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Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies.

Publication ,  Journal Article
Beynel, L; Appelbaum, LG; Luber, B; Crowell, CA; Hilbig, SA; Lim, W; Nguyen, D; Chrapliwy, NA; Davis, SW; Cabeza, R; Lisanby, SH; Deng, Z-D
Published in: Neurosci Biobehav Rev
December 2019

Online repetitive transcranial magnetic stimulation (rTMS), applied while subjects are performing a task, is widely used to disrupt brain regions underlying cognition. However, online rTMS has also induced "paradoxical enhancement". Given the rapid proliferation of this approach, it is crucial to develop a better understanding of how online stimulation influences cognition, and the optimal parameters to achieve desired effects. To accomplish this goal, a quantitative meta-analysis was performed with random-effects models fitted to reaction time (RT) and accuracy data. The final dataset included 126 studies published between 1998 and 2016, with 244 total effects for reaction times, and 202 for accuracy. Meta-analytically, rTMS at 10 Hz and 20 Hz disrupted accuracy for attention, executive, language, memory, motor, and perception domains, while no effects were found with 1 Hz or 5 Hz. Stimulation applied at and 10 and 20 Hz slowed down RTs in attention and perception tasks. No performance enhancement was found. Meta-regression analysis showed that fMRI-guided targeting and short inter-trial intervals are associated with increased disruptive effects with rTMS.

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Published In

Neurosci Biobehav Rev

DOI

EISSN

1873-7528

Publication Date

December 2019

Volume

107

Start / End Page

47 / 58

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Research Design
  • Reaction Time
  • Neuropsychological Tests
  • Humans
  • Cognition
  • Brain
  • Behavioral Science & Comparative Psychology
  • Attention
  • 42 Health sciences
 

Citation

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ICMJE
MLA
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Beynel, L., Appelbaum, L. G., Luber, B., Crowell, C. A., Hilbig, S. A., Lim, W., … Deng, Z.-D. (2019). Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies. Neurosci Biobehav Rev, 107, 47–58. https://doi.org/10.1016/j.neubiorev.2019.08.018
Beynel, Lysianne, Lawrence G. Appelbaum, Bruce Luber, Courtney A. Crowell, Susan A. Hilbig, Wesley Lim, Duy Nguyen, et al. “Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies.Neurosci Biobehav Rev 107 (December 2019): 47–58. https://doi.org/10.1016/j.neubiorev.2019.08.018.
Beynel L, Appelbaum LG, Luber B, Crowell CA, Hilbig SA, Lim W, et al. Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies. Neurosci Biobehav Rev. 2019 Dec;107:47–58.
Beynel, Lysianne, et al. “Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies.Neurosci Biobehav Rev, vol. 107, Dec. 2019, pp. 47–58. Pubmed, doi:10.1016/j.neubiorev.2019.08.018.
Beynel L, Appelbaum LG, Luber B, Crowell CA, Hilbig SA, Lim W, Nguyen D, Chrapliwy NA, Davis SW, Cabeza R, Lisanby SH, Deng Z-D. Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies. Neurosci Biobehav Rev. 2019 Dec;107:47–58.
Journal cover image

Published In

Neurosci Biobehav Rev

DOI

EISSN

1873-7528

Publication Date

December 2019

Volume

107

Start / End Page

47 / 58

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Research Design
  • Reaction Time
  • Neuropsychological Tests
  • Humans
  • Cognition
  • Brain
  • Behavioral Science & Comparative Psychology
  • Attention
  • 42 Health sciences