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Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome.

Publication ,  Journal Article
Mantovani, A; Rossi, S; Bassi, BD; Simpson, HB; Fallon, BA; Lisanby, SH
Published in: Psychiatry Res
December 30, 2013

Low-frequency repetitive transcranial magnetic stimulation (rTMS) to supplementary motor area (SMA) showed clinical benefit in obsessive-compulsive disorder (OCD). Here we tested whether clinical improvement was associated with enhanced cortical inhibition as measured by single and paired-pulse TMS variables. In 18 OCD patients receiving 4 weeks of either active or sham rTMS in a double-blind randomized trial, we assessed bilateral resting and active motor thresholds (RMT and AMT), cortical silent period (CSP), short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF). We tested correlations between changes in Yale-Brown Obsessive Compulsive Scale-Self-report (Y-BOCS-SR), Clinical Global Impression-Severity subscale (CGI-S) and cortical excitability measures. Active rTMS increased right hemisphere RMT whose change correlated with Y-BOCS-SR improvement. Baseline RMT hemispheric asymmetry, defined as the difference between left and right hemispheres RMT, and its normalization after active rTMS correlated with Y-BOCS-SR and CGI-S improvements. Active rTMS also increased right hemisphere SICI whose change correlated with Y-BOCS-SR and CGI-S at week 4, and with normalization of baseline RMT hemispheric asymmetry. Treatment-induced changes in cortical excitability measures are consistent with an inhibitory action of SMA rTMS on dysfunctional motor circuits in OCD. Correlations of neurophysiology measures with therapeutic outcome are supportive of the role of SMA in the modulation of OCD symptoms.

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Published In

Psychiatry Res

DOI

EISSN

1872-7123

Publication Date

December 30, 2013

Volume

210

Issue

3

Start / End Page

1026 / 1032

Location

Ireland

Related Subject Headings

  • Treatment Outcome
  • Transcranial Magnetic Stimulation
  • Psychiatry
  • Obsessive-Compulsive Disorder
  • Neurophysiology
  • Motor Cortex
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Mantovani, A., Rossi, S., Bassi, B. D., Simpson, H. B., Fallon, B. A., & Lisanby, S. H. (2013). Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome. Psychiatry Res, 210(3), 1026–1032. https://doi.org/10.1016/j.psychres.2013.08.054
Mantovani, Antonio, Simone Rossi, Bruce D. Bassi, Helen B. Simpson, Brian A. Fallon, and Sarah H. Lisanby. “Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome.Psychiatry Res 210, no. 3 (December 30, 2013): 1026–32. https://doi.org/10.1016/j.psychres.2013.08.054.
Mantovani A, Rossi S, Bassi BD, Simpson HB, Fallon BA, Lisanby SH. Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome. Psychiatry Res. 2013 Dec 30;210(3):1026–32.
Mantovani, Antonio, et al. “Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome.Psychiatry Res, vol. 210, no. 3, Dec. 2013, pp. 1026–32. Pubmed, doi:10.1016/j.psychres.2013.08.054.
Mantovani A, Rossi S, Bassi BD, Simpson HB, Fallon BA, Lisanby SH. Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome. Psychiatry Res. 2013 Dec 30;210(3):1026–1032.
Journal cover image

Published In

Psychiatry Res

DOI

EISSN

1872-7123

Publication Date

December 30, 2013

Volume

210

Issue

3

Start / End Page

1026 / 1032

Location

Ireland

Related Subject Headings

  • Treatment Outcome
  • Transcranial Magnetic Stimulation
  • Psychiatry
  • Obsessive-Compulsive Disorder
  • Neurophysiology
  • Motor Cortex
  • Middle Aged
  • Male
  • Humans
  • Female