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Using diffusion tensor imaging to effectively target TMS to deep brain structures.

Publication ,  Journal Article
Luber, B; Davis, SW; Deng, Z-D; Murphy, D; Martella, A; Peterchev, AV; Lisanby, SH
Published in: Neuroimage
April 1, 2022

TMS has become a powerful tool to explore cortical function, and in parallel has proven promising in the development of therapies for various psychiatric and neurological disorders. Unfortunately, much of the inference of the direct effects of TMS has been assumed to be limited to the area a few centimeters beneath the scalp, though clearly more distant regions are likely to be influenced by structurally connected stimulation sites. In this study, we sought to develop a novel paradigm to individualize TMS coil placement to non-invasively achieve activation of specific deep brain targets of relevance to the treatment of psychiatric disorders. In ten subjects, structural diffusion imaging tractography data were used to identify an accessible cortical target in the right frontal pole that demonstrated both anatomic and functional connectivity to right Brodmann area 25 (BA25). Concurrent TMS-fMRI interleaving was used with a series of single, interleaved TMS pulses applied to the right frontal pole at four intensity levels ranging from 80% to 140% of motor threshold. In nine of ten subjects, TMS to the individualized frontal pole sites resulted in significant linear increase in BOLD activation of BA25 with increasing TMS intensity. The reliable activation of BA25 in a dosage-dependent manner suggests the possibility that the careful combination of imaging with TMS can make use of network properties to help overcome depth limitations and allow noninvasive brain stimulation to influence deep brain structures.

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Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

April 1, 2022

Volume

249

Start / End Page

118863

Location

United States

Related Subject Headings

  • Young Adult
  • Transcranial Magnetic Stimulation
  • Prefrontal Cortex
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Gyrus Cinguli
  • Female
  • Diffusion Tensor Imaging
  • Deep Brain Stimulation
 

Citation

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Luber, B., Davis, S. W., Deng, Z.-D., Murphy, D., Martella, A., Peterchev, A. V., & Lisanby, S. H. (2022). Using diffusion tensor imaging to effectively target TMS to deep brain structures. Neuroimage, 249, 118863. https://doi.org/10.1016/j.neuroimage.2021.118863
Luber, Bruce, Simon W. Davis, Zhi-De Deng, David Murphy, Andrew Martella, Angel V. Peterchev, and Sarah H. Lisanby. “Using diffusion tensor imaging to effectively target TMS to deep brain structures.Neuroimage 249 (April 1, 2022): 118863. https://doi.org/10.1016/j.neuroimage.2021.118863.
Luber B, Davis SW, Deng Z-D, Murphy D, Martella A, Peterchev AV, et al. Using diffusion tensor imaging to effectively target TMS to deep brain structures. Neuroimage. 2022 Apr 1;249:118863.
Luber, Bruce, et al. “Using diffusion tensor imaging to effectively target TMS to deep brain structures.Neuroimage, vol. 249, Apr. 2022, p. 118863. Pubmed, doi:10.1016/j.neuroimage.2021.118863.
Luber B, Davis SW, Deng Z-D, Murphy D, Martella A, Peterchev AV, Lisanby SH. Using diffusion tensor imaging to effectively target TMS to deep brain structures. Neuroimage. 2022 Apr 1;249:118863.
Journal cover image

Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

April 1, 2022

Volume

249

Start / End Page

118863

Location

United States

Related Subject Headings

  • Young Adult
  • Transcranial Magnetic Stimulation
  • Prefrontal Cortex
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Gyrus Cinguli
  • Female
  • Diffusion Tensor Imaging
  • Deep Brain Stimulation