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The efficacy of acute electroconvulsive therapy in atypical depression.

Publication ,  Journal Article
Husain, MM; McClintock, SM; Rush, AJ; Knapp, RG; Fink, M; Rummans, TA; Rasmussen, K; Claassen, C; Petrides, G; Biggs, MM; Mueller, M ...
Published in: J Clin Psychiatry
March 2008

OBJECTIVE: This study examined the characteristics and outcomes of patients with major depressive disorder (MDD), with or without atypical features, who were treated with acute bilateral electroconvulsive therapy (ECT). METHOD: Analyses were conducted with 489 patients who met DSM-IV criteria for MDD. Subjects were identified as typical or atypical on the basis of the Structured Clinical Interview for DSM-IV obtained at baseline prior to ECT. Depression symptom severity was measured by the 24-item Hamilton Rating Scale for Depression (HAM-D(24)) and the 30-item Inventory of Depressive Symptomatology-Self-Report (IDS-SR(30)). Remission was defined as at least a 60% decrease from baseline in HAM-D(24) score and a total score of 10 or below on the last 2 consecutive HAM-D(24) ratings. The randomized controlled trial was performed from 1997 to 2004. RESULTS: The typical (N = 453) and atypical (N = 36) groups differed in several sociodemographic and clinical variables including gender (p = .0071), age (p = .0005), treatment resistance (p = .0014), and age at first illness onset (p < .0001) and onset of current episode (p = .0008). Following an acute course of bilateral ECT, a considerable portion of both the typical (67.1%) and the atypical (80.6%) groups reached remission. The atypical group was 2.6 (95% CI = 1.1 to 6.2) times more likely to remit than the typical group after adjustment for age, psychosis, gender, clinical site, and depression severity based on the HAM-D(24). CONCLUSION: Acute ECT is an efficacious treatment for depressed patients with typical or atypical symptom features. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00000375.

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Published In

J Clin Psychiatry

DOI

EISSN

1555-2101

Publication Date

March 2008

Volume

69

Issue

3

Start / End Page

406 / 411

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Observer Variation
  • Middle Aged
  • Male
  • Humans
  • Female
  • Electroconvulsive Therapy
 

Citation

APA
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ICMJE
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Husain, M. M., McClintock, S. M., Rush, A. J., Knapp, R. G., Fink, M., Rummans, T. A., … Kellner, C. H. (2008). The efficacy of acute electroconvulsive therapy in atypical depression. J Clin Psychiatry, 69(3), 406–411. https://doi.org/10.4088/jcp.v69n0310
Husain, Mustafa M., Shawn M. McClintock, A John Rush, Rebecca G. Knapp, Max Fink, Teresa A. Rummans, Keith Rasmussen, et al. “The efficacy of acute electroconvulsive therapy in atypical depression.J Clin Psychiatry 69, no. 3 (March 2008): 406–11. https://doi.org/10.4088/jcp.v69n0310.
Husain MM, McClintock SM, Rush AJ, Knapp RG, Fink M, Rummans TA, et al. The efficacy of acute electroconvulsive therapy in atypical depression. J Clin Psychiatry. 2008 Mar;69(3):406–11.
Husain, Mustafa M., et al. “The efficacy of acute electroconvulsive therapy in atypical depression.J Clin Psychiatry, vol. 69, no. 3, Mar. 2008, pp. 406–11. Pubmed, doi:10.4088/jcp.v69n0310.
Husain MM, McClintock SM, Rush AJ, Knapp RG, Fink M, Rummans TA, Rasmussen K, Claassen C, Petrides G, Biggs MM, Mueller M, Sampson S, Bailine SH, Lisanby SH, Kellner CH. The efficacy of acute electroconvulsive therapy in atypical depression. J Clin Psychiatry. 2008 Mar;69(3):406–411.

Published In

J Clin Psychiatry

DOI

EISSN

1555-2101

Publication Date

March 2008

Volume

69

Issue

3

Start / End Page

406 / 411

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Observer Variation
  • Middle Aged
  • Male
  • Humans
  • Female
  • Electroconvulsive Therapy