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Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease.

Publication ,  Journal Article
Boylan, LS; Pullman, SL; Lisanby, SH; Spicknall, KE; Sackeim, HA
Published in: Clin Neurophysiol
February 2001

OBJECTIVES: To evaluate the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) for Parkinson's disease (PD) by delivering stimulation at higher intensity and frequency over longer time than in previous research. Promising beneficial effects on movement during or after rTMS have been reported. METHODS: Ten patients with idiopathic PD were enrolled in a randomized crossover study comparing active versus sham rTMS to the supplementary motor area (SMA). Assessments included reaction and movement times (RT/MT), quantitative spiral analysis, timed motor performance tests, United Parkinson's Disease Rating Scale (UPDRS), patient self-report and guess as to stimulation condition. RESULTS: Two of 10 patients could not tolerate the protocol. Thirty to 45 min following stimulation, active rTMS as compared with sham stimulation worsened spiral drawing (P=0.001) and prolonged RT in the most affected limb (P=0.030). No other significant differences were detected. CONCLUSIONS: We sought clinically promising improvement in PD but found subclinical worsening of complex and preparatory movement following rTMS to SMA. These results raise safety concerns regarding the persistence of dysfunction induced by rTMS while supporting the value of rTMS as a research tool. Studies aimed at understanding basic mechanisms and timing of rTMS effects are needed.

Duke Scholars

Published In

Clin Neurophysiol

DOI

ISSN

1388-2457

Publication Date

February 2001

Volume

112

Issue

2

Start / End Page

259 / 264

Location

Netherlands

Related Subject Headings

  • Walking
  • Transcranial Magnetic Stimulation
  • Severity of Illness Index
  • Reaction Time
  • Physical Stimulation
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Movement
  • Motor Cortex
  • Middle Aged
 

Citation

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Boylan, L. S., Pullman, S. L., Lisanby, S. H., Spicknall, K. E., & Sackeim, H. A. (2001). Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease. Clin Neurophysiol, 112(2), 259–264. https://doi.org/10.1016/s1388-2457(00)00519-8
Boylan, L. S., S. L. Pullman, S. H. Lisanby, K. E. Spicknall, and H. A. Sackeim. “Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease.Clin Neurophysiol 112, no. 2 (February 2001): 259–64. https://doi.org/10.1016/s1388-2457(00)00519-8.
Boylan LS, Pullman SL, Lisanby SH, Spicknall KE, Sackeim HA. Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease. Clin Neurophysiol. 2001 Feb;112(2):259–64.
Boylan, L. S., et al. “Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease.Clin Neurophysiol, vol. 112, no. 2, Feb. 2001, pp. 259–64. Pubmed, doi:10.1016/s1388-2457(00)00519-8.
Boylan LS, Pullman SL, Lisanby SH, Spicknall KE, Sackeim HA. Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease. Clin Neurophysiol. 2001 Feb;112(2):259–264.
Journal cover image

Published In

Clin Neurophysiol

DOI

ISSN

1388-2457

Publication Date

February 2001

Volume

112

Issue

2

Start / End Page

259 / 264

Location

Netherlands

Related Subject Headings

  • Walking
  • Transcranial Magnetic Stimulation
  • Severity of Illness Index
  • Reaction Time
  • Physical Stimulation
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Movement
  • Motor Cortex
  • Middle Aged