 120% of motor threshold (MT) over the left dorsolateral prefrontal cortex (DLPFC)) needed to achieve remission in treatmen ... Full text Link to item Cite

Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception.

Journal Article AJOB Prim Res · October 2011 BACKGROUND: Deep brain stimulation (DBS) for treatment-resistant depression (TRD) is the focus of great interest and numerous studies. Given the state of this research, the risks of DBS, the uncertainty of direct benefits, and the potential for therapeutic ... Full text Link to item Cite

Transcranial magnetic stimulation: a neuroscientific probe of cortical function in schizophrenia.

Journal Article Biol Psychiatry · July 1, 2011 Transcranial magnetic stimulation (TMS) is a neuropsychiatric tool that can serve as a useful method to better understand the neurobiology of cognitive function, behavior, and emotional processing. The purpose of this article is to examine the utility of T ... Full text Link to item Cite

Repetitive transcranial magnetic stimulator with controllable pulse parameters.

Journal Article J Neural Eng · June 2011 The characteristics of transcranial magnetic stimulation (TMS) pulses influence the physiological effect of TMS. However, available TMS devices allow very limited adjustment of the pulse parameters. We describe a novel TMS device that uses a circuit topolo ... Full text Link to item Cite

Temporo-parietal junction stimulation in the treatment of depersonalization disorder.

Journal Article Psychiatry Res · March 30, 2011 This is the first clinical trial of repetitive Transcranial Magnetic Stimulation (rTMS) in depersonalization disorder (DPD). After 3weeks of right temporo-parietal junction (TPJ) rTMS, 6/12 patients responded. Five responders received 3 more weeks of right ... Full text Link to item Cite

High-frequency prefrontal repetitive transcranial magnetic stimulation for the negative symptoms of schizophrenia: a case series.

Journal Article J ECT · March 2011 OBJECTIVES: The negative symptoms of schizophrenia are difficult to treat and are predictors of poor outcome. New somatic treatments are needed to reverse these symptoms and improve function. One promising approach is repetitive transcranial magnetic stimu ... Full text Link to item Cite

Electric field strength and focality in electroconvulsive therapy and magnetic seizure therapy: a finite element simulation study.

Journal Article J Neural Eng · February 2011 We present the first computational study comparing the electric field induced by various electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) paradigms. Four ECT electrode configurations (bilateral, bifrontal, right unilateral, and focal elec ... Full text Link to item Cite

Corticomotor excitability during observation and imagination of a work of art

Journal Article Frontiers in Human Neuroscience · January 1, 2011 We examine the effects of the artistic representation - here exemplified by Michelangelo's Expulsion from Paradise - of an action on the motor system. Using single and paired- pulse transcranial magnetic stimulation we analyze corticomotor excitability dur ... Full text Cite

Corticomotor Excitability during Observation and Imagination of a Work of Art.

Journal Article Front Hum Neurosci · 2011 We examine the effects of the artistic representation - here exemplified by Michelangelo's Expulsion from Paradise - of an action on the motor system. Using single and paired- pulse transcranial magnetic stimulation we analyze corticomotor excitability dur ... Full text Link to item Cite

Influence of white matter conductivity anisotropy on electric field strength induced by electroconvulsive therapy.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2011 The goal of this study is to investigate the influence of white matter conductivity anisotropy on the electric field strength induced by electroconvulsive therapy (ECT). We created an anatomically-realistic finite element human head model incorporating tis ... Full text Link to item Cite

Repetitive transcranial magnetic stimulator with controllable pulse parameters (cTMS).

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · December 1, 2010 We describe a novel transcranial magnetic stimulation (TMS) device that uses a circuit topology incorporating two energy-storage capacitors and two insulated-gate bipolar transistors (IGBTs) to generate near-rectangular electric field E-field) pulses with ... Cite

Electroconvulsive therapy in the presence of deep brain stimulation implants: electric field effects.

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · December 1, 2010 The safety of electroconvulsive therapy (ECT) in patients who have deep brain stimulation (DBS) implants represents a significant clinical issue. A major safety concern is the presence of burr holes and electrode anchoring devices in the skull, which may a ... Cite

Regional electric field induced by electroconvulsive therapy: a finite element simulation study.

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · December 1, 2010 The goal of this study is to investigate the regional distribution of the electric field (E-field) strength induced by electroconvulsive therapy (ECT), and to contrast clinically relevant electrode configurations through finite element (FE) analysis. An FE ... Cite

Transcranial magnetic stimulation in the presence of deep brain stimulation implants: Induced electrode currents.

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · December 1, 2010 The safety of transcranial magnetic stimulation (TMS) in patients with an implanted deep brain stimulation (DBS) systems has not been thoroughly investigated. One potential safety hazard is the induction of significant voltages in the subcutaneous leads in ... Cite

Self-specific processing in the default network: a single-pulse TMS study.

Journal Article Exp Brain Res · November 2010 In examining neural processing specific to the self, primarily by contrasting self-related stimuli with non-self-related stimuli (i.e., self vs. other), neuroimaging studies have activated a consistent set of regions, including medial prefrontal cortex (MP ... Full text Link to item Cite

Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study.

Journal Article Brain Stimul · October 2010 BACKGROUND: Although transcranial magnetic stimulation (TMS) can be an effective acute antidepressant treatment, few studies systematically examine persistence of benefit. OBJECTIVE: We assessed the durability of antidepressant effect after acute response ... Full text Link to item Cite

Electroconvulsive therapy stimulus parameters: rethinking dosage.

