The Impact of Worsening Heart Failure in the United States.

Journal Article (Journal Article;Review)

In-hospital worsening heart failure represents a clinical scenario wherein a patient hospitalized for acute heart failure experiences a worsening of their condition, requiring escalation of therapy. Worsening heart failure is associated with worse in-hospital and postdischarge outcomes. Worsening heart failure is increasingly being used as an endpoint or combined endpoint in clinical trials, as it is unique to episodes of acute heart failure and captures an important event during the inpatient course. While prediction models have been developed to identify worsening heart failure, there are no known FDA-approved medications associated with decreased worsening heart failure. Continued study is warranted.

Full Text

Duke Authors

Cited Authors

  • Cooper, LB; DeVore, AD; Michael Felker, G

Published Date

  • October 2015

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 603 - 614

PubMed ID

  • 26462100

Pubmed Central ID

  • 26462100

International Standard Serial Number (ISSN)

  • 1551-7136

Digital Object Identifier (DOI)

  • 10.1016/j.hfc.2015.07.004


  • eng

Conference Location

  • United States