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Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort.

Publication ,  Journal Article
Xie, G; Myint, PK; Voora, D; Laskowitz, DT; Shi, P; Ren, F; Wang, H; Yang, Y; Huo, Y; Gao, W; Wu, Y
Published in: Atherosclerosis
November 2015

BACKGROUND: Carotid artery intima media thickness (IMT) in human is a marker of subclinical atherosclerosis with high heritability. Many genome-wide association studies (GWAS) were performed in European and American populations, yet discovery efforts have been limited in Asians. OBJECTIVE: To identify the genetic determinants of 10-year progression of IMT using GWA approach in a Chinese cohort. METHODS: Cardiovascular epidemiologic survey was carried out in 810 Chinese adults in 2012. 302,218 single-nucleotide polymorphisms (SNP) in whole genome were genotyped using gene chip and carotid IMT was measured. Most of these participants, had previous carotid IMT measurements in 2002 (n = 572), 2005 (n = 750), 2007 (n = 747), and 2010 (n = 671). General linear model (GLM) and multiple linear mixed-model (MLM) were used to assess the association between SNPs and carotid IMT. RESULTS: The mean age (SD) of the sample was 61.3 (5.1) years; 33.6% were men. The adjusted GLM showed no SNP with significance association at genome-level (all p > 1 × 10(-7)). However, using MLM, after adjusting for age, sex, number of cigarettes smoked per day, systolic blood pressure, use of antihypertensive drugs in the past 2 weeks, serum cholesterol, body mass index, fasting glucose levels, use of insulin or hypoglycemic drugs, time of measuring IMT and its interaction with SNP, we identified two novel SNPs (rs36071027 in EBF1 gene on chromosome 5 and rs975809 close to PCDH15 gene on chromosome 10) that are significantly associated with carotid IMT at genome level (p < 1 × 10(-7)) and seven novel SNPs (rs2230307 in AGL gene on chromosome 1, rs12040273 in GALNT2 gene on chromosome 1, rs4536103 in NEUROG3 gene on chromosome 10, rs9855415 in LOC647323 gene on chromosome 3, rs2472647 in PCDHGA1 gene on chromosome 5, rs17433780 in GBP3 gene on chromosome 1, and rs7625806 in DLEC1 gene on chromosome 3) which are suggestive of significant association (p < 10(-5)). CONCLUSION: The study represents the first GWAS of association between SNPs and carotid IMT in an Asian population. We identified 2 novel loci associated with carotid IMT progression over 10 years.

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Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

November 2015

Volume

243

Issue

1

Start / End Page

30 / 37

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Oligonucleotide Array Sequence Analysis
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Female
 

Citation

APA
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ICMJE
MLA
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Xie, G., Myint, P. K., Voora, D., Laskowitz, D. T., Shi, P., Ren, F., … Wu, Y. (2015). Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort. Atherosclerosis, 243(1), 30–37. https://doi.org/10.1016/j.atherosclerosis.2015.08.034
Xie, Gaoqiang, Phyo Kyaw Myint, Deepak Voora, Daniel T. Laskowitz, Ping Shi, Fuxiu Ren, Hao Wang, et al. “Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort.Atherosclerosis 243, no. 1 (November 2015): 30–37. https://doi.org/10.1016/j.atherosclerosis.2015.08.034.
Xie G, Myint PK, Voora D, Laskowitz DT, Shi P, Ren F, et al. Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort. Atherosclerosis. 2015 Nov;243(1):30–7.
Xie, Gaoqiang, et al. “Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort.Atherosclerosis, vol. 243, no. 1, Nov. 2015, pp. 30–37. Pubmed, doi:10.1016/j.atherosclerosis.2015.08.034.
Xie G, Myint PK, Voora D, Laskowitz DT, Shi P, Ren F, Wang H, Yang Y, Huo Y, Gao W, Wu Y. Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort. Atherosclerosis. 2015 Nov;243(1):30–37.
Journal cover image

Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

November 2015

Volume

243

Issue

1

Start / End Page

30 / 37

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Oligonucleotide Array Sequence Analysis
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Female