Journal Article J ECT · September 2010 In this article, we review the parameters that define the electroconvulsive therapy (ECT) electrical stimulus and discuss their biophysical roles. We also present the summary metrics of charge and energy that are conventionally used to describe the dose of ... Full text Link to item Cite

Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial.

Journal Article Arch Gen Psychiatry · May 2010 CONTEXT: Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been studied as a potential treatment for depression, but previous work had mixed outcomes and did not adequately mask sham conditions. OBJECTIVE: To test whether daily ... Full text Link to item Cite

Lateral prefrontal cortex and self-control in intertemporal choice.

Journal Article Nat Neurosci · May 2010 Disruption of function of left, but not right, lateral prefrontal cortex (LPFC) with low-frequency repetitive transcranial magnetic stimulation (rTMS) increased choices of immediate rewards over larger delayed rewards. rTMS did not change choices involving ... Full text Link to item Cite

Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder.

Journal Article Int J Neuropsychopharmacol · March 2010 In open trials, 1-Hz repetitive transcranial magnetic stimulation (rTMS) to the supplementary motor area (SMA) improved symptoms and normalized cortical hyper-excitability of patients with obsessive-compulsive disorder (OCD). Here we present the results of ... Full text Link to item Cite

WFSBP Guidelines on Brain Stimulation Treatments in Psychiatry.

Journal Article World J Biol Psychiatry · February 2010 Full text Link to item Cite

Brain stimulation in the treatment of anxiety disorders

Chapter · January 1, 2010 Introduction Brain stimulation represents a growing family of interventions that alter brain function using electrical fields that are either directly applied or indirectly induced using rapidly alternating magnetic fields. Brain stimulation techniques inc ... Full text Cite

Transcranial magnetic stimulation in the presence of deep brain stimulation implants: Induced electrode currents.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2010 The safety of transcranial magnetic stimulation (TMS) in patients with an implanted deep brain stimulation (DBS) systems has not been thoroughly investigated. One potential safety hazard is the induction of significant voltages in the subcutaneous leads in ... Full text Link to item Cite

Repetitive transcranial magnetic stimulator with controllable pulse parameters (cTMS).

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2010 We describe a novel transcranial magnetic stimulation (TMS) device that uses a circuit topology incorporating two energy-storage capacitors and two insulated-gate bipolar transistors (IGBTs) to generate near-rectangular electric field E-field) pulses with ... Full text Link to item Cite

Electroconvulsive therapy in the presence of deep brain stimulation implants: electric field effects.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2010 The safety of electroconvulsive therapy (ECT) in patients who have deep brain stimulation (DBS) implants represents a significant clinical issue. A major safety concern is the presence of burr holes and electrode anchoring devices in the skull, which may a ... Full text Link to item Cite

Regional electric field induced by electroconvulsive therapy: a finite element simulation study.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2010 The goal of this study is to investigate the regional distribution of the electric field (E-field) strength induced by electroconvulsive therapy (ECT), and to contrast clinically relevant electrode configurations through finite element (FE) analysis. An FE ... Full text Link to item Cite

Electroconvulsive therapy in the presence of deep brain stimulation implants: electric field effects.

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · 2010 Cite

Unaltered neuronal and glial counts in animal models of magnetic seizure therapy and electroconvulsive therapy.

Journal Article Neuroscience · December 29, 2009 Anatomical evidence of brain damage from electroconvulsive therapy (ECT) is lacking; but there are no modern stereological studies in primates documenting its safety. Magnetic seizure therapy (MST) is under development as a less invasive form of convulsive ... Full text Link to item Cite

Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research.

Journal Article Clin Neurophysiol · December 2009 This article is based on a consensus conference, which took place in Certosa di Pontignano, Siena (Italy) on March 7-9, 2008, intended to update the previous safety guidelines for the application of transcranial magnetic stimulation (TMS) in research and c ... Full text Link to item Cite

Effect of anatomical variability on neural stimulation strength and focality in electroconvulsive therapy (ECT) and magnetic seizure therapy (MST).

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · December 1, 2009 We present a quantitative comparison of two metrics-neural stimulation strength and focality-in electrocon-vulsive therapy (ECT) and magnetic seizure therapy (MST) using finite-element method (FEM) simulation in a spherical head model. Five stimulation mod ... Cite

FDA considers classification of ECT.

Journal Article CNS Spectr · December 2009 Full text Link to item Cite

The Structure of the Lived Experience for Persons Having Undergone rTMS for Depression Treatment.

Journal Article J Am Psychiatr Nurses Assoc · October 2009 OBJECTIVE: This phenomenological research study reports preliminary findings about experiences of persons undergoing repeated transcranial magnetic stimulation (rTMS) for depression treatment. METHODS: Giorgi's phenomenology was the method used to describe ... Full text Link to item Cite

Neurophysiological characterization of high-dose magnetic seizure therapy: comparisons with electroconvulsive shock and cognitive outcomes.

Journal Article J ECT · September 2009 Magnetic seizure therapy (MST) is under development as a means of improving cognitive outcomes with convulsive therapy through achieving better control over therapeutic seizure induction than is possible with conventional electroconvulsive therapy. In this ... Full text Link to item Cite

Translational development strategy for magnetic seizure therapy.

