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Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.

Publication ,  Journal Article
Shi, G; Yin, C; Fan, Z; Xing, L; Mostovoy, Y; Kwok, P-Y; Ashbrook, LH; Krystal, AD; Ptáček, LJ; Fu, Y-H
Published in: Curr Biol
January 11, 2021

Sufficient and efficient sleep is crucial for our health. Natural short sleepers can sleep significantly shorter than the average population without a desire for more sleep and without any obvious negative health consequences. In searching for genetic variants underlying the short sleep trait, we found two different mutations in the same gene (metabotropic glutamate receptor 1) from two independent natural short sleep families. In vitro, both of the mutations exhibited loss of function in receptor-mediated signaling. In vivo, the mice carrying the individual mutations both demonstrated short sleep behavior. In brain slices, both of the mutations changed the electrical properties and increased excitatory synaptic transmission. These results highlight the important role of metabotropic glutamate receptor 1 in modulating sleep duration.

Duke Scholars

Published In

Curr Biol

DOI

EISSN

1879-0445

Publication Date

January 11, 2021

Volume

31

Issue

1

Start / End Page

13 / 24.e4

Location

England

Related Subject Headings

  • Time Factors
  • Sleep
  • Receptors, Metabotropic Glutamate
  • Polysomnography
  • Pedigree
  • Patch-Clamp Techniques
  • Neuronal Plasticity
  • Mutation
  • Models, Animal
  • Mice, Transgenic
 

Citation

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Shi, G., Yin, C., Fan, Z., Xing, L., Mostovoy, Y., Kwok, P.-Y., … Fu, Y.-H. (2021). Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait. Curr Biol, 31(1), 13-24.e4. https://doi.org/10.1016/j.cub.2020.09.071
Journal cover image

Published In

Curr Biol

DOI

EISSN

1879-0445

Publication Date

January 11, 2021

Volume

31

Issue

1

Start / End Page

13 / 24.e4

Location

England

Related Subject Headings

  • Time Factors
  • Sleep
  • Receptors, Metabotropic Glutamate
  • Polysomnography
  • Pedigree
  • Patch-Clamp Techniques
  • Neuronal Plasticity
  • Mutation
  • Models, Animal
  • Mice, Transgenic