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Unaltered neuronal and glial counts in animal models of magnetic seizure therapy and electroconvulsive therapy.

Publication ,  Journal Article
Dwork, AJ; Christensen, JR; Larsen, KB; Scalia, J; Underwood, MD; Arango, V; Pakkenberg, B; Lisanby, SH
Published in: Neuroscience
December 29, 2009

Anatomical evidence of brain damage from electroconvulsive therapy (ECT) is lacking; but there are no modern stereological studies in primates documenting its safety. Magnetic seizure therapy (MST) is under development as a less invasive form of convulsive therapy, and there is only one prior report on its anatomical effects. We discerned no histological lesions in the brains of higher mammals subjected to electroconvulsive shock (ECS) or MST, under conditions that model closely those used in humans. We sought to extend these findings by determining whether these interventions affected the number of neurons or glia in the frontal cortex or hippocampus. Twenty-four animals received 6 weeks of ECS, MST, or anesthesia alone, 4 days per week. After perfusion fixation, numbers of neurons and glia in frontal cortex and hippocampus were determined by unbiased stereological methods. We found no effect of either intervention on volumes or total number or numerical density of neurons or glia in hippocampus, frontal cortex, or subregions of these structures. Induction of seizures in a rigorous model of human ECT and MST therapy does not cause a change in the number of neurons or glia in potentially vulnerable regions of brain. This study, while limited to young, healthy, adult subjects, provides further evidence that ECT and MST, when appropriately applied, do not cause structural damage to the brain.

Duke Scholars

Published In

Neuroscience

DOI

EISSN

1873-7544

Publication Date

December 29, 2009

Volume

164

Issue

4

Start / End Page

1557 / 1564

Location

United States

Related Subject Headings

  • Neurons
  • Neurology & Neurosurgery
  • Neuroglia
  • Male
  • Magnetic Field Therapy
  • Macaca mulatta
  • Hippocampus
  • Frontal Lobe
  • Female
  • Electroconvulsive Therapy
 

Citation

APA
Chicago
ICMJE
MLA
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Dwork, A. J., Christensen, J. R., Larsen, K. B., Scalia, J., Underwood, M. D., Arango, V., … Lisanby, S. H. (2009). Unaltered neuronal and glial counts in animal models of magnetic seizure therapy and electroconvulsive therapy. Neuroscience, 164(4), 1557–1564. https://doi.org/10.1016/j.neuroscience.2009.09.051
Dwork, A. J., J. R. Christensen, K. B. Larsen, J. Scalia, M. D. Underwood, V. Arango, B. Pakkenberg, and S. H. Lisanby. “Unaltered neuronal and glial counts in animal models of magnetic seizure therapy and electroconvulsive therapy.Neuroscience 164, no. 4 (December 29, 2009): 1557–64. https://doi.org/10.1016/j.neuroscience.2009.09.051.
Dwork AJ, Christensen JR, Larsen KB, Scalia J, Underwood MD, Arango V, et al. Unaltered neuronal and glial counts in animal models of magnetic seizure therapy and electroconvulsive therapy. Neuroscience. 2009 Dec 29;164(4):1557–64.
Dwork, A. J., et al. “Unaltered neuronal and glial counts in animal models of magnetic seizure therapy and electroconvulsive therapy.Neuroscience, vol. 164, no. 4, Dec. 2009, pp. 1557–64. Pubmed, doi:10.1016/j.neuroscience.2009.09.051.
Dwork AJ, Christensen JR, Larsen KB, Scalia J, Underwood MD, Arango V, Pakkenberg B, Lisanby SH. Unaltered neuronal and glial counts in animal models of magnetic seizure therapy and electroconvulsive therapy. Neuroscience. 2009 Dec 29;164(4):1557–1564.
Journal cover image

Published In

Neuroscience

DOI

EISSN

1873-7544

Publication Date

December 29, 2009

Volume

164

Issue

4

Start / End Page

1557 / 1564

Location

United States

Related Subject Headings

  • Neurons
  • Neurology & Neurosurgery
  • Neuroglia
  • Male
  • Magnetic Field Therapy
  • Macaca mulatta
  • Hippocampus
  • Frontal Lobe
  • Female
  • Electroconvulsive Therapy