Journal Article Exp Neurol · September 2009 Electroconvulsive therapy (ECT) has unparalleled antidepressant efficacy, but its cognitive side effects may be persistent. Research suggests that the side effects may be at least partially dissociable from the therapeutic effects of ECT, suggesting that d ... Full text Link to item Cite

Differential heart rate response to magnetic seizure therapy (MST) relative to electroconvulsive therapy: a nonhuman primate model.

Journal Article Neuroimage · September 2009 Electroconvulsive therapy (ECT) is an effective treatment for severe depression; however, the induced therapeutic seizure acts on the autonomic nervous system and results in significant cardiac effects. This is an important consideration particularly in th ... Full text Link to item Cite

Focal electrically administered seizure therapy: a novel form of ECT illustrates the roles of current directionality, polarity, and electrode configuration in seizure induction.

Journal Article Neuropsychopharmacology · July 2009 Electroconvulsive therapy (ECT) is a mainstay in the treatment of severe, medication-resistant depression. The antidepressant efficacy and cognitive side effects of ECT are influenced by the position of the electrodes on the head and by the degree to which ... Full text Link to item Cite

Brain Stimulation Therapies for Clinicians

Journal Article American Journal of Psychiatry · June 2009 Full text Cite

Regional cerebral blood flow and metabolic rate in persistent Lyme encephalopathy.

Journal Article Arch Gen Psychiatry · May 2009 CONTEXT: There is controversy regarding whether objective neurobiological abnormalities exist after intensive antibiotic treatment for Lyme disease. OBJECTIVES: To determine whether patients with a history of well-characterized Lyme disease and persistent ... Full text Link to item Cite

Decreasing procedural pain over time of left prefrontal rTMS for depression: initial results from the open-label phase of a multi-site trial (OPT-TMS).

Journal Article Brain Stimul · April 2009 BACKGROUND: There is much interest in whether daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) over several weeks may become a clinically useful antidepressant treatment. Although rTMS appears largely safe, many patients report tha ... Full text Link to item Cite

Effect of anatomical variability on neural stimulation strength and focality in electroconvulsive therapy (ECT) and magnetic seizure therapy (MST).

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2009 We present a quantitative comparison of two metrics-neural stimulation strength and focality-in electrocon-vulsive therapy (ECT) and magnetic seizure therapy (MST) using finite-element method (FEM) simulation in a spherical head model. Five stimulation mod ... Full text Link to item Cite

Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial.

Journal Article Neuropsychopharmacology · January 2009 Randomized controlled trials support the antidepressant efficacy of transcranial magnetic stimulation (TMS); however, there is individual variability in the magnitude of response. Examination of response predictors has been hampered by methodological limit ... Full text Link to item Cite

Non-invasive brain stimulation in the detection of deception: scientific challenges and ethical consequences.

Journal Article Behav Sci Law · 2009 Tools for noninvasive stimulation of the brain, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), have provided new insights in the study of brain-behavior relationships due to their ability to directly alt ... Full text Link to item Cite

Coil design considerations for deep-brain transcranial magnetic stimulation (dTMS).

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · December 1, 2008 Deep-brain transcranial magnetic stimulation (dTMS) could provide new, non-invasive therapeutic options for various psychiatric and neurological disorders. Figures of merit (FoMs) are proposed to evaluate and compare dTMS coil designs. These FoMs character ... Cite

Toward individualized post-electroconvulsive therapy care: piloting the Symptom-Titrated, Algorithm-Based Longitudinal ECT (STABLE) intervention.

Journal Article J ECT · September 2008 OBJECTIVES: Effective strategies to prolong remission after electroconvulsive therapy (ECT) are urgently needed. Fixed schedules for continuation ECT (C-ECT) cannot adapt to early signs of impending relapse. Symptom-Titrated, Algorithm-Based Longitudinal E ... Full text Link to item Cite

Remediation of sleep-deprivation-induced working memory impairment with fMRI-guided transcranial magnetic stimulation.

Journal Article Cereb Cortex · September 2008 Repetitive transcranial magnetic stimulation (rTMS) was applied to test the role of selected cortical regions in remediating sleep-deprivation-induced deficits in visual working memory (WM) performance. Three rTMS targets were chosen using a functional mag ... Full text Link to item Cite

Brain Stimulation in Psychiatry

Journal Article · August 8, 2008 Brain stimulation spans our oldest to our newest treatment modalities in psychiatry. From the introduction of convulsive therapy in the 1930s, to the growing list of novel investigational treatments (e.g., transcranial magnetic stimulation (TMS), magnetic ... Full text Cite

Quick recovery of orientation after magnetic seizure therapy for major depressive disorder.

Journal Article Br J Psychiatry · August 2008 BACKGROUND: Magnetic seizure therapy, in which seizures are elicited with a high-frequency magnetic field, is under development as a new treatment for major depressive disorder. Its use may be justified if it produces the antidepressant effects of electroc ... Full text Link to item Cite

Differential neurophysiological effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS) in non-human primates.

Journal Article Clin EEG Neurosci · July 2008 Magnetic seizure therapy (MST) is under development as a means of reducing the side effects of electroconvulsive therapy (ECT) through enhanced control over patterns of seizure induction and spread. We previously reported that chronic treatment with MST re ... Full text Link to item Cite

Differential effects of high-dose magnetic seizure therapy and electroconvulsive shock on cognitive function.

Journal Article Biol Psychiatry · June 15, 2008 BACKGROUND: Magnetic seizure therapy (MST) is under investigation as an alternative form of convulsive therapy that induces more focal seizures and spares cortical regions involved in memory. With a newly expanded version of the Columbia University Primate ... Full text Link to item Cite

rTMS strategies for the study and treatment of schizophrenia: a review.

