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Complementary topology of maintenance and manipulation brain networks in working memory.

Publication ,  Journal Article
Davis, SW; Crowell, CA; Beynel, L; Deng, L; Lakhlani, D; Hilbig, SA; Lim, W; Nguyen, D; Peterchev, AV; Luber, BM; Lisanby, SH; Appelbaum, LG ...
Published in: Sci Rep
December 13, 2018

Working memory (WM) is assumed to consist of a process that sustains memory representations in an active state (maintenance) and a process that operates on these activated representations (manipulation). We examined evidence for two distinct, concurrent cognitive functions supporting maintenance and manipulation abilities by testing brain activity as participants performed a WM alphabetization task. Maintenance was investigated by varying the number of letters held in WM and manipulation by varying the number of moves required to sort the list alphabetically. We found that both maintenance and manipulation demand had significant effects on behavior that were associated with different cortical regions: maintenance was associated with bilateral prefrontal and left parietal cortex, and manipulation with right parietal activity, a link that is consistent with the role of parietal cortex in symbolic computations. Both structural and functional architecture of these systems suggested that these cognitive functions are supported by two dissociable brain networks. Critically, maintenance and manipulation functional networks became increasingly segregated with increasing demand, an effect that was positively associated with individual WM ability. These results provide evidence that network segregation may act as a protective mechanism to enable successful performance under increasing WM demand.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 13, 2018

Volume

8

Issue

1

Start / End Page

17827

Location

England

Related Subject Headings

  • Parietal Lobe
  • Nerve Net
  • Memory, Short-Term
  • Male
  • Humans
  • Female
  • Brain Mapping
  • Adult
  • Adolescent
 

Citation

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Davis, S. W., Crowell, C. A., Beynel, L., Deng, L., Lakhlani, D., Hilbig, S. A., … Cabeza, R. (2018). Complementary topology of maintenance and manipulation brain networks in working memory. Sci Rep, 8(1), 17827. https://doi.org/10.1038/s41598-018-35887-2
Davis, S. W., C. A. Crowell, L. Beynel, L. Deng, D. Lakhlani, S. A. Hilbig, W. Lim, et al. “Complementary topology of maintenance and manipulation brain networks in working memory.Sci Rep 8, no. 1 (December 13, 2018): 17827. https://doi.org/10.1038/s41598-018-35887-2.
Davis SW, Crowell CA, Beynel L, Deng L, Lakhlani D, Hilbig SA, et al. Complementary topology of maintenance and manipulation brain networks in working memory. Sci Rep. 2018 Dec 13;8(1):17827.
Davis, S. W., et al. “Complementary topology of maintenance and manipulation brain networks in working memory.Sci Rep, vol. 8, no. 1, Dec. 2018, p. 17827. Pubmed, doi:10.1038/s41598-018-35887-2.
Davis SW, Crowell CA, Beynel L, Deng L, Lakhlani D, Hilbig SA, Lim W, Nguyen D, Peterchev AV, Luber BM, Lisanby SH, Appelbaum LG, Cabeza R. Complementary topology of maintenance and manipulation brain networks in working memory. Sci Rep. 2018 Dec 13;8(1):17827.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 13, 2018

Volume

8

Issue

1

Start / End Page

17827

Location

England

Related Subject Headings

  • Parietal Lobe
  • Nerve Net
  • Memory, Short-Term
  • Male
  • Humans
  • Female
  • Brain Mapping
  • Adult
  • Adolescent