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A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors.

Publication ,  Journal Article
Mathew, SJ; Shungu, DC; Mao, X; Smith, ELP; Perera, GM; Kegeles, LS; Perera, T; Lisanby, SH; Rosenblum, LA; Gorman, JM; Coplan, JD
Published in: Biol Psychiatry
October 1, 2003

BACKGROUND: Long-term behavioral, immunologic, and neurochemical alterations have been found in primates exposed to adverse early rearing. METHODS: Bonnet macaque (Macaca radiata) mother-infant dyads were exposed to uncertain requirements for food procurement (variable foraging demand, VFD) for a few months. Ten years later, these offspring and age- and gender-matched control subjects were studied using proton magnetic resonance spectroscopic imaging (MRSI). RESULTS: In anterior cingulate, VFD-reared subjects displayed significantly decreased N-acetylaspartate (NAA) resonance and significantly increased glutamate-glutamine-gamma-aminobutyric acid (Glx) resonance relative to the stable neurometabolite creatine (Cr). Across all subjects, NAA/Cr and Glx/Cr ratios in the anterior cingulate were negatively correlated (r = -.638, p =.014). In the medial temporal lobe, the ratio of choline-containing compounds to Cr was significantly increased in VFD subjects. CONCLUSIONS: These findings indicate that adverse early rearing in primates has an enduring impact on adult MRSI measures considered reflective of neuronal integrity and metabolism, membrane structure and glial function, and cerebral glutamate content, and that these alterations occur in the same brain regions implicated in trauma-related psychiatric disorders.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

October 1, 2003

Volume

54

Issue

7

Start / End Page

727 / 735

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Temporal Lobe
  • Stress, Psychological
  • Psychiatry
  • Male
  • Magnetic Resonance Spectroscopy
  • Macaca radiata
  • Gyrus Cinguli
  • Glutamine
  • Glutamic Acid
 

Citation

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MLA
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Mathew, S. J., Shungu, D. C., Mao, X., Smith, E. L. P., Perera, G. M., Kegeles, L. S., … Coplan, J. D. (2003). A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors. Biol Psychiatry, 54(7), 727–735. https://doi.org/10.1016/s0006-3223(03)00004-0
Mathew, Sanjay J., Dikoma C. Shungu, Xiangling Mao, Eric L. P. Smith, Gerald M. Perera, Lawrence S. Kegeles, Tarique Perera, et al. “A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors.Biol Psychiatry 54, no. 7 (October 1, 2003): 727–35. https://doi.org/10.1016/s0006-3223(03)00004-0.
Mathew SJ, Shungu DC, Mao X, Smith ELP, Perera GM, Kegeles LS, et al. A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors. Biol Psychiatry. 2003 Oct 1;54(7):727–35.
Mathew, Sanjay J., et al. “A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors.Biol Psychiatry, vol. 54, no. 7, Oct. 2003, pp. 727–35. Pubmed, doi:10.1016/s0006-3223(03)00004-0.
Mathew SJ, Shungu DC, Mao X, Smith ELP, Perera GM, Kegeles LS, Perera T, Lisanby SH, Rosenblum LA, Gorman JM, Coplan JD. A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors. Biol Psychiatry. 2003 Oct 1;54(7):727–735.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

October 1, 2003

Volume

54

Issue

7

Start / End Page

727 / 735

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Temporal Lobe
  • Stress, Psychological
  • Psychiatry
  • Male
  • Magnetic Resonance Spectroscopy
  • Macaca radiata
  • Gyrus Cinguli
  • Glutamine
  • Glutamic Acid