Journal Article Int J Neuropsychopharmacol · June 2008 Transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS) have been used increasingly over the past few years to study both the pathophysiology of schizophrenia as well as the utility of focal neuromodulation as a novel treatment for schizophrenia. ... Full text Link to item Cite

Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy.

Journal Article Brain Stimul · April 2008 BACKGROUND: While electroconvulsive therapy (ECT) in major depression is effective, cognitive effects limit its use. Reducing the width of the electrical pulse and using the right unilateral electrode placement may decrease adverse cognitive effects, while ... Full text Link to item Cite

Transcranial magnetic stimulation in the acute treatment of major depressive disorder: clinical response in an open-label extension trial.

Journal Article J Clin Psychiatry · March 2008 BACKGROUND: This report describes the results of an open-label extension study of active trans-cranial magnetic stimulation (TMS) in medication-resistant patients with major depressive disorder who did not benefit from an initial course of therapy in a pre ... Full text Link to item Cite

The efficacy of acute electroconvulsive therapy in atypical depression.

Journal Article J Clin Psychiatry · March 2008 OBJECTIVE: This study examined the characteristics and outcomes of patients with major depressive disorder (MDD), with or without atypical features, who were treated with acute bilateral electroconvulsive therapy (ECT). METHOD: Analyses were conducted with ... Full text Link to item Cite

Testing the Role of Cognitive Reserve-Associated Cortical Networks with fMRI-Guided rTMS

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2008 Link to item Cite

The author replies [13]

Journal Article New England Journal of Medicine · February 7, 2008 Cite

Electroconvulsive therapy for depression - Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · February 7, 2008 Link to item Cite

Transcranial magnetic stimulation in the treatment of major depressive disorder: a comprehensive summary of safety experience from acute exposure, extended exposure, and during reintroduction treatment.

Journal Article J Clin Psychiatry · February 2008 BACKGROUND: Transcranial magnetic stimulation (TMS) has demonstrated efficacy in the treatment of major depressive disorder; however, prior studies have provided only partial safety information. We examined the acute efficacy of TMS in a randomized sham-co ... Full text Link to item Cite

A transcranial magnetic stimulator inducing near-rectangular pulses with controllable pulse width (cTMS).

Journal Article IEEE Trans Biomed Eng · January 2008 A novel transcranial magnetic stimulation (TMS) device with controllable pulse width (PW) and near-rectangular pulse shape (cTMS) is described. The cTMS device uses an insulated gate bipolar transistor (IGBT) with appropriate snubbers to switch coil curren ... Full text Link to item Cite

Coil design considerations for deep-brain transcranial magnetic stimulation (dTMS).

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2008 Deep-brain transcranial magnetic stimulation (dTMS) could provide new, non-invasive therapeutic options for various psychiatric and neurological disorders. Figures of merit (FoMs) are proposed to evaluate and compare dTMS coil designs. These FoMs character ... Full text Link to item Cite

Dr. McClintock and Colleagues reply

Journal Article Journal of Clinical Psychiatry · January 1, 2008 Full text Cite

Magnetic seizure therapy for the treatment of depression

Journal Article Advances in Biological Psychiatry · December 1, 2007 Cognitive side effects limit the clinical utility of electroconvulsive therapy (ECT), the most effective and rapidly acting treatment for severe depression. Studies suggest that prefrontal cortical involvement may be important to preserving the efficacy of ... Full text Cite

Electroconvulsive therapy for depression.

Journal Article N Engl J Med · November 8, 2007 Full text Link to item Cite

Classical conditioned learning using transcranial magnetic stimulation.

Journal Article Exp Brain Res · November 2007 This study examined whether brain responses to transcranial magnetic stimulation (TMS) would be amenable to classical conditioning. Motor cortex in human participants was stimulated with TMS pulses, which elicited a peripheral motor response in the form of ... Full text Link to item Cite

Revisiting the backward masking deficit in schizophrenia: individual differences in performance and modeling with transcranial magnetic stimulation.

Journal Article Biol Psychiatry · October 1, 2007 BACKGROUND: Deficits in backward masking have been variably reported in schizophrenia patients, but individual differences in the expression of these deficits have not been explicitly investigated. In addition, increased knowledge of the visual system has ... Full text Link to item Cite

Repetitive Transcranial Magnetic Stimulation (rTMS) in the treatment of panic disorder (PD) with comorbid major depression.

Journal Article J Affect Disord · September 2007 BACKGROUND: Studies suggest that the dorsolateral prefrontal cortex (DLPFC) participates in neural circuitry that is dysregulated in Panic Disorder (PD) and Major Depressive Disorder (MDD). We tested whether low-frequency repetitive Transcranial Magnetic S ... Full text Link to item Cite

Neuropathologic examination after 91 ECT treatments in a 92-year-old woman with late-onset depression.

Journal Article J ECT · June 2007 Whereas pathological seizure states, such as temporal lobe epilepsy, are commonly associated with cell loss and glial scarring in the hippocampus, seizures induced via electroconvulsive therapy (ECT) have not been associated with histological evidence of n ... Full text Link to item Cite

Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates.

Journal Article J Neurosci · May 2, 2007 New neurons are generated in the adult hippocampus of many species including rodents, monkeys, and humans. Conditions associated with major depression, such as social stress, suppress hippocampal neurogenesis in rodents and primates. In contrast, all class ... Full text Link to item Cite

Motor cortex excitability after vagus nerve stimulation in major depression.

