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Applications of transcranial magnetic stimulation and magnetic seizure therapy in the study and treatment of disorders related to cerebral aging.

Publication ,  Journal Article
Luber, B; McClintock, SM; Lisanby, SH
Published in: Dialogues Clin Neurosci
March 2013

Transcranial magnetic stimulation (TMS) can be used to probe cortical function and treat neuropsychiatric illnesses. TMS has demonstrated neuroplastic effects akin to long-term potentiation and long-term depression, and therapeutic applications are in development for post-stroke recovery, Alzheimer's disease, and depression in seniors. Here, we discuss two new directions of TMS research relevant to cerebral aging and cognition. First, we introduce a paradigm for enhancing cognitive reserve, based on our research in sleep deprivation. Second, we discuss the use of magnetic seizure therapy (MST) to spare cognitive functions relative to conventional electroconvulsive therapy, and as a means of providing a more potent antidepressant treatment when subconvulsive TMS has shown modest efficacy in seniors. Whether in the enhancement of cognition as a treatment goal, or in the reduction of amnesia as a side effect, these approaches to the use of TMS and MST merit further exploration regarding their clinical potential.

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Published In

Dialogues Clin Neurosci

DOI

EISSN

1958-5969

Publication Date

March 2013

Volume

15

Issue

1

Start / End Page

87 / 98

Location

England

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Seizures
  • Psychiatry
  • Neuronal Plasticity
  • Humans
  • Electroconvulsive Therapy
  • Cognition
  • Cerebral Cortex
  • Brain Diseases
  • Aging
 

Citation

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Luber, B., McClintock, S. M., & Lisanby, S. H. (2013). Applications of transcranial magnetic stimulation and magnetic seizure therapy in the study and treatment of disorders related to cerebral aging. Dialogues Clin Neurosci, 15(1), 87–98. https://doi.org/10.31887/DCNS.2013.15.1/bluber
Luber, Bruce, Shawn M. McClintock, and Sarah H. Lisanby. “Applications of transcranial magnetic stimulation and magnetic seizure therapy in the study and treatment of disorders related to cerebral aging.Dialogues Clin Neurosci 15, no. 1 (March 2013): 87–98. https://doi.org/10.31887/DCNS.2013.15.1/bluber.
Luber, Bruce, et al. “Applications of transcranial magnetic stimulation and magnetic seizure therapy in the study and treatment of disorders related to cerebral aging.Dialogues Clin Neurosci, vol. 15, no. 1, Mar. 2013, pp. 87–98. Pubmed, doi:10.31887/DCNS.2013.15.1/bluber.

Published In

Dialogues Clin Neurosci

DOI

EISSN

1958-5969

Publication Date

March 2013

Volume

15

Issue

1

Start / End Page

87 / 98

Location

England

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Seizures
  • Psychiatry
  • Neuronal Plasticity
  • Humans
  • Electroconvulsive Therapy
  • Cognition
  • Cerebral Cortex
  • Brain Diseases
  • Aging