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TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx.

Publication ,  Journal Article
Zhang, C; Sturgis, EM; Zheng, H; Zafereo, ME; Wei, Q; Li, G
Published in: Int J Cancer
October 1, 2014

Functional polymorphisms of tumor necrosis factor-alpha (TNF-α) may play a critical role in the regulation of immune and inflammatory responses and could affect transcriptional levels of the TNF-α gene and thus contribute to carcinogenesis and outcomes of cancer patients. In a cohort study, we explored the associations between TNF-α polymorphisms and risk of recurrence of squamous cell carcinoma of the nonoropharynx (SCCNOP). We used log-rank test and multivariable Cox models to evaluate the associations between TNF-α polymorphisms and risk of recurrence. In overall comparisons, patients with the TNF-α -857 CC, TNF-α -863 CC and TNF-α -1031 TT genotypes had significantly worse disease-free survival (log-rank, p = 0.014, log-rank, p = .020, and log-rank, p = .002, respectively) and higher risk of disease recurrence than patients with the corresponding variant genotypes, respectively (hazard ratio [HR], 1.4, 95% CI, 1.1-1.9, HR, 1.4, 95% CI, 1.0-1.8 and HR, 1.6, 95% CI, 1.2-2.2, respectively). However, no significant association was detected for the TNF-α -308 polymorphism. Moreover, in further stratified analyses based on smoking status and treatment, we found that the associations of the TNF-α -857, TNF-α -863 and TNF-α -1031 polymorphisms with risk of recurrence were more pronounced in smokers and patients treated with chemoradiation. Our findings support a significant role of the TNF-α -857, TNF-α -863 and TNF-α -1031 polymorphisms in recurrence of SCCNOP, especially in smokers and patients treated with chemoradiation. Future prospective studies with larger sample size are needed to confirm these findings.

Duke Scholars

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Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

October 1, 2014

Volume

135

Issue

7

Start / End Page

1615 / 1624

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Survival Rate
  • Risk Factors
  • Promoter Regions, Genetic
  • Prognosis
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
 

Citation

APA
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ICMJE
MLA
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Zhang, C., Sturgis, E. M., Zheng, H., Zafereo, M. E., Wei, Q., & Li, G. (2014). TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx. Int J Cancer, 135(7), 1615–1624. https://doi.org/10.1002/ijc.28793
Zhang, Caiyun, Erich M. Sturgis, Hongliang Zheng, Mark E. Zafereo, Qingyi Wei, and Guojun Li. “TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx.Int J Cancer 135, no. 7 (October 1, 2014): 1615–24. https://doi.org/10.1002/ijc.28793.
Zhang C, Sturgis EM, Zheng H, Zafereo ME, Wei Q, Li G. TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx. Int J Cancer. 2014 Oct 1;135(7):1615–24.
Zhang, Caiyun, et al. “TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx.Int J Cancer, vol. 135, no. 7, Oct. 2014, pp. 1615–24. Pubmed, doi:10.1002/ijc.28793.
Zhang C, Sturgis EM, Zheng H, Zafereo ME, Wei Q, Li G. TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx. Int J Cancer. 2014 Oct 1;135(7):1615–1624.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

October 1, 2014

Volume

135

Issue

7

Start / End Page

1615 / 1624

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Survival Rate
  • Risk Factors
  • Promoter Regions, Genetic
  • Prognosis
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male