Journal Article J Clin Psychopharmacol · April 2007 Recent data suggest that inhibitory pathways may be involved in the pathophysiology of depression and in the mode of action of some antidepressant interventions. The aim of the present study was to test whether vagus nerve stimulation (VNS) can affect moto ... Full text Link to item Cite

Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey.

Journal Article Anat Rec (Hoboken) · March 2007 The rhesus monkey is widely used as an experimental animal model in the study of brain function and disease. While previous quantitative studies have provided knowledge of regional numbers, little is known of the total neocortical neuron and glial cell num ... Full text Link to item Cite

Facilitation of performance in a working memory task with rTMS stimulation of the precuneus: frequency- and time-dependent effects.

Journal Article Brain Res · January 12, 2007 Although improvements in performance due to TMS have been demonstrated with some cognitive tasks, performance improvement has not previously been demonstrated with working memory tasks. In the present study, a delayed match-to-sample task was used in which ... Full text Link to item Cite

Neurocognitive associated effects of Magnetic Seizure Therapy

Conference CLINICAL NEUROPSYCHOLOGIST · 2007 Cite

Anesthetic considerations for magnetic seizure therapy: a novel therapy for severe depression.

Journal Article Anesth Analg · July 2006 Electroconvulsive therapy (ECT) is a highly effective treatment for severe depression. However, its use is associated with significant posttreatment cognitive impairment. Magnetic seizure therapy (MST) was developed as an alternative therapy that could red ... Full text Link to item Cite

Non-pharmacological treatment modalities in children and adolescents: A review of electroconvulsive therapy, transcranial magnetic stimulation, vagus nerve stimulation, magnetic seizure therapy, and deep brain stimulation

Journal Article Clinical Neuropsychiatry · June 1, 2006 A growing range of brain stimulation techniques (Electroconvulsive Therapy, Transcranial Magnetic Stimulation, Vagus Nerve Stimulation, Magnetic Seizure Therapy, and Deep Brain Stimulation) are emerging as promising treatment modalities in a variety of med ... Cite

Evidence for impaired cortical inhibition in patients with unipolar major depression.

Journal Article Biol Psychiatry · March 1, 2006 BACKGROUND: Several lines of evidence suggest that central cortical inhibitory mechanisms, especially associated with gamma-aminobutyric acid (GABA) neurotransmission, may play a role in the pathophysiology of major depression. Transcranial magnetic stimul ... Full text Link to item Cite

Randomized controlled trial of the cognitive side-effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS).

Journal Article Int J Neuropsychopharmacol · February 2006 Magnetic seizure therapy (MST) is under development as a means of improving the cognitive side-effect profile of electroconvulsive therapy (ECT) by inducing more spatially delimited seizures that spare cortical regions involved in memory. We tested whether ... Full text Link to item Cite

Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS).

Journal Article Int J Neuropsychopharmacol · February 2006 There is evidence that motor and premotor cortex are hyperexcitable in obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS). We tested whether low-frequency repetitive transcranial magnetic stimulation (rTMS) could normalize overactive motor co ... Full text Link to item Cite

Immediate postictal effects of ECT on cerebral perfusion

Conference BIOLOGICAL PSYCHIATRY · 2006 Cite

GABA, genes and depression

Conference BIOLOGICAL PSYCHIATRY · 2006 Cite

Magnetic seizure therapy and other convulsive therapies

Journal Article Primary Psychiatry · October 1, 2005 Electroconvulsive therapy (ECT) remains an important treatment for severely depressed patients, but its use is limited by its cognitive side effects. Magnetic seizure therapy (MST) is currently being developed as a means to lower the side effects of ECT th ... Cite

Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes.

Journal Article J Clin Psychiatry · September 2005 BACKGROUND: Vagus nerve stimulation (VNS) had antidepressant effects in an initial open, acute phase pilot study of 59 participants in a treatment-resistant major depressive episode (MDE). We examined the effects of adjunctive VNS over 24 months in this co ... Full text Link to item Cite

Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings.

Journal Article J Psychiatr Res · May 2005 Cortical excitability can be assessed by transcranial magnetic stimulation (TMS). Previously we observed that TMS motor threshold (MT) was elevated in abstinent cocaine-dependent subjects. In the current study we aimed at replicating our initial finding, e ... Full text Link to item Cite

Dr. Dwork and Colleagues Reply

Journal Article American Journal of Psychiatry · January 1, 2005 Full text Cite

Astrocytic activation as evidence for brain damage.

Journal Article Am J Psychiatry · January 2005 Full text Link to item Cite

Electroconvulsive therapy and repetitive transcranial magnetic stimulation in children and adolescents: a review and report of two cases of epilepsia partialis continua.

Journal Article Child Adolesc Psychiatr Clin N Am · January 2005 Brain stimulation for the treatment of psychiatric disorders has received increasing attention over the past decade. The introduction of experimental means to stimulate the brain noninvasively with magnetic fields not only has raised interest in these nove ... Full text Link to item Cite

Magnetic seizure therapy: Development of a novel intervention for treatment resistant depression

Journal Article Clinical Neuroscience Research · July 1, 2004 Electroconvulsive therapy (ECT) is the most effective and most rapidly acting treatment for severe treatment resistant major depression, but its use is limited by its cognitive side effects. Magnetic seizure therapy (MST) is a new form of convulsive therap ... Full text Cite

Parietal cortex and representation of the mental Self.

