PI3K/Akt and apoptosis: size matters.

Published

Journal Article (Review)

Recent research has examined Akt and Akt-related serine-threonine kinases in signaling cascades that regulate cell survival and are important in the pathogenesis of degenerative diseases and in cancer. We seek to recapitulate the research that has helped to define the current understanding of the role of the Akt pathway under normal and pathologic conditions, also in view of genetic models of Akt function. In particular, we will evaluate the mechanisms of Akt regulation and the role of Akt substrates in Akt-dependent biologic responses in the decisions of cell death and cell survival. Here, we hope to establish the mechanisms of apoptosis suppression by Akt kinase as a framework for a more general understanding of growth factor-dependent regulation of cell survival.

Full Text

Duke Authors

Cited Authors

  • Franke, TF; Hornik, CP; Segev, L; Shostak, GA; Sugimoto, C

Published Date

  • December 8, 2003

Published In

Volume / Issue

  • 22 / 56

Start / End Page

  • 8983 - 8998

PubMed ID

  • 14663477

Pubmed Central ID

  • 14663477

International Standard Serial Number (ISSN)

  • 0950-9232

Digital Object Identifier (DOI)

  • 10.1038/sj.onc.1207115

Language

  • eng

Conference Location

  • England