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Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder.

Publication ,  Journal Article
Mantovani, A; Simpson, HB; Fallon, BA; Rossi, S; Lisanby, SH
Published in: Int J Neuropsychopharmacol
March 2010

In open trials, 1-Hz repetitive transcranial magnetic stimulation (rTMS) to the supplementary motor area (SMA) improved symptoms and normalized cortical hyper-excitability of patients with obsessive-compulsive disorder (OCD). Here we present the results of a randomized sham-controlled double-blind study. Medication-resistant OCD patients (n=21) were assigned 4 wk either active or sham rTMS to the SMA bilaterally. rTMS parameters consisted of 1200 pulses/d, at 1 Hz and 100% of motor threshold (MT). Eighteen patients completed the study. Response to treatment was defined as a > or = 25% decrease on the Yale-Brown Obsessive Compulsive Scale (YBOCS). Non-responders to sham and responders to active or sham rTMS were offered four additional weeks of open active rTMS. After 4 wk, the response rate in the completer sample was 67% (6/9) with active and 22% (2/9) with sham rTMS. At 4 wk, patients receiving active rTMS showed on average a 25% reduction in the YBOCS compared to a 12% reduction in those receiving sham. In those who received 8-wk active rTMS, OCD symptoms improved from 28.2+/-5.8 to 14.5+/-3.6. In patients randomized to active rTMS, MT measures on the right hemisphere increased significantly over time. At the end of 4-wk rTMS the abnormal hemispheric laterality found in the group randomized to active rTMS normalized. The results of the first randomized sham-controlled trial of SMA stimulation in the treatment of resistant OCD support further investigation into the potential therapeutic applications of rTMS in this disabling condition.

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Published In

Int J Neuropsychopharmacol

DOI

EISSN

1469-5111

Publication Date

March 2010

Volume

13

Issue

2

Start / End Page

217 / 227

Location

England

Related Subject Headings

  • Treatment Outcome
  • Transcranial Magnetic Stimulation
  • Time Factors
  • Severity of Illness Index
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Obsessive-Compulsive Disorder
  • Motor Cortex
  • Male
  • Humans
 

Citation

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Mantovani, A., Simpson, H. B., Fallon, B. A., Rossi, S., & Lisanby, S. H. (2010). Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. Int J Neuropsychopharmacol, 13(2), 217–227. https://doi.org/10.1017/S1461145709990435
Mantovani, Antonio, Helen B. Simpson, Brian A. Fallon, Simone Rossi, and Sarah H. Lisanby. “Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder.Int J Neuropsychopharmacol 13, no. 2 (March 2010): 217–27. https://doi.org/10.1017/S1461145709990435.
Mantovani A, Simpson HB, Fallon BA, Rossi S, Lisanby SH. Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2010 Mar;13(2):217–27.
Mantovani, Antonio, et al. “Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder.Int J Neuropsychopharmacol, vol. 13, no. 2, Mar. 2010, pp. 217–27. Pubmed, doi:10.1017/S1461145709990435.
Mantovani A, Simpson HB, Fallon BA, Rossi S, Lisanby SH. Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2010 Mar;13(2):217–227.
Journal cover image

Published In

Int J Neuropsychopharmacol

DOI

EISSN

1469-5111

Publication Date

March 2010

Volume

13

Issue

2

Start / End Page

217 / 227

Location

England

Related Subject Headings

  • Treatment Outcome
  • Transcranial Magnetic Stimulation
  • Time Factors
  • Severity of Illness Index
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Obsessive-Compulsive Disorder
  • Motor Cortex
  • Male
  • Humans