Journal Article Proc Natl Acad Sci U S A · April 27, 2004 For a coherent and meaningful life, conscious self-representation is mandatory. Such explicit "autonoetic consciousness" is thought to emerge by retrieval of memory of personally experienced events ("episodic memory"). During episodic retrieval, functional ... Full text Link to item Cite

Absence of histological lesions in primate models of ECT and magnetic seizure therapy.

Journal Article Am J Psychiatry · March 2004 OBJECTIVE: The authors present preliminary findings from the first nonhuman primate neuropathological study of ECT to use perfusion fixation and adequate controls and the first to compare ECT with magnetic seizure therapy, to their knowledge. METHOD: Twelv ... Full text Link to item Cite

A primate model of anterograde and retrograde amnesia produced by convulsive treatment.

Journal Article J ECT · March 2004 A nonhuman primate model of the key cognitive effects of convulsive treatment was developed and tested. Rhesus macaques were trained on 3 tasks: a long-term memory task that required selection of a constant target from a background of distracters, an anter ... Full text Link to item Cite

Magnetic Seizure Therapy (MST)

Conference EUROPEAN PSYCHIATRY · 2004 Cite

Optimization of Golgi methods for impregnation of brain tissue from humans and monkeys.

Journal Article J Neurosci Methods · December 30, 2003 Golgi impregnation is unique in its ability to display the dendritic trees of large numbers of individual neurons. However, its reputation for inconsistency leaves many investigators reluctant to embrace this methodology, particularly for the study of form ... Full text Link to item Cite

Magnetic seizure therapy improves mood in refractory major depression.

Journal Article Neuropsychopharmacology · November 2003 This report describes the successful treatment of a patient suffering from an episode of drug-resistant major depression using magnetic seizure therapy (MST). The patient suffered from recurrent major depression since adolescence. MST is a novel brain stim ... Full text Link to item Cite

A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors.

Journal Article Biol Psychiatry · October 1, 2003 BACKGROUND: Long-term behavioral, immunologic, and neurochemical alterations have been found in primates exposed to adverse early rearing. METHODS: Bonnet macaque (Macaca radiata) mother-infant dyads were exposed to uncertain requirements for food procurem ... Full text Link to item Cite

Safety and feasibility of magnetic seizure therapy (MST) in major depression: randomized within-subject comparison with electroconvulsive therapy.

Journal Article Neuropsychopharmacology · October 2003 Magnetic seizure therapy (MST) is a novel means of performing convulsive therapy using rapidly alternating strong magnetic fields. MST offers greater control of intracerebral current intensity than is possible with electroconvulsive therapy (ECT). These fe ... Full text Link to item Cite

New developments in electroconvulsive therapy and magnetic seizure therapy.

Journal Article CNS Spectr · July 2003 New findings regarding the mechanisms of action of electro-convulsive therapy (ECT) have led to novel developments in treatment technique to further improve this highly effective treatment for major depression. These new approaches include novel placements ... Full text Link to item Cite

Transcranial magnetic stimulation.

Journal Article Neurosurg Clin N Am · April 2003 TMS is a powerful new tool with extremely interesting research and therapeutic potentials. Further understanding of the ways by which TMS changes neuronal function, especially as a function of its use parameters, will improve its ability to answer neurosci ... Full text Link to item Cite

Comparison of Golgi stains of human and non-human primates

Conference Schizophrenia Research · March 2003 Full text Cite

Electroconvulsive seizures induce neurogenesis in monkeys.

Conference JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY · 2003 Cite

Update on magnetic seizure therapy: a novel form of convulsive therapy.

Journal Article J ECT · December 2002 Magnetic seizure therapy (MST) refers to the use of transcranial magnetic stimulation to induce a seizure for therapeutic purposes. MST is under investigation as a means of improving the safety profile of electroconvulsive therapy (ECT). Although both MST ... Full text Link to item Cite

Applications of TMS to therapy in psychiatry.

Journal Article J Clin Neurophysiol · August 2002 Transcranial magnetic stimulation (TMS) has been applied to a growing number of psychiatric disorders as a noninvasive probe to study the underlying neurobiologic processes involved in psychiatric disorders and as a putative treatment. Transcranial magneti ... Full text Link to item Cite

Symposium 2. New Developments in Brain Stimulation.

Journal Article The Journal of ECT · March 2002 Full text Cite

Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis.

Journal Article Int J Neuropsychopharmacol · March 2002 Transcranial magnetic stimulation (TMS) is a technology that allows for non-invasive modulation of the excitability and function of discrete brain cortical areas. TMS uses alternating magnetic fields to induce electric currents in cortical tissue. In psych ... Full text Link to item Cite

Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes.

Journal Article Biol Psychiatry · February 15, 2002 BACKGROUND: Vagus nerve stimulation has shown promising results in an open, acute phase pilot study of adults in a treatment-resistant major depressive episode. This open, naturalistic follow-up study was conducted to determine whether the initial promisin ... Full text Link to item Cite

Investigation of mood disorders by transcranial magnetic stimulation

Chapter · January 1, 2002 TMS utilizes the principle of electromagnetic induction, which was first discovered by Michael Faraday in 1831. It involves the discharge of a large current (peak current: approximately 5000 amps) from a capacitor through a copper-wire coil. A rapid time-v ... Cite

Relations between functional and structural brain abnormalities in late-life depression.

