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A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation.

Publication ,  Journal Article
Balderston, NL; Roberts, C; Beydler, EM; Deng, Z-D; Radman, T; Luber, B; Lisanby, SH; Ernst, M; Grillon, C
Published in: Nat Protoc
November 2020

Transcranial magnetic stimulation (TMS) is a noninvasive method to stimulate the cerebral cortex that has applications in psychiatry, such as in the treatment of depression and anxiety. Although many TMS targeting methods that use figure-8 coils exist, many do not account for individual differences in anatomy or are not generalizable across target sites. This protocol combines functional magnetic resonance imaging (fMRI) and iterative electric-field (E-field) modeling in a generalized approach to subject-specific TMS targeting that is capable of optimizing the stimulation site and TMS coil orientation. To apply this protocol, the user should (i) operationally define a region of interest (ROI), (ii) generate the head model from the structural MRI data, (iii) preprocess the functional MRI data, (iv) identify the single-subject stimulation site within the ROI, and (iv) conduct E-field modeling to identify the optimal coil orientation. In comparison with standard targeting methods, this approach demonstrates (i) reduced variability in the stimulation site across subjects, (ii) reduced scalp-to-cortical-target distance, and (iii) reduced variability in optimal coil orientation. Execution of this protocol requires intermediate-level skills in structural and functional MRI processing. This protocol takes ~24 h to complete and demonstrates how constrained fMRI targeting combined with iterative E-field modeling can be used as a general method to optimize both the TMS coil site and its orientation.

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Published In

Nat Protoc

DOI

EISSN

1750-2799

Publication Date

November 2020

Volume

15

Issue

11

Start / End Page

3595 / 3614

Location

England

Related Subject Headings

  • Workflow
  • Transcranial Magnetic Stimulation
  • Magnetic Resonance Imaging
  • Humans
  • Brain Mapping
  • Brain
  • Bioinformatics
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
  • 03 Chemical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Balderston, N. L., Roberts, C., Beydler, E. M., Deng, Z.-D., Radman, T., Luber, B., … Grillon, C. (2020). A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation. Nat Protoc, 15(11), 3595–3614. https://doi.org/10.1038/s41596-020-0387-4
Balderston, Nicholas L., Camille Roberts, Emily M. Beydler, Zhi-De Deng, Thomas Radman, Bruce Luber, Sarah H. Lisanby, Monique Ernst, and Christian Grillon. “A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation.Nat Protoc 15, no. 11 (November 2020): 3595–3614. https://doi.org/10.1038/s41596-020-0387-4.
Balderston NL, Roberts C, Beydler EM, Deng Z-D, Radman T, Luber B, et al. A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation. Nat Protoc. 2020 Nov;15(11):3595–614.
Balderston, Nicholas L., et al. “A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation.Nat Protoc, vol. 15, no. 11, Nov. 2020, pp. 3595–614. Pubmed, doi:10.1038/s41596-020-0387-4.
Balderston NL, Roberts C, Beydler EM, Deng Z-D, Radman T, Luber B, Lisanby SH, Ernst M, Grillon C. A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation. Nat Protoc. 2020 Nov;15(11):3595–3614.

Published In

Nat Protoc

DOI

EISSN

1750-2799

Publication Date

November 2020

Volume

15

Issue

11

Start / End Page

3595 / 3614

Location

England

Related Subject Headings

  • Workflow
  • Transcranial Magnetic Stimulation
  • Magnetic Resonance Imaging
  • Humans
  • Brain Mapping
  • Brain
  • Bioinformatics
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
  • 03 Chemical Sciences