Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders.
Publication
, Journal Article
Deng, Z-D; Luber, B; Balderston, NL; Velez Afanador, M; Noh, MM; Thomas, J; Altekruse, WC; Exley, SL; Awasthi, S; Lisanby, SH
Published in: Annu Rev Pharmacol Toxicol
January 6, 2020
Device-based neuromodulation of brain circuits is emerging as a promising new approach in the study and treatment of psychiatric disorders. This work presents recent advances in the development of tools for identifying neurocircuits as therapeutic targets and in tools for modulating neurocircuits. We review clinical evidence for the therapeutic efficacy of circuit modulation with a range of brain stimulation approaches, including subthreshold, subconvulsive, convulsive, and neurosurgical techniques. We further discuss strategies for enhancing the precision and efficacy of neuromodulatory techniques. Finally, we survey cutting-edge research in therapeutic circuit modulation using novel paradigms and next-generation devices.
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Published In
Annu Rev Pharmacol Toxicol
DOI
EISSN
1545-4304
Publication Date
January 6, 2020
Volume
60
Start / End Page
591 / 614
Location
United States
Related Subject Headings
- Pharmacology & Pharmacy
- Neurosurgical Procedures
- Mental Disorders
- Humans
- Equipment Design
- Electric Stimulation Therapy
- Convulsive Therapy
- Brain
- Animals
- 3214 Pharmacology and pharmaceutical sciences
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Deng, Z.-D., Luber, B., Balderston, N. L., Velez Afanador, M., Noh, M. M., Thomas, J., … Lisanby, S. H. (2020). Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders. Annu Rev Pharmacol Toxicol, 60, 591–614. https://doi.org/10.1146/annurev-pharmtox-010919-023253
Deng, Zhi-De, Bruce Luber, Nicholas L. Balderston, Melbaliz Velez Afanador, Michelle M. Noh, Jeena Thomas, William C. Altekruse, Shannon L. Exley, Shriya Awasthi, and Sarah H. Lisanby. “Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders.” Annu Rev Pharmacol Toxicol 60 (January 6, 2020): 591–614. https://doi.org/10.1146/annurev-pharmtox-010919-023253.
Deng Z-D, Luber B, Balderston NL, Velez Afanador M, Noh MM, Thomas J, et al. Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders. Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:591–614.
Deng, Zhi-De, et al. “Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders.” Annu Rev Pharmacol Toxicol, vol. 60, Jan. 2020, pp. 591–614. Pubmed, doi:10.1146/annurev-pharmtox-010919-023253.
Deng Z-D, Luber B, Balderston NL, Velez Afanador M, Noh MM, Thomas J, Altekruse WC, Exley SL, Awasthi S, Lisanby SH. Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders. Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:591–614.
Published In
Annu Rev Pharmacol Toxicol
DOI
EISSN
1545-4304
Publication Date
January 6, 2020
Volume
60
Start / End Page
591 / 614
Location
United States
Related Subject Headings
- Pharmacology & Pharmacy
- Neurosurgical Procedures
- Mental Disorders
- Humans
- Equipment Design
- Electric Stimulation Therapy
- Convulsive Therapy
- Brain
- Animals
- 3214 Pharmacology and pharmaceutical sciences