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · 2002 Cite

Transcranial magnetic stimulation differentially affects speed and direction judgments.

Journal Article Exp Brain Res · October 2001 This study was conducted to determine whether humans' judgments about the speed and direction of moving stimuli was differentially affected by transcranial magnetic stimulation (TMS). Subjects viewed two successively presented moving stimuli that differed ... Full text Link to item Cite

Focal prefrontal seizures induced by bilateral ECT.

Journal Article J ECT · September 2001 INTRODUCTION: It has been proposed that the greater efficacy of bilateral (BL) over right unilateral (RUL) electroconvulsive therapy (ECT) at low stimulus intensity is due to differences in site of seizure initiation. We hypothesized that focal prefrontal ... Full text Link to item Cite

ECT in the treatment of status epilepticus.

Journal Article J ECT · September 2001 INTRODUCTION: Owing to its potent anticonvulsant actions, electroconvulsive therapy (ECT) has been proposed as an intervention for treatment-resistant seizure disorders. METHOD: We review the literature on the use of ECT in treatment-resistant epilepsy and ... Full text Link to item Cite

Therapeutic application of repetitive transcranial magnetic stimulation: a review.

Journal Article Clin Neurophysiol · August 2001 Transcranial magnetic stimulation (TMS), a non-invasive means of electrically stimulating neurons in the human cerebral cortex, is able to modify neuronal activity locally and at distant sites when delivered in series or trains of pulses. Data from stimula ... Full text Link to item Cite

Protein kinase a in major depression: the link between hypothalamic-pituitary-adrenal axis hyperactivity and neurogenesis.

Journal Article CNS Spectr · July 2001 The latest and most generative biological theories of major depression center on two major hypotheses. The first focuses on the concept that hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis leads to many of the pathological changes in the bra ... Full text Link to item Cite

ECT in bipolar and unipolar depression: differences in speed of response.

Journal Article Bipolar Disord · April 2001 OBJECTIVES: There is sparse evidence for differences in response to electroconvulsive therapy (ECT) between patients with bipolar or unipolar major depression, with virtually no information on speed of response. We contrasted a large sample of bipolar (BP) ... Full text Link to item Cite

Sham TMS: intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials.

Journal Article Biol Psychiatry · March 1, 2001 Testing the therapeutic potential of transcranial magnetic stimulation (TMS) in controlled trials requires a valid sham condition. Sham TMS is typically administered by tilting the coil 45--90 degrees off the scalp, with one or two wings of the coil touchi ... Full text Link to item Cite

Magnetic seizure therapy of major depression.

Journal Article Arch Gen Psychiatry · March 2001 Full text Link to item Cite

Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation.

Journal Article Biol Psychiatry · February 15, 2001 BACKGROUND: Transcranial magnetic stimulation (TMS) provides a noninvasive method of examining cortical inhibitory and excitatory processes and cortical excitability in awake subjects. There is evidence from clinical and electroencephalographic (EEG) data ... Full text Link to item Cite

Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease.

Journal Article Clin Neurophysiol · February 2001 OBJECTIVES: To evaluate the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) for Parkinson's disease (PD) by delivering stimulation at higher intensity and frequency over longer time than in previous research. Promising benefici ... Full text Link to item Cite

PET studies of the effects of ECT on cerebral physiology

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2001 Full text Cite

Transcranial magnetic stimulation differentially affects speed and direction judgments.

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2001 Cite

The effects of vagus nerve stimulation on cognitive performance in patients with treatment-resistant depression.

Journal Article Neuropsychiatry Neuropsychol Behav Neurol · January 2001 BACKGROUND: Chronic vagus nerve stimulation (VNS) is effective in the management of treatment-resistant epilepsy. Open-trial evidence suggests that VNS has clinically significant antidepressant effects in some individuals who experience treatment-resistant ... Link to item Cite

New developments in convulsive therapy for major depression

Journal Article Epilepsy and Behavior · January 1, 2001 Electroconvulsive therapy (ECT) is highly effective in the treatment of major depression. Frontiers for enhancing ECT in the management of severe major depression include techniques to reduce cognitive side effects and improve efficacy for those patients w ... Full text Cite

Vagus nerve stimulation. A potential therapy for resistant depression?

Journal Article Psychiatr Clin North Am · December 2000 VNS builds on a long history of investigating the relationship of autonomic signals to limbic and cortical function and is one of the newest methods to physically alter brain function. VNS is a clinically useful anticonvulsant therapy in treatment resistan ... Full text Link to item Cite

Neurogenesis and depression.

Journal Article J Psychiatr Pract · November 2000 The recognition that the brain continues to generate new neurons well into adulthood has made a marked impact on the field of neuroscience in general and specifically on neurobiological models of the pathogenesis of major depression. Stress, neuroendocrine ... Full text Link to item Cite

Termination of psychotherapy: a training perspective.

Journal Article J Psychiatr Pract · November 2000 Given the constraints of the prevailing mental health system in the United States, it has become very challenging for psychiatrists to offer psychotherapy services to patients in need of this modality of treatment. In spite of this situation, the professio ... Full text Link to item Cite

Transcranial magnetic stimulation: applications in basic neuroscience and neuropsychopharmacology.

Journal Article Int J Neuropsychopharmacol · September 2000 Introduced 15 years ago, transcranial magnetic stimulation (TMS) is a non-invasive means of stimulating the cortex that has proved to be a unique tool for probing brain-behaviour relationships. While a therapeutic role for TMS in neuropsychiatry is uncerta ... Full text Link to item Cite

The effects of electroconvulsive therapy on memory of autobiographical and public events.

