Skip to main content
Journal cover image

Magnetic seizure therapy: Development of a novel intervention for treatment resistant depression

Publication ,  Journal Article
Morales, OG; Sackeim, HA; Berman, RM; Lisanby, SH
Published in: Clinical Neuroscience Research
July 1, 2004

Electroconvulsive therapy (ECT) is the most effective and most rapidly acting treatment for severe treatment resistant major depression, but its use is limited by its cognitive side effects. Magnetic seizure therapy (MST) is a new form of convulsive therapy using high-dosage repetitive transcranial magnetic stimulation (rTMS) to induce focal cortical seizures under anesthesia. MST is under study as a means of reducing the side effects of ECT through the enhanced control over the sites of seizure initiation and topography of seizure propagation afforded by the relative focality of rTMS. This review traces the stages in the development of MST, from device development, to preclinical testing, to clinical trials. The results of a study on the comparative safety of chronic MST and electroconvulsive shock in non-human primates support the safety of both interventions, and indicate that the seizures induced by MST are more focal and have less impact on deeper brain structures. This non-human primate model and a controlled clinical trial in patients with major depression, suggest that MST may induce fewer side effects and less amnesia than ECT. Ongoing work will yield the first data on the antidepressant efficacy of MST. If ultimately shown to be effective, MST could represent a new, less invasive option for patients with severe treatment resistant depression or other disorders who would otherwise require ECT. © 2004 Elsevier B.V. All rights reserved.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clinical Neuroscience Research

DOI

ISSN

1566-2772

Publication Date

July 1, 2004

Volume

4

Issue

1-2

Start / End Page

59 / 70

Related Subject Headings

  • Psychiatry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Morales, O. G., Sackeim, H. A., Berman, R. M., & Lisanby, S. H. (2004). Magnetic seizure therapy: Development of a novel intervention for treatment resistant depression. Clinical Neuroscience Research, 4(1–2), 59–70. https://doi.org/10.1016/j.cnr.2004.06.005
Morales, O. G., H. A. Sackeim, R. M. Berman, and S. H. Lisanby. “Magnetic seizure therapy: Development of a novel intervention for treatment resistant depression.” Clinical Neuroscience Research 4, no. 1–2 (July 1, 2004): 59–70. https://doi.org/10.1016/j.cnr.2004.06.005.
Morales OG, Sackeim HA, Berman RM, Lisanby SH. Magnetic seizure therapy: Development of a novel intervention for treatment resistant depression. Clinical Neuroscience Research. 2004 Jul 1;4(1–2):59–70.
Morales, O. G., et al. “Magnetic seizure therapy: Development of a novel intervention for treatment resistant depression.” Clinical Neuroscience Research, vol. 4, no. 1–2, July 2004, pp. 59–70. Scopus, doi:10.1016/j.cnr.2004.06.005.
Morales OG, Sackeim HA, Berman RM, Lisanby SH. Magnetic seizure therapy: Development of a novel intervention for treatment resistant depression. Clinical Neuroscience Research. 2004 Jul 1;4(1–2):59–70.
Journal cover image

Published In

Clinical Neuroscience Research

DOI

ISSN

1566-2772

Publication Date

July 1, 2004

Volume

4

Issue

1-2

Start / End Page

59 / 70

Related Subject Headings

  • Psychiatry