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Regional electric field induced by electroconvulsive therapy: a finite element simulation study.

Publication ,  Journal Article
Lee, WH; Deng, ZD; Kim, TS; Laine, AF; Lisanby, SH; Peterchev, AV
Published in: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
December 1, 2010

The goal of this study is to investigate the regional distribution of the electric field (E-field) strength induced by electroconvulsive therapy (ECT), and to contrast clinically relevant electrode configurations through finite element (FE) analysis. An FE human head model incorporating tissue heterogeneity and white matter anisotropy was generated based on structural magnetic resonance imaging (MRI) and diffusion tensor MRI (DT-MRI) data. We simulated the E-field spatial distributions of three standard ECT electrode placements [bilateral (BL), bifrontal (BF), and right unilateral (RUL)] and an investigational electrode configuration [focal electrically administered seizure therapy (FEAST)] . A quantitative comparison of the E-field strength was subsequently carried out in various brain regions of interests (ROIs) that have putative role in the therapeutic action and/or adverse side effects of ECT. This study illustrates how the realistic FE head model provides quantitative insight in the biophysics of ECT, which may shed light on the differential clinical outcomes seen with various forms of ECT, and may guide the development of novel stimulation paradigms with improved risk/benefit ratio.

Duke Scholars

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

ISSN

1557-170X

Publication Date

December 1, 2010

Start / End Page

2045 / 2048
 

Citation

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Lee, W. H., Deng, Z. D., Kim, T. S., Laine, A. F., Lisanby, S. H., & Peterchev, A. V. (2010). Regional electric field induced by electroconvulsive therapy: a finite element simulation study. Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2045–2048.
Lee, W. H., Z. D. Deng, T. S. Kim, A. F. Laine, S. H. Lisanby, and A. V. Peterchev. “Regional electric field induced by electroconvulsive therapy: a finite element simulation study.Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, December 1, 2010, 2045–48.
Lee WH, Deng ZD, Kim TS, Laine AF, Lisanby SH, Peterchev AV. Regional electric field induced by electroconvulsive therapy: a finite element simulation study. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2010 Dec 1;2045–8.
Lee, W. H., et al. “Regional electric field induced by electroconvulsive therapy: a finite element simulation study.Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Dec. 2010, pp. 2045–48.
Lee WH, Deng ZD, Kim TS, Laine AF, Lisanby SH, Peterchev AV. Regional electric field induced by electroconvulsive therapy: a finite element simulation study. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2010 Dec 1;2045–2048.

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

ISSN

1557-170X

Publication Date

December 1, 2010

Start / End Page

2045 / 2048