Journal Article Arch Gen Psychiatry · June 2000 BACKGROUND: Retrograde amnesia is the most persistent cognitive adverse effect of electroconvulsive therapy (ECT); however, it is not known whether ECT has differential effects on autobiographical vs impersonal memories. This study examined the short- and ... Full text Link to item Cite

A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities.

Journal Article Arch Gen Psychiatry · May 2000 BACKGROUND: Controversy persists about the use of right unilateral (RUL) and bilateral (BL) electroconvulsive therapy (ECT). While RUL ECT results in less severe short-term and long-term cognitive effects, there is concern that it is less efficacious than ... Full text Link to item Cite

Determinants of seizure threshold in ECT: benzodiazepine use, anesthetic dosage, and other factors.

Journal Article J ECT · March 2000 The electrical dosage of the ECT stimulus impacts on efficacy and cognitive side effects, yet seizure threshold (ST) may vary as much as 50-fold across patients. It would be desirable to predict ST on the basis of patient and treatment characteristics. In ... Full text Link to item Cite

Vagus nerve stimulation: a new tool for brain research and therapy.

Journal Article Biol Psychiatry · February 15, 2000 Biological psychiatry has a long history of using somatic therapies to treat neuropsychiatric illnesses and to understand brain function. These methods have included neurosurgery, electroconvulsive therapy, and, most recently, transcranial magnetic stimula ... Full text Link to item Cite

ECT and TMS: past, present, and future.

Journal Article Depress Anxiety · 2000 Full text Link to item Cite

Animal models of the mechanisms of action of repetitive transcranial magnetic stimulation (RTMS): comparisons with electroconvulsive shock (ECS).

Journal Article Depress Anxiety · 2000 Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive means of brain stimulation with a broad range of basic neuroscience and potential future clinical applications. Recent animal studies have shed some light on the mechanisms of action of r ... Full text Link to item Cite

Transcranial magnetic stimulation: applications in neuropsychiatry.

Journal Article Arch Gen Psychiatry · April 1999 In the 1990s, it is difficult to open a newspaper or watch television and not find someone claiming that magnets promote healing. Rarely do these claims stem from double-blind, peer-reviewed studies, making it difficult to separate the wheat from the chaff ... Full text Link to item Cite

4. Neuroimaging Studies of ECT

Conference The Journal of ECT · March 1999 Full text Cite

Prolactin response to electroconvulsive therapy.

Journal Article Biol Psychiatry · February 1, 1999 Full text Link to item Cite

Prolactin response to electroconvulsive therapy - Response

Journal Article BIOLOGICAL PSYCHIATRY · 1999 Cite

Magnetic stimulation therapy: A novel convulsive technique

Conference BIOLOGICAL PSYCHIATRY · 1999 Cite

The relative efficiency of altering pulse frequency or train duration when determining seizure threshold.

Journal Article J ECT · December 1998 In 12 depressed inpatients referred for bilateral electroconvulsive therapy (ECT), each patient was titrated at the first treatment session by using an ascending method-of-limits procedure with a step-wise increase in pulse frequency (frequency titration) ... Link to item Cite

Effects of electroconvulsive therapy on plasma vasopressin and oxytocin.

Journal Article Biol Psychiatry · October 1, 1998 BACKGROUND: Animal studies suggest that vasopressin has cognitive-enhancing properties and oxytocin may have amnestic effects. A clinical report suggests that the acute increase in oxytocin-associated neurophysin predicts clinical response to electroconvul ... Full text Link to item Cite

Prolactin response to electroconvulsive therapy: effects of electrode placement and stimulus dosage.

Journal Article Biol Psychiatry · January 15, 1998 BACKGROUND: It is unclear whether the serum prolactin (PRL) surge following electroconvulsive therapy (ECT) is a marker of optimal ECT administration. We investigated the relations among PRL surge, stimulus parameters, and outcome in major depressive disor ... Full text Link to item Cite

Psychosis Secondary to Brain Tumor.

Journal Article Semin Clin Neuropsychiatry · January 1998 Brain tumors may present with psychotic symptoms that resemble schizophrenia. Although psychosis secondary to brain tumor is relatively rare, the frequent lack of neurological findings can lead to misdiagnosis. Psychosis secondary to brain tumor is more co ... Link to item Cite

Motor evoked potentials to paired transcranial magnetic stimulation (TMS) in the alert and sedated rhesus monkey

Journal Article Electroencephalography and Clinical Neurophysiology · July 1997 Full text Cite

Exceptionally high seizure threshold: ECT device limitations.

Journal Article Convuls Ther · September 1996 Three patients had exceptionally high seizure threshold, as determined by an empirical titration procedure. Initial seizure threshold was 896 mC in two of the patients. The third patient had an initial threshold of 336 mC that increased to 840 mC at the en ... Link to item Cite

Prolactin response to ect: Effects of electrode placement and dosage

Journal Article Biological Psychiatry · April 1996 Full text Cite

Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging.

Journal Article J Neural Transm Suppl · 1993 Parkinson's disease (PD) is associated with changes in the substantia nigra, which communicates with subcortical nuclei. This study investigates subcortical nuclei volume in PD in vivo by magnetic resonance (MR) imaging. Caudate, putaminal, and thalamic nu ... Link to item Cite