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Motor cortex excitability after vagus nerve stimulation in major depression.

Publication ,  Journal Article
Bajbouj, M; Gallinat, J; Lang, UE; Hellen, F; Vesper, J; Lisanby, SH; Danker-Hopfe, H; Neu, P
Published in: J Clin Psychopharmacol
April 2007

Recent data suggest that inhibitory pathways may be involved in the pathophysiology of depression and in the mode of action of some antidepressant interventions. The aim of the present study was to test whether vagus nerve stimulation (VNS) can affect motor cortex excitability. Measures of motor cortical excitability were probed by using single-pulse and paired-pulse transcranial magnetic stimulation at baseline, after 10 weeks of left VNS, and additionally, in an on-off paradigm in 10 patients with treatment-resistant unipolar depression. Ten weeks of VNS was associated with a selective and pronounced increase in intracortical inhibition, whereas no changes occurred in the on-off paradigm. These results suggest that VNS is capable of changing motor cortical excitability in patients with depression.

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Published In

J Clin Psychopharmacol

DOI

ISSN

0271-0749

Publication Date

April 2007

Volume

27

Issue

2

Start / End Page

156 / 159

Location

United States

Related Subject Headings

  • Valproic Acid
  • Vagus Nerve
  • Triazines
  • Tranylcypromine
  • Reboxetine
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Paroxetine
  • Olanzapine
  • Neural Inhibition
 

Citation

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Bajbouj, M., Gallinat, J., Lang, U. E., Hellen, F., Vesper, J., Lisanby, S. H., … Neu, P. (2007). Motor cortex excitability after vagus nerve stimulation in major depression. J Clin Psychopharmacol, 27(2), 156–159. https://doi.org/10.1097/JCP.0b013e31803308f3
Bajbouj, Malek, Juergen Gallinat, Undine E. Lang, Florence Hellen, Jan Vesper, Sarah H. Lisanby, Heidi Danker-Hopfe, and Peter Neu. “Motor cortex excitability after vagus nerve stimulation in major depression.J Clin Psychopharmacol 27, no. 2 (April 2007): 156–59. https://doi.org/10.1097/JCP.0b013e31803308f3.
Bajbouj M, Gallinat J, Lang UE, Hellen F, Vesper J, Lisanby SH, et al. Motor cortex excitability after vagus nerve stimulation in major depression. J Clin Psychopharmacol. 2007 Apr;27(2):156–9.
Bajbouj, Malek, et al. “Motor cortex excitability after vagus nerve stimulation in major depression.J Clin Psychopharmacol, vol. 27, no. 2, Apr. 2007, pp. 156–59. Pubmed, doi:10.1097/JCP.0b013e31803308f3.
Bajbouj M, Gallinat J, Lang UE, Hellen F, Vesper J, Lisanby SH, Danker-Hopfe H, Neu P. Motor cortex excitability after vagus nerve stimulation in major depression. J Clin Psychopharmacol. 2007 Apr;27(2):156–159.

Published In

J Clin Psychopharmacol

DOI

ISSN

0271-0749

Publication Date

April 2007

Volume

27

Issue

2

Start / End Page

156 / 159

Location

United States

Related Subject Headings

  • Valproic Acid
  • Vagus Nerve
  • Triazines
  • Tranylcypromine
  • Reboxetine
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Paroxetine
  • Olanzapine
  • Neural Inhibition