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Frequency-specific neuromodulation of local and distant connectivity in aging and episodic memory function.

Publication ,  Journal Article
Davis, SW; Luber, B; Murphy, DLK; Lisanby, SH; Cabeza, R
Published in: Hum Brain Mapp
December 2017

A growing literature has focused on the brain's ability to augment processing in local regions by recruiting distant communities of neurons in response to neural decline or insult. In particular, both younger and older adult populations recruit bilateral prefrontal cortex (PFC) as a means of compensating for increasing neural effort to maintain successful cognitive function. However, it remains unclear how local changes in neural activity affect the recruitment of this adaptive mechanism. To address this problem, we combined graph theoretical measures from functional MRI with diffusion weighted imaging and repetitive transcranial magnetic stimulation (rTMS) to resolve a central hypothesis: how do aged brains flexibly adapt to local changes in cortical activity? Specifically, we applied neuromodulation to increase or decrease local activity in a cortical region supporting successful memory encoding (left dorsolateral PFC or DLPFC) using 5 or 1 Hz rTMS, respectively. We then assessed a region's local within-module degree, or the distributed between-module degree (BMD) between distant cortical communities. We predicted that (1) local stimulation-related deficits may be counteracted by boosting BMD between bilateral PFC, and that this effect should be (2) positively correlated with structural connectivity. Both predictions were confirmed; 5 Hz rTMS increased local success-related activity and local increases in PFC connectivity, while 1 Hz rTMS decreases local activity and triggered a more distributed pattern of bilateral PFC connectivity to compensate for this local inhibitory effect. These results provide an integrated, causal explanation for the network interactions associated with successful memory encoding in older adults. Hum Brain Mapp 38:5987-6004, 2017. © 2017 Wiley Periodicals, Inc.

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Published In

Hum Brain Mapp

DOI

EISSN

1097-0193

Publication Date

December 2017

Volume

38

Issue

12

Start / End Page

5987 / 6004

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Neuropsychological Tests
  • Neural Pathways
  • Multivariate Analysis
  • Middle Aged
  • Memory, Episodic
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
 

Citation

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ICMJE
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Davis, S. W., Luber, B., Murphy, D. L. K., Lisanby, S. H., & Cabeza, R. (2017). Frequency-specific neuromodulation of local and distant connectivity in aging and episodic memory function. Hum Brain Mapp, 38(12), 5987–6004. https://doi.org/10.1002/hbm.23803
Davis, Simon W., Bruce Luber, David L. K. Murphy, Sarah H. Lisanby, and Roberto Cabeza. “Frequency-specific neuromodulation of local and distant connectivity in aging and episodic memory function.Hum Brain Mapp 38, no. 12 (December 2017): 5987–6004. https://doi.org/10.1002/hbm.23803.
Davis SW, Luber B, Murphy DLK, Lisanby SH, Cabeza R. Frequency-specific neuromodulation of local and distant connectivity in aging and episodic memory function. Hum Brain Mapp. 2017 Dec;38(12):5987–6004.
Davis, Simon W., et al. “Frequency-specific neuromodulation of local and distant connectivity in aging and episodic memory function.Hum Brain Mapp, vol. 38, no. 12, Dec. 2017, pp. 5987–6004. Pubmed, doi:10.1002/hbm.23803.
Davis SW, Luber B, Murphy DLK, Lisanby SH, Cabeza R. Frequency-specific neuromodulation of local and distant connectivity in aging and episodic memory function. Hum Brain Mapp. 2017 Dec;38(12):5987–6004.
Journal cover image

Published In

Hum Brain Mapp

DOI

EISSN

1097-0193

Publication Date

December 2017

Volume

38

Issue

12

Start / End Page

5987 / 6004

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Neuropsychological Tests
  • Neural Pathways
  • Multivariate Analysis
  • Middle Aged
  • Memory, Episodic
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female