Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx.

Publication ,  Journal Article
Zhang, C; Sturgis, EM; Zheng, H; Zafereo, ME; Wei, Q; Li, G
Published in: Int J Cancer
October 1, 2014

Functional polymorphisms of tumor necrosis factor-alpha (TNF-α) may play a critical role in the regulation of immune and inflammatory responses and could affect transcriptional levels of the TNF-α gene and thus contribute to carcinogenesis and outcomes of cancer patients. In a cohort study, we explored the associations between TNF-α polymorphisms and risk of recurrence of squamous cell carcinoma of the nonoropharynx (SCCNOP). We used log-rank test and multivariable Cox models to evaluate the associations between TNF-α polymorphisms and risk of recurrence. In overall comparisons, patients with the TNF-α -857 CC, TNF-α -863 CC and TNF-α -1031 TT genotypes had significantly worse disease-free survival (log-rank, p = 0.014, log-rank, p = .020, and log-rank, p = .002, respectively) and higher risk of disease recurrence than patients with the corresponding variant genotypes, respectively (hazard ratio [HR], 1.4, 95% CI, 1.1-1.9, HR, 1.4, 95% CI, 1.0-1.8 and HR, 1.6, 95% CI, 1.2-2.2, respectively). However, no significant association was detected for the TNF-α -308 polymorphism. Moreover, in further stratified analyses based on smoking status and treatment, we found that the associations of the TNF-α -857, TNF-α -863 and TNF-α -1031 polymorphisms with risk of recurrence were more pronounced in smokers and patients treated with chemoradiation. Our findings support a significant role of the TNF-α -857, TNF-α -863 and TNF-α -1031 polymorphisms in recurrence of SCCNOP, especially in smokers and patients treated with chemoradiation. Future prospective studies with larger sample size are needed to confirm these findings.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

October 1, 2014

Volume

135

Issue

7

Start / End Page

1615 / 1624

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Survival Rate
  • Risk Factors
  • Promoter Regions, Genetic
  • Prognosis
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, C., Sturgis, E. M., Zheng, H., Zafereo, M. E., Wei, Q., & Li, G. (2014). TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx. Int J Cancer, 135(7), 1615–1624. https://doi.org/10.1002/ijc.28793
Zhang, Caiyun, Erich M. Sturgis, Hongliang Zheng, Mark E. Zafereo, Qingyi Wei, and Guojun Li. “TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx.Int J Cancer 135, no. 7 (October 1, 2014): 1615–24. https://doi.org/10.1002/ijc.28793.
Zhang C, Sturgis EM, Zheng H, Zafereo ME, Wei Q, Li G. TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx. Int J Cancer. 2014 Oct 1;135(7):1615–24.
Zhang, Caiyun, et al. “TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx.Int J Cancer, vol. 135, no. 7, Oct. 2014, pp. 1615–24. Pubmed, doi:10.1002/ijc.28793.
Zhang C, Sturgis EM, Zheng H, Zafereo ME, Wei Q, Li G. TNF-α promoter polymorphisms and risk of recurrence in patients with squamous cell carcinomas of the nonoropharynx. Int J Cancer. 2014 Oct 1;135(7):1615–1624.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

October 1, 2014

Volume

135

Issue

7

Start / End Page

1615 / 1624

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Survival Rate
  • Risk Factors
  • Promoter Regions, Genetic
  • Prognosis
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male